SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 10/12/2006
Date Updated: 02/04/2006
Version 1.8
Section 1 - Product and Company Information
Product Name ANISOLE, ANHYDROUS, 99.7%
Product Number 296295
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ANISOLE 100-66-3 No
Formula C7H8O
Synonyms Benzene, methoxy * Ether, methyl phenyl *
Methoxybenzene * Methyl phenyl ether * Phenyl
methyl ether
RTECS Number: BZ8050000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Combustible (USA) Flammable (EU).
Caution: Avoid contact and inhalation.
HMIS RATING
HEALTH: 1
FLAMMABILITY: 2
REACTIVITY: 0
NFPA RATING
HEALTH: 1
FLAMMABILITY: 2
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLASH POINT
109.4 癋 43 癈 Method: closed cup
AUTOIGNITION TEMP
475 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid breathing vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 108.14 AMU
pH N/A
BP/BP Range 152.0 - 155.0 癈
MP/MP Range - 37.0 癈
Freezing Point N/A
Vapor Pressure 10 mmHg 42.2 癈
Vapor Density 3.7 g/l
Saturated Vapor Conc. N/A
SG/Density 0.993 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 2.1
Decomposition Temp. N/A
Flash Point 109.4 癋 43 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 475 癈
Refractive Index 1.517
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: ETHANOL, ACETONE,
DIETHYLETHER
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
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Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
3,700 mg/kg
LD50
Oral
Rat
3700 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Gastrointestinal:Changes in structure or function of salivary
glands. Kidney, Ureter, Bladder:Hematuria.
Inhalation
Rat
> 5,000 mg/m3
LC50
Oral
Mouse
2800 mg/kg
LD50
Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on
seizure threshold. Behavioral:Excitement.
Inhalation
Mouse
3,021 mg/m3
LC50
IRRITATION DATA
Eyes
Rabbit
Remarks: No irritation effect
Skin
Rabbit
Remarks: Mild irritation effect
Skin
Rabbit
500 mg
24H
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Remarks: Moderate irritation effect
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 25 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Section 12 - Ecological Information
No data available.
ACCUMULATION
Bioaccumulation Potential: No indication of
bioaccumulation.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Anisole
UN#: 2222
Class: 3
Packing Group: Packing Group III
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Anisole
IATA UN Number: 2222
Hazard Class: 3
Packing Group: III
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
R: 10
Risk Statements: Flammable.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Combustible (USA) Flammable (EU).
Safety Statements: Keep away from sources of ignition - no
smoking.
US Statements: Caution: Avoid contact and inhalation.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
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NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2006 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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