SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 29/APR/2005
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TERT.-BUTANOL
Product Number 24127
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-METHYL-2-PROPANOL 75-65-0 200-889-7 603-005-00-1
Formula C4H10O
Molecular Weight 74.12 AMU
Synonyms Alcool butylique tertiaire (French) * Arconol *
t-Butanol * tert-Butanol * Butanol tertiaire
(French) * tert-Butyl alcohol (OSHA) * t-Butyl
hydroxide * 1,1-Dimethylethanol * Methanol,
trimethyl- * 2-Methyl-2-propanol *
2-Methylpropan-2-ol * NCI-C55367 * 2-Propanol,
2-methyl- * Trimethylcarbinol * Trimethyl
methanol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Use water spray to cool fire-exposed containers.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Vapor may travel
considerable distance to source of ignition and flash back.
Emits toxic fumes under fire conditions.
Explosion Hazards: Container explosion can occur under fire
conditions. In advanced or massive fires the area should be
evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
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EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 450 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 150 mg/m3
50 ppm
Remarks: LH
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 300 mg/m3
100 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 75 mg/m3
25 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level150 mg/m3
50 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 300 mg/m3
100 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 308 mg/m3
100 ppm
OEL STEL 462 mg/m3
150 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 82 - 83 掳C
MP/MP Range 25 - 26 掳C
Flash Point 11 掳C Method: closed cup
Flammability N/A
Autoignition Temp 480 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.4 %
Upper: 8 %
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Vapor Pressure 31 mmHg 20 掳C
SG/Density 0.775 g/cm3
Partition Coefficient N/A
Viscosity 0.003 Pas 30 掳C
Vapor Density 2.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.1 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents Copper, Copper alloys,
Alkali metals, Aluminum.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Peroxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: EO1925000
ACUTE TOXICITY
LD50
Oral
Rat
2743 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Lungs, Thorax, or
Respiration:Respiratory depression. Gastrointestinal:Other
changes.
LC50
Inhalation
Rat
> 10,000 ppm
4H
Remarks: Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea. Lungs, Thorax, or Respiration:Pulmonary
emboli.
LD50
Intraperitoneal
Mouse
399 MG/KG
Remarks: Liver:Other changes.
LD50
Intravenous
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Mouse
1538 MG/KG
LD50
Oral
Rabbit
3559 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Cardiac:Pulse rate. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Skin
Rabbit
> 2000 mg/kg
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
IRRITATION DATA
Skin
Rabbit
0.5 ml
24H
Remarks: Mild irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Exposure can cause: Gastrointestinal
disturbances. Drying, cracking, or irritation of the skin.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Kidneys. Liver. Bladder. Thyroid.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria.
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Endocrine:Thyroid tumors.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 2000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 3500 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Mouse
Dose: 103 GM/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Mouse
Dose: 135 GM/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Mouse
Dose: 20240 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
ELIMINATION
Elimination: 99.9 %
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 6,140 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 933 mg/l
Test Type: IC50 Algae
Time: 72 h
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Value: > 1,000 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1120
Class: 3
PG: II
Proper Shipping Name: Butanols
IMDG
UN#: 1120
Class: 3
PG: II
Proper Shipping Name: Butanols
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1120
Class: 3
PG: II
Proper Shipping Name: Butanols
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-005-00-1
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 20
Highly flammable. Harmful by inhalation.
S-PHRASES: 9 16
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 14746
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
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equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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