SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 28/JUN/2005
Date Updated: 21/DEC/2004
Version 1.9
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DICHLOROMETHANE
Product Number D7566
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DICHLOROMETHANE 75-09-2 200-838-9 602-004-00-3
Formula CH2Cl2
Molecular Weight 84.93 AMU
Synonyms Aerothene MM * Chlorure de methylene (French) *
Dichloromethane (DOT:OSHA) * F 30 (chlorocarbon)
* Freon 30 * HCC 30 * Khladon 30 * Methane
dichloride * Methylene bichloride * Methylene
chloride (ACGIH:OSHA) * Methylene dichloride *
Metylenu chlorek (Polish) * Narkotil *
NCI-C50102 * R30 (refrigerant) * RCRA waste
number U080 * Solaesthin * Soleana VDA *
Solmethine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Limited evidence of a carcinogenic effect.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure. For protection and handling requirements consult CFR
title 29 part 1910.1052.
STORAGE
Conditions of Storage: Store under inert gas. Keep tightly
closed. Store in a cool dry place.
SPECIAL REQUIREMENTS: Store under inert gas. Heat sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 20 MG/M3
Poland NDSCh 50 MG/M3
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Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 122 mg/m3
35 ppm
Remarks: HK
EXPOSURE LIMITS - FRANCE
Source Type Value
STEL 350 mg/m3
100 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 350 mg/m3
100 ppm
Remarks: 4
EXPOSURE LIMITS - HUNGARY
Source Type Value
STEL 350 mg/m3
100 ppm
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 50 mg/m3
15 ppm
Remarks: HK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level120 mg/m3
35 ppm
Remarks: H, K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 360 mg/m3
100 ppm
Remarks: D M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 350 mg/m3
100 ppm
OEL STEL 1,060 mg/m3
300 ppm
Remarks: Biological Monitoring Guidance value
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range 40 掳C
MP/MP Range -97 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp 662 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 14 %
Upper: 22 %
Vapor Pressure 353.111 mmHg 20 掳C
SG/Density 1.325 g/cm3
Partition Coefficient Log Kow: 1.25
Viscosity < 0.001 Pas 20 掳C
Vapor Density 2.9 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
Solvent: 0.1 g/ml diethyl ether 0.1 g/ml
EtOH 0.1 g/ml acetone
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Heat.
Materials to Avoid: Alkali metals, Aluminum.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas, Phosgene gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: PA8050000
ACUTE TOXICITY
LDLO
Oral
Human
357 mg/kg
Remarks: Peripheral Nerve and Sensation:Paresthesis.
Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Rat
1600 mg/kg
Remarks: Behavioral:Ataxia.
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LC50
Inhalation
Rat
52,000 mg/m3
LD50
Intraperitoneal
Rat
916 MG/KG
LD50
Oral
Mouse
873 mg/kg
LC50
Inhalation
Mouse
14,400 ppm
7H
LD50
Intraperitoneal
Mouse
437 MG/KG
LD50
Subcutaneous
Mouse
6460 MG/KG
LD50
Intraperitoneal
Dog
1274 MG/KG
IRRITATION DATA
Skin
Rabbit
810 mg
24H
Remarks: Severe irritation effect
Skin
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
162 mg
Remarks: Moderate irritation effect
Eyes
Rabbit
10 mg
Remarks: Mild irritation effect
Eyes
Rabbit
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500 mg
24H
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Dichloromethane is metabolized in the body producing carbon
monoxide which increases and sustains carboxyhemoglobin levels
in the blood, reducing the oxygen-carrying capacity of the
blood. A simple asphyxiant, exposure can cause anesthetic
action, difficulty in breathing, headache, and dizziness.
Prolonged or repeated contact with skin can cause defatting and
dermatitis. Contact with eyes can cause redness, tearing, and
blurred vision. Ingestion may cause gastrointestinal irritation.
CNS depression. Paresthesia. Somnolence. Convulsions.
Conjunctivitis. Pulmonary edema. Effects may be delayed.
Irregular breathing. Ingestion can cause gastrointestinal
disorders, nausea, and vomiting. Increased liver enzymes.
Weakness. Drowsiness. Heavy or prolonged skin exposure may
result in the absorption of harmful amounts of material.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Target organ: heart because methylene chloride is converted to
carbon monoxide in the body. Target organ: central nervous
system because of possible dizziness, headache, loss of
consciousness and death at high concentrations. Liver. Pancreas.
CONDITIONS AGGRAVATED BY EXPOSURE
Existing data suggests that methylene chloride may be a weak
mutagen in mammalian systems.
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Endocrine:Tumors.
Mouse
Route of Application: Inhalation
Exposure Time: 5H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Human
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5000 PPM
1H
Cell Type: fibroblast
DNA inhibition
Rat
160 UMOL/L
Cell Type: Embryo
Morphological transformation.
Rat
1275 MG/KG
Oral
DNA damage
Rat
30 UMOL/L
Cell Type: liver
DNA damage
Mouse
27760 MG/M3/6H/2W-I
Inhalation
Micronucleus test
Mouse
400 UMOL/L
Cell Type: liver
DNA damage
Mouse
4000 PPM
Inhalation
6H
DNA damage
Mouse
1720 MG/KG
Oral
DNA damage
Mouse
27760 MG/M3/6H/2W-I
Inhalation
Cytogenetic analysis
Mouse
13880 MG/M3/6H/2W-I
Inhalation
Sister chromatid exchange
Hamster
1300 UL/PLATE
Cell Type: Embryo
Morphological transformation.
Hamster
3000 PPM
Cell Type: ovary
DNA damage
Hamster
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5000 PPM
1H
Cell Type: lung
DNA inhibition
Hamster
6628 MG/L
Cell Type: ovary
Other mutation test systems
Hamster
1 UMOL/L
Cell Type: lung
Cytogenetic analysis
Hamster
6628 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
5000 PPM
1H
Cell Type: lung
Sister chromatid exchange
Hamster
3000 PPM
Cell Type: ovary
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 1250 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Urogenital system.
Species: Mouse
Dose: 1250 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 4500 PPM/24H
Route of Application: Inhalation
Exposure Time: (1-17D PREG)
Result: Effects on Newborn: Behavioral.
CMR CAT.: Carc. Cat.3
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
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Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 193 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 1,682 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1593
Class: 6.1
PG: III
Proper Shipping Name: Dichloromethane
IMDG
UN#: 1593
Class: 6.1
PG: III
Proper Shipping Name: Dichloromethane
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1593
Class: 6.1
PG: III
Proper Shipping Name: Dichloromethane
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-004-00-3
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 40
Limited evidence of a carcinogenic effect.
S-PHRASES: 23 24/25 36/37
Do not breathe vapor. Avoid contact with skin and eyes. Wear
suitable protective clothing and gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
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more.
YL-tall m3/l: 21120
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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