300 Northfield Road
Bedford, OH 44146 MATERIAL SAFETY DATA SHEET
Telephone: (440) 232-3320
-or- (800) 562-4797
Section I - IDENTITY
Common/Trade Name: Lorazepam Injection Preservative Free (2 mg/mL and 4 mg/mL in 1 mL vials)
Chemical Names: 2H,1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
Synonyms: Ativan, Lorax, Almazine, Ciloxan, Ciprobid, Euciprin, Quintor
Manufacturer's Name: BEN VENUE LABORATORIES, INC.
Address: 300 NORTHFIELD ROAD
BEDFORD, OH 44146
Emergency Telephone Number: Chemtrec: 1(800)424-9300
Telephone Number for Info.: (800)562-4797 or (440)232-3320
Medical Emergency: Professional Services: 1(800)521-5169
Date Prepared: September 12, 2006
Section II - HAZARDOUS INGREDIENTS/COMPOSITION INFORMATION
Other Limits
Component % CAS# OSHA PEL ACGIH TLV Recommended
2 礸/m3
Lorazepam 0.2 846-49-1 NONE NONE
(BVL OEL)
10 mg/ m3 (AIHA)
Propylene Glycol 81.8 57-55-6 NONE NONE
Polyethylene Glycol 18 25322-68-3 NONE NONE NONE
Lorazepam is a sterile injectable liquid drug provided in a vial.
AIHA - American Industrial Hygiene Association
Section III - HEALTH HAZARD DATA
Routes of Entry: Lorazepam Injection may be absorbed via contact with skin or eyes; inhalation of aerosols or
accidentally ingested. Under normal use with supervision of a physician, Lorazepam Injection presents little
hazard.
Health Hazard (Acute & Chronic): Lorazepam is a tranquilizer in the benzodiazepine category that is intended for
use for sedation and anti-anxiety. It is a Schedule IV Controlled Substance. It affects the central nervous
system, circulatory and digestive systems. Minimal health hazard is expected upon occupational exposure.
Carcinogenicity: NTP? NO IARC Monographs? NO OSHA Regulated? NO
Signs & Symptoms of Exposure: Acute signs and symptoms of exposure may include memory problems, anxiety,
confusion, irregular heartbeat, slurred speech, vision problems, constipation, diarrhea, nausea, vomiting, and
cramps. May cause unconsciousness. Possible teratogenic effects based upon laboratory animal data. May
cause allergic reaction based upon chronic exposure.
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Medical Conditions Gene rally Aggravated by Exposure: Lorazepam is not recommended for use in patients with
liver or kidney failure.
BVL Hazard Category: 3
BVL Occupational Exposure limit (OEL): 2 礸/m3
Section IV - FIRST AID MEASURES
Eye Exposure: Flush eyes with large volumes of water for 15 minutes or more. Seek treatment from
a physician.
Skin Exposure: Wash skin with cool, soapy water. Remove contaminated clothing.
Ingestion: If ingestion occurs, flush mouth with water and seek medical attention immediately.
If person in conscious, induce vomiting; never induce vomiting on in unconscious person.
Inhalation: If difficulty breathing, administer oxygen. Seek medical attention immediately.
If necessary, provide artificial respiration. Overdose should be treated symptomatically.
Section V - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not applicable LEL: Not Applicable UEL: Not Applicable
Flammable Limits: Not applicable
Extinguishing Media: Use water or multi-purpose ABC extinguisher
Special Fire Fighting Procedures: As with all fires, evacuate personnel to a safe area. Fire fighters
must wear self-contained breathing apparatus to avoid inhalation of smoke. Product is not expected to
present a fire hazard concern.
Unusual Fire/Explosion Hazards: None
Section VI - ACCIDENTAL RELEASE INFORMATION
Release to Land: Absorb Lorazepam with absorbent materials and dispose according to local, state, and federal
guidelines. Prevent contact with sewers and waterways. Wash area with soap and water. Wear personal
protective equipment.
Release to Air: If aerosolized, reduce exposures by ventilating area; clean up spill immediately to
prevent evaporation. Wear respiratory protection as necessary.
Release to Water: Refer to the local water authority; drain disposal is not recommended. Refer to
local, state, and federal guidelines.
Section VII - PRECAUTIONS FOR SAFE HANDLING AND USE
Steps to be taken in case material is released or spilled: See Section VI above. Wear all necessary
protective equipment including nitrile or latex gloves, protective clothing, safety glasses. A
dust/mist respirator (N95) may be necessary if excessive aerosols are generated.
Large spills may require the use of protective coveralls, boots, double gloves and SCBAs.
Waste Disposal Method: Dispose of according to local, state, and federal guidelines. Incineration at
a licensed facility is recommended.
Precautions to be taken in handling and storing: Store at room temperature (15-25癈). Protect from light.
Other Precautions: None identified.
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Section VIII - CONTROL MEASURES AND PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Under normal use, respirators should not be required if adequate ventilation is
available. A dust/mist respirator (N95) may be necessary if excessive aerosols are generated.
For large spill emergencies, self-contained breathing apparatus (SCBA) may be required.
Personnel wearing respirators should be fit tested and approved for respirator use under the OSHA
Respiratory Protection Standard, 29 CFR 1910.134.
Ventilation: Handle product in a well-ventilated area.
Protective Gloves: Nitrile or latex
Eye Protection: Safety glasses or goggles
Other Protective Clothing or Equipment: Lab coat
Work/Hygienic Practices: Wash hands following use. No eating, drinking, or smoking when
handling this product.
Section IX - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid Specific Gravity: 1.036
Appearance and Odor: Clear, colorless, no odor Melting Point: Approximately -59?C
Boiling Point: Approximately 188?C Evaporation Rate: Approx. to water
Vapor Pressure: Approximately 0.08 mmHg at 20?C Solubility in Water: Soluble
Vapor Density: 2.62 pH: Not applicable
Section X - STABILITY AND REACTIVITY DATA
Stability: Stable
Incompatibility (Materials to Avoid): None identified
Hazardous Decomposition or Byproducts: Decomposition products of this compound may include potentially
hazardous byproducts of nitrogen oxides, carbon monoxide, , and carbon dioxide.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: None identified.
Section XI - TOXICOLOGICAL INFORMATION
For Lorazepam: RTECS # DF0350000
LD50, oral, mouse = 1850 mg/kg LD50, intramuscular, mouse = 70 mg/kg
LD50, subcutaneous, mouse = > 10 gm/kg LD50, intraperitoneal, mouse = 1810 mg/kg
LD50, oral, rat = 4500 mg/kg LD50, intramuscular, rat = 59 mg/kg
LD50, subcutaneous, rat = > 10 gm/kg LD50, intraperitoneal, rat = 870 mg/kg
LD50, oral, dog = > 2 gm/kg LD50, intramuscular, dog = > 25 gm/kg
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Section XII - ENVIRONMENTAL IMPACT INFORMATION
Information is currently not available on the environmental impact of Lorazepam. Handle in a manner that prevents
spills or releases to the environment.
Section XIII - DISPOSAL INFORMATION
Lorazepam should be disposed of in accordance with national, state, local, or applicable regulations.
Incineration at an approved, permitted facility is recommended.
Section XIV - TRANSPORTATION INFORMATION
Lorazepam is not a DOT Hazardous Material.
Lorazepam is not a Marine Pollutant.
Section XV - REGULATORY INFORMATION
SARA 313 listed?: No
CERCLA listed?: No
RCRA listed?: No
TSCA listed: No
California Proposition 65 Code: D
Section XVI - OTHER DATA
1. Use of this product should be through or under the direction of a physician.
This MSDS does not address the therapeutic use of this material
2. Persons administering this drug to patients must be careful to avoid needle sticks to syringes and
other sharps used in the administration. All needle sticks must be reported to your company
Management.
3. BVL Hazard Category Definitions (internal hazard ranking used by Ben Venue Laboratories):
1 = Low Toxicity
2.= Moderate Toxicity
3 = Potent or Toxic
4 = Highly Potent or Toxic
5 = Extremely Potent or Toxic
This document is generated to distribute health, safety and environmental data. It is not a specification sheet and
none of the displayed data should be construed as a specification. Information on this MSDS sheet was obtained
from sources which we believe are reliable, and we believe that the information is complete and accurate. However,
the information is provided without any warranty, express or implied, regarding its correctness. Some of the
information presented and conclusions drawn are from sources other than direct test data of the substance. The
conditions or methods of handling, storage, use and disposal of the product are beyond our control and may also be
beyond our knowledge. It is the user's responsibility to determine the suitability of any material for a specific
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purpose and to adopt such safety precautions as may be necessary. If the product is used as a component in
another product, this MSDS information may not be applicable. For these reasons, we do not assume any
responsibility and expressly disclaim liability for any loss, damage or expense arising out of or in any way connected
with the handling, storage, use or disposal of this product.
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