SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/OCT/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HISTAMINE FREE BASE CRYSTALLINE
Product Number H7125
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HISTAMINE BASE 51-45-6 200-100-6 None
Formula C5H9N3
Molecular Weight 111.15 AMU
Synonyms beta-Aminoethylglyoxaline *
beta-Aminoethylimidazole * Eramin * Ergamine *
Ergotidine * Ethylamine, 2-imidazol-4-yl- * Free
histamine * Imidazole, 4-(2-aminoethyl)- *
1H-Imidazole-4-ethanamine *
Imidazole-4-ethylamine * 4-Imidazoleethylamine *
5-Imidazoleethylamine *
beta-Imidazolyl-4-ethylamine *
2-(4-Imidazolyl)ethylamine * Istamina (Italian)
* Theramine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin. May cause sensitization by inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing dust. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at -20掳C
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
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Appearance Color: Light yellow
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 167 掳C 0.8 mmHg
MP/MP Range 79 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides Carbon monoxide,
Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MS1050000
ACUTE TOXICITY
LD50
Intravenous
Rat
630 MG/KG
Remarks: Lungs, Thorax, or Respiration:Other changes. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Oral
Mouse
220 mg/kg
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LD50
Intraperitoneal
Mouse
725 MG/KG
LD50
Subcutaneous
Mouse
2500 MG/KG
Remarks: Behavioral:Ataxia. Behavioral:Convulsions or effect on
seizure threshold. Lungs, Thorax, or Respiration:Other changes.
LD50
Intravenous
Mouse
385 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Other changes.
LD50
Intravenous
Dog
7 MG/KG
Remarks: Cardiac:Other changes.
LD50
Intraperitoneal
Guinea pig
5 MG/KG
LD50
Intravenous
Guinea pig
180 UG/KG
SENSITIZATION
Respiratory: May cause allergic respiratory reaction.
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Smooth muscle. Heart.
CHRONIC EXPOSURE - MUTAGEN
Human
2 UMOL/L
Cell Type: Other cell types
DNA inhibition
Mouse
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200 MG/L
Cell Type: Embryo
Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 200 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22-36/37/38-42/43
Harmful if swallowed. Irritating to eyes, respiratory system
and skin. May cause sensitization by inhalation and skin
contact.
S-PHRASES: 22-26-36/37
Do not breathe dust. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing and gloves.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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