SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 26/MAY/2005
Date Updated: 13/NOV/2004
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TEMED ELECTROPHORESIS REAGENT
Product Number T9281
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
N,N,N',N'-TETRAMETHYLETHYLENEDIAMI 110-18-9 203-744-6 612-103-00-3
NE
Formula C6H16N2
Molecular Weight 116.21 AMU
Synonyms 1,2-Bis-(dimethylamino)ethane *
1,2-Ethanediamine, N,N,N',N'-tetramethyl- (9CI)
* Propamine D * Temed * Tetrameen *
N,N,N',N'-Tetramethyl-1,2-diaminoethane *
N,N,N',N'-Tetramethylethanediamine *
N,N,N',N'-Tetramethyl-1,2-ethanediamine *
Tetramethyl ethylene diamine *
N,N,N',N'-Tetramethylethylenediamine * TMEDA
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation and if swallowed. Causes
burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
SPECIAL REQUIREMENTS: Handle and store under inert gas. Air and
moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
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Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 120 - 122 掳C 760 mmHg
MP/MP Range -55 掳C
Flash Point 20 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.98 %
Upper: 9.08 %
Vapor Pressure N/A
SG/Density 0.775 g/cm3
Partition Coefficient Log Kow: 0.3
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:10 mg/ml H2O, 20掳C
complete, colorless
Other Solvents: MOSTORGANIC SOLVENTS
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to air and
moisture.
Materials to Avoid: Strong oxidizing agents Carbon dioxide.
Copper, Copper alloys
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
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RTECS NUMBER: KV7175000
ACUTE TOXICITY
LD50
Oral
Rat
268 mg/kg
Remarks: Brain and Coverings:Other degenerative changes. Spinal
Cord:Other degenerative changes.
LC50
Inhalation
Rat
1,318 ppm
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Ataxia. Behavioral:Irritability.
LD50
Oral
Mouse
630 mg/kg
LD50
Skin
Rabbit
5390 mg/kg
LD50
Subcutaneous
Rabbit
1230 MG/KG
LD50
Oral
Quail
> 316 mg/kg
IRRITATION DATA
Skin
Rabbit
10 mg
24H
Remarks: Open irritation test
Eyes
Rabbit
0.75 mg
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
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Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. Harmful if
inhaled. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2372
Class: 3
PG: II
Proper Shipping Name: 1,2-Di-(dimethylamino)ethane
IMDG
UN#: 2372
Class: 3
PG: II
Proper Shipping Name: 1,2-DI(DIMETHYLAMINO)ETHANE
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2372
Class: 3
PG: II
Proper Shipping Name: 1,2-DI-(DIMETHYLAMINO) ETHANE
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-103-00-3
INDICATION OF DANGER: F C
Highly Flammable. Corrosive.
R-PHRASES: 11 20/22 34
Highly flammable. Harmful by inhalation and if swallowed.
Causes burns.
S-PHRASES: 16 26 36/37/39 45
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1 (self-classification)
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SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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