SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2005
Date Updated: 07/JUL/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2,3-BUTANEDIONE, 97%
Product Number B85307
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2,3-BUTANEDIONE 431-03-8 207-069-8 None
Formula C4H6O2
Molecular Weight 86.09 AMU
Synonyms Biacetyl * 2,3-Butadione * Diacetyl *
2,3-Diketobutane * Dimethyl diketone *
Dimethylglyoxal * Glyoxal, dimethyl-
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation and if swallowed.
Irritating to skin. Risk of serious damage to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with an activated carbon adsorbent, take up and place in
closed containers. Transport outdoors. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Store at 2-8藲C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Very deep yellow
Property Value At Temperature or Pressure
pH 3.2
BP/BP Range 88 - 89 藲C
MP/MP Range -2 藲C
Flash Point 7 藲C Method: closed cup
Flammability N/A
Autoignition Temp 285 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.4 %
Upper: 13 %
Vapor Pressure 52.2 mmHg 20 藲C
SG/Density 0.985 g/cm3
Partition Coefficient Log Kow: -0.467
Viscosity N/A
Vapor Density 3 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble. 0.2 g/ml H2O
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents, Strong bases, Reducing
agents, Metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: EK2625000
ACUTE TOXICITY
LD50
Inhalation
Rat
4,000 mg/m3
4H
LD50
Oral
Rat
1580 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
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Behavioral:Convulsions or effect on seizure threshold.
LD50
Intraperitoneal
Rat
400 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Change in motor activity (specific assay).
Vascular:Regional or general arteriolar or venous dilation.
LD50
Skin
Rabbit
> 5000 mg/kg
LD50
Oral
Guinea pig
990 mg/kg
Remarks: Behavioral:Ataxia. Behavioral:Coma. Lungs, Thorax, or
Respiration:Dyspnea.
IRRITATION DATA
Eyes
Rabbit
Remarks: Severe irritation effect
Skin
Rabbit
500 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, headache, and vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. Harmful if inhaled.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Rat
1500 MG/KG
Oral
Unscheduled DNA synthesis
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
ALDRICH - B85307 www.sigma-aldrich.com Page 4
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2346
Class: 3
PG: II
Proper Shipping Name: Butanedione
IMDG
UN#: 2346
Class: 3
PG: II
Proper Shipping Name: Butanedione
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
UN#: 2346
Class: 3
PG: II
Proper Shipping Name: Butanedione
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 20/22 38 41
Highly flammable. Harmful by inhalation and if swallowed.
Irritating to skin. Risk of serious damage to eyes.
S-PHRASES: 16 26 39
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear eye/face protection.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
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