MSDS Code GPC001/PGB Version 4 Page 1 of 5
MATERIAL SAFETY DATA SHEET
MSDS Code GPC001/PGB/2 Version 4 Date: 6 June 2009
Prepared by: P.G. Baskeyfield Email: paul.baskeyfield@varianinc.com
Sections according to EC Regulation No 1907/2006
Section 1 Identification of the Substance/Preparation & Company/Undertaking:
Product Name: PLgel ?in ethylbenzene (MSDS refers to contents of column)
Product: Styrene divinyl benzene copolymer ?in ethylbenzene.
Co mpany: Varian, Inc.
Essex Road
Church Stretton
Shropshire, SY6 6AX
UK
Tel: 0044 1694 723581
In case of emergency USA: 800 - 424 ?9300, International 703 ?527 ?3887 CHEMTREC 24 hour numbers
Section 2 Hazards Identification:
Ethylbenzene
EU Hazard statements according to EU Regulation EC 1272/2008: Highly flammable liquid and vapour.
Harmful if inhaled.
Skin and Eyes: Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or
dermatitis. May be absorbed through the skin. Contact with the liquid may cause erythema
(redness), exfoliation and vesiculation (blistering).
Ingestion: May cause irritation of the digestive tract. May cause central nervous system depression,
characterized by excitement, followed by headache, dizziness, drowsiness, and nausea.
Inhalation: Causes respiratory tract irritation. Vapors may cause dizziness or suffocation if in high
concentration.
Styrene divinyl benzene copolymer
Not hazardous according to UN GHS, EU Regulation EC 1272/2008, or Directive 67/548/EEC
Inhalation (powder): May be harmful if inhaled. May cause upper respiratory tract & mucous membrane
irritation.
Skin and Eyes: May cause mechanical irritation.
Ingestion: May be harmful if swallowed.
Section 3 Composition/Information of Ingredients:
Refers to contents of column:
MSDS Code GPC001/PGB Version 4 Page 2 of 5
Name CAS EC Nu mber GHS Hazard 67/548/EEC Percent (w/w)
Number class & categ . approx.
Class
code
Poly(styrene-co- 9003-70-7 NA Not hazardous Not hazardous 37%
divinylbenzene)
Ethylbenzene 100-41-4 202-849-4 Flam. Liq. 2 Acute F; Xn 63%
Tox. 4 *
R: 11-20
Section 4 Emergen cy First Aid Procedures:
IF ON SKIN (or hair):Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF SWALLOWED: Call a POISON CENTRE or doctor/physician if you feel unwell. Rinse mouth. (EC 1272/2008)
IF IN EYES: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Notes to Physician: Treat symptomatically and supportively.
Section 5 Fire -Fighting Measures:
Main Hazard: Flammable liquid absorbed onto combustible solid - emits irritant
& toxic fumes. Vapors may be heavier than air. They can spread
along the ground and collect in low or confined areas.
Extinguishing Method: In case of fire: Use dry powder for extinction. (EC 1272/2008)
Special Fire Fighting Procedure: Wear self contained breathing apparatus with full face shield
operated in positive pressure mode, MSHA/NIOSH (approved or
equivalent), and full protective gear.
Unusual Fire Hazards and Explosion Hazards: Will produce black acrid smoke if burned. There is a risk of fine
powders of this type exploding if the powder is ignited whilst
airborne.
Autoignition Temperature: 810F ( 432.22 C)
Section 6 Accidental Release Measures:
General Information Ventilate the area thoroughly and shut off sources of ignition. If necessary evacuate the
area. Use protective equipment as detailed in section 8. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas.
Spills/Leaks: Clean up spills immediately, observing precautions in section 8. Do not allow powder to dry
out. Absorb spill using an absorbent, non-combustible material and gather up placing in a
clean closed container for disposal. Do not wash away into sewers.
Section 7 Handling and Storage:
Keep away from sparks/open flames. -- No smoking. Keep container tightly closed. Wear protective gloves & eye
protection. Avoid breathing dust/vapours/spray. Use only in a well-ventilated area. Store in a well-ventilated place.
Keep cool ( EC 1272/2008)
Product Specific
Read the Suppliers' Users Guide carefully before commissioning or using the product. The end caps should be
kept firmly in place during storage. .
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Section 8 Exposure Controls/Personal Protection:
Use local mechanical ventilation, i.e. always use a fume cupboard when handling this material.
Personal Protective Equipment
Respir atory protection
If required to control exposure, use only suitable respirators and components tested and approved under
appropriate government standards such as NIOSH (US) or CEN (EU).
Hand Protection : Suitable impervious gloves e.g. neoprene
Eye Protec tion : Chemical safety goggles
Section 9 Physical and Chemical Properties:
Solid: Styrene divinyl benzene copolymer: Liquid: Ethylbenzene :
Boiling Point: Does not boil Boiling Point: 136C
Melting Point: Degrades before melting Melting Point: -95.00C
Specific Gravity Density at 20C
(H 2O=1): Approximately 0.3g/ml (g/ml): 0.9
Miscibility in Not soluble in water Solubility in water: Insoluble with water
Water: and floats
Particle size Appearance Colourless liquid
and shape: 3-100,, spherical particles and odour: with aromatic odour
Appearance: White free flowing powder Flash point: 21C
Explosion limit (%) 0.8- 6.7
Section 10 Stability and Reactivity:
Styrene divinyl benzene copolymer: Ethylbenzene :
Stability: Stable Stability: Stable
Conditions to avoid: Naked flame, sparks Conditions to avoid: Naked flame, sparks
heat heat
Materials to avoid: Oxidising agents Materials to avoid: Oxidising agents
Hazardous Monomer may be Hazardous May release toxic fumes
Decomposition: formed if heated. Decomposition:
May release toxic fumes
Hazardous Hazardous Will not occur
Polymerisation: Will not occur Polymerisation:
Section 11 Toxicological Data:
Styrene divinyl benzene copolymer:
To the best of our knowledge, the chemical, physical & toxicological properties of this material have not been fully
investigated.
IARC Cancer review: Animal limited evidence - IMEDT 19,231,79.
IARC Cancer review: Group -IMSUDL 7,56, 87.
MSDS Code GPC001/PGB Version 4 Page 4 of 5
Ethylbenzene:
RTECS: CAS# 100-41-4: DA0700000.
LD50/LC50: CAS# 100-41-4:
Draize test, rabbit, eye: 500 mg Severe
Inhalation, mouse: LC50 = 35500 mg/m3/2H
Inhalation, rat: LC50 = 55000 mg/m3/2H
Oral, rat: LD50 = 3500 mg/kg
Skin, rabbit: LD50 = 17800 uL/kg.
Oral, rat: LD50 = 5.46 mg/kg
Carcinogenicity:
CAS# 100-41-4
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
California: carcinogen, initial date 6/11/04
OSHA: Select carcinogen
IARC: Group 2B carcinogen
Other: Standard Draize Test: Administration into the eye (rabbit) = 500 mg (Severe). Standard Draize Tes (Rabbit,
Skin) = 15 mg/L; Mild.
Section 12 Ecological Information:
Styrene divinyl benzene copolymer
Ethylbenzene
Ecotoxicity:
Fish: Rainbow trout: 14.0 mg/L; 96 Hr.; Static
Fish: Fathead Minnow: 12.1 mg/L; 96 Hr.; Flow-through
Fish: Bluegill/Sunfish: LC50 =150.0 mg/L; 96 Hr.; Flow-through
Water flea EC50 =2.1 mg/L; 48 Hr.; Static
Bacteria: EC50 =9.8 mg/L; 30 minutes; Micotox Test
Water flea EC50 =75.0 mg/L; 48 minutes; Static, pH6.7-8.1, 72.0 mg/L CaCO3
Other:
Shrimp (mysidoposis bahia), LC50=87.6 mg/L/96hr. Sheepshead minnow LC50=275 mg/L/96hr. Fathead minnow
LC50=42.3 mg/L/96hr in hard water &48.5 mg/L/96hr in softwater.
Section 13 Disposal Considerations:
The disposal of chemicals is covered by regulations which may vary according to location.
Contact a specialist disposal company or the local authority or advice.
Dispose of contents/container in accordance with local, regional, national, & international regulations. .
(EC 1272/2008)
Section 14 Transport Information:
IATA, IMO/IMDG, ADR/RID, DOT:
Proper Shipping Name:
Solids containing flammable liquid nos (poly(divinylbenzene), ethylbenzene )
UN 3175, Class 4.1 (Flammable Solid) , Packing Group II
Proper Shipping Name (Alternative only when transported inside chromatography columns):
Dangerous goods in apparatus
MSDS Code GPC001/PGB Version 4 Page 5 of 5
UN 3363, Class 9 , Packing Group: Not Applicable
Section 15 Regulatory Information:
Labelling in Accordance with EC Regulation 1272/2008:
Signal Word Code(s) Dgr.
GHS Hazard class & categ code: Flam. Liq. 2, Acute Tox. 4
Directive 67/548/EEC Classification: F; Xn R: 11-20
WGK (Water Danger/Protection)
CAS# 100-41-4: 1
Canadian DSL/NDSL
CAS# 100-41-4 is listed on Canada's DSL List.
Canadian Ingredient Disclosure List CAS# 100-41-4 is listed on Canada's Ingredient Disclosure List.
US Federal
TSCA CAS# 100-41-4 & 9003-70-7 are both listed on the TSCA Inventory.
Section 16 Other Information:
This material is only for chromatography, solid phase extraction, or use for purposes of technical analysis and/or
scientific research. The health and toxicological hazards of this substance have not been fully investigated;
therefore, this substance must be handled only by, or under close supervision of those qualified in the handling and
use of potentially hazardous substances. This MSDS was prepared in accordance with ANSI Z400.1-1993,
91/155/EEC, & EC 1907/2006 recommended formats. The information contained herein is believed to be accurate,
but does not purport to be all-inclusive and shall be used only as a guide. Varian, Inc., does not guarantee said
information is accurate or complete, nor shall any of this information constitute a warranty, whether expressed or
implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods for a particular
purpose. It is the user's responsibility to determine the suitability of this information and to assure the adoption of
necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact
with the above product, nor for the results obtained, or for incidental or consequential damage arising from the use
of these data. No freedom from infringement of any patent, copyright or trademark is to be inferred.
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