SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2005
Date Updated: 20/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DESIPRAMINE HYDROCHLORIDE
Product Number D3900
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DESIPRAMINE HYDROCHLORIDE 58-28-6 200-373-1 None
Formula C18H22N2 藝 HCl
Molecular Weight 302.9 AMU
Synonyms Demethylimipramine hydrochloride * Desipramine
hydrochloride * Desmethylimipramine
hydrochloride * 5H-Dibenz(b,f)azepine,
10,11-dihydro-5-(3-(methylamino)propyl)-,
hydrochloride *
10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz
(b,f)azepine hydrochloride * DMI hydrochloride *
EX 4355 * G 35020 * GMI * Imipraminedemethyl
hydrochloride * JB 8181 *
N-(gamma-Methylaminopropyl)iminodibenzyl
hydrochloride * Norpramin * NSC-114901 *
Pertofran * Pertofrane * RMI 9,384A
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin. May cause sensitization by inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place. Store with desiccant.
Store at 2-8藲C
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
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Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 214 - 218 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: ETHANOL, CHLOROFORM,
METHANOL
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: HO0525000
ACUTE TOXICITY
LD50
Oral
Rat
871 mg/kg
LD50
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Intraperitoneal
Rat
55 MG/KG
LD50
Intravenous
Rat
19 MG/KG
LD50
Oral
Mouse
315 mg/kg
LD50
Intraperitoneal
Mouse
88 MG/KG
LD50
Intravenous
Mouse
37 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Rigidity (includes catalepsy). Nutritional and Gross
Metabolic:Changes in:Body temperature decrease.
LD50
Intravenous
Dog
25 MG/KG
SENSITIZATION
Sensitization: May cause allergic reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Heart.
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 90 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Central nervous system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
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Dose: 130 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-22D PREG)
Result: Effects on Newborn: Behavioral.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38 42/43
Harmful if swallowed. Irritating to eyes, respiratory system
and skin. May cause sensitization by inhalation and skin
contact.
S-PHRASES: 22 24 26 36/37
Do not breathe dust. Avoid contact with skin. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing and
gloves.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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