Effective Date: July 6, 2009
Material Safety Data Sheet
For Emergency Call: Canadian Fertilizer Ltd. (Canada) ?(403) 527-8887
CHEMTREC (U.S.) -- (800) 424-9300
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: Urea
CAS Number: 57-13-6
Product Uses: Agricultural industry: Fertilizer, manufacturing of specialty fertilizers
Industrial application: Production of specialty pollution control solutions
Chemical Name: Urea
Chemical Family: Amides
Synonyms and Common Trade Names: Carbamide; carbonyldiamine; carbonyl diamide
Company Identification:
Manufacturer's Name: Canadian Fertilizers Limited (CFL)
Supplier's Name Canadian Fertilizers Limited
1250-52nd Street NW, Medicine Hat, Alberta, T1A 7N1
Address:
Telephone: (403) 527-8887
2. COMPOSITION/INFORMATION ON INGREDIENTS
Weight
Component Name CAS Number
Percentage
Urea 95.4-97.6 57-13-6
Biuret (H2NCONHCONH2) 1.0-1.5 108-19-0
Water 0.1-0.4 7732-18-5
Urea reaction products with formaldehyde 1.3-2.7 68611-64-3
(primarily methylenediurea)
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Effective Date: July 6, 2009
3. HAZARDS IDENTIFICATION
Emergency Overview
Notice! When heated, decomposes to carbon dioxide and ammonia; if burned, emits small
amounts of nitrogen oxides. Can cause redness and irritation of skin and eyes.
White granules with either no odor or having a slight odor of ammonia (in the presence of
moisture).
Potential Health Effects
Eyes: Eye irritant. May cause irritation, redness and pain.
Skin: Skin irritant. May cause irritation, redness, itching and pain. Not expected to be toxic by dermal
exposure.
Inhalation: Not expected to be toxic by inhalation. Urea dust may cause coughing and irritation of the
nose, throat and respiratory tract.
Ingestion: Not found to be toxic by oral exposure. May cause irritation of the digestive tract if
ingested. Nausea, vomiting, diarrhea and transient disorientation may occur in the event a large
quantity has been ingested.
Pre-Existing Medical Conditions: Conditions aggravated by exposure may include skin disorders
and respiratory (asthma-like) disorders.
Late Toxicities: Urea is not known to cause mutagenic, carcinogenic or reproductive effects from
concentrations or exposure routes normally experienced in the workplace.
4. FIRST AID
Eyes: Move victim away from exposure and into fresh air. If irritation or redness develops, flush eyes
with clean water. For direct contact, hold eyelids open and flush eye(s) immediately with clean water
for at least 15 minutes. Seek medical attention if necessary.
Skin: Flush affected area(s) with large amounts of water. If skin surface is damaged, apply a clean
dressing. If skin surface is not damaged, cleanse affected area(s) thoroughly by washing with mild
soap and water. Wash contaminated clothing before reuse. If irritation or redness develops, seek
medical attention.
Inhalation: Remove victim from source and allow to rest in well ventilated area. If breathing is
difficult, obtain immediate medical attention.
Ingestion: Rinse mouth and drink plenty of water. Seek medical attention if necessary.
Notes to Physician: None
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Effective Date: July 6, 2009
5. FIRE FIGHTING MEASURES
Flammability: Urea is not flammable.
Flash Point (test method): Not applicable
Flammable Limits: Not applicable
Explosive Limits: Not applicable
Autoignition Temperature: Not applicable
Extinguishing Media: Use extinguishing media suitable for surrounding fire.
NFPA Fire Rating: Flammability 0
Health Hazard 1
Instability 0
Specific Hazard Not applicable
Key: Least = 0, Slight = 1, Moderate = 2, High = 3, Extreme = 4
Special Firefighting Procedures: Fire fighters should use NIOSH approved self-contained breathing
apparatus and full protective equipment when fighting chemical fires.
Unusual Fire and Explosive Hazards: At elevated temperatures, urea forms hazardous
decomposition products, including ammonia. Refer to Section 10 for details. Explosive on contact
with halogens such as chlorine.
6. ACCIDENTAL RELEASE MEASURES
Recover any reusable product, taking care not to generate excess dust. Use caution as product may
be slippery when wet. Keep product out of sewage and drainage systems and all bodies of water.
Clean up spills immediately.
Place contaminated materials in disposable containers and dispose of in a manner consistent with
applicable regulations. Contact local environmental or health authorities for approved disposal of this
material.
Neutralizing Chemicals: Not applicable
7. HANDLING AND STORAGE
Handling: The use of respiratory protection is advised when dust concentrations exceed any
established exposure limits (see Section 8).
Storage: Keep dry. Urea will absorb moisture from air. If storage piles become wet, surrounding floor
may be slippery. Reacts with hypochlorites to form nitrogen trichloride, which explodes
spontaneously in air. Reacts with nitric acid to form urea nitrate that decomposes explosively when
heated.
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Effective Date: July 6, 2009
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Ventilation: Use process enclosure, general dilution ventilation or local exhaust systems, where
necessary, to maintain airborne dust concentrations below the OSHA standard or other applicable
regulations.
Preventive Measures / Specific Personal Protective Equipment
Eyes: Personal protective equipment is not normally required.
Skin: Personal protective equipment is not normally required.
Respiratory: Protection is not normally required unless relevant exposure standards are exceeded.
Use appropriate respirators when adequate engineering and work practice controls are not
technically feasible or when performing certain maintenance, repair or emergency operations where
excessive exposure could occur.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 requirements must be
followed whenever workplace conditions warrant a respirator's use.
Exposure Guidelines*
Although standards for urea have not been established, the following nuisance dust standards are
applicable.
10 mg/m3 ?inhalable particulate; 3 mg/m3 ?respirable particulate
ACGIH TLV:
15 mg/m3 TWA (total) (7); 5 mg/m3 TWA (respirable)
OSHA PEL:
*
TLV = Threshold Limit Values; PEL = Permissible Exposure Limits;
TWA = 8-hour Time-weighted Average
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: White granules
Odor: Odorless or slight ammonia odor
Odor threshold level: Not available
Physical state: Solid
pH: 7.2 (10% water solution)
Vapor pressure: Not applicable
Vapor density (air = 1): Not applicable
Boiling point: Not applicable
Melting point: Decomposes at 270.8癋 (132.7癈)
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Effective Date: July 6, 2009
Solubility in water (per 100 g water): 119 g at 77癋 (25癈)
Specific gravity (H2O = 1): Not applicable
Bulk Density: 44 to 49 lbs/ft3
Evaporation rate (butyl acetate = 1): Not applicable
Viscosity: 1.78 mPas (46% solution) at 68癋 (20癈); 1.81 mPas (46% solution) at 278.60癋 (137癈);
1.90 mPas (saturated solution) at 68癋 (20癈)
Percentage volatile by volume (%): Not applicable
Molecular weight: 60.06
Molecular formula: NH2CONH2
Octanol Water Partition Coefficient (KOW): 0.026
10. STABILITY AND REACTIVITY
Stability (thermal, light, etc.): Stable under normal conditions of storage and handling.
Incompatibility (materials to avoid): Nitric acid, sodium nitrite, nitrosyl perchlorate, gallium
perchlorate, hypochlorites, phosphorus pentachloride.
Hazardous Decomposition Products: When heated above melting point, decomposes to ammonia
and carbon dioxide. If burned, emits small amounts of nitrogen oxides.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: Decomposes when heated above melting point.
11. TOXICOLOGICAL INFORMATION
Urea
Oral LD50: Ranges from 11.5 g/kg (female mouse) to 15 g/kg (female rat)
Dermal LD50: No data available
Inhalation LC50: No data available
Urea dust at 22 mg/m3 caused mild irritation (species not specified).
Sensitization Capability: No data available
Synergistic Chemicals: No data available
Subchronic Toxicity: In a repeated dose toxicity study, urea at 10%, 20% and 40% in ointment was
applied to the back skin of rats for 4 weeks. No dose-dependent toxicity was observed. There were
no consistent treatment-related effects on standard haematological parameters, clinical chemistry,
organ weights or organ histopathology, including the testicles, prostate, seminal vesicles, ovaries and
the uterus.
Chronic Toxicity: In a chronic toxicity and carcinogenicity screening study conducted in mice over
12 months, urea was administered at 0, 0.45%, 0.9% and 4.5% in the diet. No pathology was
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Effective Date: July 6, 2009
reported immediately following treatment period. After 4 months, testes, prostate and uterus were
histologically examined for occurrence of tumors in the survivors. Although there was a statistically
increased incidence of interstitial cell adenomas of the testis in the high dose group, its biological
significance was deemed questionable, since the lesion may occur in 100% of controls.
Teratogenicity: In a single oral dose study in mice, 2,000 mg/kg administered on day 10 of
pregnancy was not teratogenic. Urea in water was given in 2 doses 12 hours apart by gavage to rats
during pregnancy for 14 days and the dams were allowed to deliver. No hypertrophy or other kidney
changes were detected nor were any teratogenic effects noted. Urea caused developmental effects
in chick embryos when injected into eggs.
Mutagenicity: Urea was negative in tests of bacterial mutagenicity and demonstrated low clastogenic
potential in non-bacterial mutagenicity tests. Chromosome breakage has been observed in some
laboratory tests using extremely high concentrations of urea. At near lethal doses, urea was
mutagenic in in-vivo non-bacterial tests in mice.
Urea is not recognized as a carcinogen by IARC, NTP or OSHA.
Biuret
Oral rat LD50: No data available
Dermal rat LD50: No data available
Inhalation LC50: No data available
Mutagenicity: No data available
Teratogenicity: No data available
Sensitization Capability: No data available
Synergistic Chemicals: No data available
Biuret is not recognized as a carcinogen by IARC, NTP or the Occupational Safety and Health
Administration (OSHA).
Methylenediurea
No toxicity data was located in the toxicology or medical literature for methylenediurea. Based on the
toxicology testing of urea, which contains methylenediurea, methylenediurea is expected to have a
low order of acute and chronic toxicity. Direct contact with eyes and skin may cause irritation,
redness, itching and pain.
Oral LD50: No data available
Dermal LD50: No data available
Inhalation LC50: No data available
Mutagenicity: No data available
Teratogenicity: No data available
Sensitization Capability: No data available
Synergistic Chemicals: No data available
Methylenediurea is not recognized as a carcinogen by IARC, NTP or OSHA.
12. ECOLOGICAL INFORMATION
Large amounts of urea can damage plant seedlings and inhibit germination. As a readily available
source of nitrogen, urea can also foster excessive growth of algae or microorganisms in water
systems.
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Effective Date: July 6, 2009
Urea is non-toxic to aquatic organisms as defined by USEPA.
Fish 96 hour LC50: >9,100 mg/L
Daphnia 24 hour EC50: >10,000 mg/L
Ecotoxicity Information: The cell multiplication toxicity threshold values for bacteria, green algae,
and protozoa are >10,000, >10,000, and 29 mg/L, respectively. The critical range for the creek chub
is 16,000 to 30,000 mg/L in Detroit river water.
Environmental Fate Information: Particulate-phase urea is physically washed out of the
atmosphere by dry and wet deposition. In the soil, urea degrades rapidly, usually within 24 hours;
however, degradation may be slower depending on soil type, moisture content and urea formulation.
The ultimate degradation products are carbon dioxide and ammonia. The soil mobility is high based
on an organic carbon partition coefficient of 8. In water, biodegradation to carbon dioxide and
ammonia is the major fate pathway. The biodegradation rate increases with increasing temperature
and presence of phytoplankton. Oxidation of urea by nitrifying bacteria can increase biological oxygen
demand. Bioaccumulation of urea is very low. The 72-hour bioconcentration factor (BCF) for carp is
reported to be 1.
13. DISPOSAL CONSIDERATIONS
Urea is not considered a hazardous waste under Federal Hazardous Waste Regulations 40 CFR
261. Consult local, state and/or provincial environmental regulatory authorities for acceptable
disposal procedures and locations. Follow standard disposal procedures.
14. TRANSPORT INFORMATION
Urea is not listed as a hazardous material by the U.S. Department of Transportation (DOT), Transport
Canada (TC), International Maritime Organization (IMO) and the United Nations (UN).
15. REGULATORY INFORMATION
United States
OSHA (Occupational Safety and Health Administration): This material is considered to be
hazardous as defined by the OSHA Hazard Communication Standard.
CERCLA (Comprehensive Environmental Response, Compensation and Liability Act): This
product does not contain Reportable Quantity substances.
SARA TITLE III (Superfund Amendment and Reauthorization Act of 1986): No federal
requirements. User should contact local and state regulatory agencies for information on additional or
more stringent reporting requirements.
Sections 311/312: This product has been reviewed according to the USEPA "Hazard Categories"
promulgated under Sections 311 and 312 of SARA Title III and is considered, under applicable
definitions, to meet the following categories:
Acute: yes Chronic: no Fire: no Reactivity: no
DOT (Department of Transportation): Please refer to Section 14 (Transport Information) for
guidance concerning transportation.
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Effective Date: July 6, 2009
PROPOSITION 65: Not listed
This material has not been identified as a carcinogen by NTP, IARC or OSHA.
Canada
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA): This product is on the Domestic
Substances List (DSL) and is acceptable for use under the provisions of CEPA.
CANADIAN WHMIS CLASSIFICATION: Not a WHMIS controlled product
WHMIS: This product is not considered hazardous according to WHMIS
16. DOCUMENTARY INFORMATION AND DISCLAIMER OF EXPRESSED AND IMPLIED
WARRANTIES
MSDS Prepared By: Environmental Health Decisions (949-481-8600)
Preparation Date: April 8, 2009
Issue Date: July 6, 2009
Previous Issue Date: April 17, 2006
CFL believes the information contained herein is accurate; however, CFL makes no guarantees or
warranties with respect to such accuracy and assumes no liability in connection with the use of the
information contained herein by any party. The provision of the information contained herein by CFL
is not intended to be and should not be construed as legal advice or as ensuring compliance by other
parties. Judgments as to the suitability of the information contained herein for the party's own use or
purposes are solely the responsibility of that party. Any party handling, transferring, transporting,
storing, applying or otherwise using this product should review thoroughly all applicable laws, rules,
regulations, standards and good engineering practices. Such thorough review should occur before
the party handles, transfers, transports, stores, applies or otherwise uses this product.
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