SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 27/MAY/2005
Date Updated: 22/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TERBUTALINE HEMISULFATE
Product Number T2528
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TERBUTALINE HEMISULFATE 23031-32-5 245-386-3 None
Formula C12H19NO3 路 0.5H2O4S
Molecular Weight 274.3 AMU
Synonyms 1,3-Benzenediol,
5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-,
sulfate (2:1) (salt) * Brethine * Bricanyl *
alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenz
yl alcohol sulfate (2:1) (salt) *
1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol
sulphate * Terbutaline sulfate * Terbutaline
sulphate
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause sensitization by inhalation and skin contact. Possible
risk of harm to the unborn child.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear protective equipment.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
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Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DN9000000
ACUTE TOXICITY
LD50
Oral
Rat
8700 mg/kg
LD50
Intraperitoneal
Rat
220 MG/KG
LD50
Subcutaneous
Rat
130 MG/KG
LD50
Intravenous
Rat
69 MG/KG
LD50
Oral
Mouse
205 mg/kg
Remarks: Autonomic Nervous System: Sympathomimetic.
LD50
Intraperitoneal
Mouse
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130 MG/KG
LD50
Subcutaneous
Mouse
260 MG/KG
LD50
Intravenous
Mouse
36 MG/KG
LD50
Oral
Dog
1520 mg/kg
LD50
Intravenous
Dog
116 MG/KG
LD50
Oral
Rabbit
> 8000 mg/kg
LD50
Intravenous
Rabbit
110 MG/KG
SENSITIZATION
Sensitization: May cause allergic reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause bronchodilation, nervousness, muscle tremors,
headache, tachycardia, palpitations, drowsiness, nausea,
vomiting, and sweating. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.
TARGET ORGAN INFORMATION
Lungs. Heart. Nerves.
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (17-19D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
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Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (17-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Respiratory system.
Species: Mouse
Dose: 24 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Guinea pig
Dose: 20 GM/KG
Route of Application: Subcutaneous
Exposure Time: (11-20D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 2500 NG/KG
Route of Application: Subcutaneous
Exposure Time: (39W PREG)
Result: Maternal Effects: Other effects. Vascular:BP lowering
not charactertized in autonomic section.
Species: Woman
Dose: 1 MG/KG
Route of Application: Oral
Exposure Time: (26W PREG)
Result: Maternal Effects: Other effects.
Species: Rat
Dose: 120 MG/KG
Route of Application: Subcutaneous
Exposure Time: (30D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (17-19D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Physical.
Species: Mouse
Dose: 3 GM/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
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Dose: 192 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-12D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 42/43 63
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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