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Material Safety Data Sheet
Isobutyl alcohol
ACC# 11640
Section 1 - Chemical Product and Company Identification
MSDS Name: Isobutyl alcohol
Catalog Numbers: AC158280000, AC158280010, AC158280025, AC167700000,
AC167700010, AC167700025, AC167705000, AC295710000, AC295710010, AC295710025,
AC412650000, AC412655000, AC412660000, AC412665000, A397-1, A397-4, A397J4, S76776
Synonyms: 1-Hydroxymethylpropane; Isobutanol; Isopropylcarbinol; 2-Methyl-1-propanol; IBA.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS
78-83-1 Isobutyl alcohol 99 201-148-0
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: colorless, oily liquid. Flash Point: 28 deg C.
Warning! Flammable liquid and vapor. May cause severe eye irritation and possible injury.
Breathing vapors may cause drowsiness and dizziness. Causes skin and respiratory tract irritation.
Target Organs: Central nervous system, respiratory system, eyes, skin.
Potential Health Effects
Eye: May cause severe eye irritation. May cause chemical conjunctivitis and corneal damage. A drop
of isobutanol instilled into a rabbit's eye caused moderate to severe irritation but no permanent injury to
the cornea. No evidence of eye irritation was noted with repeated 8-hour exposures at 100 ppm
isobutanol vapor.
Skin: Causes skin irritation. May be absorbed through the skin. Repeated or prolonged exposure may
cause drying and cracking of the skin.
Ingestion: Aspiration hazard. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
May cause central nervous system depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure. Aspiration of material into the lungs may cause
chemical pneumonitis, which may be fatal.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized
by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation.
Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause
corneal abnormalities and loss of appetite and weight. May cause burning sensation in the chest.
Chronic: Not available. In studies of limited size, administration of isobutyl alcohol by
subcutaneous injection or by gavage has been reported to cause an increased incidence of benign
and malignant tumors in rats. The relevance of these findings to humans is unknown.
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Section 4 - First Aid Measures
Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get
medical aid immediately.
Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes.
Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
If vomiting occurs naturally, have victim lean forward.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing
is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand,
MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly
toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep
fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may
be spread by the use of water. Flammable liquid and vapor. Vapors are heavier than air and may travel to
a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media: Dry chemical, alcohol foam, carbon dioxide.
Flash Point: 28 deg C ( 82.40 deg F)
Autoignition Temperature: 415 deg C ( 779.00 deg F)
Explosion Limits, Lower:1.7
Upper: 10.6
NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in
suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used
to reduce vapors.
Section 7 - Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.
Ground and bond containers when transferring material. Use spark-proof tools and explosion
proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Storage: Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away
from incompatible substances. Flammables-area.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped with an
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eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep
airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
50 ppm TWA; 150 mg/m3 TWA
Isobutyl alcohol 50 ppm TWA 100 ppm TWA; 300 mg/m3 TWA
1600 ppm IDLH
OSHA Vacated PELs: Isobutyl alcohol: 50 ppm TWA; 150 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Appearance: colorless, oily
Odor: mild odor - sweetish odor - slightly musty
pH: Not available.
Vapor Pressure: 10.5 mm Hg @ 25 deg C
Vapor Density: 2.6 (air=1)
Evaporation Rate:0.6 (butyl acetate=1)
Viscosity: 4 cps @ 20 deg C
Boiling Point: 107 - 108 deg C
Freezing/Melting Point:-108 deg C
Decomposition Temperature:Not available.
Solubility: Partially soluble.
Specific Gravity/Density:0.802
Molecular Formula:C4H10O
Molecular Weight:74.12
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures. May form unstable peroxides.
Conditions to Avoid: Ignition sources, excess heat, prolonged exposure to air, confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
RTECS#:
CAS# 78-83-1: NP9625000
LD50/LC50:
CAS# 78-83-1:
Inhalation, mouse: LC50 = 15500 mg/m3/2H;
Inhalation, rabbit: LC50 = 2630 mg/m3/4H;
Inhalation, rat: LC50 = 19200 mg/m3/4H;
Oral, mouse: LD50 = 3500 mg/kg;
Oral, rabbit: LD50 = 74.1 mg/kg;
Oral, rat: LD50 = 2460 mg/kg;
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Skin, rabbit: LD50 = 3400 mg/kg;
.
Carcinogenicity:
CAS# 78-83-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information found
Teratogenicity: Based on a study in experimental animals, isobutyl alcohol is not anticipated to increase
the risk of adverse pregnancy outcome at typical exposure levels. (REPROTOX)
Reproductive Effects: No information found
Mutagenicity: No information found
Neurotoxicity: No information found
Other Studies:
Section 12 - Ecological Information
Ecotoxicity: Fish: Fathead Minnow: 1430g/L; 96H; Fish: Fathead Minnow: 1430g/L; 96H; No data available.
Environmental: Terrestrial: When spilled on soil, isobutyl alcohol will both evaporate and leach into
the ground due to its relatively high vapor pressure and low adsorption to soil. Aquatic: When released
into water, isobutyl alcohol will volatilize (half-life in a river approximately 4 days). Atmospheric:
When released into the atmosphere, isobutyl alcohol will photodegrade with a half-life ranging from hours
in polluted urban atmospheres, to days in cleaner atmospheres.
Physical: Readily biodegrades but does not bioconcentrate.
Other: No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous
waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to ensure
complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 78-83-1: waste number U140 (Ignitable waste, Toxic waste).
Section 14 - Transport Information
US DOT Canada TDG
Shipping Name: ISOBUTANOL ISOBUTANOL
Hazard Class: 3 3
UN Number: UN1212 UN1212
Packing Group: III III
Additional Info: FLASHPOINT 28 C
Section 15 - Regulatory Information
US FEDERAL
TSCA
CAS# 78-83-1 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 78-83-1: Effective 3/7/86, Sunset 3/7/96
Chemical Test Rules
CAS# 78-83-1: 40 CFR 799.5000
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Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 78-83-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 78-83-1: immediate, fire.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 78-83-1 can be found on the following state right to know lists: California, New
Jersey, Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI
Risk Phrases:
R 10 Flammable.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 13 Keep away from food, drink and animal feeding stuffs.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
S 46 If swallowed, seek medical advice immediately and show this con
tainer or label.
S 7/9 Keep container tightly closed and in a well-ventilated place.
WGK (Water Danger/Protection)
CAS# 78-83-1: 1
Canada - DSL/NDSL
CAS# 78-83-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 78-83-1 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
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MSDS Creation Date: 12/12/1997
Revision #11 Date: 6/07/2006
The information above is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party
or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher
has been advised of the possibility of such damages.
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