SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/NOV/2004
Date Updated: 12/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CITRININ FROM PENICILLIUM CITRINUM
Product Number 00302
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CITRININ FROM PENICILLIUM CITRINUM 518-75-2 208-257-2 None
Formula C13H14O5
Molecular Weight 250.25 AMU
Synonyms Citrinin *
(3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-o
xo-3H-2-benzopyran-7-carboxylic acid
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER EYE CONTACT
Assure adequate flushing of the eyes by separating the eyelids
with fingers.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
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Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Sensitive to light.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DJ2275000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
50 MG/KG
LD50
Subcutaneous
Rat
67 MG/KG
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax,
or Respiration:Respiratory stimulation. Blood:Other changes.
LD50
Oral
Mouse
112 mg/kg
LD50
Intraperitoneal
Mouse
35 MG/KG
Remarks: Lungs, Thorax, or Respiration:Respiratory stimulation.
LD50
Subcutaneous
Mouse
73 MG/KG
LD50
Oral
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Rabbit
134 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Gastrointestinal:Hypermotility, diarrhea. Kidney, Ureter,
Bladder:Changes in tubules (including acute renal failure, acute
tubular necrosis).
LD50
Intraperitoneal
Rabbit
50 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Kidney, Ureter, Bladder:Changes in tubules (including acute
renal failure, acute tubular necrosis).
LD50
Intravenous
Rabbit
19 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Miosis (pupilliary constriction). Lungs, Thorax, or
Respiration:Dyspnea. Gastrointestinal:Changes in structure or
function of salivary glands.
LD50
Subcutaneous
Guinea pig
37 MG/KG
Remarks: Lungs, Thorax, or Respiration:Respiratory stimulation.
LD50
Oral
Hamster
75 mg/kg
LD50
Intraperitoneal
Hamster
66 MG/KG
IRRITATION DATA
Skin
Guinea pig
40 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Can cause CNS depression. Exposure can cause: Nausea,
headache, and vomiting. Narcotic effect. Damage to the heart. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. High concentrations are extremely destructive to
tissues of the mucous membranes and upper respiratory tract,
eyes, and skin.
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TARGET ORGAN INFORMATION
Damage to the heart. Kidneys. Nerves. Liver.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 60W
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Oral
Exposure Time: 32W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
300 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Rat
200 MG/L
Cell Type: fibroblast
DNA damage
Rat
100 MG/L
Cell Type: fibroblast
DNA inhibition
Hamster
30 UMOL/L
Cell Type: lung
Micronucleus test
Hamster
200 MG/L
Cell Type: ovary
DNA damage
Hamster
100 MG/L
Cell Type: ovary
DNA inhibition
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
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Species: Rat
Dose: 35 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 35 MG/KG
Route of Application: Subcutaneous
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rat
Dose: 35 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 35 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
UN#: 2811
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Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25 40
Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S-PHRASES: 26 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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