Nycomed US Inc.
MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI, and Canadian WHMIS
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
TRADE NAME/MATERIAL NAME: Benzoyl Peroxide Hydrating Wash
Benzoyl Peroxide Hydrating Wash
DESCRIPTION:
18754-758-51, 0168-0758-47
NDC #:
Benzoyl Peroxide
CHEMICAL NAME (for active ingredient):
Peroxide
CHEMICAL FAMILY (for active ingredient):
5.75% Dermal Solution
HOW SUPPLIED:
C14H10O4
FORMULA (for active ingredient):
Pharmaceutical for Human Use
PRODUCT USE:
SUPPLIER/MANUFACTURER'S NAME: NYCOMED US INC.
60 Baylis Road
ADDRESS:
Melville, NY 11747
1-631-454-7677
BUSINESS PHONE/GENERAL MSDS INFORMATION:
EMERGENCY PHONE (U.S./Canada/Puerto Rico): 1-800-424-9300
EMERGENCY PHONE (OUTSIDE U.S.): +1-631-454-7677
NOTE: ALL United States Occupational Safety and Health Administration Standard (29 CFR 1910.1200), U.S. State equivalent Standards, and Canadian WHMIS [Controlled
Products Regulations] required information is included in appropriate sections based on the U.S. ANSI Z400.1-2004 format. This product has been classified in accordance
with the hazard criteria of the countries listed above.
2. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Product Description: This product is a smooth, white liquid with a waxy odor. Health
Hazards: The chief health hazard associated with exposure during normal use and handling is the potential for mild
irritation of contaminated skin. Individuals who have had allergic reactions to products containing Benzoyl Peroxide or
other components of this product may experience allergic reactions to this product. Flammability Hazards: When
involved in a fire, this material may decompose and produce irritating vapors and toxic gases (e.g., carbon oxides and
nitrogen oxides). Reactivity Hazards: This product is not reactive. Environmental Hazards: This product has not
been tested for environmental effects. Emergency Considerations: Emergency responders should wear appropriate
protection for situation to which they respond.
3. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # % w/w
Benzoyl Peroxide 94-36-0 5.75%
Urea 57-13-6 10.00%
Water and other components. Each of the other components is present in less The remaining components do not Balance
than 1 percent concentration (0.1% concentration for potential carcinogens, contribute any significant additional
reproductive toxins, respiratory tract sensitizers, and mutagens). hazards.
PART II What should I do if a hazardous situation occurs?
4 FIRST-AID MEASURES
Persons developing hypersensitivity reactions should receive medical attention. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Take a copy of label and MSDS to physician or health professional with the
contaminated individual.
SKIN EXPOSURE: If adverse skin effects occur, discontinue use. Seek medical attention.
EYE EXPOSURE: If this product contaminates the eyes, rinse eyes under gently running water. Use sufficient force to
open eyelids and then "roll" eyes while flushing. Minimum flushing is for 15 minutes. The contaminated individual must
seek medical attention if any adverse effect continues after rinsing.
INHALATION: If vapors of this product are inhaled, causing irritation, remove victim to fresh air. If necessary, use
artificial respiration to support vital functions.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
4 FIRST-AID MEASURES (Continued)
INGESTION: If this product is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR MOST CURRENT
INFORMATION. If professional advice is not available, do not induce vomiting. Never induce vomiting or give diluents
(milk or water) to someone who is unconscious, having convulsions, or unable to swallow. If victim is convulsing,
maintain an open airway and obtain immediate medical attention.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Pre-existing eye conditions may be aggravated by repeated
overexposures to this product.
RECOMMENDATIONS TO PHYSICIANS: This product should only be given to patients by persons experienced in
management of patients receiving the type of therapy intended for this product. Treat symptoms and eliminate
exposure.
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not flammable.
NFPA RATING
AUTOIGNITION TEMPERATURE: Not established.
FLAM MAB ILITY
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL): Not applicable. Upper (UEL): Not applicable.
0
Use extinguishing media
FIRE EXTINGUISHING MATERIALS:
appropriate for surrounding fire.
2 0
Water Spray: OK Carbon Dioxide: OK HEALTH INSTAB ILITY
Foam: OK Dry Chemical: OK
Halon: OK Other: Any "ABC" Class
FIRE EXTINGUISHING MATERIALS NOT TO BE USED: None known.
UNUSUAL FIRE AND EXPLOSION HAZARDS: This product contains a OTHER
known skin sensitizer, and so this product presents a contact hazard to Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate
firefighters. If heated to high temperatures for a prolonged period, the 3 = Serious 4 = Severe
water in this product can evaporate off and the residue may ignite.
When involved in a fire, this material may decompose and produce irritating vapors and toxic gases (e.g., carbon oxides
and nitrogen oxides).
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Not sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: Incipient fire responders should wear eye protection. Structural
firefighters must wear Self-Contained Breathing Apparatus (SCBA) and full protective equipment. If protective
equipment is contaminated by this product, it should be thoroughly washed with running water prior to removal of
SCBA respiratory protection. Firefighters whose protective equipment becomes contaminated should thoroughly
shower with warm, soapy water and should receive medical evaluation if they experience any adverse effects.
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: Proper protective equipment should be used. In the event of a spill, clear the area
and protect people. The atmosphere must have levels of components lower than those listed in Section 8 (Exposure
Controls-Personal Protection) if applicable, and have at least 19.5 percent oxygen before personnel can be allowed into
the area without Self-Contained Breathing Apparatus (SCBA).
Small Spills: Wear goggles and gloves while wiping up small spills of this product with polypad or sponge.
Large Spills: Trained personnel following pre-planned procedures should handle non-incidental releases. Access to the spill
areas should be restricted. Protective apparel should be used with a respirator when there is any danger of mists or sprays
being generated. Minimum Personal Protective Equipment should be rubber gloves, rubber boots, face shield, and Tyvek suit.
The dispersal of mists or sprays into surrounding air and the possibility of inhalation is a serious matter and should be treated as
such. Minimum level of personal protective equipment for releases in which the level of oxygen is less than 19.5% or is
unknown must be Level B: triple-gloves (rubber gloves and nitrile gloves over latex gloves), chemical resistant suit and
boots, hard hat, and Self-Contained Breathing Apparatus. Absorb spilled liquid using polypads or other suitable absorbent
material. Prevent material from entering sewer or confined spaces, waterways, soil or public waters. Monitor area and confirm
levels are bellow exposure limits given in Section 8 (Exposure Controls-Personal Protection), if applicable, before non-response
personnel are allowed into the spill area.
Decontaminate the area of the spill thoroughly using detergent and water. Place all spill residue in an appropriate
container and seal. Dispose of in accordance with applicable Federal, State, and local procedures (see Section 13,
Disposal Considerations).
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
PART III How can I prevent hazardous situations from occurring?
7. HANDLING and USE
WORK PRACTICES AND HYGIENE PRACTICES: As with all chemicals, avoid getting this product ON YOU or IN
YOU. Do not eat, drink, smoke, or apply cosmetics while handling this product. Wash hands thoroughly after
handling this product or equipment and containers that contain this product. Avoid breathing mists generated by this
product. Use in a well-ventilated location. Follow SPECIFIC USE INSTRUCTIONS supplied with this product.
Particular care in working with this product must be practiced in pharmacies and other preparation areas, during
manufacture of this product, and during patient administration.
STORAGE AND HANDLING PRACTICES: Employees must be trained to properly use this product. Use of this
product should be performed in a designated area for working with drugs. Ensure product is properly labeled. Store
this product away from incompatible materials. Store this product in original container. Post warning and "NO
SMOKING" signs in storage and use areas, as appropriate. Empty packages may contain residual liquid or vapors;
therefore, empty packages should be handled with care.
PRODUCT PREPARATION INSTRUCTIONS FOR MEDICAL PERSONNEL: Handle this material following standard
medical practices and following the recommendations presented on the Package Insert.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: When cleaning non-
disposable equipment, wear latex or butyl rubber (double gloving is recommended), goggles, and lab coat. Wash
equipment with soap and water. Wipe equipment down with damp sponge or polypad. Collect all rinsates and dispose
of according to applicable U.S. Federal, State, and local hazardous waste disposal regulations or waste disposal
regulations of Canada. All disposable items contaminated with this product should be disposed of properly.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. Follow standard medical product
handling procedures. During decontamination of work surfaces, workers should wear the same equipment
recommended in Section 6 (Accidental Release Measures) of this MSDS.
EXPOSURE LIMITS/GUIDELINES:
CHEMICAL NAME CAS # EXPOSURE LIMITS IN AIR
ACGIH-TLVs OSHA-PELs NIOSH-RELs NIOSH OTHER
TWA STEL TWA STEL TWA STEL IDLH
mg/m3 mg/m3 mg/m3 mg/m3 mg/m3 mg/m3 mg/m3 mg/m3
Benzoyl Peroxide 94-36-0 5 NE 5 NE 5 NE 1500 DFG MAKs:
TWA = 5 (Inhalable fraction of the aerosol)
PEAK = 1 MAK 15 min, average value
Urea 57-13-6 NE NE NE NE NE NE NE AIHA WEELs:
TWA = 10
NE = Not Established. See Section 16 for Definitions of Terms Used.
The following information on appropriate Personal Protective Equipment is provided to assist employers in complying with OSHA
regulations found in 29 CFR Subpart I (beginning at 1910.132) or equivalent standards of Canada (including CSA Standard Z94.4-
02 and CSA Standard Z94.3-07). Please reference applicable regulations and standards for relevant details.
RESPIRATORY PROTECTION: A respirator is not required for routine conditions of use of this product. If respiratory
protection is needed, use only respiratory protection authorized in the U.S. Federal OSHA Respiratory Protection
Standard (29 CFR 1910.134), equivalent U.S. State standards, or Canadian CSA Standard Z94.4-02. Oxygen levels
below 19.5% are considered IDLH by OSHA. In such atmospheres, use of a full-facepiece pressure/demand SCBA or
a full facepiece, supplied air respirator with auxiliary self-contained air supply is required under OSHAs Respiratory
Protection Standard (1910.134-1998).
EYE PROTECTION: Not normally needed during normal use. If necessary, refer to U.S. OSHA 29 CFR 1910.133 or
Canadian CSA Standard Z94.3-07.
HAND PROTECTION: For situations in which prolonged skin contact is anticipated, double glove, using latex, nitrile,
or rubber gloves. Check gloves for leaks. Wash hands before putting on gloves and after removing gloves. Gloves
should cover the gown cuff. If necessary, refer to U.S. OSHA 29 CFR 1910.138 or appropriate standards of Canada.
BODY PROTECTION: During patient administration, use of lightweight cotton gown or other medical attire is
recommended. If a hazard of injury to the feet exists due to falling objects, rolling objects, where objects may pierce the
soles of the feet or where employee's feet may be exposed to electrical hazards, use foot protection, as described in
U.S. OSHA 29 CFR 1910.136 or appropriate standards of Canada.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
9. PHYSICAL and CHEMICAL PROPERTIES
BOILING POINT: Not established. FREEZING/MELTING POINT: < 0癈 (32癋)
EVAPORATION RATE (nBuAc = 1): Not established. SOLUBILITY IN WATER: Soluble.
VAPOR PRESSURE (air = 1): Not established. SPECIFIC GRAVITY (water = 1): Approximately 1.0
ODOR THRESHOLD: Not established. pH: 2.8?.6
COEFFICIENT WATER/OIL DISTRIBUTION: Not established.
APPEARANCE AND COLOR: This product is a smooth, white liquid with a waxy odor.
HOW TO DETECT THIS SUBSTANCE (warning properties): There are not distinguishing characteristics to identify the
product in event of accidental release.
10. STABILITY and REACTIVITY
STABILITY: This product is stable.
DECOMPOSITION PRODUCTS: If exposed to extremely high temperatures, thermal decomposition may generate
irritating fumes and toxic gases (e.g., carbon oxides and nitrogen oxides).
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: This product is generally compatible with other
common materials in a medical facility. Acids, strong oxidizers, water reactive materials, and other chemicals that
could affect its performance should be avoided.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Avoid heat and contact with incompatible chemicals.
PART IV Is there any other useful information about this material?
11. TOXICOLOGICAL INFORMATION
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE: The
HAZARDOUS MATERIAL IDENTIFICATION SYSTEM
health hazard information provided below is pertinent to medical
employees handling this product in an occupational setting. This
product is designed for injection. The following paragraphs describe the
(BLUE) 2
HEA LTH HAZARD
symptoms of exposure by route of exposure.
INHALATION: Inhalation of mists or sprays of this product, especially
in a poorly ventilated space, may cause irritation, coughing, and
sneezing.
FLAMMABILITY HAZARD (RED) 0
CONTACT WITH SKIN or EYES: Skin contact can cause irritation,
which can be alleviated with cool compresses. Prolonged or
repeated skin contact can cause flaky skin, redness, inflammation,
and swelling. Eye contact may cause irritation, burning, redness, and
PHYSICAL HAZARD (YELLOW) 0
tearing.
SKIN ABSORPTION: The Benzoic Acid component of this product can
be absorbed through intact skin. Skin absorption over large areas of
skin and for prolonged periods of time may cause difficulty breathing. PROTECTIVE EQUIPMENT
INGESTION: Ingestion is not a significant route of occupational
overexposure. Acute ingestion of large quantities of this product or
EYES HANDS BODY
chronic ingestion caused by poor hygiene practices may cause R IRATORY
ESP
nausea, vomiting, and diarrhea.
INJECTION: Though not anticipated to be a significant route of SS
EE ECTION 8 SS
EE ECTION 8
overexposure for this product, injection (via punctures or lacerations by
contaminated objects) may cause redness at the site of injection.
For Routine Industrial Use and Handling Applications
GENERAL TOXICITY INFORMATION: Symptoms described in patients
given therapeutic doses of this substance include the following. Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate
3 = Serious 4 = Severe * = Chronic hazard
For Males and Females: Persons using the product in therapeutic
doses may experience allergic contact dermatitis (itchy, irritated, red skin) and skin dryness.
IRRITANCY OF PRODUCT: This product may irritate contaminated tissue.
SENSITIZATION OF PRODUCT: Individuals who have had allergic reactions to products containing Benzoyl Peroxide or
other components of this product may experience allergic reactions to this product.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to this product may
cause the following health effects:
Acute: The primary health effects that may be experienced by medical personnel exposed to this product is irritation
of contaminated skin. Eye contact may cause irritation.
Chronic: Prolonged or repeated skin contact can cause flaky skin, redness, inflammation, and swelling.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
11. TOXICOLOGICAL INFORMATION (Continued)
TARGET ORGANS:
Acute: Occupational Exposure: Skin. Therapeutic Doses: Eyes.
Chronic: Occupational Exposure: Skin. Therapeutic Doses: Eyes.
TOXICITY DATA: The toxicity data available for the active component of this product, Benzoyl Peroxide, is presented in
this MSDS. Additional data are available for the excipient components of this product, but are not presented in this
MSDS; Contact Nycomed US Inc. for more information.
BENZOYL PEROXIDE: BENZOYL PEROXIDE (continued: BENZOYL PEROXIDE (continued:
Standard Draize Test (Skin-Human) 5%/48 hours LD50 (Intraperitoneal-Mouse) 147 mg/kg DNA Inhibition (Human Cells-Not Otherwise
Standard Draize Test (Skin-Human) 5% TDLo (Skin-Mouse) 24 g/kg/30 weeks/intermittent: Specified) 56 祄ol/L
Standard Draize Test (Skin-Human) 5%/8 Tumorigenic: equivocal tumorigenic agent by Mutation Test Systems-Not Otherwise Specified
weeks/intermittent: Severe RTECS criteria; Skin and Appendages: tumors (Human Cells-Not Otherwise Specified) 56 祄ol/L
Standard Draize Test (Eye-Rabbit) 500 mg/24 TDLo (Skin-Mouse) 64,000 mg/kg/40 Mutation in Mammalian Somatic Cells (Human-
hours: Mild weeks/intermittent: Tumorigenic: carcinogenic by Kidney) 300 祄ol/L
LD50 (Oral-Rat) 7710 mg/kg: Lungs, Thorax, or RTECS criteria, facilitates action of known DNA Repair (Bacteria-Escherichia coli) 250 礸/well
Respiration: cyanosis; Liver: other changes; carcinogen; Skin and Appendages: tumors Unscheduled DNA Synthesis (Rat-Liver) 100 pmol/L
Kidney/Ureter/Bladder: other changes in urine TDLo (Skin-Mouse) 28,800 mg/kg/18 DNA Damage (Mouse Cells -Not Otherwise
composition weeks/intermittent: Tumorigenic: carcinogenic by Specified) 1 祄ol/L
LD50 (Oral-Rat) 6400 mg/kg RTECS criteria, facilitates action of known Morphological Transformation (Mouse-Fibroblast)
LD50 (Oral-Mouse) 1200 mg/kg carcinogen; Skin and Appendages: tumors 0.1 祄ol/L/21 days
LD50 (Skin-Mammal-Species Unspecified) > 1 g/kg DNA Damage (Human Cells-Not Otherwise Specific Locus Test (Mouse-Fibroblast) 25 祄ol/L/5
LD50 (Intraperitoneal-Rat) 372.8 mg/kg Specified) 100 祄ol/L weeks
CARCINOGENIC INFORMATION: Data from several studies employing a strain of mice that is highly susceptible to
developing cancer suggest that Benzoyl Peroxide acts as a tumor promoter. The clinical significance of these
findings to humans is unknown.
Components of this product are listed by agencies tracking the carcinogenic potential of chemical compounds, as
follows:
BENZOYL PEROXIDE: IARC-3 (Not Classifiable as to Carcinogenicity to Humans); ACGIH-TLV-A4 C (Not Classifiable as a Human Carcinogen)
The remaining components of this product are not found on the following lists: U.S. EPA, U.S. NTP, U.S. OSHA, U.S.
NIOSH, GERMAN MAK, IARC, or ACGIH and therefore are neither considered to be nor suspected to be cancer-
causing agents by these agencies.
REPRODUCTIVE TOXICITY INFORMATION: Benzoyl Peroxide is rated as Pregnancy Category C (RISK CANNOT BE
RULED OUT; Human evidence is lacking, but animal evidence is positive.). Listed below is information concerning
the effects of this compound on animal or human reproductive systems.
Mutagenicity: Benzoyl Peroxide has not been found to be mutagenic (Ames Test) and there are no published data indicating it
impairs fertility.
Embryotoxicity: Animal studies have not been performed to evaluate the embryotoxicity of Benzoyl Peroxide. No human data are
available.
Teratogenicity: Animal studies have not been performed to evaluate the teratogenicity of Benzoyl Peroxide. No human data are
available.
Reproductive Toxicity: Animal studies have not been performed to evaluate the reproductive toxicity of Benzoyl Peroxide. No
human data are available.
A mutagen is a chemical that causes permanent changes to genetic material (DNA) such that the changes will propagate through generation lines. An
embryo toxin is a chemical that causes damage to a developing embryo (i.e. within the first eight weeks of pregnancy in humans), but the damage
does not propagate across generational lines. A teratogen is a chemical that causes damage to a developing fetus, but the damage does not
propagate across generational lines. A reproductive toxin is any substance that interferes in any way with the reproductive process.
ACGIH BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, there are no ACGIH Biological Exposure Indices (BEIs)
determined for this product.
12. ECOLOGICAL INFORMATION
ALL WORK PRACTICES MUST BE AIMED AT ELIMINATING ENVIRONMENTAL CONTAMINATION.
ENVIRONMENTAL STABILITY: This product has not been tested for persistence, biodegradability, bioconcentration,
soil absorption or mobility. The following environmental data are available for the components of this product:
BENZOYL PEROXIDE:
Persistence and Biodegradability: If released into the atmosphere, Benzoyl Peroxide will exist both in the vapor and particulate phases in the ambient atmosphere,
based on an estimated vapor pressure of 7.1X10-5 mm Hg at 25癈. The maximum absorption of Benzoyl Peroxide, dissolved in dioxane, in the UV spectrum was
determined to be 275 nm, with no adsorption reported above 320 nm. An estimated Koc value of 1,800 suggests that Benzoyl Peroxide will have low mobility in soil.
Volatilization from moist soil may occur based upon an estimated Henry's Law constant of 0.012 atm-cu m/mole. Volatilization from dry soil surfaces should be
important given the vapor pressure of this compound. In the Japanese MITI test, Benzoyl Peroxide (present at 100 ppm) reached 84 percent of its theoretical BOD
in 21 days, using an activated sludge inoculum. In water, Benzoyl Peroxide is expected to adsorb to sediment or particulate matter based on its Koc value. This
compound is expected to volatilize from water surfaces given its estimated Henry's Law constant. Estimated half-lives from a model river and model lake are 16 days
and 123 days, respectively.
Bioconcentration: An estimated BCF of 250 was calculated for Benzoyl Peroxide, using an experimental log Kow of 3.46 and a recommended regression-derived
equation. According to a classification scheme, this BCF suggests that bioconcentration in aquatic organisms is high.
Soil Adsorption/Mobility: The Koc of Benzoyl Peroxide is estimated as approximately 1,800, using a measured log Kow of 3.46 and a regression-derived equation.
According to a recommended classification scheme, this estimated Koc value suggests that Benzoyl Peroxide is expected to have low mobility in soil.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
12. ECOLOGICAL INFORMATION (Continued)
EFFECT OF MATERIAL ON PLANTS or ANIMALS: No specific information is currently available on the effect of this
product on plants or animals in the environment. This product may be harmful to contaminated plant and animal life,
especially in large quantities.
EFFECT OF CHEMICAL ON AQUATIC LIFE: Release of this product to an aquatic environment may be harmful to
aquatic plant and animal life in contaminated bodies of water, especially in large quantities.
UREA:
Toxicity Threshold (Scenedesmus quadricauda green algae) > 10,000 mg/l, toxic effect: multiplication inhibition of cell. /Time not specified
Toxicity Threshold (Entosiphon sulcatum protozoa) > 29 mg/L, toxic effect: inhibition of cell multiplication./Time not specified
Toxicity Threshold (Pseudomonas putida) > 10,000 mg/L toxic effect: inhibition of cell multiplication. /Time not specified
ENVIRONMENTAL EXPOSURE CONTROLS: Controls should be engineered to prevent release to the environment,
including procedures to prevent spills, atmospheric release and release to waterways.
OTHER ADVERSE EFFECTS: No component of this product is known to have ozone depletion potential.
13. DISPOSAL CONSIDERATIONS
DISPOSAL METHODS: It is the responsibility of the generator to determine at the time of disposal whether the product
meets the criteria of a hazardous waste per regulations of the area in which the waste is generated and/or disposed of.
Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product, if unaltered
by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory
authority. Shipment of wastes must be done with appropriately permitted and registered transporters.
DISPOSAL CONTAINERS: Waste materials must be placed in and shipped in appropriate 5-gallon or 55-gallon poly or
metal waste pails or drums. Permeable cardboard containers are not appropriate and should not be used. Ensure that
any required marking or labeling of the containers be done to all applicable regulations.
PRECAUTIONS TO BE FOLLOWED DURING WASTE HANDLING: Wear proper protective equipment when handling
waste materials.
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate U.S. Federal, State,
and local regulations or with regulations of Canada. This product, if unaltered by handling, may be disposed of by
treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. All gowns, gloves,
and disposable materials used in the preparation or handling of this drug should be disposed of in accordance with
established hazardous waste disposal procedures. Handle as if capable of transmitting infectious agents.
Incineration is recommended. Reusable equipment should be cleaned with soap and water.
U.S. EPA WASTE NUMBER: Not applicable to wastes consisting only of this product.
14. TRANSPORTATION INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION SHIPPING REGULATIONS: This product is not classified as hazardous
under regulations of U.S. DOT 49 CFR 172.101.
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: This product is not
classified as Dangerous Goods, per regulations of Transport Canada.
15. REGULATORY INFORMATION
UNITED STATES REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: Components of this product are not subject to the reporting requirements
of Sections 302, 304, and 313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
CHEMICAL NAME SARA 302 SARA 304 SARA 313
(40 CFR 355, Appendix A) (40 CFR Table 302.4) (40 CFR 372.65)
Benzoyl Peroxide No No Yes
U.S. SARA THRESHOLD PLANNING QUANTITY: There are no specific Threshold Planning Quantities this product.
The default Federal MSDS submission and inventory requirement filing threshold of 10,000 lb (4,540 kg) therefore
applies, per 40 CFR 370.20.
U.S. CERCLA REPORTABLE QUANTITIES (RQ): Not applicable
U.S. TSCA INVENTORY STATUS: This product is regulated by the Food and Drug Administration; it is not subject to
requirements under TSCA.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): No component is
on the California Proposition 65 Lists.
OTHER U.S. FEDERAL REGULATIONS: Not applicable.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
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Nycomed US Inc.
15. REGULATORY INFORMATION (Continued)
ANSI LABELING (Based on 129.1, Provided to Summarize Occupational Exposure Hazards): WARNING! MAY
CAUSE ALLERGIC SKIN REACTION. MAY CAUSE SKIN, EYE, AND RESPIRATORY TRACT IRRITATION. Do not
taste or swallow. Avoid contact with skin or clothing. Avoid breathing mists or sprays. Keep container tightly closed.
Use only with adequate ventilation. Wash thoroughly after handling. Wear gloves, goggles, and appropriate body
protection during handling or administration. FIRST-AID: In case of contact, flush eyes with plenty of water. If inhaled,
remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, call a
physician immediately. Do NOT induce vomiting unless directed by a physician. Never give anything by mouth to an
unconscious person. IN CASE OF FIRE: Use water fog, dry chemical, CO2, or "alcohol" foam. IN CASE OF SPILL:
Wipe up spilled product. Place residual in appropriate container and seal. Dispose of according to applicable
regulations. Consult Material Safety Data Sheet for additional information.
CANADIAN REGULATIONS:
CANADIAN DSL/NDSL INVENTORY STATUS: This product regulated by the Therapeutic Products Programme (TPP)
of Health Canada and so it is exempt from requirements of the DSL/NDSL Inventory.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: The components of
this product are not on the CEPA Priorities Substances Lists.
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN WHMIS CLASSIFICATION AND SYMBOLS: Not applicable.
16. OTHER INFORMATION
This Material Safety Data Sheet is offered pursuant to OSHA's Hazard Communication Standard, 29 CFR, 1910.1200. Other government regulations must be reviewed
for applicability to this product. To the best of Nycomed US Inc.'s knowledge, the information contained herein is reliable and accurate as of this date; however,
accuracy, suitability or completeness are not guaranteed and no warranties of any type, either express or implied, are provided. The information contained herein
relates only to this specific product. If this product is combined with other materials, all component properties must be considered. Data may be changed from time to
time. Be sure to consult the latest edition.
CHEMICAL SAFETY ASSOCIATES, Inc.
PREPARED BY:
PO Box 3519, La Mesa, CA 91944-3519
800/441-3365 - 619/670-0609
April 9, 2009
DATE OF PRINTING:
DEFINITION OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these, which are commonly used, include the following:
CAS #: This is the Chemical Abstract Service Number that uniquely identifies EXPOSURE LIMITS IN AIR (continued):
each constituent. LOQ: Limit of Quantitation.
MAK: Federal Republic of Germany Maximum Concentration Values in the
EXPOSURE LIMITS IN AIR:
CEILING LEVEL: The concentration that shall not be exceeded during any part of workplace.
the working exposure. NE: Not Established. When no exposure guidelines are established, an entry of
DFG MAK Germ Cell Mutagen Categories: 1: Germ cell mutagens that have NE is made for reference.
been shown to increase the mutant frequency in the progeny of exposed humans. NIC: Notice of Intended Change.
2: Germ cell mutagens that have been shown to increase the mutant frequency in NIOSH CEILING: The exposure that shall not be exceeded during any part of the
the progeny of exposed mammals. 3A: Substances that have been shown to workday. If instantaneous monitoring is not feasible, the ceiling shall be assumed
induce genetic damage in germ cells of human of animals, or which produce as a 15-minute TWA exposure (unless otherwise specified) that shall not be
mutagenic effects in somatic cells of mammals in vivo and have been shown to exceeded at any time during a workday.
reach the germ cells in an active form. 3B: Substances that are suspected of NIOSH RELs: NIOSH's Recommended Exposure Limits.
being germ cell mutagens because of their genotoxic effects in mammalian PEL: OSHA's Permissible Exposure Limits. This exposure value means exactly
somatic cell in vivo; in exceptional cases, substances for which there are no in the same as a TLV, except that it is enforceable by OSHA. The OSHA
vivo data, but that are clearly mutagenic in vitro and structurally related to known Permissible Exposure Limits are based in the 1989 PELs and the June, 1993 Air
in vivo mutagens. 4: Not applicable (Category 4 carcinogenic substances are Contaminants Rule (Federal Register: 58: 35338-35351 and 58: 40191). Both the
those with non-genotoxic mechanisms of action. By definition, germ cell mutagens current PELs and the vacated PELs are indicated. The phrase, "Vacated 1989
are genotoxic. Therefore, a Category 4 for germ cell mutagens cannot apply. At PEL" is placed next to the PEL that was vacated by Court Order.
some time in the future, it is conceivable that a Category 4 could be established SKIN: Used when a there is a danger of cutaneous absorption.
for genotoxic substances with primary targets other than DNA [e.g. purely STEL: Short Term Exposure Limit, usually a 15-minute time-weighted average
aneugenic substances] if research results make this seem sensible.) 5: Germ cell (TWA) exposure that should not be exceeded at any time during a workday, even
mutagens, the potency of which is considered to be so low that, provided the MAK if the 8-hr TWA is within the TLV-TWA, PEL-TWA or REL-TWA.
value is observed, their contribution to genetic risk for humans is expected not to TLV: Threshold Limit Value. An airborne concentration of a substance that
be significant. represents conditions under which it is generally believed that nearly all workers
DFG MAK Pregnancy Risk Group Classification: Group A: A risk of damage to may be repeatedly exposed without adverse effect. The duration must be
the developing embryo or fetus has been unequivocally demonstrated. Exposure considered, including the 8-hour.
of pregnant women can lead to damage of the developing organism, even when TWA: Time Weighted Average exposure concentration for a conventional 8-hr
MAK and BAT (Biological Tolerance Value for Working Materials) values are (TLV, PEL) or up to a 10-hr (REL) workday and a 40-hr workweek.
observed. Group B: Currently available information indicates a risk of damage to HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARD
the developing embryo or fetus must be considered to be probable. Damage to RATINGS: This rating system was developed by the National Paint and Coating
the developing organism cannot be excluded when pregnant women are exposed, Association and has been adopted by industry to identify the degree of chemical
even when MAK and BAT values are observed. Group C: There is no reason to hazards.
fear a risk of damage to the developing embryo or fetus when MAK and BAT HEALTH HAZARD: 0 Minimal Hazard: No significant health risk, irritation of skin or
values are observed. Group D: Classification in one of the groups A瑿 is not yet eyes not anticipated. Skin Irritation: Essentially non-irritating. Mechanical irritation
possible because, although the data available may indicate a trend, they are not may occur. PII or Draize = 0. Eye Irritation: Essentially non-irritating, minimal
sufficient for final evaluation. effects clearing in < 24 hours. Mechanical irritation may occur. Draize = 0. Oral
IDLH: Immediately Dangerous to Life and Health. This level represents a Toxicity LD50 Rat: > 5000 mg/kg. Dermal Toxicity LD50 Rat or Rabbit: > 2000
concentration from which one can escape within 30-minutes without suffering mg/kg. Inhalation Toxicity 4-hrs LC50 Rat: > 20 mg/L.
escape-preventing or permanent injury.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
PAGE 7 OF 9
Nycomed US Inc.
DEFINITION OF TERMS (Continued)
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARD HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARD
RATINGS (continued): RATINGS (continued):
HEALTH HAZARD (continued): 1 Slight Hazard: Minor reversible injury may occur; PHYSICAL HAZARD (continued): 1 (continued) Unstable Reactives: Substances
may irritate the stomach if swallowed; may defat the skin and exacerbate existing that may decompose condense, or self-react, but only under conditions of high
dermatitis. Skin Irritation: Slightly or mildly irritating. PII or Draize > 0 < 5. Eye temperature and/or pressure and have little or no potential to cause significant
Irritation: Slightly to mildly irritating, but reversible within 7 days. Draize > 0 25. heat generation or explosion hazard. Substances that readily undergo hazardous
Oral Toxicity LD50 Rat: > 500?000 mg/kg. Dermal Toxicity LD50 Rat or Rabbit: > polymerization in the absence of inhibitors. Substances that readily undergo
1000?000 mg/kg. Inhalation Toxicity LC50 4-hrs Rat: > 2?0 mg/L. 2 Moderate hazardous polymerization in the absence of inhibitors. 2 Water Reactivity:
Hazard: Temporary or transitory injury may occur; prolonged exposure may affect Materials that may react violently with water. Organic Peroxides: Materials that, in
the CNS. Skin Irritation: Moderately irritating; primary irritant; sensitizer. PII or themselves, are normally unstable and will readily undergo violent chemical
Draize 5, with no destruction of dermal tissue. Eye Irritation: Moderately to change, but will not detonate. These materials may also react violently with water.
severely irritating; reversible corneal opacity; corneal involvement or irritation Explosives: Division 1.4 explosives. Explosive substances where the explosive
clearing in 8?1 days. Draize = 26?00, with reversible effects. Oral Toxicity LD50 effects are largely confined to the package and no projection of fragments of
Rat: > 50?00 mg/kg. Dermal Toxicity LD50 Rat or Rabbit: > 200?000 mg/kg. appreciable size or range are expected. An external fire must not cause virtually
Inhalation Toxicity LC50 4-hrs Rat: > 0.5? mg/L. 3 Serious Hazard: Major injury instantaneous explosion of almost the entire contents of the package.
likely unless prompt action is taken and medical treatment is given; high level of Compressed Gases: Pressurized and meet OSHA definition but < 514.7 psi
toxicity; corrosive. Skin Irritation: Severely irritating and/or corrosive; may cause absolute at 21.1癈 (70癋) [500 psig]. Pyrophorics: No Rating. Oxidizers: Packing
destruction of dermal tissue, skin burns, and dermal necrosis. PII or Draize > 5?, Group II oxidizers. Solids: any material that, either in concentration tested, exhibits
with destruction of tissue. Eye Irritation: Corrosive, irreversible destruction of a mean burning time of less than or equal to the mean burning time of a 2:3
ocular tissue; corneal involvement or irritation persisting for more than 21 days. potassium bromate/cellulose mixture and the criteria for Packing Group I are not
Draize > 80 with effects irreversible in 21 days. Oral Toxicity LD50 Rat: > 1?0 met. Liquids: any material that exhibits a mean pressure rise time less than or
mg/kg. Dermal Toxicity LD50 Rat or Rabbit: > 20?00 mg/kg. Inhalation Toxicity equal to the pressure rise of a 1:1 aqueous sodium chlorate solution
LC50 4-hrs Rat: > 0.05?.5 mg/L. 4 Severe Hazard: Life-threatening; major or (40%)/cellulose mixture and the criteria for Packing Group I are not met.
permanent damage may result from single or repeated exposures; extremely Reactives: Substances that may polymerize, decompose, condense, or self-react
toxic; irreversible injury may result from brief contact. Skin Irritation: Not at ambient temperature and/or pressure, but have a low potential (or low risk) for
appropriate. Do not rate as a 4, based on skin irritation alone. Eye Irritation: Not significant heat generation or explosion. Substances that readily form peroxides
appropriate. Do not rate as a 4, based on eye irritation alone. Oral Toxicity LD50 upon exposure to air or oxygen at room temperature. 3 Water Reactivity: Materials
Rat: 1 mg/kg. Dermal Toxicity LD50 Rat or Rabbit: 20 mg/kg. Inhalation Toxicity that may form explosive reactions with water. Organic Peroxides: Materials that
LC50 4-hrs Rat: 0.05 mg/L. are capable of detonation or explosive reaction, but require a strong initiating
FLAMMABILITY HAZARD: 0 Minimal Hazard: Materials that will not burn in air source or must be heated under confinement before initiation; or materials that
when exposure to a temperature of 815.5癈 (1500癋) for a period of 5 minutes. 1 react explosively with water. Explosives: Division 1.3 explosives. Explosive
Slight Hazard: Materials that must be pre-heated before ignition can occur. substances that have a fire hazard and either a minor blast hazard or a minor
Material requires considerable pre-heating, under all ambient temperature projection hazard or both, but do not have a mass explosion hazard. Compressed
conditions before ignition and combustion can occur. This usually includes the Gases: Pressure 514.7 psi absolute at 21.1癈 (70癋) [500 psig]. Pyrophorics: No
following: Materials that will burn in air when exposed to a temperature of 815.5癈 Rating. Oxidizers: Packing Group I oxidizers. Solids: any material that, in either
(1500癋) for a period of 5 minutes or less; Liquids, solids and semisolids having a concentration tested, exhibits a mean burning time less than the mean burning
flash point at or above 93.3癈 (200癋) (i.e. OSHA Class IIIB); and Most ordinary time of a 3:2 potassium bromate/cellulose mixture. Liquids: any material that
combustible materials (e.g. wood, paper, etc.). 2 Moderate Hazard: Materials that spontaneously ignites when mixed with cellulose in a 1:1 ratio, or which exhibits a
must be moderately heated or exposed to relatively high ambient temperatures mean pressure rise time less than the pressure rise time of a 1:1 perchloric acid
before ignition can occur. Materials in this degree would not, under normal (50%)/cellulose mixture. Unstable Reactives: Substances that may polymerize,
conditions, form hazardous atmospheres in air, but under high ambient decompose, condense, or self-react at ambient temperature and/or pressure and
temperatures or moderate heating may release vapor in sufficient quantities to have a moderate potential (or moderate risk) to cause significant heat generation
produce hazardous atmospheres with air. This usually includes the following: or explosion. 4 Water Reactivity: Materials that react explosively with water
Liquids having a flash-point at or above 37.8癈 (100癋); Solid materials in the form without requiring heat or confinement. Organic Peroxides: Materials that are
of course dusts that may burn rapidly but that generally do not form explosive readily capable of detonation or explosive decomposition at normal temperature
atmospheres; Solid materials in a fibrous or shredded form that may burn rapidly and pressures. Explosives: Division 1.1 & 1.2 explosives. Explosive substances
and create flash fire hazards (e.g. cotton, sisal, hemp); and Solids and semisolids that have a mass explosion hazard or have a projection hazard. A mass explosion
(e.g. viscous and slow flowing as asphalt) that readily give off flammable vapors. 3 is one that affects almost the entire load instantaneously. Compressed Gases: No
Serious Hazard: Liquids and solids that can be ignited under almost all ambient Rating. Pyrophorics: Add to the definition of Flammability 4. Oxidizers: No 4 rating.
temperature conditions. Materials in this degree produce hazardous atmospheres Unstable Reactives: Substances that may polymerize, decompose, condense, or
with air under almost all ambient temperatures, or, unaffected by ambient self-react at ambient temperature and/or pressure and have a high potential (or
temperature, are readily ignited under almost all conditions. This usually includes high risk) to cause significant heat generation or explosion.
the following: Liquids having a flash point below 22.8癈 (73癋) and having a NATIONAL FIRE PROTECTION ASSOCIATION HAZARD RATINGS:
boiling point at or above 38癈 (100癋) and those liquids having a flash point at or HEALTH HAZARD: 0 Materials that, under emergency conditions, would offer no
above 22.8癈 (73癋) and below 37.8癈 (100癋) (i.e. OSHA Class IB and IC); hazard beyond that of ordinary combustible materials. Gases and vapors with an
Materials that on account of their physical form or environmental conditions can LC50 for acute inhalation toxicity greater than 10,000 ppm. Dusts and mists with an
form explosive mixtures with air and are readily dispersed in air (e.g., dusts of LC50 for acute inhalation toxicity greater than 200 mg/L. Materials with an LD50 for
combustible solids, mists or droplets of flammable liquids); and Materials that burn acute dermal toxicity greater than 2000 mg/kg. Materials with an LD50 for acute
extremely rapidly, usually by reason of self-contained oxygen (e.g. dry oral toxicity greater than 2000 mg/kg. Materials essentially non-irritating to the
nitrocellulose and many organic peroxides). 4 Severe Hazard: Materials that will respiratory tract, eyes, and skin. 1 Materials that, under emergency conditions,
rapidly or completely vaporize at atmospheric pressure and normal ambient can cause significant irritation. Gases and vapors with an LC50 for acute inhalation
temperature or that are readily dispersed in air, and that will burn readily. This toxicity greater than 5,000 ppm but less than or equal to 10,000 ppm. Dusts and
usually includes the following: Flammable gases; Flammable cryogenic materials; mists with an LC50 for acute inhalation toxicity greater than 10 mg/L but less than
Any liquid or gaseous material that is liquid while under pressure and has a flash or equal to 200 mg/L. Materials with an LD50 for acute dermal toxicity greater than
point below 22.8癈 (73癋) and a boiling point below 37.8癈 (100癋) (i.e. OSHA 1000 mg/kg but less than or equal to 2000 mg/kg. Materials that slightly to
Class IA); and Materials that ignite spontaneously when exposed to air at a moderately irritate the respiratory tract, eyes and skin. Materials with an LD50 for
temperature of 54.4癈 (130癋) or below (pyrophoric). acute oral toxicity greater than 500 mg/kg but less than or equal to 2000 mg/kg. 2
PHYSICAL HAZARD: 0 Water Reactivity: Materials that do not react with water. Materials that, under emergency conditions, can cause temporary incapacitation
Organic Peroxides: Materials that are normally stable, even under fire conditions or residual injury. Gases with an LC50 for acute inhalation toxicity greater than
and will not react with water. Explosives: Substances that are Non-Explosive. 3,000 ppm but less than or equal to 5,000 ppm. Any liquid whose saturated vapor
Compressed Gases: No Rating. Pyrophorics: No Rating. Oxidizers: No 0 rating. concentration at 20癈 (68癋) is equal to or greater than one-fifth its LC50 for acute
Unstable Reactives: Substances that will not polymerize, decompose, condense, inhalation toxicity, if its LC50 is less than or equal to 5000 ppm and that does not
or self-react.). 1 Water Reactivity: Materials that change or decompose upon meet the criteria for either degree of hazard 3 or degree of hazard 4. Dusts and
exposure to moisture. Organic Peroxides: Materials that are normally stable, but mists with an LC50 for acute inhalation toxicity greater than 2 mg/L but less than or
can become unstable at high temperatures and pressures. These materials may equal to 10 mg/L. Materials with an LD50 for acute dermal toxicity greater than 200
react with water, but will not release energy violently. Explosives: Division 1.5 & mg/kg but less than or equal to 1000 mg/kg. Compressed liquefied gases with
1.6 explosives. Substances that are very insensitive explosives or that do not have boiling points between -30癈 (-22癋) and -55癈 (-66.5癋) that cause severe tissue
a mass explosion hazard. Compressed Gases: Pressure below OSHA definition. damage, depending on duration of exposure. Materials that are respiratory
Pyrophorics: No Rating. Oxidizers: Packaging Group III oxidizers; Solids: any irritants. Materials that cause severe, but reversible irritation to the eyes or are
material that in either concentration tested, exhibits a mean burning time less than lachrymators. Materials that are primary skin irritants or sensitizers. Materials
or equal to the mean burning time of a 3:7 potassium bromate/cellulose mixture whose LD50 for acute oral toxicity is greater than 50 mg/kg but less than or equal
and the criteria for Packing Group I and II are not met. Liquids: any material that to 500 mg/kg.
exhibits a mean pressure rise time less than or equal to the pressure rise time of a
1:1 nitric acid (65%)/cellulose mixture and the criteria for Packing Group I and II
are not met.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
PAGE 8 OF 9
Nycomed US Inc.
DEFINITION OF TERMS (Continued)
NATIONAL FIRE PROTECTION ASSOCIATION HAZARD RATINGS NATIONAL FIRE PROTECTION ASSOCIATION HAZARD RATINGS
(continued): (continued):
HEALTH HAZARD (continued): 3 Materials that, under emergency conditions, can INSTABILITY HAZARD: 0 Materials that in themselves are normally stable, even
cause serious or permanent injury. Gases with an LC50 for acute inhalation toxicity under fire conditions. Materials that have an instantaneous power density (product
greater than 1,000 ppm but less than or equal to 3,000 ppm. Any liquid whose of heat of reaction and reaction rate) at 250癈 (482癋) below 0.01 W/mL.
saturated vapor concentration at 20癈 (68癋) is equal to or greater its LC50 for Materials that do not exhibit an exotherm at temperatures less than or equal to
acute inhalation toxicity, if its LC50 is less than or equal to 3000 ppm and that does 500癈 (932癋) when tested by differential scanning calorimetry. 1 Materials that in
not meet the criteria for degree of hazard 4. Dusts and mists with an LC50 for acute themselves are normally stable, but that can become unstable at elevated
inhalation toxicity greater than 0.5 mg/L but less than or equal to 2 mg/L. Materials temperatures and pressures. Materials that have an instantaneous power density
with an LD50 for acute dermal toxicity greater than 40 mg/kg but less than or equal (product of heat of reaction and reaction rate) at 250癈 (482癋) at or above 0.01
to 200 mg/kg. Materials that are corrosive to the respiratory tract. Materials that W/mL and below 10 W/mL. 2 Materials that readily undergo violent chemical
are corrosive to the eyes or cause irreversible corneal opacity. Materials corrosive change at elevated temperatures and pressures. Materials that have an
to the skin. Cryogenic gases that cause frostbite and irreversible tissue damage. instantaneous power density (product of heat of reaction and reaction rate) at
Compressed liquefied gases with boiling points below -55癈 (-66.5癋) that cause 250癈 (482癋) at or above 10 W/mL and below 100W/mL. 3 Materials that in
frostbite and irreversible tissue damage. Materials with an LD50 for acute oral themselves are capable of detonation or explosive decomposition or explosive
toxicity greater than 5 mg/kg but less than or equal to 50 mg/kg. 4 Materials that, reaction, but that require a strong initiating source or that must be heated under
under emergency conditions, can be lethal. Gases with an LC50 for acute confinement before initiation. Materials that have an estimated instantaneous
inhalation toxicity less than or equal to 1,000 ppm. Any liquid whose saturated power density (product of heat of reaction and reaction rate) at 250癈 (482癋) at
vapor concentration at 20癈 (68癋) is equal to or greater than ten times its LC50 for or above 100 W/mL and below 1000 W/mL. Materials that are sensitive to thermal
acute inhalation toxicity, if its LC50 is less than or equal to 1000 ppm. Dusts and or mechanical shock at elevated temperatures and pressures. 4 Materials that in
mists whose LC50 for acute inhalation toxicity is less than or equal to 0.5 mg/L. themselves are readily capable of detonation or explosive decomposition or
Materials whose LD50 for acute dermal toxicity is less than or equal to 40 mg/kg. explosive reaction at normal temperatures and pressures. Materials that are
Materials whose LD50 for acute oral toxicity is less than or equal to 5 mg/kg. sensitive to localized thermal or mechanical shock at normal temperatures and
FLAMMABILITY HAZARD: 0 Materials that will not burn under typical fire pressures. Materials that have an estimated instantaneous power density (product
conditions, including intrinsically noncombustible materials such as concrete, of heat of reaction and reaction rate) at 250癈 (482癋) of 1000 W/mL or greater.
stone, and sand. Materials that will not burn in air when exposed to a temperature FLAMMABILITY LIMITS IN AIR:
of 816癈 (1500癋) for a period of 5 minutes in according with Annex D of NFPA Much of the information related to fire and explosion is derived from the National
704. 1 Materials that must be preheated before ignition can occur. Materials in this Fire Protection Association (NFPA). Flash Point: Minimum temperature at which a
degree require considerable preheating, under all ambient temperature conditions, liquid gives off sufficient vapor to form an ignitable mixture with air near the
before ignition and combustion can occur: Materials that will burn in air when surface of the liquid or within the test vessel used. Autoignition Temperature:
exposed to a temperature of 816癈 (1500癋) for a period of 5 minutes in according Minimum temperature of a solid, liquid, or gas required to initiate or cause self-
with Annex D of NFPA 704. Liquids, solids, and semisolids having a flash point at sustained combustion in air with no other source of ignition. LEL: Lowest
or above 93.4癈 (200癋) (i.e. Class IIIB liquids). Liquids with a flash point greater concentration of a flammable vapor or gas/air mixture that will ignite and burn with
than 35癈 (95癋) that do not sustain combustion when tested using the Method of a flame. UEL: Highest concentration of a flammable vapor or gas/air mixture that
Testing for Sustained Combustibility, per 49 CFR 173, Appendix H or the UN will ignite and burn with a flame.
Recommendations on the Transport of Dangerous Goods, Model Regulations TOXICOLOGICAL INFORMATION:
(current edition) and the related Manual of Tests and Criteria (current edition). Human and Animal Toxicology: Possible health hazards as derived from human
Liquids with a flash point greater than 35癈 (95癋) in a water-miscible solution or data, animal studies, or from the results of studies with similar compounds are
dispersion with a water non-combustible liquid/solid content of more than 85% by presented. LD50: Lethal Dose (solids & liquids) that kills 50% of the exposed
weight. Liquids that have no fire point when tested by ASTM D 92, Standard Test animals. LC50: Lethal Concentration (gases) that kills 50% of the exposed animals.
Method for Flash and Fire Points by Cleveland Open Cup, up to the boiling point ppm: Concentration expressed in parts of material per million parts of air or water.
of the liquid or up to a temperature at which the sample being tested shows an mg/m3: Concentration expressed in weight of substance per volume of air. mg/kg:
obvious physical change. Combustible pellets with a representative diameter of Quantity of material, by weight, administered to a test subject, based on their body
greater than 2 mm (10 mesh). Most ordinary combustible materials. Solids weight in kg. TDLo: Lowest dose to cause a symptom. TCLo: Lowest
containing greater than 0.5% by weight of a flammable or combustible solvent are concentration to cause a symptom. TDo, LDLo, and LDo, or TC, TCo, LCLo, and
rated by the closed cup flash point of the solvent. 2 Materials that must be LCo: Lowest dose (or concentration) to cause lethal or toxic effects. Cancer
moderately heated or exposed to relatively high ambient temperatures before Information: IARC: International Agency for Research on Cancer. NTP: National
ignition can occur. Materials in this degree would not under normal conditions form Toxicology Program. RTECS: Registry of Toxic Effects of Chemical Substances.
hazardous atmospheres with air, but under high ambient temperatures or under IARC and NTP rate chemicals on a scale of decreasing potential to cause human
moderate heating could release vapor in sufficient quantities to produce cancer with rankings from 1 to 4. Subrankings (2A, 2B, etc.) are also used. Other
hazardous atmospheres with air. Liquids having a flash point at or above 37.8癈 Information: BEI: ACGIH Biological Exposure Indices, represent the levels of
(100癋) and below 93.4癈 (200癋) (i.e. Class II and Class IIIA liquids.) Solid determinants which are most likely to be observed in specimens collected from a
materials in the form of powders or coarse dusts of representative diameter healthy worker who has been exposed to chemicals to the same extent as a
between 420 microns (40 mesh) and 2 mm (10 mesh) that burn rapidly but that worker with inhalation exposure to the TLV.
generally do not form explosive mixtures with air. Solid materials in fibrous or ECOLOGICAL INFORMATION:
shredded form that burn rapidly and create flash fire hazards, such as cotton, EC: Effect concentration in water. BCF: Bioconcentration Factor, which is used to
sisal, and hemp. Solids and semisolids that readily give off flammable vapors. determine if a substance will concentrate in life forms that consume contaminated
Solids containing greater than 0.5% by weight of a flammable or combustible plant or animal matter. TLm: Median threshold limit. log KOW or log KOC: Coefficient
solvent are rated by the closed cup flash point of the solvent. 3 Liquids and solids of Oil/Water Distribution is used to assess a substance's behavior in the
that can be ignited under almost all ambient temperature conditions. Materials in environment.
this degree produce hazardous atmospheres with air under almost all ambient
REGULATORY INFORMATION:
temperatures or, though unaffected by ambient temperatures, are readily ignited
U.S.:
under almost all conditions. Liquids having a flash point below 22.8癈 (73癋) and
EPA: U.S. Environmental Protection Agency. ACGIH: American Conference of
having a boiling point at or above 37.8癈 (100癋) and those liquids having a flash
Governmental Industrial Hygienists, a professional association that establishes
point at or above 22.8癈 (73癋) and below 37.8癈 (100癋) (i.e. Class IB and IC
exposure limits. OSHA: U.S. Occupational Safety and Health Administration.
liquids). Materials that on account of their physical form or environmental
NIOSH: National Institute of Occupational Safety and Health, which is the
conditions can form explosive mixtures with air and are readily dispersed in air.
research arm of OSHA. DOT: U.S. Department of Transportation. TC: Transport
Flammable or combustible dusts with representative diameter less than 420
Canada. SARA: Superfund Amendments and Reauthorization Act. TSCA: U.S.
microns (40 mesh). Materials that burn with extreme rapidity, usually by reason of
Toxic Substance Control Act. CERCLA: Comprehensive Environmental
self-contained oxygen (e.g. dry nitrocellulose and many organic peroxides). Solids
Response, Compensation, and Liability Act. Marine Pollutant status according to
containing greater than 0.5% by weight of a flammable or combustible solvent are
the DOT; CERCLA or Superfund; and various state regulations. This section also
rated by the closed cup flash point of the solvent. 4 Materials that will rapidly or
includes information on the precautionary warnings that appear on the material's
completely vaporize at atmospheric pressure and normal ambient temperature or
package label.
that are readily dispersed in air and will burn readily. Flammable gases.
CANADA:
Flammable cryogenic materials. Any liquid or gaseous materials that is liquid while
WHMIS: Canadian Workplace Hazardous Materials Information System. TC:
under pressure and has a flash point below 22.8癈 (73癋) and a boiling point
Transport Canada. DSL/NDSL: Canadian Domestic/Non-Domestic Substances
below 37.8癈 (100癋) (i.e. Class IA liquids). Materials that ignite when exposed to
List.
air, Solids containing greater than 0.5% by weight of a flammable or combustible
solvent are rated by the closed cup flash point of the solvent.
BENZOYL PEROXIDE HYDRATING WASH MSDS EFFECTIVE DATE: APRIL 08, 2009
PAGE 9 OF 9
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