Material Safety Data Sheet
Nalidixic acid
ACC# 01074
Section 1 - Chemical Product and Company Identification
MSDS Name: Nalidixic acid
Catalog Numbers: AC169900000, AC169900050, AC169900250, BP908-25
Synonyms: Nalidic acid; Nalidixin; Nalidixinic acid; Nalurin.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS
389-08-2 Nalidixic acid >98 206-864-7
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: white to light yellow powder.
Warning! May cause allergic respiratory and skin reaction. May cause eye, skin, and
respiratory tract irritation. Possible risk of harm to the unborn child. May cause central nervous
system depression. Light sensitive.
Target Organs: Central nervous system, respiratory system, eyes, skin.
Potential Health Effects
Eye: May cause painful sensitization to light. May cause visual abnormalities including: blurring,
abnormal color vision, loss of sight.
Skin: May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. May be harmful if absorbed through the skin.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause
central nervous system depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure. May cause blood abnormalities. Exposure may
cause hallucinations, convulsions, abnormal touch sensations and increased intracranial pressure.
https://fscimage.fishersci.com/msds/01074.htm (1 of 6) [3/21/2007 4:58:15 AM]
May cause stiff and swollen joints.
Inhalation: May cause allergic respiratory reaction. May cause respiratory tract irritation. May
cause effects similar to those described for ingestion.
Chronic: Possible cancer hazard based on tests with laboratory animals. May cause reproductive
and fetal effects.
Section 4 - First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the
upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or
water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire,
irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Wear a self contained breathing apparatus and appropriate personal protection.
(See Exposure Controls, Personal Protection section). Sweep up, then place into a suitable
container for disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before
reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact
with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from
incompatible substances. Hormones and antibiotics room.
https://fscimage.fishersci.com/msds/01074.htm (2 of 6) [3/21/2007 4:58:15 AM]
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped with an
eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations
low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Nalidixic acid none listed none listed none listed
OSHA Vacated PELs: Nalidixic acid: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's
eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European
Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Powder
Appearance: white to light yellow
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:225 - 231 deg C
Decomposition Temperature:Not available.
Solubility: 0.1 mg/ml (23 c)
Specific Gravity/Density:Not available.
Molecular Formula:C12H12N2O3
Molecular Weight:232.24
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures. Light sensitive.
Conditions to Avoid: High temperatures, light, dust generation.
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
https://fscimage.fishersci.com/msds/01074.htm (3 of 6) [3/21/2007 4:58:15 AM]
Section 11 - Toxicological Information
RTECS#:
CAS# 389-08-2: QN2885000
LD50/LC50:
CAS# 389-08-2:
Oral, mouse: LD50 = 572 mg/kg;
Oral, rat: LD50 = 2040 mg/kg;
.
Carcinogenicity:
CAS# 389-08-2:
q ACGIH: Not listed.
California: carcinogen, initial date 5/15/98
q
NTP: Not listed.
q
IARC: Not listed.
q
Epidemiology: No information available.
Teratogenicity: Effects on Embryo/Fetus: Fetal death, orl-rat TDLo=3300 mg/kg and orl-rbt
TDLo=10400 mg/kg. Specific Developmental Abnormalities: Craniofacial, Musculoskeletal, orl-rat
TDLo=3300 mg/kg.
Reproductive Effects: Effects on Fertility: Litter Size, orl-rat TDLo=3300 mg/kg and orl-rbt
TDLo=10400 mg/kg.
Mutagenicity: DNA Damage: E. coli, 25 mg/l. DNA Inhibition: Human cell types, 500 mg/l;
Mouse cell types, 10 mmol/L.
Neurotoxicity: No information available.
Other Studies:
Section 12 - Ecological Information
Ecotoxicity: No data available. No information available.
Environmental: No information reported.
Physical: No information available.
Other: None.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult state and local hazardous waste regulations
to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
https://fscimage.fishersci.com/msds/01074.htm (4 of 6) [3/21/2007 4:58:15 AM]
Section 14 - Transport Information
US DOT Canada TDG
Shipping Name: Not regulated as a hazardous material No information available.
Hazard Class:
UN Number:
Packing Group:
Section 15 - Regulatory Information
US FEDERAL
TSCA
CAS# 389-08-2 is not listed on the TSCA inventory. It is for research and development use
only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 389-08-2: immediate, delayed.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 389-08-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
The following statement(s) is(are) made in order to comply with the California Safe
Drinking Water Act:
WARNING: This product contains Nalidixic acid, a chemical known to the state of California to
https://fscimage.fishersci.com/msds/01074.htm (5 of 6) [3/21/2007 4:58:15 AM]
cause cancer.
California No Significant Risk Level: CAS# 389-08-2: 28 鎔/day NSRL
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 40 Limited evidence of a carcinogenic effect.
R 42/43 May cause sensitization by inhalation and skin contact.
R 63 Possible risk of harm to the unborn child.
Safety Phrases:
S 22 Do not breathe dust.
S 24 Avoid contact with skin.
S 36/37 Wear suitable protective clothing and gloves.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 389-08-2: 2
Canada - DSL/NDSL
CAS# 389-08-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
MSDS Creation Date: 9/08/1998
Revision #5 Date: 6/13/2006
The information above is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume
no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for
their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
https://fscimage.fishersci.com/msds/01074.htm (6 of 6) [3/21/2007 4:58:15 AM]
|