Material Safety Data Sheet
Revision: 01/25/2001
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and t he US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Nalidixic Acid 19436 None
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Outside USA & Canada 703 527 3887
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Nalidixic Acid 389-08-2 ~99% --- R:22 Harmful if swallowed
R:36/37/38 Irritating to eyes,
respiratory system and skin
S:22 Do not breathe dust
S:36/37 Wear suitable
protective clothing and gloves
HAZARDS IDENTIFICATION CHIP
Harmful
HCS
Irritant
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove conta minated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. No unusual fire or
explosion hazards known.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat , safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequat e ventilation. Do not allow to enter drinking
water supplies, waste water or soil.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat , safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Use a dequate ventilation. Store
ambient and keep container tightly closed.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the information
contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet must be determined by the user
to be in accordance with appropriate applicable regulations.
For Further Asia Pacific Canada Former Soviet Union Japan Norway Spain USA
Information, +852 2811 8693 1 800 463 5800 +7 (095) 232 0250 81 3 5331 9337 63 89 23 10 935 944 950 USB Corporation
contact your (216) 765-5000
local USB Australia Central and East Europe France Latin America Portugal Sweden If purchased from
authorized +61 2 9894 5188 +43 1 982 3826 0169 18 28 00 +55 11 3667 5700 01 417 70 35 018 164000 Amersham Pharmacia
distributor, Biotech use
Amersham Austria Denmark Germany Middle East and Africa South East Asia Switzerland 1 800 526 3593
Pharmacia 01 576 0616 10 +45 4516 2400 07 61 49 03 0 +30 (1) 96 00 687 60 3 724 2080 01 802 81 50
Biotech
Belgium Finland Italy Netherlands South East Europe UK
0800 73888 358 (9) 512 3940 02 27322 1 0165 580 410 +43 (1) 982 3826 0800 515313
MSDS information may be continued on back of page.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat , safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need f or respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the haza rd. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: White to slightly yellow crystalline powder Boiling Point: No data available
Vapor Pressure: No data available Vapor Density: No data available
PROPERTIES
Solubility (Water): Slightly soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical Formula: C12-H12-N2-O3 Melting Point: 225 - 231 C.
STABILITY AND REACTIVITY Product is stable. Hazardous polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation, dermatitis and hypersensitive individuals may experience an allergic
reaction.
INHALATION: May cause irritation, and hypersensitive individua ls may experience an allergic reaction.
INGESTION: Chronic ingestion or excessive dosage may cause diarrhea, nause a, gastrointestinal irritation,
neurological disorders, anemia, intracranial hypertension, and respiratory failure. May be harmful if
swallowed.
ADDITIONAL INFORMATION:
Reproductive effects, mutation, tumorigenic and toxicity data listed in RTECS under QN2885000.
Oral Human (woman) TDLo = 40 mg/kg. Oral Rat LD50 = 2040 mg/kg (Tokyo, Japan - 1980) Toxic effects
may included nausea, vomiting, convulsions, hyperglycemia, sweating, metabolic acidosis, changes in
leukocyte (WBC) count, coma and possibly death.
Reproductive: Effects on embryo or fetus included fetotoxicity (e xcept death, e.g. stunted fetus)(1980) and
fetal death(1980).
Specific developmental abnormalities - musculoskeletal system (19 71).
Fertility - litter size (e.g. number of fetuses per litter; measured before birth)(1980).
Carcinogenicity data:
NTP Carcinogenesis Studies (feed): Clear evidence: rat (1989).
Equivocal evidence: mouse (1989).
Tumorigenic data: Carcinogenic by RTECS criteria (1989).
Equivocal tumorigenic agent by RTECS criteria (1989).
Definition(s):
NTP = National Toxicology Program Annual Report on Carcinogens.
RTECS = Registry of Toxic Effects of Chemical Substance s.
ECOLOGICAL INFORMATION Toxic for aquatic organisms. Bactericidal effect.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, stat e, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - No applicable information.
SARA 313 - No applicable information.
EPA TSCA Section 8(b) - No applicable information.
Exposure Limits - Not established.
California Proposition 65 -This product is or contains chemical(s) known to the State of California to cause
cancer.
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