SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 28/JUN/2005
Date Updated: 24/MAY/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIETHYL ETHER, REAGENT GRADE
Product Number 443522
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIETHYL ETHER STABILIZED WITH BHT 60-29-7 200-467-2 603-022-00-4
Ingredient Name Percent CAS # EC no Annex I
Index Number
Stabilized with: None None None
BUTYLATED HYDROXYTOLUENE 128-37-0 204-881-4 None
Symbols: Xn
R-Phrases: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system and
skin.
Formula C4H10O
Molecular Weight 74.12 AMU
Synonyms Aether * Anaesthetic ether * Anesthesia ether *
Anesthetic ether * Diaethylaether (German) *
Diethyl ether (DOT:OSHA) * Diethyl oxide *
Dwuetylowy eter (Polish) * Etere etilico
(Italian) * Ether * Ether ethylique (French) *
Ethoxyethane * Ethyl ether (ACGIH:OSHA) * Oxyde
d'ethyle (French) * RCRA waste number U117 *
Solvent ether
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Extremely flammable. May form explosive peroxides. Harmful if
swallowed. Repeated exposure may cause skin dryness or cracking.
Vapors may cause drowsiness and dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Water may be ineffective.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
SPECIAL REQUIREMENTS: Light sensitive. Air sensitive. Heat
sensitive. Do not distill to dryness. Refrigerate before opening.
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8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 600 MG/M3
Poland NDSP -
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 308 mg/m3
100 ppm
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 303 mg/m3
100 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 1,200 mg/m3
400 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 600 mg/m3
200 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level900 mg/m3
300 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1,200 mg/m3
400 ppm
Remarks: D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 1,230 mg/m3
400 ppm
OEL STEL 1,540 mg/m3
500 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 34.6 掳C 760 mmHg
MP/MP Range -116 掳C
Flash Point -40 掳C Method: closed cup
Flammability N/A
Autoignition Temp 160 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.8 %
Upper: 48 %
Vapor Pressure 442.552 mmHg 20 掳C
SG/Density 0.71 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May form peroxides of unknown stability.
Conditions to Avoid: Light. Heat. Air.
Materials to Avoid: Oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: KI5775000
ACUTE TOXICITY
LDLO
Oral
Man
260 mg/kg
LD50
Oral
Rat
1215 mg/kg
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LC50
Inhalation
Mouse
31,000 ppm
30M
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intraperitoneal
Mouse
2420 MG/KG
LD50
Intravenous
Mouse
996 MG/KG
LD50
Skin
Rabbit
>20 ML/KG
IRRITATION DATA
Eyes
Human
100 ppm
Skin
Rabbit
360 mg
Remarks: Open irritation test
Eyes
Rabbit
100 mg
Remarks: Moderate irritation effect
Skin
Guinea pig
50 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Contact with eyes can cause redness, tearing, and blurred
vision. Prolonged or repeated contact with skin can cause
defatting and dermatitis. Exposure can cause: Coughing, chest
pains, difficulty in breathing. Dizziness. Drowsiness. To the
best of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Kidneys. Liver. G.I. System. Skeletal
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muscle.
CHRONIC EXPOSURE - MUTAGEN
Mouse
2850 MG/L
Cell Type: Embryo
DNA inhibition
Hamster
1 PPH
Cell Type: fibroblast
Other mutation test systems
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Daphnia magna Pimephales promelas (Fathead
minnow)
Time: 96 h
Value: 2,560 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1155
Class: 3
PG: I
Proper Shipping Name: Diethyl ether
IMDG
UN#: 1155
Class: 3
PG: I
Proper Shipping Name: ETHYL ETHER
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1155
Class: 3
PG: I
Proper Shipping Name: ETHYL ETHER
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-022-00-4
INDICATION OF DANGER: F+ Xn
Extremely Flammable. Harmful.
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R-PHRASES: 12 19 22 66 67
Extremely flammable. May form explosive peroxides. Harmful if
swallowed. Repeated exposure may cause skin dryness or
cracking. Vapors may cause drowsiness and dizziness.
S-PHRASES: 9 16 29 33
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
Take precautionary measures against static discharges.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 2366
YL-group: 4
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
Declaration Number: 7377
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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