Technical Bulletin
N-ETHYLMORPHOLINE (NEM)
NEM is a clear, low-color, water miscible, liquid, tertiary amine.
SALES SPECIFICATIONS
Property Specifications Test Method*
Appearance Clear and substantially free of foreign matter ST-30.1
Color, Pt-Co 30 max. ST-30.12
NEM, wt% 99 min. ST-5.5
Water, wt% 0.2 max. ST-31.53, 6
*Methods of Test are available from Huntsman Corporation upon request.
ADDITIONAL INFORMATION
Regulatory Information Typical Physical Properties
Boiling point, 癈 (癋)
DOT/TDG Classification Polyamines, flammable 138 (280)
Flash point, TCC, 癈 (癋)
corrosive, n.o.s. (N-Ethylmorpholine) 32 (90)
Melting point, 癈 (癋)
HMIS Code 3-3-0 -63 (-81)
WHMIS Classification B2, E pH 10.9
CAS Number 100-74-3 Specific gravity, 20/20癈 0.9
Vapor pressure, mm Hg, 20癈 (68癋) 5
Chemical Control Laws
Viscosity, cSt, 20癈 (68癋) 1.2
Australia, AICS Listed
Water solubility (%) > 10
Canada, DSL Listed
Europe, EINECS/ELINCS Listed
Japan, METI Listed
United States, TSCA Listed
TOXICITY AND SAFETY
Acute Toxicity
The results of acute toxicity testing using n-ethylmorpholine (NEM) indicate that this product is considered to be
moderately toxic by single oral exposures and slightly toxic by single dermal exposures. The oral LD50 in rats and
the dermal LD50 in rabbits are 1.11 g/kg and 1.98 g/kg, respectively. Acute irritation studies have shown this product
to be extremely irritating/corrosive to the skin of rabbits, with a Draize dermal irritation score of 8.0 (maximum score
8.0). Given the results of the dermal irritation study, it is assumed that NEM will be extremely irritating and corrosive
to the eyes, as well.
Genetic Toxicity
A battery of genetic toxicity studies, comprised of an Ames Assay, a Mouse Lymphoma Forward Mutation Assay
and a Cell Transformation Assay (BALB/3T3 cells) were conducted using n-ethylmorpholine. These studies were
negative (non-genotoxic) in their responses to NEM.
Human Health Effects and First Aid On the basis of the above animal toxicity studies, the principal health hazard
from accidental exposures to n-ethylmorpholine is a moderate to severe irritation/corrosion of the eyes, skin, and
mucous membranes. Chemical-type goggles with face shield must be worn during handling or use of the undiluted
product or concentrated solutions. Contact lenses should not be worn. Protective clothing, and gloves resistant to
chemicals and petroleum distillates, must be worn. Should accidental eye and skin contact occur, flush eyes with
large amounts of water for at least 15 minutes, after which a physician should be consulted. During flushing of the
eyes, eyelids should be held apart to permit rinsing of entire surface of eye and lids. For skin contact, immediately
flush skin with large amounts of water for at least 15 minutes. Clothing wet with the product must be removed immediately and
laundered before reuse.
If NEM is accidentally ingested, and the individual is conscious and can swallow, they should be given two large glasses of
water, after which a physician should be consulted. Since this product is expected to produce severe irritation/corrosion of
mucous membranes, vomiting should not be induced, due to the possibility of lung damage from aspiration of the product into
the lungs during vomiting.
Under usual circumstances, exposure to harmful quantities of vapor should not be a health problem, however, exposure to
appreciable concentrations of n-ethylmorpholine vapors has been shown to result in irritation to the eyes, nose and throat, and
may produce corneal edema and temporary and reversible hazy or blurred vision. These symptoms disappear when exposure
to NEM is terminated. Adequate ventilation should be provided where a large quantity of product is exposed, or where mists or
vapors are generated. Spills in confined areas should be cleaned up promptly, using appropriate personal protective
equipment.
The American Conference of Governmental Industrial Hygienists (ACGIH) has established a Threshold Limit Value (TLV) for
NEM at 5 ppm as an 8-hour time weighted average (TWA) and has included a "SKIN" notation. For further information, please
refer to the Material Safety Data Sheet (MSDS) for this product. Contact lenses should not be worn. Protective clothing, and
gloves resistant to chemicals and petroleum distillates, must be worn. Should accidental eye and skin contact occur, flush eyes
with large amounts of water for at least 15 minutes, after which a physician should be consulted. During flushing of the eyes,
eyelids should be held apart to permit rinsing of entire surface of eye and lids. For skin contact, immediately flush skin with
large amounts of water for at least 15 minutes. Clothing wet with the product must be removed immediately and laundered
before reuse.
HANDLING AND STORAGE
In order to maintain the high degree of purity with which n-ethylmorpholine (NEM) is manufactured and shipped, the following
storage and handling considerations are recommended:
Dry Inert Gas Blanket: This product should be stored under a dry inert gas blanket, such as nitrogen, to minimize
contamination resulting from contact with air and water.
Materials of Construction: Clean carbon steel is satisfactory as a material of construction for storage tanks and transfer
systems, provided adequate precautions are observed to guard against rust contamination. In those cases where additional
precautions are needed to preserve low color, stainless steel or aluminum should be used. Copper, or alloys containing copper,
should be avoided.
Storage Temperature: NEM has an extremely low viscosity and freezing point (-73.5癋). It will not freeze or become viscous
during normal handling even though subjected to very severe weather conditions.
Spills or Leaks: Eliminate all sources of ignition in case of spills or leaks. Spills should be removed by absorbent materials or
by washing with water.
Flammability: For transportation purposes, NEM is classed as a flammable liquid (closed cup flash point, 90癋). Because of
the flammable nature of NEM, the product should be used only in a well-ventilated area and precautions should be taken to
avoid exposure to sparks and open flames.
AVAILABILITY
NEM is available in bulk and in 55-gallon drums. Samples are available by contacting our sample department at 1-800-662-
0924.
5013-0408
Huntsman Corporation
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