SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 22/JUL/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DEHYDROISOANDROSTERONE CRYSTALLINE
Product Number D4000
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(+)-DEHYDROISOANDROSTERONE, 97% 53-43-0 200-175-5 None
Formula C19H28O2
Molecular Weight 288.43 AMU
Synonyms Androstenolone * Androst-5-en-17-one,
3-hydroxy-, (3-beta)- (9CI) * 17-Chetovis *
trans-Dehydroandrosterone *
Dehydroepiandrosterone *
5-Dehydroepiandrosterone *
Dehydroisoandrosterone *
5,6-Dehydroisoandrosterone * DHEA * Diandron *
Diandrone * 5,6-Didehydroisoandrosterone *
17-Hormoforin *
3-beta-Hydroxy-5-androsten-17-one *
(3-beta)-3-Hydroxyandrost-5-en-17-one *
Prasterone * Psicosterone
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Rubber gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Very faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
SIGMA - D4000 www.sigma-aldrich.com Page 2
MP/MP Range 148 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
11 - Toxicological Information
RTECS NUMBER: BV8396000
ACUTE TOXICITY
LD50
Oral
Rat
> 10000 mg/kg
LD50
Subcutaneous
Rat
1 GM/KG
LD50
Oral
Mouse
> 10000 mg/kg
LD50
Subcutaneous
Mouse
900 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause masculinization, nitrogen and water retention,
electrolyte imbalance, adverse reproductive effects, androgenic
side effects pregnant females should avoid exposure. To the best
of our knowledge, the chemical, physical, and toxicological
SIGMA - D4000 www.sigma-aldrich.com Page 3
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption. Causes eye and skin irritation.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 84W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 52D
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
Mouse
Route of Application: Implant
Exposure Time: 50D
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
CHRONIC EXPOSURE - MUTAGEN
Rat
500 MG/KG
Oral
Unscheduled DNA synthesis
Rat
3780 MG/KG
Oral
14D
DNA inhibition
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 300 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 240 MG/KG
Route of Application: Intramuscular
Exposure Time: (13-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Endocrine system. Specific Developmental Abnormalities:
Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1800 MG/KG
SIGMA - D4000 www.sigma-aldrich.com Page 4
Route of Application: Oral
Exposure Time: (2-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Abortion.
Species: Rat
Dose: 3500 NG/KG
Route of Application: Oral
Exposure Time: (8-21D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
Effects on Newborn: Other postnatal measures or effects.
Species: Rat
Dose: 357 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 300 MG/KG
Route of Application: Subcutaneous
Exposure Time: (20D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat
Dose: 600 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PREG)
Result: Maternal Effects: Other effects. Endocrine:Change in LH.
Endocrine:Estrogenic.
Species: Rat
Dose: 240 MG/KG
Route of Application: Intramuscular
Exposure Time: (13-20D PREG)
Result: Maternal Effects: Ovaries, fallopian tubes.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
SIGMA - D4000 www.sigma-aldrich.com Page 5
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36/37/38
Irritating to eyes, respiratory system and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA - D4000 www.sigma-aldrich.com Page 6
|