SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/AUG/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DI-TERT-BUTYL DICARBONATE,
REAGENTPLUS(TM), 99%
Product Number 205249
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DI-TERT-BUTYL DICARBONATE 24424-99-5 246-240-1 None
Formula C10H18O5
Molecular Weight 218.25 AMU
Synonyms Bis(1,1-dimethylethyl) dicarbonate *
BOC-anhydride * tert-Butyl dicarbonate *
Di-tert-butyl oxydiformate * Di-tert-butyl
pyrocarbonate * Formic acid, oxydi-,
di-tert-butyl ester (7CI,8CI * Pyrocarbonic acid
di-tert-butyl ester
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Very toxic by inhalation. Irritating to eyes,
respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Always open containers slowly to
allow any excess pressure to vent. Do not breathe vapor. Do not
get in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Incompatible Materials: Avoid contact with acid.
Store at 2-8藲C
SPECIAL REQUIREMENTS: May develop pressure. Open carefully.
8 - Exposure Controls / Personal Protection
SIAL - 205249 www.sigma-aldrich.com Page 2
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 56 - 57 藲C 0.5 mmHg
MP/MP Range 22 藲C
Flash Point 37 藲C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.95 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents, Reducing agents Avoid
contact with acid., Bases
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: HT0230000
SIAL - 205249 www.sigma-aldrich.com Page 3
ACUTE TOXICITY
LC50
Inhalation
Rat
100 mg/m3
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Lungs, Thorax, or Respiration:Dyspnea.
Nutritional and Gross Metabolic:Weight loss or decreased weight
gain.
LD50
Oral
Mammal
> 5000 mg/kg
LD50
Skin
Mammal
> 2000 mg/kg
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be fatal if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2929
Class: 6.1
PG: I
Proper Shipping Name: Toxic liquid, flammable,
organic, n.o.s.
IMDG
UN#: 2929
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: TOXIC LIQUID, FLAMMABLE,
ORGANIC, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
SIAL - 205249 www.sigma-aldrich.com Page 4
Technical Name: Required
IATA
UN#: 2929
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Toxic liquid, flammable,
organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 10 26 36/37/38
Flammable. Very toxic by inhalation. Irritating to eyes,
respiratory system and skin.
S-PHRASES: 7/9 16 26 28 36/37 45
Keep container tightly closed and in well-ventilated place.
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. After contact with skin, wash immediately
with plenty of water. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIAL - 205249 www.sigma-aldrich.com Page 5
|