SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 09/19/2008
Date Updated: 02/05/2006
Version 1.4
Section 1 - Product and Company Information
Product Name 2-CHLOROETHANOL, 99%
Product Number 185744
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
2-CHLOROETHANOL 107-07-3 Yes
Formula C2H5ClO
Synonyms Aethylenechlorhydrin (German) * 2-Chloorethanol
(Dutch) * 2-Chloraethanol (German) *
2-Chlorethanol (German) * delta-Chloroethanol *
2-Chloroethanol (OSHA) * beta-Chloroethyl alcohol
* 2-Chloroethyl alcohol * Chloroethylowy alkohol
(Polish) * 2-Cloroetanolo (Italian) *
Ethyleen-chloorhydrine (Dutch) * Ethylene
chlorhydrin * Ethylene chlorohydrin (ACGIH:OSHA)
* Ethylene glycol, chlorohydrin * Glicol
monocloridrina (Italian) * Glycol chlorohydrin *
Glycolmonochloorhydrine (Dutch) *
Glycomonochlorhydrin * Glycol monochlorohydrin *
Monochlorhydrine du glycol (French) *
2-Monochloroethanol * NCI-C50135
RTECS Number: KK0875000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU).
Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to respiratory system and skin. Risk of serious damage
to eyes.
Readily absorbed through skin. Combustible. Target organ(s):
Kidneys. Liver.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 2
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
131 癋 55 癈 Method: closed cup
EXPLOSION LIMITS
Lower: 5 % Upper: 16 %
AUTOIGNITION TEMP
425 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
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METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Use protective clothing, gloves, and mask. Avoid
prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH Ceiling co1 PPM
Remarks: Skin
USA MSHA Standard-air TWA 5 PPM (16 MG/M3)
USA OSHA. PEL 8H TWA 5 PPM (16 MG/M3) (SKIN)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH Ceiling co1 PPM (SK)
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 1 MG/M3
Poland NDSCh 3 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
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Molecular Weight 80.51 AMU
pH N/A
BP/BP Range 127.0 - 129.0 癈
MP/MP Range - 89.0 癈
Freezing Point N/A
Vapor Pressure 5 mmHg 20 癈
Vapor Density 2.78 g/l
Saturated Vapor Conc. N/A
SG/Density 1.202 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content < 0.1 %
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 131 癋 55 癈 Method: closed cup
Explosion Limits Lower: 5 %
Upper: 16 %
Flammability N/A
Autoignition Temp 425 癈
Refractive Index 1.442
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Readily absorbed through skin. May be fatal if
absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be fatal if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Kidneys. Liver. Eyes. Cardiovascular
system.
SIGNS AND SYMPTOMS OF EXPOSURE
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Nausea, headache, and vomiting. Exposure can cause: To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
TOXICITY DATA
Inhalation
Man
305 ppm
LCLO
Remarks: Kidney, Ureter, Bladder:Other changes. Liver:Other
changes.
Oral
Rat
71 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea.
Inhalation
Rat
290 mg/m3
LC50
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea.
Skin
Rat
293 mg/kg
LD50
Subcutaneous
Rat
84 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
Behavioral:Somnolence (general depressed activity).
Oral
Mouse
81 mg/kg
LD50
Inhalation
Mouse
385 mg/m3
LC50
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea.
Skin
Mouse
18 mg/kg
LD50
Intraperitoneal
Mouse
97 MG/KG
LD50
Subcutaneous
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Mouse
98 MG/KG
LD50
Skin
Rabbit
67 mg/kg
LD50
Intraperitoneal
Rabbit
80 MG/KG
LD50
Subcutaneous
Rabbit
100 MG/KG
LD50
Oral
Guinea pig
110 mg/kg
LD50
Remarks: Kidney, Ureter, Bladder:Other changes.
Gastrointestinal:Other changes. Behavioral:General anesthetic.
Inhalation
Guinea pig
870 mg/m3
LC50
Intraperitoneal
Guinea pig
85 MG/KG
LD50
Subcutaneous
Guinea pig
75 MG/KG
LD50
IRRITATION DATA
Skin
Rabbit
200 mg
2H
Remarks: Mild irritation effect
Eyes
Rabbit
2 mg
Remarks: Severe irritation effect
Eyes
Rabbit
33 mg
Remarks: Moderate irritation effect
Eyes
Rabbit
9 mg
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6H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is probably
not carcinogenic based on its IARC, ACGIH, NTP, or EPA
classification.
NTP CARCINOGEN LIST
Rating: No evidence.
Species: Mouse/rat
Route: Skin
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 1100 MG/KG
Route of Application: Oral
Exposure Time: (6-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Hepatobiliary system.
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Route: Oral
Dose: 20 MG/L
Mutation test: Other mutation test systems
Species: Rat
Dose: 12 GM/L
Cell Type: liver
Mutation test: Other mutation test systems
Species: Rat
Route: Inhalation
Dose: 1 MG/M3
Mutation test: Other mutation test systems
Species: Rat
Route: Inhalation
Dose: 1 MG/M3
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Oral
Dose: 500 UG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 80 MG/L (+S9)
Cell Type: lymphocyte
Mutation test: Mutation in microorganisms
Species: Hamster
Dose: 980 MG/L
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Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 1200 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Ethylene chlorohydrin
UN#: 1135
Class: 6.1
Packing Group: Packing Group I
Hazard Label: Poison inhalation hazard
Hazard Label: Flammable liquid
PIH: Zone B
IATA
Proper Shipping Name: Ethylene chlorohydrin
IATA UN Number: 1135
Hazard Class: 6.1
Packing Group: I
Not Allowed - Aircraft: Not permitted for air
transport.
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T+
Indication of Danger: Very toxic.
R: 26/27/28
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed.
S: 7/9-28-45
Safety Statements: Keep container tightly closed and in
well-ventilated place. After contact with skin, wash immediately
with plenty of soap-suds. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed. Irritating to respiratory system and skin.
Risk of serious damage to eyes.
Safety Statements: Avoid exposure - obtain special instructions
before use. Keep away from sources of ignition - no smoking.
Wear suitable protective clothing, gloves, and eye/face
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protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
US Statements: Readily absorbed through skin. Combustible.
Target organ(s): Kidneys. Liver.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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