SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/NOV/2004
Date Updated: 12/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ARSENIC(III) OXIDE, 99.99%
Product Number 255483
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ARSENIC TRIOXIDE 1327-53-3 215-481-4 033-003-00-0
Formula As2O3
Molecular Weight 197.84 AMU
Synonyms Acide arsenieux (French) * Anhydride arsenieux
(French) * Arsenic blanc (French) * Arsenic
oxide * Arsenic(III) oxide * Arsenic sesquioxide
* Arsenic trioxide (ACGIH) * Arsenicum album *
Arsenigen saure (German) * Arsenious acid *
Arsenious oxide * Arsenious trioxide * Arsenite
* Arsenolite * Arsenous acid * Arsenous acid
anhydride * Arsenous anhydride * Arsenous oxide
* Arsenous oxide anhydride * Arsentrioxide *
Arsodent * Claudelite * Claudetite * Crude
arsenic * Diarsenic trioxide * RCRA waste number
P012 * White arsenic
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Also very toxic if swallowed. Causes burns. Very
toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
Carc. Cat.1
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.05 mg/m3
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EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.1 mg/m3, E
Remarks: 4
Remarks: TRK,2,5,25,TRGS 901-21
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.1 mg/m3
Remarks: E K M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL TWA 0.1MG(AS)/M3
Remarks: Carcinogen.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 3.738 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Conditions of Instability: May decompose on exposure to moist air
or water.
Conditions to Avoid: Heat.
Materials to Avoid: Oxidizing agents, Metals.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Arsenic oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CG3325000
ACUTE TOXICITY
LDLO
Oral
Man
114 mg/kg
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Acute pulmonary edema. Kidney, Ureter, Bladder:Urine
volume decreased.
LDLO
Oral
Man
29 mg/kg
Remarks: Behavioral:Sleep. Behavioral:Muscle weakness.
Gastrointestinal:Hypermotility, diarrhea.
LDLO
Oral
Man
286 mg/kg
Remarks: Cardiac:Arrythmias (including changes it conduction).
Liver:Liver function tests impaired. Other changes
LDLO
Oral
Human
1.429 mg/kg
LDLO
Oral
Man
2857 mg/kg
Remarks: Behavioral:Coma. Liver:Fatty liver degeneration.
Kidney, Ureter, Bladder:Renal function tests depressed.
LD50
Oral
Rat
14.6 mg/kg
LD50
Intraperitoneal
Rat
871 MG/KG
LD50
Oral
Mouse
31.5 mg/kg
LD50
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Subcutaneous
Mouse
9800 UG/KG
LD50
Intravenous
Mouse
10700 UG/KG
LD50
Oral
Rabbit
20.19 mg/kg
SENSITIZATION
Respiratory: May cause allergic respiratory reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Prolonged exposure to arsenic compounds can cause
exfoliation and pigmentation of skin, herpes, inflammation of
nerves, and nasal septum ulceration. Dry mouth, a metallic
taste, drowsiness, loss of appetite, excessive salivation,
nausea, vomiting and a foul, garlic-like breath.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
G.I. System. Heart. Brain. Kidneys. Skin. Bone marrow.
Peripheral nervous system.
CONDITIONS AGGRAVATED BY EXPOSURE
Exposure to arsenic compounds can cause burning and dryness of
the oral and nasal cavities, muscle spasms, irritation of the
gastrointestinal tract, nausea, vomiting and diarrhea which can
progress to shock and death.
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Rat
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
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Hamster
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.
Rat
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Hamster
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Hamster
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.
Rat
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Hamster
Route of Application: Intratracheal
Exposure Time: 24W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Hamster
Route of Application: Intratracheal
Exposure Time: 24W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Hamster
Route of Application: Intratracheal
Exposure Time: 15W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.
IARC CARCINOGEN LIST
Rating: Group 1
CHRONIC EXPOSURE - MUTAGEN
Human
1 UMOL/L
Cell Type: lung
Unscheduled DNA synthesis
Human
500 UMOL/L
Cell Type: HeLa cell
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DNA inhibition
Human
1200 NMOL/L
Cell Type: leukocyte
Cytogenetic analysis
Human
2 UG/CM3
Cell Type: lymphocyte
Sister chromatid exchange
Mouse
1 MG/KG
Intraperitoneal
Micronucleus test
Mouse
20 ML/KG
Oral
DNA inhibition
Mouse
3696 MG/KG
Oral
Cytogenetic analysis
Mouse
28500 UG/M3
Cell Type: Other cell types
Cytogenetic analysis
Hamster
250 NMOL/L
Cell Type: lung
Micronucleus test
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 8250 UG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Immune and
reticuloendothelial system. Effects on Newborn: Behavioral.
Species: Mouse
Dose: 1650 UG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Mouse
Dose: 28500 UG/M3/4H
Route of Application: Inhalation
Exposure Time: (9-12D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
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Dose: 260 UG/M3/4H
Route of Application: Inhalation
Exposure Time: (9-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (30W PREG)
Result: Effects on Newborn: Apgar score (human only). Effects on
Newborn: Other neonatal measures or effects.
Species: Rat
Dose: 30 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Maternal Effects: Other effects. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth).
Species: Rat
Dose: 10 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Eye, ear.
Species: Rat
Dose: 20800 UG/KG
Route of Application: Intratracheal
Exposure Time: (8W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mouse
Dose: 224 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Mouse
Dose: 3636 MG/KG
Route of Application: Oral
Exposure Time: (1-18D PREG)
Result: Effects on Fertility: Abortion.
CMR CAT.: Carc. Cat.1
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
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of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1561
Class: 6.1
PG: II
Proper Shipping Name: Arsenic trioxide
IMDG
UN#: 1561
Class: 6.1
PG: II
Proper Shipping Name: Arsenic trioxide
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1561
Class: 6.1
PG: II
Proper Shipping Name: Arsenic trioxide
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 033-003-00-0
NOTA: E
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 45 28 34 50/53
May cause cancer. Also very toxic if swallowed. Causes burns.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S-PHRASES: 53 45 60 61
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible). This material and its container must be
disposed of as hazardous waste. Avoid release to the
environment. Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
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shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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