SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 17/MAR/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HYDROCORTISONE 21-ACETATE
Product Number H4126
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HYDROCORTISONE 21-ACETATE 50-03-3 200-004-4 None
Formula C23H32O6
Molecular Weight 404.5 AMU
Synonyms Abbocort * Acetate-AS * Aceto-cort *
21-Acetoxy-11-beta,17-alpha-dihydroxypregn-4-ene-
3,20-dione * Bambicort * Berlison F * Biocortar
* Carmol HC * Chemysone * Collusul-HC * Compound
F acetate * Cortacream * Cortaid * Cortef
acetate * Cortell * Cortes * Corticosterone,
17-hydroxy-, 21-acetate * Cortifoam * Cortisol
acetate * Cortril acetate * Cortril acetate-AS *
11-beta,17-alpha-Dihydroxy-21-acetoxypregesterone
* Epifoam * Eye-Cort * Fernisone * HA *
Hycortole acetate * Hydrin-2 *
17-alpha-Hydroxycorticosterone acetate *
17-alpha-Hydrocorticosterone 21-acetate *
Hydrocortisat * Hydrocortisone acetate *
Hydrocortisone 21-acetate * Hydrocortistab *
Hydrocortone acetate * Hydrosone * Hydroxy
corticosterone acetate *
17-Hydroxycorticosterone acetate *
17-Hydroxycorticosterone-21-acetate * Hysone-A *
Isopto-hydrocortisone * Lanacort * Mysone * NSC
741 * Pabracort * Pregn-4-ene-3,20-dione,
21-(acetoxy)-11,17-dihydroxy-, (11-beta)- *
Pregn-4-ene-3,20-dione,
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Possible risk of harm to the unborn child.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 223 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to light.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GM8960000
ACUTE TOXICITY
LD50
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Intraperitoneal
Mouse
2300 MG/KG
LD50
Subcutaneous
Mouse
45050 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Readily absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.
TARGET ORGAN INFORMATION
Immune system. Pituitary. Adrenal cortex.
CHRONIC EXPOSURE - MUTAGEN
Mouse
60 MG/KG
Intraperitoneal
DNA damage
Mouse
150 MG/KG
Intraperitoneal
Other mutation test systems
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 1500 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rat
Dose: 600 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-14D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Species: Rat
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Dose: 200 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-14D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Mouse
Dose: 125 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Mouse
Dose: 250 MG/KG
Route of Application: Subcutaneous
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Mouse
Dose: 75 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-12D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Mouse
Dose: 84 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-12D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PREG)
Result: Specific Developmental Abnormalities: Eye, ear.
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Intramuscular
Exposure Time: (10-21D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Effects on Newborn: Live birth
index (# fetuses per litter; measured after birth).
Species: Mouse
Dose: 320 MG/KG
Route of Application: Intramuscular
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 200 MG/KG
Route of Application: Parenteral
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
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(including nose and tongue).
Species: Rabbit
Dose: 13 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Central nervous system. Specific Developmental Abnormalities:
Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 2 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (2-5D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 350 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1-7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
Dose: 64 MG/KG
Route of Application: Intramuscular
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Pig
Dose: 100 MG/KG
Route of Application: Intramuscular
Exposure Time: (12D PRE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
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Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 63
Possible risk of harm to the unborn child.
S-PHRASES: 36/37
Wear suitable protective clothing and gloves.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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