SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 26/MAY/2005
Date Updated: 16/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PACLITAXEL, 95%
Product Number 417017
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PACLITAXEL FROM TAXUS BREVIFOLIA 33069-62-4 None None
Ingredient Name Percent CAS # EC no Annex I
Index Number
The hazards identified None None None
with this product are
those associated with
the residual solvents
that are used in the
manufacturing process.
METHANOL <= 4 67-56-1 200-659-6 603-001-00-X
Symbols: F T
R-Phrases: 11 23/24/25 39/23/24/25
Highly flammable. Toxic by inhalation, in contact with skin and if
swallowed. Toxic: danger of very serious irreversible effects
through inhalation, in contact with skin and if swallowed.
2-PROPANOL <= 4 67-63-0 200-661-7 603-117-00-0
Symbols: F Xi
R-Phrases: 11 36 67
Highly flammable. Irritating to eyes. Vapors may cause drowsiness
and dizziness.
ETHYL ALCOHOL, <= 1 64-17-5 200-578-6 603-002-00-5
NON-DENATURED, 200 PROOF
Symbols: F
R-Phrases: 11
Highly flammable.
Formula C47H51NO14
Molecular Weight 853.93 AMU
Synonyms BMS 181339-01 * NSC-125973 * Paclitaxel * Taxol
* Taxol A
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation, in contact with skin and if swallowed.
Harmful: danger of serious damage to health by prolonged exposure
through inhalation in contact with skin, and if swallowed.
Irritating to respiratory system and skin. Risk of serious damage
to eyes. May cause sensitization by inhalation and skin contact.
Possible risk of impaired fertility. Possible risk of irreversible
effects.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
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7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated
exposure. Do not use if skin is cut or scratched. Wash
thoroughly after handling.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH 3-8
BP/BP Range N/A
MP/MP Range 213 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.2 g/cm3
Partition Coefficient Log Kow: > 99
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. > 100 掳C
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DA8340700
ACUTE TOXICITY
LDLO
Intravenous
Woman
4,995 mg/kg
LD50
Intraperitoneal
Rat
32,530 mg/kg
LD50
Intraperitoneal
Mouse
128 mg/kg
LD50
Intravenous
Mouse
12 mg/kg
LDLO
Intravenous
Woman
4995 MG/KG
3H-C
Remarks: Cardiac:Cardiomyopathy including infarction.
Blood:Leukopenia. Blood:Thrombocytopenia.
LD50
Intraperitoneal
Rat
32530 UG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
LD50
Intraperitoneal
Mouse
128 MG/KG
Remarks: Skin and Appendages: Other: Hair. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
LD50
Intravenous
Mouse
12 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory
depression.
SENSITIZATION
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Respiratory: May cause allergic respiratory reaction.
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Damage to the liver. Alopecia. Nausea,
headache, and vomiting. Damage to the kidneys. Can cause severe
cardiotoxicity and bone marrow suppression.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. Harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Cardiovascular system. Heart. Nerves. Eyes. Kidneys. Liver. Bone
marrow. Lungs. Blood. Skin. G.I. System.
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Mouse
20 MG/KG
Subcutaneous
Micronucleus test
Hamster
80 UG/L
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 6600 UG/KG
Route of Application: Intravenous
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Newborn: Delayed effects.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 84 MG/KG
Route of Application: Intravenous
Exposure Time: (9W MALE/2W PRE/1-7D PREG)
Result: Maternal Effects: Other effects. Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora
lutea). Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 26 MG/KG
Route of Application: Intravenous
Exposure Time: (17-21D PREG/21D POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Behavioral. Effects on
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Newborn: Physical.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 20/21/22 48/20/21/22 37/38 41 42/43 62 68
Harmful by inhalation, in contact with skin and if swallowed.
Harmful: danger of serious damage to health by prolonged
exposure through inhalation in contact with skin, and if
swallowed. Irritating to respiratory system and skin. Risk of
serious damage to eyes. May cause sensitization by inhalation
and skin contact. Possible risk of impaired fertility. Possible
risk of irreversible effects.
S-PHRASES: 22 26 36/37/39 45
Do not breathe dust. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
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