MATERIAL SAFETY
DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT AND COMPANY INFORMATION
May be Pressurized with an Inert Gas
CHEMICAL NAME; CLASS: FLAMMABLE LIQUID MIXTURE
Containing 1,3-Butadiene (0.1-1%), Methanol (0.1-1%), Butane (1-10%), 1-Butene (1-10%),
cis-2-Butene (1-10%), Isobutylene (1-10%), 2-Methyl-2-Butene (1-10%),
3-Methyl-1-Butene (1-10%),Methyl tert-Butyl Ether (1-10%), Pentane (1-10%),
and Isopentane (Balance)
NOTE: This mixture may contain other components at a ppm level that do not affect the physical or health hazards of the mixture, as
described in this Material Safety Data Sheet.
SYNONYMS: Not Applicable
CHEMICAL FAMILY: Not Applicable
FORMULA: Not Applicable
Document Number: 40123
Item Number: 615A, 615B
PRODUCT USE: For general analytical/synthetic chemical uses.
MANUFACTURED/SUPPLIED FOR:
ADDRESS: 11426 Fairmont Parkway
La Porte, TX 77571-6000
EMERGENCY PHONE: CHEMTREC: 1-800-424-9300
BUSINESS PHONE: 1-800-248-1427
General MSDS Information: 1-713/868-0440
Fax on Demand: 1-800/231-1366
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 1 OF 12
2. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: This liquid is a colorless, highly flammable mixture with a sharp, aromatic odor (due
to the presence of 1,3-Butadiene). Inhalation of the vapors of this liquid mixture is irritating to the respiratory
system and can cause central nervous system depression, producing symptoms such as headaches, nausea,
dizziness, drowsiness, confusion, and unconsciousness. Inhalation of high concentrations of vapors of this liquid
may be fatal. Skin and eye contact can be irritating. Prolonged or repeated exposure may cause skin irritation
and long term health effects (e.g., eye damage). 1,3-Butadiene and Methyl tert-Butyl Ether, components of this
liquid mixture, may be carcinogenic to humans. Vapors of this liquid mixture are heavier than air and may spread
long distances. Distant ignition and flashback are possible. Flame or high temperature impinging on a localized
area of the cylinder of this liquid mixture can cause the cylinder to burst or rupture without activating the cylinder's
relief devices. Provide adequate fire protection during emergency response situations.
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE: The most significant routes of occupational
overexposure are by inhalation and skin and eye contact.
INHALATION: Inhalation of the vapors of this liquid mixture may irritate the nose, throat, and upper respiratory tract
and may also cause depression of the central nervous system. Symptoms of central nervous system depression
include headache, nausea, hallucinations, dizziness, drowsiness, incoordination, unconsciousness, and in cases of
extreme overexposure, death. Inhalation of high concentrations of this liquid mixture's vapors (as may occur if this
liquid mixture is used or released in a poorly ventilated area or confined space, or during a release of large
quantities) may be fatal.
There is information currently available on the effects of human overexposure to Isopentane and Pentane (the main
components of this liquid mixture). Effects of such exposure to Isopentane and Pentane can be summarized as
indicated on the following page:
EFFECTS OF OVEREXPOSURES TO PENTANE AND ISOMERS (INCLUDING ISOPENTANE):
CONCENTRATION OBSERVED EFFECT
Brief (10 minute) up to 5,000 ppm: No symptoms.
Higher than 5,000 ppm: Exhilaration, dizziness, and headache can occur.
130,000 ppm: Collapse and death.
Long term: Can cause chronic neurological disorder causing damage to the nerves in the
hands and feet (peripheral neuropathy).
Severe overexposure to the vapors of this liquid mixture could lead to mild blurring of vision to blindness (due to the
presence of Methanol). Repeated or prolonged exposures to this liquid mixture may have long term health effects
due to the accumulation of Methanol in the body.
CONTACT WITH SKIN or EYES: Exposure to the liquid mixture can cause blisters upon contact with the skin.
Prolonged contact of the liquid mixture with the skin can cause itching, redness, pigmentation, swelling, and burning
pain. This liquid mixture will act as a defatting agent and prolonged or repeated skin contact will cause irritation and
dermatitis (inflammation, reddening, and swelling). Contact of concentrated vapors of this liquid with the eyes may
be slightly irritating. Contact of the liquid with the eyes can cause irritation and redness to the eyes. Prolonged
contact may result in eye damage or permanent blindness (due primarily to Methanol).
SKIN ABSORPTION: Skin absorption is not a significant route of overexposure for the components of this liquid
mixture. Methanol (present in low concentration) may be absorbed through the skin, causing effects such as those
described for Methanol under "Inhalation".
INGESTION: Ingestion is not anticipated to be a significant route of overexposure for this liquid mixture. This liquid
mixture cannot be swallowed because the body temperature is above the boiling point, causing the liquid to boil off
when it comes in contact with body tissue.
INJECTION: Injection is not anticipated to be a significant route of overexposure for this liquid. If this liquid mixture
is "injected" (as may occur through punctures by contaminated, sharp objects), local swelling and irritation can occur.
OTHER HEALTH EFFECTS: Though no epidemiological studies have specifically identified 1,3-Butadiene (a
component of this liquid mixture) as a human carcinogen, 1,3-Butadiene must be viewed as a suspected human
carcinogen. Methyl tert-Butyl Ether (a component of this liquid mixture) is considered possibly carcinogenic to
humans.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to this liquid
mixture may cause the following health effects:
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 2 OF 12
2. HAZARD IDENTIFICATION (Continued)
ACUTE: Inhalation of the vapors of this liquid mixture can irritate the nose, throat, and upper respiratory system.
Inhalation of vapors can also cause central nervous system depression. Depending on the vapor concentration,
symptoms of central nervous system depression can include headaches, nausea, dizziness, drowsiness, confusion,
and unconsciousness. Inhalation of high concentrations of the vapors can be fatal. Contamination of skin or eyes
can be irritating.
CHRONIC: 1,3-Butadiene and Methyl tert-Butyl Ether (components of this liquid mixture) are possible human
carcinogens. Repeated or prolonged exposures to this liquid mixture may cause long term health effects, such as
dermatitis, damage to the nerves in the hands and feet, or blindness. Butane, Isopentane, and Pentane
(components of this liquid mixture) may cause weak cardiac sensitization, based on animal tests. See Section 11
(Toxicological Information) for further information.
TARGET ORGANS: Respiratory system, central nervous system, skin, and eyes.
3. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # mole % EXPOSURE LIMITS IN AIR
ACGIH OSHA
OTHER
TLV STEL PEL STEL IDLH
ppm ppm ppm ppm ppm ppm
1,3-Butadiene 2, A2
106-99-0 0.1-1.0% NE 1 5 2000 NIOSH: Carcinogen;
Reduce to lowest feasible
Note: Stabilized (Suspected (Based on
limit; OSHA Action Level:
with a trace amount Human PEL)
0.5
of hydroquinone, Carcinogen)
catechol, or tertiary Carcinogen:
butyl alcohol EPA-B2 IARC-2A MAK-
A2 NIOSH-X NTP-2B
Methanol 67-56-1 0.1-1.0% 200 (skin) 250 200 250 6000 NIOSH REL: STEL= 0.5,C
(skin) (Vacate (skin)
d 1989 DFG MAK: 0.5
PEL)
800
Butane 106-97-8 1.0-10.0% NE 800 NE NE NIOSH REL: 800
(Vacated DFG MAK: 1000
1989 PEL)
1-Butene 25167-67-3 1.0-10.0% There are no specific exposure limits for 1-Butene. 1-Butene is a simple asphyxiant
(SA).
cis-2-Butene 590-18-1 1.0-10.0% There are no specific exposure limits for cis-2-Butene. cis-2-Butene is a simple
asphyxiant (SA).
Isobutylene There are no specific exposure limits for Isobutylene. Isobutylene is a simple
115-11-7 1.0-10.0%
asphyxiant (SA).
2-Methyl-2-Butene There are no specific exposure limits for 2-Methyl-2-Butene. 2-Methyl-2-Butene is a
513-35-9 1.0-10.0%
simple asphyxiant (SA).
3-Methyl-1-Butene There are no specific exposure limits for 3-Methyl-1-Butene. 3-Methyl-1-Butene is a
563-45-1 1.0-10.0%
simple asphyxiant (SA). Oxygen levels should be maintained above 19.5%.
Methyl tert-Butyl 1634-04-4 1.0-10.0% 40 NE NE NE NE Carcinogen:
Ether A3 IARC-2B
(Animal
Carcinogen)
Pentane 109-66-0 1.0-10.0% 600 750 1000 1500 NIOSH REL: 120
750
600 (Based TWA: 610, C (15
(Vacated
(Vacated on LEL) min)
1989 PEL)
1989 PEL) DFG MAK: 1000
Isopentane 78-78-4 Balance 600 750 1000 1500 NIOSH REL: 120
750
600 TWA: 610, C (15
(Vacated
(Vacated min)
1989 PEL)
1989 PEL) DFG MAK: 1000
Other components in low ppm The low ppm level components of this liquid do not contribute to the health hazards or alter the physical
levels hazards associated with this liquid mixture. All hazard information pertinent to this liquid mixture has
been provided in this Material Safety Data Sheet, per the requirements of the OSHA Hazard
Communication Standard (29 CFR 1910.1200) and State Equivalent standards.
This material is classified as hazardous under OSHA regulations in the United States and the WHMIS in
Canada.
NE = Not Established C = Ceiling Limit See Section 16 for Definitions of Terms Used.
NOTE: All WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-2004 format.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 3 OF 12
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS LIQUID
MIXTURE WITHOUT ADEQUATE PERSONAL PROTECTIVE EQUIPMENT, OR BY THEMSELVES. If
necessary, Self-Contained Breathing Apparatus and fire-retardant clothing should be worn.
Remove victim(s) to fresh air as quickly as possible. Only trained personnel should administer supplemental oxygen
and/or cardio-pulmonary resuscitation if necessary.
INHALATION: If vapors, mists, or sprays of this liquid mixture are inhaled, remove victim to fresh air. If necessary,
use artificial respiration to support vital functions. Remove or cover gross contamination to avoid exposure to
rescuers.
SKIN EXPOSURE: If this liquid mixture contaminates the skin, immediately begin decontamination with running
water. Minimum flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to
contaminate eyes. Victim must seek medical attention if any adverse reaction occurs.
EYE EXPOSURE: If the liquid or vapors of this liquid mixture enter the eyes, open victim's eyes while under gently
running water. Use sufficient force to open eyelids. Have victim "roll" eyes. Minimum flushing is for 15 minutes.
Victim must seek immediate medical attention.
Victim(s) must be taken for medical attention. Rescuers should be taken for medical attention if necessary. Take
copy of label and MSDS to physician or other health professional with victim(s).
5. FIRE-FIGHTING MEASURES
The following information is the highest and lowest values of all components related to flammability.
FLASH POINT (1-Butene) [method]: -80癈 (-112癋) [closed cup]
AUTOIGNITION TEMPERATURE:
(Methyl tert-Butyl Ether): 224癈 (435癋)
FLAMMABLE LIMITS (in air by volume, %):
Isopentane: Lower (LEL): 1.4%
Isobutylene: Upper (UEL): 9.6%
FIRE EXTINGUISHING MATERIALS:
Water Spray: YES (for cooling only) Carbon Dioxide: YES
Foam: YES Dry Chemical: YES
Halon: YES Other: Any "B" Class.
UNUSUAL FIRE AND EXPLOSION HAZARDS: This is a flammable liquid. When involved in a fire, this liquid
mixture may decompose and produce toxic vapors and gases (including carbon monoxide and carbon dioxide). The
vapors of this liquid mixture are heavier than air and may spread long distances. Distant ignition and flashback are
possible. The components of this liquid mixture can float on water; therefore, water contaminated with this liquid
mixture can spread the flammable liquid and can spread fire. Due to the presence of 1,3-Butadiene and 2-Methyl-2-
Butene, this liquid mixture may become unstable and react at elevated temperatures or pressure or on long
standing.
DANGER! Fires impinging (direct flame) on the outside surface of unprotected cylinders of this liquid mixture can be
very dangerous. Exposure to fire could cause a catastrophic failure of the cylinder releasing the contents into a
fireball and explosion of released vapor. The resulting fire and explosion can result in severe equipment damage
and personnel injury or death over a large area around the cylinder. For massive fires in large areas, use unmanned
hose holder or monitor nozzles; if this is not possible, withdraw from area and allow fire to burn.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: This liquid mixture can accumulate static charge by flow or agitation.
Static discharge may cause this liquid mixture to ignite.
SPECIAL FIRE-FIGHTING PROCEDURES: In the event of fire, cool containers of this liquid mixture with water to
prevent failure. Use a water spray or fog to reduce or direct vapors. Water may not be effective in actually
extinguishing a fire involving this liquid mixture, due to the low flash points of the components. Stop the leak or
discharge if possible. For small releases, if it is not possible to stop the leak and it does not endanger personnel, let
the fire burn itself out.
Incipient fire responders should wear eye protection. Structural firefighters must wear Self-Contained Breathing
Apparatus and full protective equipment. If this liquid mixture is involved in a fire, fire runoff water should be
contained to prevent possible environmental damage. If necessary, decontaminate fire-response equipment with
soap and water solution.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 4 OF 12
5. FIRE-FIGHTING MEASURES (Continued)
If the fire is extinguished before the leak is sealed, the leaking liquid could explosively re-ignite without warning and
cause extensive damage, injury, or fatality. In this case, increase ventilation to prevent flammable or explosive
mixture formation. Evacuation may be necessary. Refer to the North American Emergency Response Guidebook
for additional information.
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Evacuate immediate area. Uncontrolled releases should be responded to by trained personnel
using pre-planned procedures. Proper protective equipment should be used.
Eliminate any possible sources of ignition and provide maximum explosion-proof ventilation. If the liquid is leaking
from a cylinder or valve, contact the supplier. Adequate fire protection must be provided. Use only non-sparking
tools and equipment during the response.
Minimum Personal Protective Equipment should be Level B: triple-gloves (rubber gloves and nitrile gloves,
over latex gloves), chemical resistant suit and boots, hard-hat, and Self-Contained Breathing Apparatus.
Locate and seal the source of the leaking liquid. Monitor the surrounding area for combustible vapor levels.
Combustible vapor levels must be below 10% of the LEL (see Section 5, Fire-Fighting Measures, for LEL
information) before personnel are permitted to enter the area. If necessary, ventilate area.
Monitor the surrounding area (and the original area of the release) for the levels of the components of this liquid
mixture and oxygen. The components must be below exposure levels listed in Section 2 (Composition and
Information on Ingredients) and the atmosphere must have 19.5 percent oxygen before personnel can be allowed
in the area without Self-Contained Breathing Apparatus.
Eliminate all sources of ignition before cleanup operations begin. Use non-sparking tools. Absorb spilled liquid with
activated carbon, polypads, or other suitable absorbent materials. Prevent material from entering sewer or confined
spaces. Decontaminate the area thoroughly. Place all spill residue in an appropriate container and seal. If
necessary, decontaminate spill response equipment with soap and water solution. Dispose of in accordance with
Federal, State, and local hazardous waste disposal regulations (see Section 13, Disposal Considerations).
THIS IS A FLAMMABLE LIQUID: Protection of all personnel and the area must be maintained. All responders
must be adequately protected from exposure.
7. HANDLING AND STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: Avoid breathing the vapors or sprays generated by this liquid
mixture. Be aware of any signs of dizziness or fatigue; exposures to fatal concentrations of this liquid mixture could
occur without any significant warning symptoms. Eyewash stations and safety showers should be accessible in
areas of use. Non-sparking tools should be used.
STORAGE AND HANDLING PRACTICES: Cylinders should be stored upright (with valve protection cap in place)
and firmly secured to prevent falling or being knocked over. Cylinders can be stored in the open, but in such cases,
should be protected against extremes of weather and from the dampness of the ground to prevent rusting. Cylinders
should be properly labeled. If this liquid mixture is used in other types of containers, only use portable containers
and dispensing equipment (faucet, pump, drip can) approved for flammable liquids.
Cylinders should be stored in dry, well-ventilated areas away from sources of heat, ignition, and direct sunlight.
Keep storage area clear of materials that can burn. Do not allow area where cylinders are stored to exceed 52癈
(125癋). Store containers away from heavily trafficked areas and emergency exits. Store away from process and
liquid production areas, elevators, building and room exits, or main aisles leading to exits. Protect cylinders against
physical damage.
STORAGE AND HANDLING PRACTICES (continued): Cylinders should be separated from oxygen cylinders or
other oxidizers by a minimum distance of 20 ft. or by a barrier of non-combustible material at least 5 ft. high, having a
fire-resistance rating of at least 0.5 hours. Isolate from other incompatible chemicals (refer to Section 10, Stability
and Reactivity).
Storage areas must meet national electrical codes for Class 1 Hazardous Areas. Post "No Smoking or Open
Flames" signs in storage or use areas. Consider installation of leak detection and alarm for storage and use areas.
Have appropriate extinguishing equipment in the storage area (e.g., sprinkler system, portable fire extinguishers).
Keep the smallest amount on-site as is necessary. Full and empty cylinders should be segregated. Use a first-in,
first-out inventory system to prevent full containers from being stored for long periods of time.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 5 OF 12
7. HANDLING AND STORAGE (Continued)
Use non-sparking ventilation systems, approved explosion-proof equipment, and appropriate electrical systems.
Electrical equipment used in handling operations or located in storage areas should be non-sparking or explosion
proof. Use a check valve in the discharge line to prevent hazardous backflow. Never tamper with pressure relief
devices in valves and cylinders.
SPECIAL PRECAUTIONS FOR HANDLING CYLINDERS: Cylinders of liquid mixtures can present significant
safety hazards. The following rules are applicable to work situations in which cylinders are being used:
Before Use: Move cylinders with a suitable hand truck. Do not drag, slide, or roll cylinders. Do not drop cylinders
or permit them to strike each other. Secure cylinders firmly. Leave the valve protection cap (where provided) in
place until cylinder is ready for use.
During Use: Use designated CGA fittings and other support equipment. Do not use adapters. Use piping and
equipment adequately designed to withstand pressures to be encountered. Do not heat cylinder by any means to
increase the discharge rate of the liquid mixture from the cylinder. Do not use oils or grease on cylinder-handling
fittings or equipment. Do not "crack" valve open before connecting it since self-ignition may occur. Leak check
system with leak detection solution, never with flame. Immediately contact the supplier if there are any difficulties
associated with operating cylinder valve.
Never insert an object (e.g., wrench, screwdriver, pry bar, etc.) into valve cap openings. Doing so may damage the
valve, causing a leak to occur. Use an adjustable strap wrench to remove overly tight or rusted caps. Never strike
an arc on a cylinder or make a cylinder part of an electric circuit.
After Use: Close main cylinder valve. Valves should be closed tightly. Replace valve protection cap. Mark empty
cylinders "EMPTY".
NOTE: Use only DOT or ASME code containers designed for flammable liquid storage. Earth-ground and bond all
lines and equipment associated with this liquid mixture.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain that application equipment is locked and
tagged-out safely. Purge equipment with inert gas (e.g., nitrogen) before attempting repairs. Always use this liquid
mixture in areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. Provide natural or explosion-
proof ventilation adequate to ensure that the concentration of combustible vapors does not reach the lower
flammability limit as indicated in Section 5, Fire-Fighting Measures. Local exhaust ventilation is preferred because it
prevents vapor dispersion into the work place by eliminating it at its source. If appropriate, install automatic
monitoring equipment to detect the level of flammable vapors and oxygen. Ensure eyewash/safety shower stations
are available near areas where this liquid mixture is used.
RESPIRATORY PROTECTION: Maintain exposure levels of the components of this mixture below the levels listed
in Section 2 (Composition and Information on Ingredients). Maintain oxygen level above 19.5% in the workplace.
Use supplied air respiratory protection if component levels exceed exposure limits, if oxygen level is below 19.5%
(air-purifying respirators will not function), or during emergency response to a release of this liquid mixture. During
an emergency situation, before entering the area, check for combustible vapor level as well as oxygen-deficient
atmospheres. If respiratory protection is required, follow the requirements of the Federal OSHA Respiratory
Protection Standard (29 CFR 1910.134) or equivalent State standards.
The following NIOSH respiratory protection recommendations for Pentane are included for additional information.
They also apply to Isopentane, the main component of this mixture.
CONCENTRATION RESPIRATORY EQUIPMENT
Up to 1200 ppm: Supplied Air Respirator (SAR).
Up to 1500 ppm: SAR operated in continuous-flow mode, full facepiece Self-Contained Breathing
Apparatus (SCBA), or full facepiece SAR.
Emergency or Planned Entry into Unknown Concentration or IDLH Conditions: Positive pressure, full facepiece
SCBA or positive pressure, full facepiece SAR with an auxiliary positive pressure SCBA.
Escape: Gas mask with organic vapor cartridge or escape-type SCBA should be used.
The IDLH concentration for Pentane, based on the LEL, is 1500 ppm. This value may also apply to Isopentane.
EYE PROTECTION: Splash goggles or safety glasses and face shield.
HAND PROTECTION: Wear leather gloves when handling cylinders of this liquid mixture. During use of this liquid
mixture, chemical impervious gloves should be used. Use triple gloves for spill response (see Section 6, Accidental
Release Measures). Otherwise, wear glove protection appropriate to the specific operation for which this liquid
mixture is used.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 6 OF 12
8. EXPOSURE CONTROLS - PERSONAL PROTECTION (Continued)
BODY PROTECTION: Use body protection appropriate for task. Cotton clothing is recommended to prevent static
electric build up. Safety shoes are recommended when handling cylinders.
9. PHYSICAL and CHEMICAL PROPERTIES
Unless otherwise specified, the following information is for Isopentane, the main component of this liquid
mixture.
VAPOR DENSITY (air = 1): 2.5
BOILING POINT: 28癈 (82癋)
FREEZING/MELTING POINT: -160癈 (-256癋) pH: Not applicable
SPECIFIC GRAVITY (water = 1) @ 20癈 (68癋): 0.62 MOLECULAR WEIGHT: 72.15
SOLUBILITY IN WATER: Insoluble. EXPANSION RATIO: Not applicable.
EVAPORATION RATE: Not available. SPECIFIC VOLUME: Not applicable.
ODOR THRESHOLD: 4 mg/m3 (for 1,3-Butadiene)
VAPOR PRESSURE @ 21癈 (69.8癋): 595 mm Hg
LOG COEFFICIENT WATER/OIL DISTRIBUTION: Log P (oct) = 3.2-3.3
The following information is for this mixture.
APPEARANCE AND COLOR: Clear, colorless liquid with a sharp, aromatic odor (due to 1,3-Butadiene).
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor may be a distinctive characteristic of this
liquid mixture. It may not be reliable for detection, however, because exposure to hazardous concentrations may
occur before the odor is detected.
10. STABILITY and REACTIVITY
STABILITY: Stable at standard temperatures and pressures. Due to the presence of 1,3-Butadiene and 2-Methyl-2-
Butene, this liquid mixture may become unstable and react at elevated temperatures or pressure or on long
standing.
DECOMPOSITION PRODUCTS: If this liquid mixture is involved in a fire, it will ignite to yield toxic fumes of carbon
monoxide and carbon dioxide. Uninhibited 1,3-Butadiene may form explosive organic peroxides when exposed to
air.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: This liquid mixture is incompatible with strong
oxidizers (e.g., chlorine, bromine pentafluoride, oxygen, oxygen difluoride, and nitrogen trifluoride), strong acids, and
strong bases. This liquid mixture may react readily with numerous organic compounds (e.g., styrene, amines, and
diazo compounds) and inorganic compounds (e.g., hydrogen sulfide and sulfur) in the presence of specific catalysts
(typically aluminum or transition metal compounds), due to the presence of 1,3-Butadiene. This liquid mixture may
also be incompatible with alkali metals, aldehydes, and acyl chlorides, due to the presence of Methanol.
HAZARDOUS POLYMERIZATION: 1,3-Butadiene, a component present in low concentration, may react and
polymerize at elevated temperatures. 2-Methyl-2-Butene, a component of this liquid mixture, may polymerize after
standing for long periods.
CONDITIONS TO AVOID: Contact with incompatible materials and exposure to heat, sparks, and other sources of
ignition.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 7 OF 12
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following toxicology data are available for the components of this liquid mixture present in
concentrations greater than or equal to 1%:
1,3-BUTADIENE: 1,3-BUTADIENE (continued): 1-BUTENE: There are currently no
Micronucleus Test-Mouse: Inhalation 100 Inhalation-Human TCLo: 8000 ppm: Eye specific toxicology data available for
ppm/ 6 hours/ 2 days-continuous effects, Pulmonary system effects 1-Butene. 1-Butene is a Simple
3/
Mutation in Mammalian Somatic Cells- Inhalation-Rat LC50: 285 g/m 4 hours Asphyxiant.
3
Mouse: lymphocyte 20 pph Inhalation-Mouse LC50: 270 g/m /2 hours cis-2-BUTENE: There are currently no
Inhalation-Rat TCLo: 8000 ppm/ 6 hours Inhalation-Rabbit, adult LCLo: 25 pph/ 23 specific toxicology data for cis-2-
(6-15 days preg): Teratogenic effects minutes Butene. cis-2-Butene is a Simple
Inhalation-Rat TCLo: 625 ppm/ 6 hours/ BUTANE: Asphyxiant.
61 weeks: Carcinogenic effects 3
Inhalation-Rat LC50: 658 g/m / 4 hour ISOBUTYLENE
Inhalation-Mouse TCLo: 1250 ppm/ 6 3
Inhalation-Mouse LC50: 680 g/m / 2 hour 3
Inhalation-Rat LC50: 620 g/m /4 hours
hours/ 60 weeks-intermittent: 3
INHALATION (mouse): Butane is Inhalation-Mouse LC50: 415 g/m /2 hours
Carcinogenic effects
reported to be anesthetic to mice at ISOPENTANE:
Inhalation-Rat TC: 1000 ppm/ 6 hours/ 2
13% concentration in 25 minutes, at Inhalation-Mouse LCLo: 419 g/m3/2
years-intermittent: Carcinogenic
22% in 1 minute. hours
effects
INHALATION (dog): Butane is reported
Inhalation-Rat TC: 8000 ppm/ 6 hours/ 2 METHANOL:
to be anesthetic to dogs at 25%
years-intermittent: Neoplastic effects Skin Irritancy (rabbit) 500 mg/ 24 hours;
concentration. Butane is also a weak
Inhalation-Rat TC: 8000 ppm/ 6 hours/ 15 moderate
cardiac sensitizer (high
weeks-intermittent:: Carcinogenic Eye Irritancy (rabbit) 40 mg; moderate
concentrations can cause abnormal
effects DNA Inhibition System (lymphocyte,
heartbeats in animals under stress).
Inhalation-Human TCLo: 2000 ppm/ 7 human) 300 mmol/L
hours: Eye effects Microsomal Mutagenicity Assay
Oral-Rat LD50: 5480 mg/kg (lymphocyte, mouse) 7900 mg/L
TOXICITY DATA (continued):
METHANOL (continued): METHANOL (continued): 2-METHYL-2-BUTENE: There are
TDLo (oral, rat) = 7500 mg/kg; TCLo (inhalation, human) = 300 ppm; currently no specific toxicology data
reproductive effects eye, central nervous system, for 2-Methyl-2-Butene. 2-Methyl-2-
TCLo (inhalation, rat) = 10000 ppm/ 7 pulmonary effects Butene is a Simple Asphyxiant.
hours, teratogenic effects LC50 (inhalation, rat) = 64000 ppm/4 hours 3-METHYL-1-BUTENE: There are
LDLo (oral, man) = 6422 mg/kg; central LD50 (intraperitoneal, rat) = 7529 mg/kg currently no specific toxicology data
nervous system, pulmonary, LD50 (intravenous, rat) = 2131 mg/kg for 3-Methyl-1-Butene. 3-Methyl-1-
gastrointestinal effects LD50 (oral, mouse) = 7300 mg/kg Butene is a Simple Asphyxiant.
TDLo (oral, man) = 3429 mg/kg; eye LD50 (intraperitoneal, mouse) = 10765
METHYL tert-BUTYL ETHER:
effects mg/kg
Oral-Rat LD50: 4 g/kg
LDLo (oral, human) = 428 mg; central LD50 (subcutaneous, mouse) = 9800
Inhalation-Rat LC50: 23,576 ppm/4 hours
nervous system, pulmonary effects mg/kg
Intraperitoneal-Rat LD: >148 mg/kg
LDLo (oral, human) = 143 mg/kg; eye, LD50 (intravenous, mouse) = 4710 mg/kg
Intravenous-Rat LDLo: 148 mg/kg
pulmonary, gastrointestinal effects LD50 (dermal, rabbit) = 20000 mg/kg 3
Inhalation-Mouse LC50: 141 g/m /15
TDLo (oral, woman) = 4000 mg/kg; eye, LDLo (oral, monkey) = 7000 mg/kg
minutes
pulmonary, gastrointestinal effects LCLo (inhalation, monkey) = 1000 ppm
3
PENTANE:
TCLo (inhalation, human) = 86000 mg/m ; LDLo (skin, monkey) = 393 mg/kg
Intravenous-Mouse LD50: 446 mg/kg
eye, pulmonary effects 3
Inhalation-Rat LC50: 364 g/m /4 hours
LD50 (oral, rat) = 5628 mg/kg 3
Inhalation-Mouse LCLo: 325 g/m /2 hours
SUSPECTED CANCER AGENT: 1,3-Butadiene and Methyl tert-Butyl Ether (components of this liquid mixture) are
listed as follows:
1,3-BUTADIENE: 1,3-BUTADIENE (continued):
EPA- B2, Probable Human Carcinogen. ACGIH TLV-A2, Suspected Human Carcinogen.
IARC-2A, Probably Carcinogenic to Humans. NIOSH-X, Carcinogen defined with no further explanation.
MAK-A2, Unmistakably carcinogenic in animal experimentation only. METHYL tert-BUTYL ETHER:
NTP-Group 2, Reasonably Anticipated to be a Carcinogen. ACGIH TLV A3, Animal Carcinogen.
IARC-2B, Possibly Carcinogenic to Humans (limited human
evidence, sufficient animal evidence).
The other components of this liquid mixture are not found on the following lists: FEDERAL OSHA Z LIST, NTP,
CAL/OSHA, and IARC and therefore are neither considered to be nor suspected to be cancer-causing agents by
these agencies.
IRRITANCY OF PRODUCT: The liquid or vapors of this mixture can irritate the eyes, nose, throat, and skin.
SENSITIZATION OF PRODUCT: The components of this liquid mixture are not known to cause sensitization in
humans; however, Butane, Isopentane and Pentane may cause weak cardiac sensitization, based on animal tests.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this liquid
mixture and its components on the human reproductive system.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 8 OF 12
11. TOXICOLOGICAL INFORMATION (Continued)
Mutagenicity: Animal and human mutagenic data are reported for Methanol (a component of this liquid mixture)
based on clinical studies on lymphocytes exposed to this compound. Animal mutagenic data are available for 1,3-
Butadiene (a component of this liquid mixture); these data were obtained during clinical studies on specific animal
tissues exposed to relatively high doses of this compound.
Embryotoxicity: This liquid mixture is not reported to cause embryotoxic effects in humans.Teratogenicity: This
liquid mixture is not reported to cause teratogenic in humans. Animal teratogenic data are available for 1,3-
Butadiene and Methanol (components of this liquid mixture); these data were obtained during clinical studies on
specific animal tissues exposed to relatively high doses of these compounds.
Reproductive Toxicity: This liquid mixture is not expected to cause adverse reproductive effects in humans. Animal
reproductive data are available for Methanol (a component of this liquid mixture); these data were obtained during
clinical studies on specific animal tissues exposed to relatively high doses of this compound.
A mutagen is a chemical that causes permanent changes to genetic material (DNA) such that the changes will propagate
through generational lines. An embryotoxin is a chemical that causes damage to a developing embryo (i.e., within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical that causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance that interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Acute or chronic respiratory conditions, central nervous
system conditions, eye disorders, or skin problems may be aggravated by overexposure to this liquid mixture.
RECOMMENDATIONS TO PHYSICIANS: Administer oxygen if necessary, treat symptoms, and eliminate
exposure.
BIOLOGICAL EXPOSURE INDICES (BEIs): Biological Exposure Indices (BEIs) are applicable for this liquid
mixture are provided below.
CHEMICAL DETERMINANT SAMPLING TIME BEI
METHANOL
End of shift 15 mg/L
Methanol in urine
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: The components of this liquid mixture will be degraded over time into other organic
compounds. Additional environmental data are available for components as follows:
1,3-BUTADIENE: Log Kow = 1.99. Water Solubility = 735 mg/L at 20 C. Log BCF = estimated, 19.1. Bioconcentration factor does not indicate
that bioconcentration in aquatic organisms is important. This chemical is expected to be biodegraded in the environment.
BUTANE: Log Kow = 2.89. Water Solubility = 6.4 ppm at 25癈. Log BCF (n-butane) = calculated, 1.78 and 1.97, respectively. Expected Half-life =
0.13 hr. Bioconcentration factors do not indicate that bioconcentration in aquatic organisms is important.
METHANOL: log Kow = -0.77. Water Solubility = Miscible. BOD (g/g) = 0.76-1.12 standard dilution/sewage seed. Methanol occurs naturally as a
plant volatile and during microbial degradation of biological wastes. When released on land or water, it is apt to volatilize and biodegrade. The
estimated half-life in water is 5.3 hours to 2.6 days. Methanol is highly mobile in soil. The Bioconcentration Factor for Methanol is 2.0.
METHYL tert-BUTYL ETHER: Biodegradation; activated sludge aqueous screening study suggests this compound is may be resistant to
biodegradation in the environment. Bioconcentration (BCF) = 1.5 in Japanese carp; this compound will not be expected to bioconcentrate in
aquatic organisms.
PENTANE: Log Kow = 3.39. Water Solubility = 38.5 mg/L. Koc = 580-1600. LOG BCF (n-pentane) = calculated, 1.90 and 2.35, respectively.
Photolysis, hydrolysis, and bioconcentration are not anticipated to be important fate processes. Biodegradation and soil adsorption are
anticipated to be more important processes for this compound.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: This liquid mixture may be harmful or fatal to contaminated
plant and animal life (especially if large quantities of this liquid mixture are released). Refer to Section 11
(Toxicological Information) for additional information on effects on animals.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 9 OF 12
12. ECOLOGICAL INFORMATION (Continued)
EFFECT OF CHEMICAL ON AQUATIC LIFE: This liquid mixture can be harmful or fatal to contaminated aquatic
plant and animal life. This material floats on water and can potentially form slicks which are capable of creating
oxygen-deprived waterways and severely contaminating coastal and shore life. Aquatic toxicity data are available for
components as follows:
1, 3-BUTADIENE: TLm pinperch 71.5 mg/L/24 hours.
METHANOL: METHANOL (continued): METHANOL (continued):
LC50 (Pimephales promelas, fathead LD0 (Colpoda, protozoa) = 1,250 mg/L EC50 (Salmo gairdneri, fish) = 13,000
minnow) = 29.4 mg/L/ 96 hours NOEC (Daphnia, crustaceans) = 10,000 mg/kg/ 96 hours
EC0 (Pseudomonas putida, bacteria) = mg/L/ 48 hours LC50 (Lepomis macrochirus, fish) =
6,600 mg/L/ 16 hours EC50 (Daphnia magna Straus, 15,400 mg/L/ 96 hours
EC0 (Microcystis aeruginosa, algae) = crustaceans) > 10,000 mg/L/ 24 EC50 (Lepomis macrochirus, fish) =
530 mg/L/ 8 days hours 12,700 mg/L/ 96 hours
EC0 (Scenedesmus quadricauda) = 8,000 LC50 (Artemia salina, crustaceans) > LC50 (Alburnus alburnus, fish) = 28,000
mg/L/ 7 days 10,000 mg/L/ 24 hours mg/L/ 96 hours
LD0 (Scenedesmus, algae) = 10,000 LC50 (trout) = 8,000 mg/L/ 48 hours LC50 (Nitocra spinipes) = 12,000 mg/L/ 96
mg/L LC0 (creek chub) = 8,000 mg/L/ 24 hours hours
EC0 (Entosiphon sulcatum, protozoa) > LC100 (creek chub) = 17,000 mg/L/ 24
10,000 mg/L/ 72 hours hours
EC0 (Uronema parduczi Chatton-Lwoff, LC50 (Salmo gairdneri, fish) = 20,100
protozoa) > 10,000 mg/L mg/L/ 96 hours
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State,
and local regulations. Return cylinders with any residual liquid mixture to Air Liquide. Do not dispose of locally.
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME: Flammable liquids, n.o.s. (Isopentane, Methyl tert-Butyl Ether or
Isopentane, Butane)
HAZARD CLASS NUMBER and DESCRIPTION: 3 (Flammable Liquid)
UN IDENTIFICATION NUMBER: UN 1993
PACKING GROUP: Not applicable.
DOT LABEL(S) REQUIRED: Flammable Liquid
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (1996): 128
MARINE POLLUTANT: The components of this liquid mixture are not classified by the DOT as Marine Pollutants
(as defined by 49 CFR 172.101, Appendix B).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS
CONSIDERED AS DANGEROUS GOODS. Use the above information for the preparation of Canadian Shipments.
15. REGULATORY INFORMATION
U.S. SARA REPORTING REQUIREMENTS: The components of this liquid mixture are subject to the reporting
requirements of Sections 302, 304, and 313 of Title III of the Superfund Amendments and Reauthorization Act, as
follows:
COMPONENT SARA 302 SARA 304 SARA 313
1,3-Butadiene NO YES YES
Methanol NO YES YES
Methyl tert-Butyl Ether NO YES YES
This product is subject to the reporting requirements of Sections 311 and 312 of Title III of the Superfund
Amendments and Reauthorization Act (40 CFR 370.21)
U.S. SARA THRESHOLD PLANNING QUANTITY: Not applicable.
U.S. CERCLA REPORTABLE QUANTITIES (RQ): 1,3-Butadiene = 10 lb; Methanol = 5000 lb; Methyl tert-Butyl
Ether = 1000 lb.
CANADIAN DSL INVENTORY STATUS: The components of this mixture are listed on the Canadian DSL
Inventory.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 10 OF 12
15. REGULATORY INFORMATION (Continued)
U.S. TSCA INVENTORY STATUS: The components of this liquid mixture are listed on the TSCA Inventory.
OTHER U.S. FEDERAL REGULATIONS:
?1,3-Butadiene, Isopentane, Methanol, and Pentane are subject to the requirements of CFR 29 1910.1000; they
are listed in Table Z.1. Butane was subject to the requirements of CFR 29 1910.1000 (under the 1989 PELs);
Butane is no longer listed on Table Z.1. 1-Butene, cis-2-Butene, Isobutylene, 3-Methyl-1-Butene, 2-Methyl-2-
Butene, and Methyl tert-Butyl Ether are not subject to these reporting requirements.
?This liquid mixture does not contain any Class I or Class II ozone depleting chemicals (40 CFR part 82).
?1,3-Butadiene, Butane, 1-Butene, cis-2-Butene, Isobutylene, Isopentane, 2-Methyl-1-Butene, 3-Methyl-1-Butene,
and Pentane are subject to the reporting requirements of Section 112(r) of the Clean Air Act. The Threshold
Quantity for these components is 10,000 lb. Methanol, 2-Methyl-2-Butene, and Methyl tert-Butyl Ether are not
subject to these requirements.
?1,3-Butadiene, Butane, 1-Butene, cis-2-Butene, Isobutylene, Isopentane, 2-Methyl-1-Butene, 3-Methyl-1-Butene,
and Pentane are listed under 40 CFR part 68 in Table 3, as Regulated Substances (Flammable Substances) in
quantities of 10,000 lb (4,553 kg) or greater. Methanol, 2-Methyl-2-Butene, and Methyl tert-Butyl Ether are not
listed under this regulation.
?Depending on specific operations involving the use of this liquid mixture, the regulations of the Process Safety
Management of Highly Hazardous Chemicals may be applicable (29 CFR 1910.119). Under this regulation the
components of this liquid mixture are not listed in Appendix A; however, any process that involves a flammable
liquid on-site, in one location, in quantities of 10,000 lb (4,553 kg) or greater is covered under this regulation
unless it is used as a fuel.
CALIFORNIA PROPOSITION 65: 1,3-Butadiene (a component of this liquid mixture) is on the California Proposition
65 lists. WARNING: This product contains a chemical known to the State of California to cause cancer.
U.S. STATE REGULATORY INFORMATION: The components of this liquid mixture are covered under the
following specific State regulations:
Methanol, 2-Methyl-2-Butene, 3-Methyl-
Alaska - Designated Toxic and Hazardous Michigan - Critical Materials Register: 1,3-
1-Butene, Pentane.
Butadiene.
Substances: 1,3-Butadiene, Butane,
Rhode Island - Hazardous Substance List:
Methanol, Pentane. Minnesota - List of Hazardous
1,3-Butadiene, Butane, 1-Butene,
California - Permissible Exposure Limits Substances: 1,3-Butadiene, Butane,
Methanol, Pentane.
Pentane.
for Chemical Contaminants: 1,3-
Texas - Hazardous Substance List: 1,3-
Butadiene, Butane, Methanol, Pentane. Missouri - Employer Information/Toxic
Butadiene, Methanol, Pentane.
Florida - Substance List: 1,3-Butadiene, Substance List: 1,3-Butadiene, Butane,
cis-2-Butene, Isobutylene, Isopentane, Methanol, Pentane.
Methanol, 2-Methyl-2-Butene, 3-Methyl- New Jersey - Right to Know Hazardous
West Virginia - Hazardous Substance List:
1-Butene, Pentane. Substance List: 1,3-Butadiene, Butane,
1,3-Butadiene, Methanol, Pentane.
Illinois - Toxic Substance List: 1,3- 1-Butene, Isobutylene, Isopentane,
Wisconsin - Toxic and Hazardous
Butadiene, Butane, Pentane. Methyl tert-Butyl Ether, Pentane.
Substances: 1,3-Butadiene, Methanol,
Kansas - Section 302/313 List: 1,3- North Dakota - List of Hazardous
Pentane.
Butadiene, Isopentane, Methanol, Methyl Chemicals, Reportable Quantities:
tert-Butyl Ether. Methanol.
Massachusetts - Substance List: 1,3- Pennsylvania - Hazardous Substance List:
Butadiene, Butane, cis-2-Butene, 1,3-Butadiene, Butane, 1-Butene, cis-2-
Isobutylene, Isopentane, Methanol, 2- Butene, Isobutylene, Isopentane,
Methyl-2-Butene, 3-Methyl-1-Butene,
Pentane.
OTHER CANADIAN REGULATIONS: This liquid mixture is categorized as a Controlled Product, Hazard Classes
B2, and D2A, as per the Controlled Product Regulations.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 11 OF 12
16. OTHER INFORMATION
HAZARDOUS MATERIAL INFORMATION
NFPA RATING SYSTEM
FLAMMABILITY
HEALTH 2
(BLUE)
4
0
2
HEALTH REACTIVITY
FLAMMABILITY 4
(RED)
OTHER
REACTIVITY (YELLOW) 0
PROTECTIVE EQUIPMENT B
EYES HANDS BODY
RESPIRATORY
See Section 8
For routine industrial applications
MIXTURES: When two or more gases, liquefied gases, or liquids
are mixed, their hazardous properties may combine to create additional, unexpected hazards. Obtain and
evaluate the safety information for each component before you produce the mixture. Consult an Industrial
Hygienist or other trained person when you make your safety evaluation of the end product. Remember, gases
and liquids have properties which can cause serious injury or death.
Further information about gas mixtures can be found in the following pamphlets published by: Compressed Gas
Association Inc. (CGA), 4221 Walney Road 5th floor, Chantilly, VA 20151-2923 Telephone: (703) 788-2700
P-1 "Safe Handling of Compressed Gases in Containers"
AV-1 "Safe Handling and Storage of Compressed Gases"
"Handbook of Compressed Gases"
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
Fax on Demand: 1-800/231-1366
This Material Safety Data Sheet is offered pursuant to OSHA's Hazard Communication Standard, 29 CFR, 1910.1200. Other government
regulations must be reviewed for applicability to this product. To the best of Air Liquide's knowledge, the information contained herein is
reliable and accurate as of this date; however, accuracy, suitability or completeness are not guaranteed and no warranties of any type, either
express or implied, are provided. The information contained herein relates only to this specific product. If this product is combined with other
materials, all component properties must be considered. Data may be changed from time to time. Be sure to consult the latest edition.
FLAMMABLE LIQUID MIXTURE (40123) MSDS EFFECTIVE DATE: AUGUST 31, 2005
PAGE 12 OF 12
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