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Biomolecules for research                             MATERIAL SAFETY DATA SHEET









Section 1 : Substance Identification



                Streptozocin

      Name:                                                            CAS Number:       18883-66-4



      Catalog Number: EI-138                                           Chemical Formula:       C8H15N3O7



      Synonyms: U-9889                                                 Chemical Class:     Carbohydrate,

                                                                                           Antibiotic



      Company Identification:      BIOMOL International L.P.

                                  5120 Butler Pike.

                                  Plymouth Meeting PA 19462-1202 USA

                                  (610)941-0430 (9am-5pm ET)









Section 2 : Health Hazard Data



      Acute Health Effects: Exposure may cause nausea, vomiting and alterations in liver functions.

      Chronic Health Effects: This compound is toxic to the kidneys. This toxicity is dose related,

      cumulative, and can be severe or fatal. Streptozocin may effect glucose metabolism. A diabetic

      effect has been observed. Effects of the blood are rare, but some toxicity has been observed. This

      product is an irritant to tissues and may lead to local ulceration and necrosis. This product has

      been shown in animal studies to be mutagenic, carcinogenic, and teratogenic.









Section 3 : First Aid Measures

      Eye Contact: Check for and remove contact lenses. DO NOT use eye ointment. Flush eyes with

              running water for at least 15 minutes separating eyelids. Seek medical attention

      Skin Contact: Wash with soap and water for 15 minutes.

      Inhalation: Remove victim to fresh air. If breathing is difficult, administer oxygen. If breathing stops,

              administer artificial respiration. Seek medical attention immediately. Provide chemical label and

              MSDS if possible.

      Ingestion: Remove dentures and clear mouth. Call physician or poison control immediately. Provide

      chemical label and MSDS information if possible.

Section 4 : Fire and Explosion Data



     Flammability: Flammable

     Flash Point: Not Available

     Combustion Products: Toxic carbon oxides (CO, CO2) and nitrogen oxides (NO, NO2)

     Extinguishing Media: Carbon Dioxide, Dry chemical powder, Water

     Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to

             prevent contact with skin and eyes.

     Unusual Fire/Explosion Hazards: As with all finely divided organic powders, it is advisable to

             eliminate explosion hazards with methods such as grounding mechanical equipment to prevent

             static charge, inerting the atmosphere, or controlling dust levels.









Section 5 : Spill or Leak Procedures



     Cleanup Procedures: Rinse spills down the drain with water

     Waste Disposal Method: Rinse waste water down the drain. Degradation by strong alkali is very rapid

           but generates diazomethane, which is toxic.









Section 6 : Storage and Handling Precautions



     Protective Equipment: For spill clean up, goggles, lab coat, gloves and an MSHA/NIOSH

             approved respirator should be worn to avoid contact.

     Storage and Handling: Avoid generating dust. Avoid contact with skin eyes and clothing. Wash

             thoroughly after handling. Launder exposed clothing before reuse. Store at below 4°C,

             Hazardous decomposition may occur if product is stored at room temperature. Protect from light.









Section 7 : Physical Data



     Appearance: Ivory or Tan Crystalline Powder                    Odor: Not Available

     Molecular Weight: 265.22                                       Taste: Not Available

     Boiling Point: Not Available                                   Melting Point: 115°C (decomposes)

     Solubility: Alcohols or Ketones or Water                       Vapor Density: Negligible

     Specific Gravity: Not Available                                Vapor Pressure: Negligible

     Volatility: Negligible









Section 8 : Stability and Reactivity Data



     Stability: This material is stable if stored as directed Store below 4°C!

     Conditions to Avoid: Exposure to light

     Incompatibles: None known

         Hazardous Polymerization: This product is characterized by a strong exotherm beginning at 108°C.

               The gas which is evolved accounts for approximately 38% of the sample. The heat given off

               during thermal decomposition indicates that the product should be stored at temperatures no

               higher then 4°C since the first trace of decomposition would quickly raise the temperature of the

               material resulting in "runaway" decomposition.









Section 9 : Toxicity Data



         RTECS#:

         Oral LD50:         Rat : 5150mh/kg                                 Mouse : 310mg/kg

         S.C. LD50:        Mouse : 335mg/kg

         I.P. LD50:        Mouse : 219mg/kg

         I.V. LD50:        Mouse : 274.8mg/kg                               Rat : 108-176mg/kg

                           Dog : 25-50 mg/kg









Section 10 : Ecological Data



         Exotoxicological Information:            Not available









The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of

safe use of this material rests entirely with the user.





Emergency Contact:



BIOMOL International L.P.

5120 Butler Pike

Plymouth Meeting, PA 19462 USA



(610) 941-0430







Last Revised : 9/17/97