SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/NOV/2004
Date Updated: 19/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name (-)-ARTERENOL FREE BASE
Product Number A7257
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(-)-ARTERENOL FREE BASE 51-41-2 200-096-6 None
Formula C8H11NO3
Molecular Weight 169.2 AMU
Synonyms Adrenor * Aktamin *
l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol *
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol *
l-alpha-(Aminomethyl)-3,4-dihydroxybenzyl
alcohol * (-)-alpha-(Aminomethyl)protocatechuyl
alcohol * Arterenol * l-Arterenol *
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-,
(R)- (9CI) *
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol *
l-3,4-Dihydroxyphenylethanolamine * Levarterenol
* Levoarterenol * Levonoradrenaline *
Levonorepinephrine * Levophed * (-)-Noradrec *
Noradrenalin * Noradrenalina (Italian) *
(-)-Noradrenaline * D-(-)-Noradrenaline *
l-Noradrenaline * Noradrenline * Norartrinal *
(-)-Norepinephrine * L-Norepinephrine *
Norepirenamine * Sympathin E
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at -20掳C
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 220 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Protect from light.
Materials to Avoid: Acids, Bases, Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thermal decomposition may
produce carbon monoxide, carbon dioxide, and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DN5950000
ACUTE TOXICITY
LD50
Intravenous
Rat
100 UG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
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Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Oral
Mouse
20 mg/kg
LD50
Intraperitoneal
Mouse
6 MG/KG
LD50
Subcutaneous
Mouse
5 MG/KG
LD50
Intravenous
Mouse
550 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause hypertension, headache, anxiety,
palpitations, and respiratory difficulty.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Heart. Smooth muscle.
CHRONIC EXPOSURE - MUTAGEN
Human
5800 NMOL/L
Cell Type: Other cell types
DNA inhibition
Rat
25 UMOL/L
Cell Type: lung
DNA damage
Mouse
5800 NMOL/L
Cell Type: Other cell types
DNA inhibition
CHRONIC EXPOSURE - TERATOGEN
Species: Hamster
Dose: 2 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-10D PREG)
Result: Specific Developmental Abnormalities: Hepatobiliary
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system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Exposure during pregnancy can provoke uterine
contractions which can result in fetal asphyxia.
Species: Rat
Dose: 8 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7-14D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 60 UG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse
Dose: 16 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-10D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Guinea pig
Dose: 10 UG/KG
Route of Application: Intravenous
Exposure Time: (63D PREG)
Result: Maternal Effects: Other effects. Vascular:Measurement of
regional blood flow. Effects on Embryo or Fetus: Extra embryonic
structures (e.g., placenta, umbilical cord).
Species: Hamster
Dose: 2 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
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UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 28
Very toxic if swallowed.
S-PHRASES: 36/37 45
Wear suitable protective clothing and gloves. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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