Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 1 of 5
1. IDENTIFICATION OF SUBSTANCE
Name: MAGNESIUM SULFATE INJECTION 10%
Manufacturer: Department of Pharmacy
Duke University Medical Center
Box 3089
Durham, NC 27710
919-684-5125
Information Department: Occupational and Environmental Safety Office
Duke University Medical Center
Box 3914
Durham, NC 27710
919-684-5996
Emergency Information:
Regional Poison Control Center
800-848-6946
2. COMPOSITION/INFORMATION ON INGREDIENTS
Chemical Characterization/Description: Magnesium sulfate solution
Synonym(s): Epsom salts
Dangerous Components (CAS#, Hazardous Chemical, Percent):
7487-88-9 Magnesium sulfate 10%
108-95-2 Phenol <1%
7732-18-5 Water and saline Balance
3. HAZARDS IDENTIFICATION
Hazard Description:
Magnesium sulfate is moderately toxic by ingestion, intraperitoneal, and
subcutaneous routes. (Hazard description based on concentrated constituents; this
product is an aqueous solution.)
NFPA Ratings (scale 0-4):
1
Health
0
Fire:
0
Reactivity:
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 2 of 5
TRADE NAME: MAGNESIUM SULFATE INJECTION 10%
4. FIRST AID MEASURES
Inhalation:
Remove victim to fresh air. Give oxygen or artificial respiration if necessary.
Skin Contact:
IMMEDIATELY flood affected skin with water while removing and isolating all
contaminated clothing. Gently wash all affected skin areas thoroughly with soap
and water. Seek medical attention if warranted.
Eye Contact:
First check the victim for contact lenses and remove if present. Flush victim's
eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center. Do not put any
ointments, oils, or medication in the victim's eyes without specific instructions
from a physician. IMMEDIATELY transport the victim after flushing eyes to a
hospital even if no symptoms (such as redness or irritation) develop.
Ingestion:
DO NOT INDUCE VOMITING. Magnesium sulfate can cause excessive bowel
movement if swallowed.
If the victim is conscious and not convulsing, rinse out the mouth with water. Give
1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital
or poison control center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure
that the victim's airway is open, and lay the victim on his/her side with the head
lower than the body. Transport the victim IMMEDIATELY to a hospital.
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 3 of 5
TRADE NAME: MAGNESIUM SULFATE INJECTION 10%
5. FIRE-FIGHTING MEASURES
Suitable Extinguishing Agents:
Use appropriate extinguishing media for surrounding fire.
Protective Equipment:
Self-contained breathing apparatus and protective equipment for fire fighting.
6. ACCIDENTAL RELEASE MEASURES
Personnel Precautions:
Wear gloves (disposable surgical) and eye protection (chemical splash goggles).
Environmental Precautions:
None necessary under normal conditions of use.
Measures for Cleaning/Collection:
Use absorbent paper to pick up all liquid spill material. Seal the absorbent paper,
as well as contaminated clothing, in a vapor-tight plastic bag for eventual
disposal. Wash all contaminated surfaces with a soap and water solution.
7. HANDLING AND STORAGE
Handling:
Wear PPE when handling this material. Wash hands after handling.
Storage:
Store in a cool, dry, well-ventilated location.
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 4 of 5
TRADE NAME: MAGNESIUM SULFATE INJECTION 10%
8. EXPOSURE CONTROLS AND PERSONAL PROTECTION
Engineering Controls:
None necessary under conditions of normal use.
Control Parameters:
Chemical Limit Reference
Magnesium sulfate N/A N/A
Phenol 5 ppm (skin) ACGIH TLV-TWA
Personal Protective Equipment:
Respiratory Protection
None necessary under conditions of normal use.
Skin Protection
Wear disposable surgical gloves when using this chemical. If this chemical
comes into contact with your gloves, or if a tear/puncture develops, remove
gloves at once and wash hands.
Eye Protection
Splash-proof safety goggles should be worn while handling this chemical.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid Color and Odor: Colorless, odorless
pH: 5-7 Boiling/Freezing Points (癈):
Approx. same as water.
Flashpoint (癈): N/A Autoignition Temperature (癈): N/A
Explosion Properties: N/A
Vapor Pressure (mm Hg): N/A Vapor Density (air = 1): N/A
Specific Gravity (water = 1): Solubility: Soluble in water (aqueous
Approx. same as water. solution).
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 5 of 5
TRADE NAME: MAGNESIUM SULFATE INJECTION 10%
10. STABILITY AND REACTIVITY
General: This product is stable.
Materials to Avoid: A potentially explosive reaction may occur when magnesium
sulfate is heated with ethoxyethynyl alcohols.
Hazardous Decomposition Products. When heated to decomposition, product
may emit toxic fumes of SOx .
11. TOXICOLOGICAL INFORMATION
Acute Toxicity: Magnesium sulfate is moderately toxic by ingestion,
intraperitoneal, and subcutaneous routes. The oral TD Lo for magnesium sulfate is
428 mg/kg (human).
Signs/Symptoms of Overexposure: Magnesium sulfate can cause excessive
bowel movement if swallowed.
Chronic Toxicity: This product is not considered a carcinogen by NTP, IARC or
OSHA. Magnesium sulfate is an experimental teratogen.
12. ECOLOGICAL EFFECTS
None anticipated under normal conditions of use.
13. DISPOSAL CONSIDERATIONS
Dispose of all waste and contaminated materials associated with this chemical as
specified by existing local, state and federal regulations concerning hazardous
waste disposal. Contact the Occupational and Environmental Safety Office for
specific guidance.
14. TRANSPORT INFORMATION
Proper shipping name (DOT): Not regulated by this mode of transportation.
15. REGULATORY INFORMATION
Magnesium sulfate is reported in EPA TSCA Inventory.
16. OTHER INFORMATION
This information is based on our present knowledge; however this shall not
constitute a guarantee for any specific product features. No toxicity data are
available on this specific formulation; this health hazard assessment is based on
information that is available for its components.
Printed on 05/03/00 Reviewed on 05/03/00
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