SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/26/2007
Date Updated: 02/05/2006
Version 1.6
Section 1 - Product and Company Information
Product Name BUTYL ACETATE, >=99.5%, A.C.S. REAGENT
Product Number 402842
Brand SIAL
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
BUTYL ACETATE 123-86-4 No
Formula C6H12O2
Synonyms Acetate de butyle (French) * Acetic acid n-butyl
ester * Butile (acetati di) (Italian) *
Butylacetat (German) * Butyl acetate (OSHA) *
n-Butyl acetate (ACGIH:OSHA) * 1-Butyl acetate *
Butylacetaten (Dutch) * Butyle (acetate de)
(French) * Butylester kyseliny octove (Czech) *
Butyl ethanoate * Octan n-butylu (Polish)
RTECS Number: AF7350000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable. Toxic.
Toxic by inhalation. Irritating to respiratory system and skin.
Risk of serious damage to eyes.
Target organ(s): Central nervous system.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
Forms explosive mixtures in air.
FLASH POINT
74 癋 23 癈 Method: closed cup
EXPLOSION LIMITS
Lower: 1.7 % Upper: 7.6 %
AUTOIGNITION TEMP
421 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back. Flammable liquid. Emits toxic
fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Evacuate area
and keep personnel upwind.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
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rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses. Avoid
contaminating sewers and waterways with this material.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood. Mechanical exhaust. Ground all equipment,
vessels, tables, and other metallic objects that may come into
contact with the product.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 200 PPM
USA ACGIH TWA 150 PPM
USA MSHA Standard-air TWA 150 PPM (700 MG/M3)
USA OSHA. PEL 8H TWA 150 PPM (710 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 150 PPM
STEL 200 PPM
EXPOSURE LIMITS
Country Source Type Value
USA ACGIH TWA STEL 150,200 ppm
USA OSHA. TWA STEL 150,200 ppm
USA NIOSH 10,000 ppm
USA NIOSH IDLH-1990
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1,700 ppm
Poland NDSCh IDLH-1994
Poland NDS 950 MG/M3
Poland NDSP 200 MG/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 116.16 AMU
pH N/A
BP/BP Range 126.0 - 127.0 癈
MP/MP Range - 78.0 癈
Freezing Point - 78.0 癈
Vapor Pressure 8 mmHg 20 癈
Vapor Density 4 g/l
Saturated Vapor Conc. N/A
SG/Density 0.881 g/cm3
Bulk Density N/A
Odor Threshold 7.0 - 20.0 ppm
Volatile% N/A
VOC Content N/A
Water Content < 0.1 %
Solvent Content N/A
Evaporation Rate 1
Viscosity 0.732 Pas 20 癈
Surface Tension 14.5 mN/m 25 癈
Partition Coefficient Log Kow: 1.82
Decomposition Temp. N/A
Flash Point 74 癋 23 癈 Method: closed cup
Explosion Limits Lower: 1.7 %
Upper: 7.6 %
Flammability N/A
Autoignition Temp 421 癈
Refractive Index 1.394
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Other Solvents: ACETONE, ETHER,
PROPYLENGLYCOL
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong reducing
agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
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Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Drowsiness. Exposure can cause:
TOXICITY DATA
Oral
Rat
*
LD50
4 HRS
Inhalation
Rat
9.6 MG/L TO >29.2 MG/L
LC50
Skin
Rabbit
17,600 mg/kg
LD50
Oral
Rat
10768 mg/kg
LD50
Remarks: Liver:Other changes. Lungs, Thorax, or
Respiration:Other changes. Behavioral:Somnolence (general
depressed activity).
Inhalation
Rat
390 ppm
LC50
Remarks: Blood: Hemorrhage. Lungs, Thorax, or Respiration:Acute
pulmonary edema. Behavioral:Change in motor activity (specific
assay).
Oral
Mouse
6000 mg/kg
LD50
Inhalation
Mouse
6,000 mg/m3
LC50
Intraperitoneal
Mouse
1230 MG/KG
LD50
Oral
Rabbit
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3200 mg/kg
LD50
Skin
Rabbit
> 17600 mg/kg
LD50
Oral
Guinea pig
4700 mg/kg
LD50
Oral
Mammal
4300 mg/kg
LD50
Inhalation
Mammal
40,000 mg/m3
LC50
IRRITATION DATA
Eyes
Rabbit
Remarks: Moderate irritation effect
Eyes
Human
300 ppm
Skin
Rabbit
500 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1500 PPM/7H
Route of Application: Inhalation
Exposure Time: (7-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
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Test Type: EC50 Algae
Time: 24 h
Value: 1,200 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 72.8 - 205.0 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 100 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 64.0 - 121.0 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 17.0 - 19.0 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Butyl acetates
UN#: 1123
Class: 3
Packing Group: Packing Group III
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Butyl acetates
IATA UN Number: 1123
Hazard Class: 3
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
R: 10-66-67
Risk Statements: Flammable. Repeated exposure may cause skin
dryness or cracking. Vapors may cause drowsiness and dizziness.
S: 25
Safety Statements: Avoid contact with eyes.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable. Toxic.
Risk Statements: Toxic by inhalation. Irritating to respiratory
system and skin. Risk of serious damage to eyes.
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Safety Statements: Keep away from sources of ignition - no
smoking. Take precautionary measures against static discharges.
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective clothing.
US Statements: Target organ(s): Central nervous system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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