SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 15/NOV/2004
Date Updated: 12/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ANILINE FREE BASE
Product Number A9880
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ANILINE 62-53-3 200-539-3 612-008-00-7
Formula C6H7N
Molecular Weight 93.13 AMU
Synonyms Aminobenzene * Aminophen * Anilin (Czech) *
Anilina (Italian, Polish) * Aniline and
homologues (ACGIH:OSHA) * Aniline oil * Anyvim *
Benzenamine * Benzene, amino * Benzidam * Blue
Oil * C.I. 76000 * C.I. Oxidation Base 1 *
Cyanol * Huile d'aniline (French) * Krystallin *
Kyanol * NCI-C03736 * Phenylamine * RCRA waste
number U012
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect. Toxic: danger of
serious damage to health by prolonged exposure through inhalation,
in contact with skin and if swallowed. Very toxic to aquatic
organisms.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating water supply. Avoid contaminating sewers and
waterways with this material.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat and open flame. Store in a cool dry place. Store under
nitrogen.
SPECIAL REQUIREMENTS: Handle under inert gas. Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 5 MG/M3
Poland NDSCh 20 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 4 mg/m3
1 ppm
Remarks: HK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 8 mg/m3
2 ppm
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 4 mg/m3
1 ppm
Remarks: HK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level4 mg/m3
1 ppm
Remarks: H, K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 8 mg/m3
2 ppm
Remarks: H M D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 4 mg/m3
1 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 8.8 20 掳C Concentration: 36
g/l
BP/BP Range 184 掳C 760 mmHg
MP/MP Range -6 掳C
Flash Point 70 掳C Method: closed cup
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Flammability N/A
Autoignition Temp 615 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.3 %
Upper: 11 %
Vapor Pressure 0.7 mmHg 25 掳C
SG/Density 1.021 g/cm3
Partition Coefficient Log Kow: 0.91
Viscosity 4.4 Pas 20 掳C
Vapor Density 3.22 g/l 184 掳C
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.1 %
Surface Tension 42.12 mN/m 25 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Solvent: Soluble.
Other Solvents: MEOH, DIETHYL ETHER
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Conditions to Avoid: Protect from moisture.
Materials to Avoid: Oxidizing agents Iron and iron salts., Zinc
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: BW6650000
ACUTE TOXICITY
LD50
Oral
Rat
250 mg/kg
LD50
Skin
Rabbit
820 mg/kg
LC50
Inhalation
Mouse
247.5 ppm
4 HR
LD50
Oral
Rat
250 mg/kg
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LD50
Skin
Rat
1400 mg/kg
LD50
Intraperitoneal
Rat
420 MG/KG
LD50
Oral
Mouse
464 mg/kg
LC50
Inhalation
Mouse
175 ppm
7H
LD50
Intraperitoneal
Mouse
492 MG/KG
LD50
Subcutaneous
Mouse
200 MG/KG
LD50
Oral
Dog
195 mg/kg
LD50
Skin
Cat
254 mg/kg
LD50
Skin
Rabbit
820 UL/KG
LD50
Intravenous
Rabbit
64 MG/KG
LD50
Oral
Guinea pig
400 mg/kg
LD50
Skin
Guinea pig
1290 mg/kg
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LD50
Intraperitoneal
Guinea pig
100 MG/KG
LD50
Oral
Quail
750 mg/kg
LD50
Oral
Mammal
500 mg/kg
LC50
Inhalation
Mammal
2,500 mg/m3
LD50
Oral
Bird (wild)
562 mg/kg
IRRITATION DATA
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
102 mg
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer. Exposure can cause: Cyanosis.
Headache. Vomiting. Nausea. Incoordination. Fatigue. Dizziness.
Drowsiness. Confusion. Weakness. Unconsciousness. Symptoms may
be delayed.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
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Blood. Bladder. Kidneys. Central nervous system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 29W
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
300 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
105 MG/KG
Intraperitoneal
DNA damage
Rat
300 MG/KG
Cell Type: S. typhimurium
Body fluid assay
Rat
200 UMOL/L
Cell Type: liver
Sister chromatid exchange
Mouse
50 MG/KG
Intraperitoneal
Micronucleus test
Mouse
500 UMOL/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
500 MG/L
Cell Type: lymphocyte
specific locus test
Mouse
800 UG/L
Cell Type: fibroblast
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Morphological transformation.
Mouse
300 MG/KG
Intraperitoneal
DNA damage
Mouse
21500 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
1 GM/KG
Oral
DNA damage
Mouse
210 MG/KG
Intraperitoneal
Sister chromatid exchange
Mouse
2500 UMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
444 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
50 MG/L
Cell Type: ovary
Sister chromatid exchange
Hamster
500 UG/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 4480 MG/KG
Route of Application: Oral
Exposure Time: (6-13D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
CMR CAT.: Carc. Cat.3
12 - Ecological Information
ELIMINATION
Elimination: > 90 %
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: SELENASTRUM
Time: 72 h
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Value: 19 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 80 - 380 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 40.7 - 59.10 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 10.96 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 124 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1547
Class: 6.1
PG: II
Proper Shipping Name: Aniline
IMDG
UN#: 1547
Class: 6.1
PG: II
Proper Shipping Name: Aniline
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1547
Class: 6.1
PG: II
Proper Shipping Name: Aniline
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-008-00-7
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 20/21/22 40 48/23/24/25 50
Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect. Toxic: danger of
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serious damage to health by prolonged exposure through
inhalation, in contact with skin and if swallowed. Very toxic
to aquatic organisms.
S-PHRASES: 28 36/37 45 61
After contact with skin, wash immediately with plenty of
soap-suds. Wear suitable protective clothing and gloves. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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