MATERIAL SAFETY DATA SHEET



1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION



VENTANA MEDICAL SYSTEMS INC.                   EMERGENCY TELEPHONE NUMBER:

1910 E. Innovation Park Drive                  (800) 424-9300 (USA/Canada)

Tucson, Arizona 85755                          (CHEMTREC)

(520) 887-2155                                 +1 (703) 527-3887 (International)



MSDS NUMBER: 00232464



SUBSTANCE: Symphony N2+



PRODUCT NUMBER(S): 900-213



PRODUCT USE: clinical/research



CREATION DATE: Feb 09 2007

REVISION DATE: Mar 05 2009





2. HAZARDS IDENTIFICATION



NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=0 REACTIVITY=0



EC CLASSIFICATION:

Xn   Harmful



RISK PHRASES:

 R 22 Harmful if swallowed.



EMERGENCY OVERVIEW:

COLOR: red or purple

PHYSICAL FORM: liquid

ODOR: odorless

MAJOR HEALTH HAZARDS: harmful if swallowed, respiratory tract irritation, skin irritation, eye

irritation, central nervous system depression, nerve damage, kidney damage



POTENTIAL HEALTH EFFECTS:

INHALATION:

SHORT TERM EXPOSURE: irritation, headache, drowsiness, dizziness, loss of coordination

LONG TERM EXPOSURE: irritation, wheezing, headache, lung damage

SKIN CONTACT:

SHORT TERM EXPOSURE: irritation, allergic reactions, absorption may occur, nausea, vomiting,

stomach pain, difficulty breathing, headache, drowsiness, dizziness, disorientation, hyperactivity, emotional

disturbances, hallucinations, tremors, loss of coordination, visual disturbances, lung congestion, heart

damage, kidney damage, liver damage, nerve damage, brain damage, convulsions, coma

LONG TERM EXPOSURE: irritation, allergic reactions

EYE CONTACT:

SHORT TERM EXPOSURE: irritation

LONG TERM EXPOSURE: irritation

INGESTION:

SHORT TERM EXPOSURE: irritation, nausea, vomiting, digestive disorders, stomach pain, difficulty

breathing, headache, drowsiness, dizziness, disorientation, hyperactivity, emotional disturbances,

hallucinations, tremors, loss of coordination, visual disturbances, lung congestion, heart damage, kidney

damage, liver damage, nerve damage, brain damage, convulsions, coma

LONG TERM EXPOSURE: irritation, kidney damage





3. COMPOSITION, INFORMATION ON INGREDIENTS



COMPONENT: NON-HAZARDOUS

CAS NUMBER: Not assigned.

EC NUMBER: Not assigned.

PERCENTAGE: 60-100

EC CLASSIFICATION: No classification assigned.



COMPONENT: ETHYLENE GLYCOL

CAS NUMBER: 107-21-1

EC NUMBER (EINECS): 203-473-3

PERCENTAGE: 15-40

EC CLASSIFICATION: Xn

RISK PHRASES: 22



COMPONENT: ALUMINUM SULFATE, OCTADECAHYDRATE

CAS NUMBER: 7784-31-8

EC NUMBER: Not assigned.

PERCENTAGE: 1-5

EC CLASSIFICATION: Xn

RISK PHRASES: 22-36-37-38



COMPONENT: PROPRIETARY COMPONENT

CAS NUMBER: Proprietary

EC NUMBER: Not assigned.

PERCENTAGE: <1

EC CLASSIFICATION: Xn; Xi; Sensitizing; N; Carcinogen Category 3; Mutagen Category 3

RISK PHRASES: 22-40-41-43-50-68



COMPONENT: SODIUM IODATE

CAS NUMBER: 7681-55-2

EC NUMBER (EINECS): 231-672-5

PERCENTAGE: <1

EC CLASSIFICATION: O; Xn

RISK PHRASES: 8-22-36-37-38





4. FIRST AID MEASURES



INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not

breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate

medical attention.



SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated

clothing before reuse. Get medical attention, if needed.



EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical

attention.



INGESTION: If swallowed, get medical attention.



NOTE TO PHYSICIAN: For inhalation, consider oxygen.





5. FIRE FIGHTING MEASURES



FIRE AND EXPLOSION HAZARDS: Negligible fire hazard.



EXTINGUISHING MEDIA: Use extinguishing agents appropriate for surrounding fire.



FIRE FIGHTING: Move container from fire area if it can be done without risk. Avoid inhalation of

material or combustion by-products.



SENSITIVITY TO MECHANICAL IMPACT: Not sensitive



SENSITIVITY TO STATIC DISCHARGE: Not sensitive



FLASH POINT: not flammable



HAZARDOUS COMBUSTION PRODUCTS:

Thermal decomposition or combustion products: oxides of carbon





6. ACCIDENTAL RELEASE MEASURES



OCCUPATIONAL RELEASE:

Stop leak if possible without personal risk. Small spills: Absorb with sand or other non-combustible material.

Collect spilled material in appropriate container for disposal.





7. HANDLING AND STORAGE

STORAGE: Store and handle in accordance with all current regulations and standards. Avoid direct sunlight.

Store in a well-ventilated area. Store at room temperature. See original container for storage

recommendations. Keep separated from incompatible substances.





8. EXPOSURE CONTROLS, PERSONAL PROTECTION



EXPOSURE LIMITS:

Symphony N2+:

No occupational exposure limits established.



VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits.



EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact.

Provide an emergency eye wash fountain and quick drench shower in the immediate work area.



CLOTHING: Lab coat or apron.



GLOVES: Wear appropriate chemical resistant gloves.



PROTECTIVE MATERIAL TYPES: latex, vinyl



RESPIRATOR: No respirator is required under normal conditions of use.





9. PHYSICAL AND CHEMICAL PROPERTIES



PHYSICAL STATE: liquid

COLOR: red or purple

ODOR: odorless

BOILING POINT: Not available

FREEZING POINT: Not available

VAPOR PRESSURE: Not available

VAPOR DENSITY: Not available

SPECIFIC GRAVITY: Not available

WATER SOLUBILITY: miscible

PH: acidic

VOLATILITY: Not available

ODOR THRESHOLD: Not available

EVAPORATION RATE: Not available

COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available





10. STABILITY AND REACTIVITY



REACTIVITY: Stable at normal temperatures and pressure.



CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition. Avoid contact with

incompatible materials.



INCOMPATIBILITIES: oxidizing materials, acids, alkalis

HAZARDOUS DECOMPOSITION:

Thermal decomposition or combustion products: oxides of carbon



POLYMERIZATION: Will not polymerize.





11. TOXICOLOGICAL INFORMATION



ETHYLENE GLYCOL:

IRRITATION DATA: 0.012 percent/3 day(s) eyes-rat; 555 mg open skin-rabbit mild; 500 mg/24 hour(s)

eyes-rabbit mild; 100 mg/1 hour(s) eyes-rabbit mild; 0.012 ppm/3 day(s) eyes-rabbit; 1440 mg/6 hour(s)

eyes-rabbit moderate

TOXICITY DATA: 9530 ul/kg skin-rabbit LD50; 4700 mg/kg oral-rat LD50

CARCINOGEN STATUS: ACGIH: A4 -Not Classifiable as a Human Carcinogen

LOCAL EFFECTS:

Irritant: inhalation, skin, eye

ACUTE TOXICITY LEVEL:

Moderately Toxic: ingestion

Slightly Toxic: dermal absorption

TARGET ORGANS: nervous system, kidneys



ALUMINUM SULFATE, OCTADECAHYDRATE:

TOXICITY DATA: 370 mg/kg oral-rat LD50

LOCAL EFFECTS:

Irritant: inhalation, skin, eye

ACUTE TOXICITY LEVEL:

Toxic: ingestion





12. ECOLOGICAL INFORMATION



OTHER ECOLOGICAL INFORMATION: The following data are from studies using 100% ethylene glycol.



ETHYLENE GLYCOL:

FISH TOXICITY: >10000000 ug/L 96 hour(s) LC50 (Mortality) Fathead minnow (Pimephales promelas)



INVERTEBRATE TOXICITY: >100000 ug/L 48 hour(s) LC50 (Mortality) Common shrimp (Crangon

crangon)



ALGAL TOXICITY: 112000 ug/L 48 hour(s) (Population Growth) Cryptomonad (Chilomonas paramecium)



OTHER TOXICITY: 326000 ug/L 48 hour(s) LC50 (Mortality) Clawed toad (Xenopus laevis)





13. DISPOSAL CONSIDERATIONS



Dispose in accordance with all applicable regulations.

14. TRANSPORT INFORMATION



U.S. DEPARTMENT OF TRANSPORTATION: Not regulated.



CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated.



LAND TRANSPORT ADR: Not regulated.



LAND TRANSPORT RID: Not regulated.



AIR TRANSPORT IATA: Not regulated.



AIR TRANSPORT ICAO: Not regulated.



MARITIME TRANSPORT IMDG: Not regulated.





15. REGULATORY INFORMATION



U.S. REGULATIONS:

CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4):

ETHYLENE GLYCOL: 5000 LBS RQ

ALUMINUM SULFATE: 5000 LBS RQ



SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart

B): Not regulated.



SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart

C): Not regulated.



SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B

and C):

ACUTE: Yes

CHRONIC: Yes

FIRE: No

REACTIVE: No

SUDDEN RELEASE: No



SARA TITLE III SECTION 313 (40 CFR 372.65):

ETHYLENE GLYCOL



STATE REGULATIONS:

California Proposition 65: Not regulated.



CANADIAN REGULATIONS:

WHMIS CLASSIFICATION: D2A, D2B.



EUROPEAN REGULATIONS:

EC CLASSIFICATION (CALCULATED):

Xn      Harmful



DANGER/HAZARD SYMBOL:









EC RISK AND SAFETY PHRASES:

 R 22 Harmful if swallowed.

 S 60    This material and its container must be disposed of as hazardous waste.





16. OTHER INFORMATION



EC RISK PHRASES:

 R8    Contact with combustible material may cause fire.

 R 22    Harmful if swallowed.

 R 36    Irritating to eyes.

 R 37    Irritating to respiratory system.

 R 38    Irritating to skin.

 R 40    Limited evidence of a carcinogenic effect.

 R 41    Risk of serious damage to eyes.

 R 43    May cause sensitization by skin contact.

 R 50    Very toxic to aquatic organisms.

 R 68    Possible risk of irreversible effects.



"RTECS? is a United States trademark owned and licensed under authority of the U.S. Government, by

and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved.



Limitations: The information and recommendations set forth in this MSDS are believed to be correct

as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this

MSDS and disclaims all liability from reliance thereon.