SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 25/NOV/2004
Date Updated: 14/MAR/2004
Version 1.4
According to 91/155/EEC
1 - Product and Company Information
Product Name VITAMIN C, PH EUR
Product Number 95212
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ASCORBIC ACID (VITAMIN C) 50-81-7 200-066-2 None
Formula C6H8O6
Molecular Weight 176.12 AMU
Synonyms Adenex * Allercorb * Antiscorbic vitamin *
Antiscorbutic vitamin * Arco-cee * Ascoltin *
Ascorbajen * Ascorbate * Ascorbic acid *
L(+)-Ascorbic acid * Ascor-B.I.D. * Ascorbutina
* Ascorin * Ascorteal * Ascorvit * Cantan *
Cantaxin * Catavin C * Cebicure * Cebid * Cebion
* Cebione * Cecon * Cee-caps TD * Cee-vite *
Cegiolan * Ceglion * Celaskon * ce lent * Celin
* Cemagyl * Ce-Mi-Lin * Cemill * Cenetone *
Cereon * Cergona * Cescorbat * Cetamid *
Cetane-caps TD * Cetemican * Cevalin * Cevatine
* Cevex * Cevi-bid * Cevimin * CE-VI-Sol *
Cevital * Cevitamic acid * Cevitamin * Cevitan *
Cevitex * Cewin * Ciamin * Cipca * Citriscorb *
C-Level * C-Long * Colascor * Concemin * C-Quin
* C-Span * C-Vimin * Dora-C-500 * Davitamon C *
Duoscorb * L-threo-Hex-2-enonic acid,
gamma-lactone * Hicee * Hybrin * IDO-C *
3-Keto-L-gulofuranolactone *
L-3-Ketothreohexuronic acid lactone * Kyselina
askorbova (Czech) * Laroscorbine * Lemascorb *
Liqui-Cee * L-Lyxoascorbic acid * NCI-C54808 *
NSC 33832 * 3-Oxo-L-gulofuranolactone *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH 1 - 2.5
BP/BP Range N/A
MP/MP Range 193 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:1 M in H2O, 20藲C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Sensitive to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CI7650000
ACUTE TOXICITY
LDLO
Intravenous
Woman
900 MG/KG
Remarks: Kidney, Ureter, Bladder:Changes in tubules (including
acute renal failure, acute tubular necrosis).
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LD50
Oral
Rat
11900 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Somnolence (general depressed
activity). Gastrointestinal:Hypermotility, diarrhea.
LD50
Subcutaneous
Rat
>10 GM/KG
LD50
Intravenous
Rat
>4 GM/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity).
LD50
Oral
Mouse
3367 mg/kg
LD50
Intraperitoneal
Mouse
643 MG/KG
LD50
Intravenous
Mouse
518 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Chronic ingestion of large doses may cause gastrointestinal
disturbances including nausea and diarrhea, urinary effects
involving urine acidification, oxalate and uric crystallizaton
in the bladder and kidney, and decreased reaction times and
psychomotor coordination.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Human
200 UMOL/L
Cell Type: fibroblast
DNA damage
Human
200 UMOL/L
Cell Type: Other cell types
DNA damage
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Human
2500 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
200 UMOL/L
Cell Type: Other cell types
DNA inhibition
Human
200 UMOL/L
Cell Type: fibroblast
Other mutation test systems
Human
200 UMOL/L
Cell Type: Other cell types
Other mutation test systems
Human
200 MG/L
Cell Type: Other cell types
DNA inhibition
Mouse
4500 MG/KG
Intraperitoneal
3D
Micronucleus test
Mouse
500 UMOL/L
Cell Type: liver
Other mutation test systems
Mouse
1600 MG/KG
Intraperitoneal
Cytogenetic analysis
Mouse
1600 MG/KG
Intraperitoneal
Sister chromatid exchange
Hamster
400 MG/L
Cell Type: ovary
Micronucleus test
Hamster
300 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
500 MG/L
Cell Type: ovary
Sister chromatid exchange
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Mammal
500 UMOL/L
Cell Type: lymphocyte
DNA damage
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 6680 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 800 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 2500 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Guinea pig
Dose: 19500 MG/KG
Route of Application: Oral
Exposure Time: (30-58D PREG/10D POST)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Guinea pig
Dose: 5800 MG/KG
Route of Application: Oral
Exposure Time: (1-58D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Viability index (e.g., # alive at day 4 per # born alive).
Species: Guinea pig
Dose: 2471 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
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14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EC.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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