SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 28/JUN/2005
Date Updated: 13/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIETHANOLAMINE, 99%
Product Number D83303
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIETHANOLAMINE 111-42-2 203-868-0 603-071-00-1
Formula C4H11NO2
Molecular Weight 105.14 AMU
Synonyms Bis(2-hydroxyethyl)amine * DEA * Diaethanolamin
(German) * Diethanolamin (Czech) *
Diethanolamine (ACGIH) * Diethylamine,
2,2'-dihydroxy- * Diethylolamine *
2,2'-Dihydroxydiethylamine *
Di(2-hydroxyethyl)amine * Diolamine *
2-(2-Hydroxyethylamino)ethanol *
2,2'-Iminobisethanol * 2,2'-Iminodiethanol *
NCI-C55174
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to skin. Risk of serious damage
to eyes. Harmful: danger of serious damage to health by prolonged
exposure if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Air sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 2 mg/m3
0.46 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
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Source Type Value
TRGS 900 OEL 15 mg/m3, E
Remarks: 20,H,NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 15 mg/m3
3 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level15 mg/m3
3 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 13 mg/m3
3 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 13 mg/m3
3 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 11 - 12
BP/BP Range 217 掳C 150 mmHg
MP/MP Range 27 - 31 掳C
Flash Point 138 掳C Method: closed cup
Flammability N/A
Autoignition Temp 365 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.6 %
Upper: 10.6 %
Vapor Pressure N/A
SG/Density 1.097 g/cm3
Partition Coefficient Log Kow: -2.18
Viscosity N/A
Vapor Density 3.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. > 270 掳C
Solvent Content N/A
Water Content < 0.2 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:1 M in H2O, 20掳C
complete, colorless
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10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Absorbs carbon dioxide from air.
Materials to Avoid: Oxidizing agents Copper, Copper alloys, Zinc,
Galvanized iron.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: KL2975000
ACUTE TOXICITY
LD50
Oral
Rat
710 mg/kg
LD50
Skin
Rabbit
12,200 mg/kg
LD50
Oral
Rat
620 UL/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Tremor. Skin and Appendages:
Other: Hair.
LD50
Intraperitoneal
Rat
120 MG/KG
LD50
Subcutaneous
Rat
2200 MG/KG
LD50
Intravenous
Rat
778 MG/KG
LD50
Intramuscular
Rat
1500 MG/KG
LD50
Oral
Mouse
3300 mg/kg
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Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intraperitoneal
Mouse
210 MG/KG
LD50
Oral
Rabbit
2200 mg/kg
LD50
Skin
Rabbit
7640 UL/KG
Remarks: Behavioral:Ataxia. Other changes Skin and
Appendages:Skin: After systemic exposure: Dermatitis, other
LD50
Oral
Guinea pig
2000 mg/kg
LD50
Skin
Guinea pig
11900 UL/KG
IRRITATION DATA
Skin
Rabbit
50 mg
Remarks: Open irritation test
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
5,500 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.75 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
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Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Blood.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Skin
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 18382 MG/KG
Route of Application: Oral
Exposure Time: (14D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 15 GM/KG
Route of Application: Skin
Exposure Time: (6-15D PREG)
Result: Maternal Effects: Other effects. Effects on Newborn:
Other postnatal measures or effects.
Species: Rabbit
Dose: 4550 MG/KG
Route of Application: Skin
Exposure Time: (6-18D PREG)
Result: Maternal Effects: Other effects.
12 - Ecological Information
ELIMINATION
Elimination: > 90 %
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Time: 72 h
Value: 75 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 55 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 1,460 mg/l
Test Type: LC50 Fish
Species: Cyprinus carpio
Time: 96 h
Value: > 540 mg/l
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Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: > 100 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-071-00-1
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 38 41 48/22
Harmful if swallowed. Irritating to skin. Risk of serious
damage to eyes. Harmful: danger of serious damage to health by
prolonged exposure if swallowed.
S-PHRASES: 26 36/37/39 46
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. If swallowed, seek
medical advice immediately and show this container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
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Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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