SIGMA-ALDRICH



                         Material Safety Data Sheet



                                                 Date Printed: 08/DEC/2005

                                                 Date Updated: 14/MAR/2004

                                                               Version 1.2

                                                   According to 91/155/EEC



Classified as Hazardous according to the criteria of EU Annex 1 and

NOHSC.



1 - Product and Company Information



Product Name                   5-HYDROXYTRYPTAMINE HYDROCHLORIDE

Product Number                 H9523



Company                        Sigma-Aldrich Pty. Ltd.

                               12 Anella Avenue

                               Castle Hill NSW 2154

                               Australia

Technical Phone #              +61 2 9841 0555 (1800 800 097)

Fax                            +61 2 9841 0500 (1800 800 096)

Emergency Phone #              +44 8701906777 (1800 448 465)



2 - Composition/Information on Ingredients



Product Name                          CAS #       EC no      Annex I

                                                             Index Number

5-HYDROXYTRYPTAMINE HYDROCHLORIDE     153-98-0    None       None



Formula             C10H12N2O · HCl

Molecular Weight    212.68 AMU



3 - Hazards Identification



SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT

   Harmful by inhalation, in contact with skin and if swallowed.

   Irritating to eyes, respiratory system and skin.





4 - First Aid Measures



AFTER INHALATION

   If inhaled, remove to fresh air. If not breathing give

   artificial respiration. If breathing is difficult, give oxygen.



AFTER SKIN CONTACT

   In case of skin contact, flush with copious amounts of water for

   at least 15 minutes. Remove contaminated clothing and shoes.

   Call a physician.



AFTER EYE CONTACT

   In case of contact with eyes, flush with copious amounts of

   water for at least 15 minutes. Assure adequate flushing by

   separating the eyelids with fingers. Call a physician.



AFTER INGESTION

   If swallowed, wash out mouth with water provided person is

   conscious. Call a physician.



5 - Fire Fighting Measures

EXTINGUISHING MEDIA

   Suitable: Water spray. Carbon dioxide, dry chemical powder, or

   appropriate foam.



SPECIAL RISKS

   Specific Hazard(s): Emits toxic fumes under fire conditions.



SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS

   Wear self-contained breathing apparatus and protective clothing

   to prevent contact with skin and eyes.



6 - Accidental Release Measures



PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL

   Evacuate area.



PROCEDURE(S) OF PERSONAL PRECAUTION(S)

   Wear respirator, chemical safety goggles, rubber boots, and

   heavy rubber gloves.



METHODS FOR CLEANING UP

   Sweep up, place in a bag and hold for waste disposal. Avoid

   raising dust. Ventilate area and wash spill site after material

   pickup is complete.



7 - Handling and Storage



HANDLING

   Directions for Safe Handling: Do not breathe dust. Avoid contact

   with eyes, skin, and clothing. Avoid prolonged or repeated

   exposure.



STORAGE

   Conditions of Storage: Keep tightly closed.

   Store at 2-8°C



SPECIAL REQUIREMENTS: Light sensitive.



8 - Exposure Controls / Personal Protection



ENGINEERING CONTROLS

   Safety shower and eye bath. Mechanical exhaust required.



GENERAL HYGIENE MEASURES

   Wash thoroughly after handling.



PERSONAL PROTECTIVE EQUIPMENT

   Respiratory Protection: Government approved respirator.

   Hand Protection: Compatible chemical-resistant gloves.

   Eye Protection: Chemical safety goggles.



9 - Physical and Chemical Properties



Appearance              Physical State: Solid

                        Color: Faintly grey

                        Form: Powder



Property                Value                 At Temperature or Pressure



pH                      N/A

BP/BP Range             N/A





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MP/MP Range             167 °C

Flash Point             N/A

Flammability            N/A

Autoignition Temp       N/A

Oxidizing Properties    N/A

Explosive Properties    N/A

Explosion Limits        N/A

Vapor Pressure          N/A

SG/Density              N/A

Partition Coefficient   N/A

Viscosity               N/A

Vapor Density           N/A

Saturated Vapor Conc.   N/A

Evaporation Rate        N/A

Bulk Density            N/A

Decomposition Temp.     N/A

Solvent Content         N/A

Water Content           <5%

Surface Tension         N/A

Conductivity            N/A

Miscellaneous Data      N/A

Solubility              N/A



10 - Stability and Reactivity



STABILITY

   Stable: Stable.

   Conditions to Avoid: Light.

   Materials to Avoid: Strong oxidizing agents.



HAZARDOUS DECOMPOSITION PRODUCTS

   Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,

   Nitrogen oxides, Hydrogen chloride gas.



HAZARDOUS POLYMERIZATION

   Hazardous Polymerization: Will not occur



11 - Toxicological Information



SIGNS AND SYMPTOMS OF EXPOSURE

   Can cause CNS depression. Exposure can cause: Nausea, headache,

   and vomiting. Narcotic effect. Damage to the heart.



ROUTE OF EXPOSURE

   Skin Contact: Causes skin irritation.

   Skin Absorption: Harmful if absorbed through skin.

   Eye Contact: Causes eye irritation.

   Inhalation: Harmful if inhaled. Material is irritating to mucous

   membranes and upper respiratory tract.

   Ingestion: Harmful if swallowed.



TARGET ORGAN INFORMATION

   Damage to the heart. Liver. Endocrine system. Nerves. Smooth

   muscle. Vascular system.



CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

   Result: Overexposure may cause reproductive disorder(s) based on

   tests with laboratory animals.



12 - Ecological Information



No data available.





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13 - Disposal Considerations



SUBSTANCE DISPOSAL

   Contact a licensed professional waste disposal service to dispose

   of this material. Dissolve or mix the material with a combustible

   solvent and burn in a chemical incinerator equipped with an

   afterburner and scrubber. Observe all federal, state, and local

   environmental regulations.



14 - Transport Information



RID/ADR

   Non-hazardous for road transport.



IMDG

   Non-hazardous for sea transport.



IATA

   Non-hazardous for air transport.



15 - Regulatory Information



CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES

   INDICATION OF DANGER: Xn

     Harmful.

   R-PHRASES: 20/21/22-36/37/38

     Harmful by inhalation, in contact with skin and if swallowed.

     Irritating to eyes, respiratory system and skin.

   S-PHRASES: 22-26-36

     Do not breathe dust. In case of contact with eyes, rinse

     immediately with plenty of water and seek medical advice. Wear

     suitable protective clothing.



COUNTRY SPECIFIC INFORMATION



Germany

   WGK: 3



16 - Other Information



WARRANTY

   The above information is believed to be correct but does not

   purport to be all inclusive and shall be used only as a guide. The

   information in this document is based on the present state of our

   knowledge and is applicable to the product with regard to

   appropriate safety precautions. It does not represent any

   guarantee of the properties of the product. Sigma-Aldrich Inc.,

   shall not be held liable for any damage resulting from handling or

   from contact with the above product. See reverse side of invoice

   or packing slip for additional terms and conditions of sale.

   Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited

   paper copies for internal use only.



DISCLAIMER

   For R&D use only. Not for drug, household or other uses.









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