SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2005
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DEXAMETHASONE, 98%
Product Number 861871
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DEXAMETHASONE 50-02-2 200-003-9 None
Formula C22H29FO5
Molecular Weight 392.47 AMU
Synonyms Aeroseb-dex * Aphtasolon * Azium * Calonat *
Corsone * Decaderm * Decadron * Decasone *
Decaspray * Dectancyl *
1-Dehydro-16-alpha-methyl-9-alpha-fluorohydrocort
isone * Dekacort * Deltafluorene * Dergramin *
Deronil * Desadrene * Desametasone *
Desamethasone * Desameton * Dexa-Cortidelt *
Dexa-Cortisyl * Dexadeltone * Dexalona *
Dexameth * Dexamethasone * Dexamethasone alcohol
* Dexamethazone * Dexapolcort * Dexaprol *
Dexa-Scheroson * Dexason * Dexone * Dextelan *
Dezone * DXMS * Fluorocort * delta(sup
1)-9-alpha-Fluoro-16-alpha-methylcortisol *
9-alpha-Fluoro-16-alpha-methylprednisolone *
9-alpha-Fluoro-16-alpha-methyl-1,4-pregnadiene-11
-beta,17-alpha,21-triol-3,20-dione *
4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trih
ydroxypregna-1,4-diene-3,20-dione *
9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl
pregna-1,4-diene-3,20-dione *
9-alpha-Fluoro-11-beta,17-alpha,21-trihydroxy-16-
alpha-methylpregna-1,4-diene-3,20-dione *
Fortecortin * Gammacorten * Hexadecadrol *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause sensitization by skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing dust. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place. Store in the dark.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required.
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GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 262 - 264 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen fluoride.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TU3980000
ACUTE TOXICITY
LD50
Oral
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Rat
> 3000 mg/kg
LD50
Intraperitoneal
Rat
54 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Gastrointestinal:Hypermotility,
diarrhea. Skin and Appendages: Other: Hair.
LD50
Subcutaneous
Rat
14 MG/KG
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain.
LD50
Intraperitoneal
Mouse
410 MG/KG
LD50
Subcutaneous
Mouse
4400 MG/KG
LD50
Subcutaneous
Rabbit
7200 UG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Gastrointestinal:Hypermotility, diarrhea.
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Pituitary.
CHRONIC EXPOSURE - MUTAGEN
Human
2 MMOL/L
Cell Type: liver
DNA
Human
10 MG/L
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Cell Type: lymphocyte
Cytogenetic analysis
Human
1 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
1 UMOL/L
Cell Type: Other cell types
DNA damage
Rat
100 NMOL/L
Cell Type: Other cell types
DNA inhibition
Rat
10 UMOL/L
Cell Type: Other cell types
DNA inhibition
Mouse
1 MG/KG
Intraperitoneal
Micronucleus test
Mouse
1 MMOL/L
Cell Type: Bone marrow
Unscheduled DNA synthesis
Mouse
3 MG/KG
Skin
DNA inhibition
Mouse
3 MG/KG
Skin
Other mutation test systems
Mouse
1 UMOL/L
Cell Type: leukocyte
Other mutation test systems
Mouse
10 NMOL/L
Cell Type: leukocyte
DNA inhibition
Mouse
100 UG/KG
Intraperitoneal
Sister chromatid exchange
Chicken
150 PMOL/L
Cell Type: Embryo
DNA inhibition
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CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 6 MG/KG
Route of Application: Oral
Exposure Time: (8-13D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 2 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
Species: Rat
Dose: 880 UG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 7500 UG/KG
Route of Application: Oral
Exposure Time: (15-17D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Body wall.
Species: Rat
Dose: 4200 UG/KG
Route of Application: Skin
Exposure Time: (9W MALE/2W PRE-7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 1500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (17-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Respiratory system.
Species: Rat
Dose: 2 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (20D PREG)
Result: Specific Developmental Abnormalities: Respiratory system.
Species: Rat
Dose: 1500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (16D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
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Species: Rat
Dose: 700 UG/KG
Route of Application: Subcutaneous
Exposure Time: (12-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Endocrine system.
Species: Rat
Dose: 900 UG/KG
Route of Application: Subcutaneous
Exposure Time: (8-16D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 1100 UG/KG
Route of Application: Subcutaneous
Exposure Time: (7-17D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Effects on
Newborn: Growth statistics (e.g., reduced weight gain).
Species: Rat
Dose: 3600 UG/KG
Route of Application: Subcutaneous
Exposure Time: (8-16D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Specific Developmental
Abnormalities: Craniofacial (including nose and tongue).
Species: Rat
Dose: 11 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Body wall. Specific Developmental Abnormalities:
Cardiovascular (circulatory) system.
Species: Rat
Dose: 1500 UG/KG
Route of Application: Subcutaneous
Exposure Time: (16-20D PREG
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific Developmental Abnormalities: Endocrine system.
Species: Rat
Dose: 1500 UG/KG
Route of Application: Parenteral
Exposure Time: (16D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain). Effects on Newborn: Physical.
Species: Mouse
Dose: 5 MG/KG
Route of Application: Oral
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Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 3600 UG/KG
Route of Application: Subcutaneous
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 28800 UG/KG
Route of Application: Subcutaneous
Exposure Time: (7-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 10 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 400 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intramuscular
Exposure Time: (13D PREG)
Result: Specific Developmental Abnormalities: Skin and skin
appendages.
Species: Mouse
Dose: 1200 UG/KG
Route of Application: Ocular
Exposure Time: (10-13D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 6 MG/KG
Route of Application: Ocular
Exposure Time: (10-13D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Mouse
Dose: 6 MG/KG
Route of Application: Parenteral
Exposure Time: (16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
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Dose: 400 UG/KG
Route of Application: Parenteral
Exposure Time: (16D PREG)
Result: Specific Developmental Abnormalities: Respiratory system.
Species: Rabbit
Dose: 400 UG/KG
Route of Application: Oral
Exposure Time: (13-16D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rabbit
Dose: 2 MG/KG
Route of Application: Oral
Exposure Time: (13-16D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 130 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rabbit
Dose: 390 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rabbit
Dose: 554 UG/KG
Route of Application: Ocular
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Gastrointestinal
system. Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Other developmental
abnormalities.
Species: Rabbit
Dose: 360 UG/KG
Route of Application: Parenteral
Exposure Time: (25-27D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
Species: Hamster
Dose: 4 MG/KG
Route of Application: Intramuscular
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Cattle, Horse
Dose: 60 UG/KG
Route of Application: Intramuscular
Exposure Time: (39W PREG)
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Result: Specific Developmental Abnormalities: Immune and
reticuloendothelial system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 8800 UG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetal death.
Species: Rat
Dose: 8800 UG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Species: Rat
Dose: 1802 UG/KG
Route of Application: Skin
Exposure Time: (26W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rat
Dose: 5 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (14-18D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 3 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (14-15D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 3 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D MALE)
Result: Paternal Effects: Other effects on male.
Species: Rat
Dose: 800 UG/KG
Route of Application: Subcutaneous
Exposure Time: (15-22D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
Effects on Newborn: Other postnatal measures or effects.
Species: Dog
Dose: 18 MG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Monkey
Dose: 3700 MG/KG
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Route of Application: Intramuscular
Exposure Time: (18-23W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain). Effects on
Newborn: Physical.
Species: Rabbit
Dose: 1600 UG/KG
Route of Application: Intramuscular
Exposure Time: (25-26D PREG)
Result: Maternal Effects: Parturition.
Species: Rabbit
Dose: 2 MG/KG
Route of Application: Parenteral
Exposure Time: (25-26D PREG)
Result: Maternal Effects: Parturition.
Species: Pig
Dose: 6667 UG/KG
Route of Application: Intramuscular
Exposure Time: (14W PREG)
Result: Maternal Effects: Parturition.
Species: Pig
Dose: 6670 UG/KG
Route of Application: Parenteral
Exposure Time: (14W PREG)
Result: Maternal Effects: Parturition.
Species: Pig
Dose: 3750 UG/KG
Route of Application: Parenteral
Exposure Time: (14W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Guinea pig
Dose: 2 MG/KG
Route of Application: Subcutaneous
Exposure Time: (51-52D PREG)
Result: Maternal Effects: Other effects.
Species: Domestic Animals
Dose: 560 UG/KG
Route of Application: Intravenous
Exposure Time: (22-23D PREG)
Result: Maternal Effects: Other effects. Effects on Newborn:
Delayed effects.
Species: Domestic Animals
Dose: 560 UG/KG
Route of Application: Intravenous
Exposure Time: (27-28D PREG)
Result: Effects on Newborn: Physical.
Species: Horse, donkey
Dose: 1905 UG/KG
Route of Application: Intramuscular
Exposure Time: (45W PREG)
Result: Maternal Effects: Parturition.
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Species: Horse, donkey
Dose: 800 UG/KG
Route of Application: Intramuscular
Exposure Time: (45-46W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Domestic Animals
Dose: 120 UG/KG
Route of Application: Intramuscular
Exposure Time: (40W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn: Other
postnatal measures or effects.
Species: Horse, donkey
Dose: 889 UG/KG
Route of Application: Parenteral
Exposure Time: (45-46W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Mammal
Dose: 877 MG/KG
Route of Application: Subcutaneous
Exposure Time: (20D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 43
May cause sensitization by skin contact.
S-PHRASES: 36/37
Wear suitable protective clothing and gloves.
16 - Other Information
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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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