SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/03/2004
Date Updated: 09/02/2002
Version 1.3
Section 1 - Product and Company Information
Product Name HEXAMETHYLENETETRAMINE, 99%
Product Number H11300
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
HEXAMETHYLENETETRAMINE 100-97-0 No
Formula C6H12N4
Synonyms Aceto HMT * Aminoform * Ammoform *
Ammonioformaldehyde * Cystamin * Cystogen *
Esametilentetramina (Italian) * Formamine *
Formin * Hexaform * Hexamethylenamine *
Hexamethyleneamine * Hexamethylenetetraamine *
Hexamethylentetramin (German) *
Hexamethylentetramine * Hexilmethylenamine * HMT
* Methamin * Methenamine * Preparation AF *
Resotropin * 1,3,5,7-Tetraazaadamantane *
1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane *
Uritone * Urotropin * Urotropine
RTECS Number: MN4725000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Harmful.
May cause sensitization by inhalation and skin contact.
Target organ(s): Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 2
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
FLASH POINT
482 癋 250 癈 Method: closed cup
AUTOIGNITION TEMP
410 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Avoid raising dust. Sweep up, place in a bag and hold for waste
disposal. Ventilate area and wash spill site after material
pickup is complete.
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Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid contact with eyes, skin, and clothing.
Avoid breathing dust. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
SPECIAL REQUIREMENTS
Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 4 MG/M3
Poland NDSCh -
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Colorless
Form: Crystals
Property Value At Temperature or Pressure
Molecular Weight 140.19 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 280 癈
Freezing Point N/A
Vapor Pressure < 0.01 mmHg 20 癈
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.331 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
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Decomposition Temp. N/A
Flash Point 482 癋 250 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 410 癈
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: ETHANOL, ACETONE, CHLOROFORM
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions to Avoid: Protect from moisture.
Materials to Avoid: Strong acids, Reacts with acids liberating
formaldehyde, Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SENSITIZATION
Sensitization: May cause allergic reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Kidneys.
TOXICITY DATA
Intravenous
Rat
9200 MG/KG
LD50
Oral
Mouse
569 mg/kg
LD50
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
Subcutaneous
Mouse
215 MG/KG
LD50
Remarks: Behavioral:Tremor. Gastrointestinal:Changes in
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structure or function of salivary glands.
Intravenous
Mouse
17700 UL/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Subcutaneous
Dose: 140 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 100 UMOL/L
Cell Type: HeLa cell
Mutation test: Other mutation test systems
Species: Human
Dose: 1 MMOL/L
Cell Type: HeLa cell
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 25 GM/KG
Mutation test: Dominant lethal test
Species: Mouse
Route: Oral
Dose: 25 GM/KG
Mutation test: Dominant lethal test
Species: Hamster
Dose: 10 MG/L
Cell Type: kidney
Mutation test: Morphological transformation.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Hexamethylenetetramine
UN#: 1328
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Class: 4.1
Packing Group: Packing Group III
Hazard Label: Flammable solid
PIH: Not PIH
IATA
Proper Shipping Name: Hexamethylenetetramine
IATA UN Number: 1328
Hazard Class: 4.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F Xn
Indication of Danger: Highly Flammable. Harmful.
R: 11 42/43
Risk Statements: Highly flammable. May cause sensitization by
inhalation and skin contact.
S: 16 22 24 37
Safety Statements: Keep away from sources of ignition - no
smoking. Do not breathe dust. Avoid contact with skin. Wear
suitable gloves.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Harmful.
Risk Statements: May cause sensitization by inhalation and skin
contact.
Safety Statements: Keep away from sources of ignition - no
smoking. Do not breathe dust. Avoid contact with skin. Wear
suitable gloves.
US Statements: Target organ(s): Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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