SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 11/MAY/2004
Version 1.2
According to 91/155/EEC
1 - Product and Company Information
Product Name (+-)-SULPIRIDE
Product Number S8010
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(+-)-SULPIRIDE 15676-16-1 239-753-7 None
Formula C15H23N3O4S
Molecular Weight 341.4 AMU
Synonyms Abilit * Aiglonyl *
5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)meth
yl)-2-methoxybenzamide * Benzamide,
5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)meth
yl)-2-methoxy- (9CI) * Coolspan * Dobren *
Dogmatil * Dogmatyl * Eglonyl *
N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-su
lfamoylbenzamide *
N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-
anisamide * Guastil * Miradol * Mirbanil *
Misulvan * Omperan * Pyrkappl * R.D. 1403 *
Sernevin * Splotin * Sulpirid * Sulpiride *
Sulpyrid * Sursumid
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: BZ3400000
ACUTE TOXICITY
LD50
Oral
Rat
9800 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
LD50
Intraperitoneal
Rat
210 MG/KG
LD50
Subcutaneous
Rat
360 MG/KG
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LD50
Intravenous
Rat
40 MG/KG
LD50
Oral
Mouse
1700 mg/kg
LD50
Intraperitoneal
Mouse
170 MG/KG
LD50
Subcutaneous
Mouse
290 MG/KG
LD50
Intravenous
Mouse
48 MG/KG
LD50
Oral
Dog
2000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
LD50
Subcutaneous
Dog
350 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Respiratory depression.
LD50
Intravenous
Dog
137 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Respiratory depression.
LD50
Oral
Rabbit
4000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
LD50
Subcutaneous
Rabbit
2 GM/KG
Remarks: Behavioral:Somnolence (general depressed activity).
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Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Respiratory depression.
LD50
Intravenous
Rabbit
63 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Respiratory depression.
SIGNS AND SYMPTOMS OF EXPOSURE
Tachycardia, arrhythmias, hypertension, fatigue, agitation,
sleep disorders, overstimulation, amenorrhoea, galactorrhoea,
gynaecomastia, extrapyramidal dysfunction, impotence, skin rash,
and photosensitization. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated. Exposure can cause:
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat Rat
Dose: 1015 MG/KG 1015 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (29D PRE) (29D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes. Maternal
Effects: Menstrual cycle changes or disorders. Maternal Effects:
Ovaries, fallopian tubes. Maternal Effects: Menstrual cycle
changes or disorders.
Species: Rat Rat
Dose: 181 MG/KG 181 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (1D PRE) (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Effects on Fertility: Other measures of fertility
Species: Dog Dog
Dose: 45500 MG/KG 45500 MG/KG
Route of Application: Oral Oral
Exposure Time: (91D PRE) (91D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Uterus, cervix, vagina.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
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Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EC.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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