SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/OCT/2005
Date Updated: 12/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name METHYL-D3 ALCOHOL-D, 100.0 ATOM % D
Product Number 194166
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
METHANOL-D4,* ATOM % D 811-98-3 212-378-6 603-001-00-X
Formula CD4O
Molecular Weight 36.07 AMU
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Toxic by inhalation, in contact with skin and if
swallowed. Toxic: danger of very serious irreversible effects
through inhalation, in contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure. Do not use if skin is cut or scratched. Wash
thoroughly after handling.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Store in a cool dry place. Store
under nitrogen.
SPECIAL REQUIREMENTS: Store under inert gas. Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
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Poland NDS 100 MG/M3
Poland NDSCh 300 MG/M3
Poland NDSP -
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 65.4 掳C 760 mmHg
MP/MP Range N/A
Flash Point 11 掳C Method: closed cup
Flammability N/A
Autoignition Temp 385 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 6 %
Upper: 36 %
Vapor Pressure N/A
SG/Density 0.89 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Oxidizing agents, Alkali metals, Reducing
agents, Acids, Acid chlorides, Acid anhydrides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
ACUTE TOXICITY
LDLO
Oral
Man
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6422 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting. Lungs, Thorax, or
Respiration:Dyspnea. Brain and Coverings:Changes in circulation
(hemorrhage,thrombosis, etc.).
LDLO
Oral
Human
428 mg/kg
Remarks: Lungs, Thorax, or Respiration:Other changes.
Behavioral:Headache.
LDLO
Oral
Human
143 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting. Lungs, Thorax, or
Respiration:Dyspnea. Sense Organs and Special Senses (Nose, Eye,
Ear, and Taste):Eye:Optic nerve neuropathy.
LD50
Oral
Rat
5628 mg/kg
LC50
Inhalation
Rat
64,000 ppm
4H
LD50
Intraperitoneal
Rat
7529 MG/KG
LD50
Intravenous
Rat
2131 MG/KG
LD50
Oral
Mouse
7300 mg/kg
LD50
Intraperitoneal
Mouse
10765 MG/KG
LD50
Subcutaneous
Mouse
9800 MG/KG
LD50
Intravenous
Mouse
4710 MG/KG
LD50
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Oral
Monkey
7000 mg/kg
Remarks: Behavioral:Coma. Behavioral:Ataxia. Behavioral:Muscle
weakness.
LD50
Oral
Rabbit
14200 mg/kg
LD50
Skin
Rabbit
15800 mg/kg
LD50
Intraperitoneal
Rabbit
1826 MG/KG
LD50
Intravenous
Rabbit
8907 MG/KG
LD50
Intraperitoneal
Guinea pig
3556 MG/KG
LD50
Intraperitoneal
Hamster
8555 MG/KG
IRRITATION DATA
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
40 mg
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Weakness. Confusion. Drowsiness. Unconsciousness. May cause
convulsions. Dizziness. Methyl alcohol may be fatal or cause
blindness if swallowed. Cannot be made non-poisonous. Ingestion
can cause: Nausea, headache, and vomiting. Gastrointestinal
disturbances.
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ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. Toxic if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Heart. Liver. Kidneys. Eyes. Central nervous system.
CHRONIC EXPOSURE - MUTAGEN
Human
300 MMOL/L
Cell Type: lymphocyte
DNA inhibition
Rat
10 UMOL/KG
Oral
DNA damage
Mouse
7900 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
1 GM/KG
Oral
Cytogenetic analysis
Mouse
75 MG/KG
Intraperitoneal
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 35295 MG/KG
Route of Application: Oral
Exposure Time: (1-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Biochemical and
metabolic.
Species: Rat
Dose: 20000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 20000 PPM/7H
Route of Application: Inhalation
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
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Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 10000 PPM/7H
Route of Application: Inhalation
Exposure Time: (7-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 5200 UL/KG
Route of Application: Oral
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Eye, ear. Effects on
Embryo or Fetus: Fetotoxicity (except death, e.g., stunted
fetus).
Species: Mouse
Dose: 40 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse
Dose: 4 GM/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 1500 PPM/6H
Route of Application: Inhalation
Exposure Time: (7-9D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Mouse
Dose: 5000 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Central nervous system.
Species: Mouse
Dose: 2000 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 7500 MG/KG
Route of Application: Oral
Exposure Time: (17-19D PREG)
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Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 35295 MG/KG
Route of Application: Oral
Exposure Time: (1-15D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Female
fertility index (e.g., # females pregnant per # sperm positive
females; # females pregnant per # females mated ). Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Rat
Dose: 20 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).
Species: Rat
Dose: 200 PPM/20H
Route of Application: Oral
Exposure Time: (78W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 7500 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Mouse
Dose: 15000 PPM
Route of Application: Inhalation
Exposure Time: (7-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
Dose: 5 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (5D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 19,000 mg/l
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Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 24,500 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1230
Class: 3
PG: II
Proper Shipping Name: Methanol
IMDG
UN#: 1230
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Methanol
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1230
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Methanol
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-001-00-X
INDICATION OF DANGER: F-T
Highly Flammable. Toxic.
R-PHRASES: 11-23/24/25-39/23/24/25
Highly flammable. Toxic by inhalation, in contact with skin and
if swallowed. Toxic: danger of very serious irreversible
effects through inhalation, in contact with skin and if
swallowed.
S-PHRASES: 7-16-36/37-45
Keep container tightly closed. Keep away from sources of
ignition - no smoking. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
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SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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