EtO - MSDS
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Material Safety Data Sheets--Ethylene Oxide
Statement of Hazards:
Section 1
Chemical Product & Company Identification DANGER!
Extremely flammable liquid and gas under pressure. May form
Product: ANPROLENE / EOGas explosive mixtures with air. Highly reactive. May be harmful if
inhaled and may cause delayed lung injury, respiratory system and
Manufactured by: nervous system damage. Inhalation may cause dizziness or
drowsiness. Liquid contact may cause frostbite. May cause allergic
Andersen Sterilizers, Inc. skin reaction. Harmful if swallowed. May cause adverse blood
effects, liver and kidney damage based on animal data. Cancer and
Health Science Park
reproductive hazard.
3154 Caroline Drive
Haw River, NC 27258 USA
HAZARD RATINGS: (0 = minimum; 4 = maximum)
Information Telephone Number: (336) 376-8622
Health = 3
HMIS RATING:
Emergency Telephone Number Flammability = 4
Reactivity = 3
(24 HRS, 7 DAYS PER WEEK)
Personal Protection Code = x (Consult your
CHEM-TEL (800)-255-3924
supervisor or standard operating procedures
for special handling directions.)
Section 2
Composition/ Information on Ingredients Health = 3
NFPA RATING:
Flammability = 4
Chemical Name: Ethylene Oxide Reactivity = 3
Weight By %: 84 to 97%
Exposure Limits:
Chemical Family: Epoxide
TWA (8 hr) STEL (15-min)
Formula: (CH2)2O
OSHA 1 ppm 5 ppm
Molecular Weight: 44.06 gms/mole
ACGIH 1 ppm n/a
CAS Number: 75-21-8
CAS Name: Oxirane
PRIMARY ROUTES OF EXPOSURE: Inhalation; eye contact, skin
Synonyms: EO, EtO, Dihydroxirene,
contact/absorption
1-2 Epoxyethane, Dimethylene Oxide,
Oxane, Oxirane, Alkene Oxide, Alpha/
SIGNS AND SYMPTOMS OF OVEREXPOSURE: Effects include
Beta-Oxidoethane, Oxacyclopropane.
skin, eye and respiratory tract irritation or burns. Central nervous
Product Uses: Chemical intermediate for production of
system effects initially cause headache, dizziness and nausea and in
antifreeze, polyester resins, non-ionic
extreme cases, unconsciousness and death. Peripheral nerve
surfactants and specialty solvents; sterilizing
damage may result in muscular weakness, giddiness, irrational
agent for controlling microorganisms in health
behavior and loss of sensation in the extremities. Dulling of the
care applications; fumigant for controlling
sense of smell may occur.
insect infestation in whole and ground spices
and cosmetics.
ACUTE HEALTH EFFECTS:
Section 3
INHALATION: Inhaling concentrated vapor may cause serious
Hazard Identification
health effects. Inhalation may progressively cause mucous
membrane and respiratory irritation, headache, vomiting, cyanosis,
EMERGENCY OVERVIEW drowsiness, weakness, in coordination, CNS depression,
lachrymation, nasal discharge and salivation, gasping, and labored
Colorless liquid or heavier-than-air gas with a sweet, ether-like odor. breathing. Delayed effects may include nausea, diarrhea, edema of
Extremely flammable liquefied gas which burns in the absence of the lungs, paralysis and convulsions. NOTE: Ethylene Oxide has a
oxygen and can explode when exposed to elevated temperatures. high odor threshold (>250 ppm) and the sense of smell does not
Toxic when inhaled. Causes severe skin and eye irritation or burns provide adequate protection against its toxic effects.
and respiratory tract irritation; effects may be delayed. Harmful if
swallowed or absorbed through the skin. Contact with liquid may EYE CONTACT: Liquid Ethylene Oxide is severely irritating and
cause frostbite. corrosive to the eyes and contact can cause swelling of the
conjunctiva and irreversible corneal injury. Contact with liquid
Ethylene Oxide can cause frostbite. Vapors may cause eye irritation,
tearing, redness and swelling of the conjunctiva.
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EtO - MSDS
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SKIN CONTACT: Prolonged contact with liquid Ethylene Oxide can INGESTION: If patient is conscious give plenty of water ( minimum
cause a local erythema, edema, and formation of blisters. Response of two glasses) but DO NOT INDUCE VOMITING. This material is
is more severe on damp skin. There may be a latency period of corrosive. Keep head lower than hips to avoid aspiration, should
several hours prior to the onset of symptoms. Ethylene Oxide may vomiting occur. Get medical attention immediately.
be absorbed by the skin, and sustained contact may produce
adverse effects such as headache, dizziness, nausea, and vomiting. MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE:
Ethylene Oxide is a skin sensitizer and some individuals may suffer Preexisting skin, eye and respiratory disorders; lung, blood, nervous
an allergic skin reaction. Skin contact may also cause allergic system and peripheral nerve disorders.
contact dermatitis in some exposed individuals. Liquid Ethylene
Oxide evaporates rapidly and may chill the skin causing frostbite. NOTE TO PHYSICIANS: Respiratory symptoms include nausea,
vomiting and irritation of the nose and throat. Pulmonary edema
INGESTION: This relatively unlikely route of exposure is expected to may occur. Respiratory effects may be delayed. Consider oxygen
cause severe irritation and burns of the mouth and throat, abdominal administration. If a chemical burn is present decontaminate skin
pain, nausea, vomiting, collapse and coma. Aspiration may occur and treat as any thermal burn. No specific antidote is known,
during swallowing or vomiting, resulting in lung damage. however consider gastric lavage and administration of a charcoal
slurry.
CHRONIC HEALTH EFFECTS:
Section 5
Fire Fighting Measures
SKIN CONTACT: Long term effects are unknown but are expected
to be similar to acute effects of skin exposure.
FLASH POINT (TEST METHOD):
EYE CONTACT: Some cases of cataract formation have been Tag Closed Cup: -4F (-20C)
reported.
FLAMMABLE LIMITS IN AIR (% BY VOLUME);
INHALATION: Respiratory irritation which can result in permanent, Upper flammable limit: 100%
lung injury, chromosomal aberrations and peripheral neurotoxic Lower flammable limit: 3.0% (30,000 ppm)
effects with a numbing of the sense of smell. Cognitive and CNS Flammability: 4
impairment may result from long term exposures. NEFA HAZARD RATING:
Health 3 Reactivity: 3
INGESTION: May cause anemia, gastrointestinal irritation, effects 804 F (429C); burns in the absence of air
on liver, kidneys, and adrenal glands. AUTOIGNITION TEMPERATURE:
CARCINOGENICITY:
OSHA classifies Ethylene Oxide as a cancer/ reproductive hazard EXTINGUISHING MEDIA: Carbon dioxide, dry chemical or water
and considers that, at excessive levels, Ethylene Oxide may present spray for small fires. Water spray, polymer or alcohol resistant
reproductive, mutagenic, genotoxic, neurologic and skin sensitization foams for large fires. Dilution of liquid Ethylene Oxide with 23
hazards. volumes of water should render it non-flammable. Dilution with 100
ACGIH classifies Ethylene Oxide as "A2"- suspected human parts water to one part of Ethylene Oxide vapor may be required to
carcinogen. control build up of flammable vapors in closed systems. Water spray
NTP classifies Ethylene Oxide as a known human carcinogen. can be used to reduce intensity of flames to cool fire-exposed
IARC classifies Ethylene Oxide in Group 1 (carcinogenic to humans). containers and to dilute spills to render non-flammable.
NIOSH classifies Ethylene Oxide as a potential human carcinogen.
HAZARDOUS DECOMPOSITION PRODUCTS: Carbon monoxide
Section 4 and carbon dioxide.
First Aid Measures
UNUSUAL FIRE AND EXPLOSION HAZARDS: Ethylene Oxide is
EYE CONTACT: Immediately flush eyes, including the entire dangerously explosive under fire condition; it is flammable over an
surface of the eyes and under the eyelids, gently but thoroughly with
extremely large range of concentrations in air and burns in the
plenty of running water for at least 15 minutes. Obtain medical absence of oxygen. Liquid Ethylene Oxide is lighter than water
attention immediately. NOTE: Never wear contact lenses when (floats) and vapors are heavier than air and may travel along ground
working with Ethylene Oxide. long distances to sources of ignition and then flash back. Containers
should not be subject to temperatures hotter than 127F (52 C).
SKIN CONTACT: Immediately flush skin thoroughly with water for at Vapors are extremely flammable and are readily ignited by static
least 15 minutes while removing contaminated clothing and shoes. charge, sparks and flames at concentrations above 3%.
Obtain medical attention immediately. Wash clothing before reuse
and discard contaminated leather articles such as shoes and belts.
Section 6
Accidental Release Measures
INHALATION: Remove exposed person to fresh air. If breathing
has stopped, give artificial respiration then have qualified personnel
administer oxygen, if needed. Get immediate medical attention. PRECAUTIONS: Treat any Ethylene Oxide leak as an emergency.
Evacuate all personnel from the area except those directly engaged
in stopping the leak or in cleaning up. If an Anprolene ampoule
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EtO - MSDS
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is inadvertently dropped and activated before it is sealed inside of VENTILATION: Install and operate general and local exhaust
the sterilization liner bag, it will still take time for the Ethylene Oxide ventilation systems powerful enough to maintain airborne levels of
to diffuse out of the gas release bag and into the room. At one full Ethylene Oxide below the OSHA PEL in the worker's breathing area.
minute after activation there is less than 1 ppm measured at a AAMI / ANSI ST41 Good Hospital Practice: Ethylene Oxide
distance of 18 inches from the gas release bag. In the case of a Sterilization and Sterility Assurance Guidelines, Section 3.4
premature activation the operator should immediately: recommends a minimum of 10 room makeup air changes per hour.
?Place the Anprolene ampoule inside the sterilizer Emission controls must be in compliance with Federal, State and
?Close the sterilizer door local regulations.
?Turn the power on; and
?Press the button to the right of PURGE OTHER PROTECTION: Sterilizer must be electrically grounded/
This will cause the purge and ventilation pumps to turn on and bonded. Practice good personal hygiene; always wash thoroughly
evacuate the Ethylene Oxide from the sterilizer and exhaust it from after using this material. Do not eat drink or smoke in work area.
the workspace. Allow a full 14 hour cycle before you open the door
Section 9
to remove and dispose the used Anprolene ampoule.
Physical and Chemical Properties
Section 7
Handling and Storage 50.9篎 (10.5篊)
Boiling Point:
-169?F (-111.7篊)
Freezing Point
HANDLING AND STORAGE PRECAUTIONS: Have established 0.871 at 20篊
Specific Gravity:
handling and emergency response procedures in place prior to use. 1094 mm Hg @ 20篊
Vapor Pressure:
Make sure that the sterilizer is properly grounded. Protect 1.5
Vapor Density (Air =1)
containers from physical damage and regularly inspect them for 100%
Solubility in Water:
cracks or leaks. 44.06 gms/mole
Molecular Weight:
100%
Percent Volatile by Volume
ENGINEERING CONTROLS: Ethylene Oxide, a major fire hazard, Not applicable
Evaporation rate (Butyl Acetate = 1)
can burn in the absence of oxygen. All electrical devices used in 7, neutral (100 grams/
PH:
areas processing or handling Ethylene Oxide must be engineered liter in water)
and designed to the applicable local electrical/fire codes. Colorless liquid or gas
Appearance and Odor:
Safeguards can include designing electrical devices as explosion with sweet ether-like
proof and/or intrinsically safe. ATTENTION: Ethylene Oxide vapors odor. Odor threshold:
are colorless and odorless above OSHA'S permissible exposure 261 ppm (detectable);
level. An air monitoring system and/or AirScan?badges are 600-700 ppm recognizable).
recommended to determine airborne exposure levels. Log Octanol/Water
-0.3
Partition Coefficient (log Kow):
STORAGE SEGREGATION: Store Ethylene Oxide in a cool, dry,
well-ventilated area away from incompatible chemicals and sources
Section 10
of ignition. Store Anprolene?refill kits upright; do not drop and
Stability and Reactivity
move in a carefully supervised manner. DO NOT STORE IN
DIRECT SUNLIGHT.
STABILITY: Material is stable for extended periods in closed
SHIPPING AND STORAGE CONTAINERS: (See 49 CFR 173.4) airtight, pressurized containers at room temperature, under normal
All Anprolene?refill kits containing Ethylene Oxide are packaged storage and handling conditions. Vapors may explode when
and shipped in accordance with the small quantities exemption exposed to common ignition sources.
under 49 CFR 173.4(c) and DOT approval CA 9803005 issued April
9, 1998. CONDITIONS TO AVOID: Storage at warm temperatures or any
exposure of storage or shipping containers to hot temperatures.
Prevent exposure to all sources of ignition such as heat, flame,
Section 8
lighted tobacco products, or electrical or mechanical sparks.
Exposure Controls/Personal Protection
HAZARDOUS DECOMPOSITION PRODUCTS: Ethylene Oxide
EXPOSURE LIMITS: undergoes thermal decomposition to form carbon dioxide and carbon
monoxide gases.
0.5 ppm
OSHA ACTION LEVEL (8 HR. TWA)
Section 11
1 ppm
OSHA PEL (8 HR TWA)
Toxicological Information
OSHA 15 MINUTE EXCURSION LIMIT 5 ppm; 9 mg/m3
ACGIHTLV/TWA 1 ppm; 1.8 mg/m3
IDLH: 800 ppm TOXICOLOGICAL- ACUTE INHALATION: LC50 (1 hr. exposure)
5748 ppm (male rat)
EYE PROTECTION: NEVER WEAR CONTACT LENSES when
4439 ppm (female rat)
working with Ethylene Oxide.
5029 ppm (rat ?combined sexes)
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EtO - MSDS
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REPRODUCTIVE EFFECTS: Some limited epidemiological data
Various mammalian species exposed to lethal concentrations of
suggests that women exposed to Ethylene Oxide have a greater
Ethylene Oxide had symptoms of mucous membrane irritation,
incidence of miscarriages. A one-generation reproduction study in
central nervous system depression, lacrimation, nasal discharge,
rats showed decreased number of pups at 100 ppm, but not at 33
salivation, nausea, vomiting, diarrhea, respiratory irritation,
ppm. In a two-generation reproduction study involving exposure of
incoordination, and convulsions.
rats to Ethylene Oxide vapor for 5 hrs/day, 5 days/week, there was
TOXICOLOGICAL-CHRONIC INHALATION: Symptoms of chronic parental toxicity at 33 ppm and 100 ppm. The no-observable effect
exposure are similar to those observed in acute studies, including concentration for adult toxicity, offspring effect and reproductive
lung, kidney and liver damage and testicular tubule degeneration in effect was 10 ppm.
some species. Studies demonstrated neuromuscular effects as the
TERATOLOGY: Inhalation development toxicity studies with rats
most sensitive indicator of Ethylene Oxide over exposure.
exposed to Ethylene Oxide vapor at concentrations of 50 ppm, 125
ppm and 225 ppm showed that maternal toxicity occurred at 125 and
TOXICOLOGICAL-ACUTE DERMAL: No dermal LD50 information
is available on this product. It is expected to be corrosive to rabbit 225 ppm. Fetotoxicity, evidenced by reduced fetal body weight,
skin. occurred at all concentrations. At 225 ppm and to a lesser extent at
125 ppm an increased incidence of skeletal variants was found.
TOXICOLOGICAL ?CHRONIC DERMAL: No chronic dermal
There was no evidence of embryotoxicity or malformations.
toxicity data are available on this product.
TARGET ORGANS: Overexposure to this product may affect the
TOXICOLOGICAL- EYE: No eye irritation animal data are available
skin, eyes, respiratory system, liver, kidneys, brain, blood,
on this product. However, it is expected to extremely irritating to
reproductive system, and central nervous system.
rabbit eyes.
Section 12
TOXICOLOGICAL-ACUTE INGESTION: The acute oral LD50 for Ecological Information
This product is; 72 mg/kg, rat.
ECOTOXICOLOGICAL DATA: Ethylene Oxide hydrolyzes to
TOXICOLOGICAL-CHRONIC INGESTION: The effects of chronic
ethylene glycol. Biodegradation of Ethylene Oxide occurs at a
ingestion of this product are unknown.
moderate rate after acclimation (3-5% degradation after 5 days; 52%
after 20 days). Biodegradation is expected in a wastewater treatment
CARCINOGENICITY: A recent assessment of available
plant. Ethylene Oxide has an estimated half-life in the atmosphere
epidemiology studies related to Ethylene Oxide concluded that the
of 211 days. A high adsorptivity in soil is expected.
evidence indicates that Ethylene Oxide does not cause heart disease,
an excess of cancers overall, or brain, stomach or pancreatic cancers Section 13
which were seen in some animal and isolated human studies. The Disposal Consideration
findings with respect to leukemia and non-Hodgkins lymphoma are
less definitive. While the majority of the evidence does not indicate
WASTE MANAGEMENT/DISPOSAL: Dispose used Anprolene
that Ethylene Oxide causes these cancers, there are some
ampoules, sterilization liner bags, indicators and accessories as you
suggestive trends. Longer follow-up of Ethylene Oxide workers is
would ordinary trash.
needed to better clarify these relationships. Two inhalation studies
with rats demonstrated carcinogenic responses consisting of
However, unused Anprolene ampoules containing Ethylene Oxide
increased incidences of mono-nuclear cell leukemia, peritoneal
are a RCRA hazardous waste with waste code U115 (Commercial
mesotheliomas , and primary brain tumors. In 2-year inhalation
chemical product - listed for toxicity and ignitability). Unused
studies with mice there was evidence of carcinogenic activity as
Anprolene ampoules containing Ethylene Oxide may be incinerated
indicated by dose-related incidences of benign or malignant
in an approved hazardous waste incinerator or can be biologically
neoplasms of the uterus, mammary gland, and hematopoietic system
treated in an approved facility. Unused Anprolene ampoules
(lymphoma).
containing Ethylene Oxide are banned from land disposal.
MUTAGENICITY: While Ethylene Oxide has demonstrated, in
Dispose of waste materials in accordance with all applicable Federal,
epidemiological studies with exposed workers, an increased
State and local laws and regulations.
incidence of chromosomal aberrations and sister chromatid
exchanges, the relevance of such effects to human health hazard Section 14
evaluation is currently uncertain. In rodent studies, dose related Transport Information
exposure to Ethylene Oxide induces increases in numbers of adducts
in DNA and hemoglobin. Laboratory studies with mice have shown
TRANSPORTATION DATA:
that acute exposure to Ethylene Oxide at 300 ppm and above caused
Ethylene Oxide
DOT Proper shipping Name:
testicular injury as evidenced by concentration-related increased
2.3 (Poison Gas)
DOT Class or Division:
embryonic deaths following mating of exposed males to non-exposed
UN 1040
Identification Number
females (Dominant-Lethal Test).
n/a
Packing Group:
"This package conforms to 49 CFR
DOT Label:
NEUROTOXICITY: Effects are similar to those of acute (short term)
173.4"
exposure, namely headaches, nausea, diarrhea, lethargy, and
See section 7, "Handling and
DOT Packaging
irrational behovior. Muscle weakness, loss of sensation in the
storage"
extremities and a reduction in the sense of smell and/or taste may
CA-9803005
DOT Approval:
also result. Studies on workers Indicate that CNS and cognitive
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EtO - MSDS
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Section 15 OSHA- Occupational Safety and Health Administration
Regulatory Information p/p- parts per part
PEL- Permissible exposure Limit
U.S. REGULATIONS: PVC- Polyvinyl chloride
ppm- Parts per million
p.s.i.g- Pounds per square inch (gauge pressure)
TSCA status: Listed
RCRA- Resource, Conservation and Recovery Act
CERCLA Section 103 (40 CFR 302.4): listed
SARA- Superfund Amendment and Reauthorization Act of 1990
10 lb. Reportable Quantity
STEL- Short-term exposure Limit
SARA Section 304 (40 CFR 356.40): Listed
TDG-Transportation of Dangerous Goods
1 lb Reportable Quantity
TLV- Threshold Limit Value
SARA Section 311/312 (40 CFR 370.21) Hazard categories met:
TSCA- Toxic Substance Control Act
Acute, Chronic, Fire, Reactive, Sudden Release
TWA- Time Weighted Average
SARA Section 313 (40 CFR 372.65); Listed
VOC- Volatile organic compound
OSHA (29 CFR 1910. 1200): Meets criteria as a hazardous material
WHMIS-Workplace Hazardous Material Information System
OSHA (29 CFR 1910. 1047): Ethylene Oxide Standard
EPA list of Hazardous Air Contaminants: Listed
EPA Organic Hazardous Air Pollutant (HAP) list: Listed Section 17
EPA list of Pesticide Chemicals (40 CFR 180.151): Listed Disclaimer
EPA NESHAPS (40 CFR 63.360)
VOC Rule: 100% VOC
It is imperative that the user/reader be familiar with and adhere to
STATE RIGHT-TO-KNOW REGULATIONS: OSHA regulations which are specific to Ethylene Oxide
(29CFR1910.1047) as well as any other applicable Federal, State, or
local government regulations. Regulations listed in Section 15 of this
California Proposition 65: Listed; cancer hazard; reproductive hazard
document may not be all inclusive and are subject to change. The
California Director's List: Listed
data in this MSDS is furnished gratuitously independent of any sale
Florida Hazardous Substance List: Listed
of the product only for your investigation and independent
Massachusetts Extraordinarily Hazardous Substance List: Listed
verification. While the information is believed to be correct,
Minnesota Hazardous Substance List: Listed
Andersen makes no representation as to the accuracy of the
New Jersey Hazardous Substance List: Listed on 0882
information contained herein. Andersen shall in no event be
(Special Hazardous Substance: Environmental
responsible for any damages of whatsoever nature directly or
Hazardous Substance)
indirectly resulting from publication or use of, or negligence upon
Pennsylvania Right-to-know List: Listed
data contained herein. No Warranty (either expressed or implied) of
Section 16 merchantability or of fitness for any purpose with respect to the
product or to the data herein is made hereunder.
Other Information
MSDS Revision Date: 12/14/07
GLOSSARY OF TERMS AND ABBREVIATIONS:
ACGIH- American Conference of Governmental Industrial Hygienists
CERCLA- Comprehensive Environmental Response, Compensation
and Liability Act.
CAS- Chemical Abstract Service
CFR- Code of Federal Regulations
CNS- Central Nervous System
DOT- U.S. Department of Transportation
EPA- U. S. Environmental Protection Agency
HMIS- Hazardous Materials information Sheet
IARC- International Agency for Research on Cancer
IDL- ingredient Disclosure List
IDLH- Immediately dangerous to life and health
HAP- Hazardous Air Pollutant
LC50 - Median lethal dose that kills 50% of an exposed population by
the inhalation route
LD50- Median lethal dose that kills 50% of an exposed population by
the oral (or dermal) route
NESHAPS- National Emission Standards for Hazardous Air
Pollutants
NFPA- National Fire Protection Association
NIOSH- National Institute of Occupational Safety and Health
NTP- National Toxicology Program
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