SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/JUN/2005
Date Updated: 12/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ETHYLENEDIAMINETETRAACETIC ACID, 99.995%
Product Number 431788
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ETHYLENEDIAMINETETRAACETIC ACID 60-00-4 200-449-4 None
Formula C10H16N2O8
Molecular Weight 292.24 AMU
Synonyms Acide ethylenediaminetetracetique (French) *
Celon A * Celon ATH * Cheelox * Cheelox BF acid
* Chemcolox 340 * Clewat TAA * Complexon II *
3,6-Diazaoctanedioic acid,
3,6-bis(carboxymethyl) * Edathamil * Edetic acid
* EDTA * EDTA (chelating agent) * EDTA acid *
Endrate *
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
* Ethylenediaminetetraacetate *
Ethylenediaminetetraacetic acid *
Ethylenediamine-N,N,N',N'-tetraacetic acid *
Ethylenedinitrilotetraacetic acid * Gluma
cleanser * Glycine,
N,N'-1,2-ethanediylbis(N-(carboxymethyl)- (9CI)
* Hamp-ene acid * Havidote * ICRF 185 *
Komplexon II * Kyselina ethylendiamintetraoctova
(Czech) * Metaquest A * Nervanaid B acid *
Nullapon B acid * Nullapon BF acid * Perma kleer
50 acid * Questex 4H * SEQ 100 * Sequestrene AA
* Sequestric acid * Sequestrol * Tetrine acid *
Titriplex * Trilon BS * Trilon BW * Versene acid
* Vinkeil 100 * Warkeelate acid * YD 30
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
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Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH 2.5 23 掳C Concentration: 10
g/l
BP/BP Range N/A
MP/MP Range 250 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient Log Kow: -3.34
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1M in NaOH 1M, 20掳C complete,
colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AH4025000
ACUTE TOXICITY
LD50
Oral
Rat
4,000 mg/kg
LD50
Oral
Rat
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2,580 mg/kg
LD50
Intraperitoneal
Rat
397 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Mouse
30 mg/kg
LD50
Intraperitoneal
Mouse
250 MG/KG
LD50
Intravenous
Mouse
28500 UG/KG
IRRITATION DATA
Skin
Rabbit
Remarks: No irritation effect
Eyes
Rabbit
Remarks: Moderate irritation effect
SENSITIZATION
Sensitization: Will not occur
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Rat
600 UMOL/L
Cell Type: Other cell types
DNA inhibition
Mouse
186 MG/KG
Intraperitoneal
Micronucleus test
Mouse
15 MG/KG
Oral
Micronucleus test
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Mouse
40500 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
50 MMOL/L
Intraperitoneal
Cytogenetic analysis
Mouse
25200 UMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
100 UMOL/L
Cell Type: Embryo
Unscheduled DNA synthesis
Hamster
500 UG/L
Cell Type: fibroblast
DNA inhibition
Hamster
30 UMOL/L
Cell Type: Embryo
Sister chromatid exchange
Rabbit
250 UMOL/L
Cell Type: kidney
DNA inhibition
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue). Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system. Specific Developmental Abnormalities:
Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
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Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 3 GM/KG
Route of Application: Subcutaneous
Exposure Time: (7-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 113 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 34 - 62 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 44.2 - 76.50 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36
Irritating to eyes.
S-PHRASES: 26
In case of contact with eyes, rinse immediately with plenty of
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water and seek medical advice.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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