MSDS #7866 COVER SHEET
78440 Halt Cocktail (100X)
Component # Description
1861281 Protease & Phosphatase Inhibitor
1861274 0.5 M EDTA
78444 Halt Cocktail (100X)
Component # Description
1861284 Protease & Phosphatase Inhibitor
1861283 0.5 M EDTA
78446 Halt Cocktail (100X)
Component # Description
1861282 Protease & Phosphatase Inhibitor
1861276 0.5 M EDTA
Pierce PO BOX 117 (815) 968-0747 www.thermo.com
3747 N. Meridian Road Rockford, IlL 61105 (815) 968-7316 fax
Halt Protease Phosphatase Inhibitor Cocktail
Material Safety Data Sheet
2. Hazards identification
Halt Protease Phosphatase Inhibitor Cocktail
No known significant effects or critical hazards.
Teratogenicity :
No known significant effects or critical hazards.
Developmental effects :
1. Product and company identification No known significant effects or critical hazards.
Fertility effects :
: Halt Protease Phosphatase Inhibitor Cocktail
Product name Contains material which causes damage to the following organs: heart, bones, teeth.
Target organs :
Contains material which may cause damage to the following organs: kidneys,
: ThermoFisher Scientific : ThermoFisher Scientific
Supplier Manufacturer
gastrointestinal tract, upper respiratory tract, skin, central nervous system (CNS), eye,
Pierce Biotechnology Pierce Biotechnology
lens or cornea.
P.O. Box 117 P.O. Box 117
Rockford, IL 61105 Rockford, IL 61105 Over-exposure signs/symptoms
United States United States
: Adverse symptoms may include the following:
Inhalation
815.968.0747 or 815.968.0747
respiratory tract irritation
800.874.3723 800.874.3723
coughing
78441 78443 78445 78447 1861280 1861281 1861282 1861284 1901696
Product No. : : No specific data.
Ingestion
7864
MSDS # : : Adverse symptoms may include the following:
Skin
Validation date : 12/7/2007. irritation
redness
12/7/2007.
Print date :
: Adverse symptoms may include the following:
Eyes
Responsible name : MSDS_Specialist
pain or irritation
CHEMTREC: Use of
:
In case of emergency
watering
800.424.9300 Substance/Preparation Refer to the instruction booklet for
redness
OUTSIDE US: proper and intended use.
202.483.7616 Otherwise, contact supplier for : Pre-existing skin and digestive disorders and disorders involving any other target organs
Medical conditions
specific applications. mentioned in this MSDS as being at risk may be aggravated by over-exposure to this
aggravated by over-
product.
exposure
2. Hazards identification The preparation is not classified as dangerous according to Directive 1999/45/EC and its amendments.
: Not classified.
Classification
: Liquid.
Physical state
See toxicological information (section 11)
: Odorless.
Odor
: This material is considered hazardous by the OSHA Hazard Communication Standard
OSHA/HCS status
3. Composition/information on ingredients
(29 CFR 1910.1200).
: WARNING ! United States
Emergency overview
Name CAS number %
HARMFUL IF SWALLOWED. CAUSES RESPIRATORY TRACT, EYE AND SKIN
IRRITATION. MAY BE HARMFUL IF ABSORBED THROUGH SKIN. CONTAINS Trade Secret #4 1-3
MATERIAL THAT CAN CAUSE TARGET ORGAN DAMAGE. SUSPECT CANCER Trade Secret #1 1-3
HAZARD - CONTAINS MATERIAL WHICH MAY CAUSE CANCER. Trade Secret #2 1-3
Toxic if swallowed. Harmful in contact with skin. Irritating to eyes, respiratory system Europe
and skin. Avoid exposure - obtain special instructions before use. Do not breathe vapor : Preparation
Substance/preparation
or mist. Do not ingest. Do not get in eyes. Avoid contact with skin and clothing.
Ingredient name CAS % EC number Classification
Contains material that can cause target organ damage. Contains material which may
number
cause cancer. Risk of cancer depends on duration and level of exposure. Use only with
Trade Secret #4 1-3 Xn; R22 [1]
adequate ventilation. Keep container tightly closed and sealed until ready for use. Wash
Trade Secret #1 1-3 T; R25 [1] [2]
thoroughly after handling.
Xi; R36/38
: Dermal contact. Eye contact. Inhalation. Ingestion.
Routes of entry R32
Trade Secret #2 1-3 Xn; R22 [1]
Potential acute health effects
Xi;
: Irritating to respiratory system.
Inhalation
R36/37/38
: Toxic if swallowed.
Ingestion
There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and
: Harmful in contact with skin. Irritating to skin.
Skin in the concentrations applicable, are classified as hazardous to health or the environment and hence require
: Irritating to eyes.
Eyes reporting in this section.
Potential chronic health effects [1] Substance classified with a health or environmental hazard
: Contains material that can cause target organ damage.
Chronic effects [2] Substance with a workplace exposure limit
: Contains material which may cause cancer. Risk of cancer depends on duration and
Carcinogenicity Occupational exposure limits, if available, are listed in section 8.
level of exposure.
: No known significant effects or critical hazards.
Mutagenicity
1/9 2/9
12/7/2007. 12/7/2007.
Halt Protease Phosphatase Inhibitor Cocktail Halt Protease Phosphatase Inhibitor Cocktail
4. First aid measures 6. Accidental release measures
: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting : No action shall be taken involving any personal risk or without suitable training.
Eye contact Personal precautions
the upper and lower eyelids. Check for and remove any contact lenses. Get medical Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
attention. entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist.
Provide adequate ventilation. Wear appropriate respirator when ventilation is
: Get medical attention immediately. Flush contaminated skin with plenty of water.
Skin contact
inadequate. Put on appropriate personal protective equipment (see section 8).
Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with
water before removing or wear gloves. Continue to rinse for at least 10 minutes. Wash : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
Environmental precautions
clothing before reuse. Clean shoes thoroughly before reuse. and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
: Get medical attention immediately. Move exposed person to fresh air. If it is suspected
Inhalation
that fumes are still present, the rescuer should wear an appropriate mask or self- : Stop leak if without risk. Move containers from spill area. Approach release from
Large spill
contained breathing apparatus. Keep person warm and at rest. If not breathing, if upwind. Prevent entry into sewers, water courses, basements or confined areas. Wash
breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen spillages into an effluent treatment plant or proceed as follows. Contain and collect
by trained personnel. It may be dangerous to the person providing aid to give mouth-to- spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or
mouth resuscitation. If unconscious, place in recovery position and get medical attention diatomaceous earth and place in container for disposal according to local regulations
immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or (see section 13). Dispose of via a licensed waste disposal contractor. Contaminated
waistband. absorbent material may pose the same hazard as the spilled product. Note: see section
1 for emergency contact information and section 13 for waste disposal.
: Get medical attention immediately. Wash out mouth with water. Remove dentures if
Ingestion
any. Move exposed person to fresh air. Keep person warm and at rest. If material has : Stop leak if without risk. Move containers from spill area. Dilute with water and mop up
Small spill
been swallowed and the exposed person is conscious, give small quantities of water to if water-soluble or absorb with an inert dry material and place in an appropriate waste
drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not disposal container. Dispose of via a licensed waste disposal contractor.
induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the
7. Handling and storage
head should be kept low so that vomit does not enter the lungs. Never give anything by
mouth to an unconscious person. If unconscious, place in recovery position and get
: Put on appropriate personal protective equipment (see section 8). Eating, drinking and
Handling
medical attention immediately. Maintain an open airway. Loosen tight clothing such as
smoking should be prohibited in areas where this material is handled, stored and
a collar, tie, belt or waistband.
processed. Workers should wash hands and face before eating, drinking and smoking.
: No action shall be taken involving any personal risk or without suitable training. If it is
Protection of first-aiders Do not get in eyes or on skin or clothing. Do not breathe vapor or mist. Do not ingest.
suspected that fumes are still present, the rescuer should wear an appropriate mask or Use only with adequate ventilation. Wear appropriate respirator when ventilation is
self-contained breathing apparatus. It may be dangerous to the person providing aid to inadequate. Keep in the original container or an approved alternative made from a
give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water compatible material, kept tightly closed when not in use. Empty containers retain
before removing or wear gloves. product residue and can be hazardous. Do not reuse container.
See section 11 for more detailed information on health effects and symptoms. : Store in accordance with local regulations. Store in original container protected from
Storage
direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials
5. Fire-fighting measures (see section 10) and food and drink. Keep container tightly closed and sealed until ready
for use. Containers that have been opened must be carefully resealed and kept upright
: In a fire or if heated, a pressure increase will occur and the container may burst.
Flammability of the product
to prevent leakage. Do not store in unlabeled containers. Use appropriate containment
Extinguishing media to avoid environmental contamination.
: Use an extinguishing agent suitable for the surrounding fire.
Suitable
8. Exposure controls/personal protection
: None known.
Not suitable
: Promptly isolate the scene by removing all persons from the vicinity of the incident if
Special exposure hazards Product name Exposure limits
there is a fire. No action shall be taken involving any personal risk or without suitable
United States
training.
Trade Secret #1 ACGIH TLV (United States).
: Decomposition products may include the following materials:
Hazardous combustion
TWA: 2.5 mg/m?8 hour(s).
carbon oxides
products
MSHA Standard Air (United States).
phosphorus oxides
TWA: 2.5 mg/m?8 hour(s).
halogenated compounds
NIOSH REL (United States).
metal oxide/oxides
TWA: 2.5 mg/m?8 hour(s).
: Fire-fighters should wear appropriate protective equipment and self-contained breathing
Special protective OSHA PEL (United States).
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
equipment for fire-fighters TWA: 2.5 mg/m?8 hour(s).
OSHA PEL Z2 (United States, 11/2006).
TWA: 2.5 mg/m?8 hour(s). Form: Dust
ACGIH TLV (United States, 1/2007). Notes: as F
TWA: 2.5 mg/m? (as F) 8 hour(s).
NIOSH REL (United States, 12/2001). Notes: as F
TWA: 2.5 mg/m? (as F) 10 hour(s).
OSHA PEL (United States, 11/2006). Notes: as F
TWA: 2.5 mg/m? (as F) 8 hour(s).
3/9 4/9
12/7/2007. 12/7/2007.
Halt Protease Phosphatase Inhibitor Cocktail Halt Protease Phosphatase Inhibitor Cocktail
8. Exposure controls/personal protection 11 . Toxicological information
OSHA PEL 1989 (United States, 3/1989). Notes: as F United States
TWA: 2.5 mg/m? (as F) 8 hour(s).
Acute toxicity
Europe Product/ingredient name Result Species Dose Exposure
Trade Secret #4 LD Dermal Rabbit >300 mg/kg -
sodium fluoride EU OEL (Europe, 5/2006). Notes: Indicative
LD50 Oral Mouse 2650 mg/kg -
8 hours: 2.5 mg/m?8 hour(s).
LD50 Oral Rat 1800 mg/kg -
Consult local authorities for acceptable exposure limits.
Trade Secret #1 LD50 Dermal Rat 175 mg/kg -
: If this product contains ingredients with exposure limits, personal, workplace atmosphere
Recommended monitoring LD50 Rat 22 mg/kg -
or biological monitoring may be required to determine the effectiveness of the ventilation
procedures Intraperitoneal
or other control measures and/or the necessity to use respiratory protective equipment.
LD50 Intravenous Rat 26 mg/kg -
: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor
Engineering measures LD50 Oral Mouse 57 mg/kg -
or mist, use process enclosures, local exhaust ventilation or other engineering controls LD50 Oral Rat 52 mg/kg -
to keep worker exposure to airborne contaminants below any recommended or statutory LD50 Oral Rabbit 200 mg/kg -
limits. LD50 Oral Rat 31 mg/kg -
LD50 Rat 175 mg/kg -
: Wash hands, forearms and face thoroughly after handling chemical products, before
Hygiene measures
Subcutaneous
eating, smoking and using the lavatory and at the end of the working period. Appropriate
LDLo Dermal Mouse 300 mg/kg -
techniques should be used to remove potentially contaminated clothing. Wash
LDLo Oral Woman 90 mg/kg -
contaminated clothing before reusing. Ensure that eyewash stations and safety showers
LDLo Oral Human 71 mg/kg -
are close to the workstation location.
TDLo Parenteral Rat 35 mg/kg -
Personal protection
TDLo Parenteral Rat 9 mg/kg -
: Use a properly fitted, air-purifying or air-fed respirator complying with an approved
Respiratory Trade Secret #2 LD50 Oral Rat 330 mg/kg -
standard if a risk assessment indicates this is necessary. Respirator selection must be LD50 Oral Rat 330 mg/kg -
based on known or anticipated exposure levels, the hazards of the product and the safe LD50 Rat 50 mg/kg -
working limits of the selected respirator. Subcutaneous
: Chemical-resistant, impervious gloves complying with an approved standard should be
Hands LDLo Oral Rabbit 100 mg/kg -
worn at all times when handling chemical products if a risk assessment indicates this is TDLo Rat 4.6 ug/kg -
necessary. Intraperitoneal
TDLo Rat 4.6 mg/kg -
: Safety eyewear complying with an approved standard should be used when a risk
Eyes
Intraperitoneal
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts. : Not available.
Conclusion/Summary
: Personal protective equipment for the body should be selected based on the task being
Skin Chronic toxicity
performed and the risks involved and should be approved by a specialist before handling : Not available.
Conclusion/Summary
this product.
Carcinogenicity
: Emissions from ventilation or work process equipment should be checked to ensure they
Environmental exposure
: To the best of our knowledge, the toxicological properties of this substance have not
Conclusion/Summary
comply with the requirements of environmental protection legislation. In some cases,
controls
been thoroughly investigated.
fume scrubbers, filters or engineering modifications to the process equipment will be
Classification
necessary to reduce emissions to acceptable levels.
Product/ingredient name ACGIH IARC EPA NIOSH NTP OSHA
Trade Secret #1 A4 3 - - Possible -
9. Physical and chemical properties Trade Secret #2 - - - None. - None.
Mutagenicity
: Liquid.
Physical state
: Not available.
Conclusion/Summary
: Odorless.
Odor
Teratogenicity
: Soluble in the following materials: cold water.
Solubility
: Not available.
Conclusion/Summary
10 . Stability and reactivity Reproductive toxicity
Europe
: The product is stable. Under normal conditions of storage and use, hazardous
Stability
: Not available.
Conclusion/Summary
polymerization will not occur.
: No known significant effects or critical hazards.
Chronic effects
: Avoid exposure - obtain special instructions before use.
Conditions to avoid
: No known significant effects or critical hazards.
Carcinogenicity
: No specific data.
Materials to avoid
: No known significant effects or critical hazards.
Mutagenicity
: Under normal conditions of storage and use, hazardous decomposition products should
Hazardous decomposition
not be produced.
products : No known significant effects or critical hazards.
Teratogenicity
: No known significant effects or critical hazards.
Developmental effects
5/9 6/9
12/7/2007. 12/7/2007.
Halt Protease Phosphatase Inhibitor Cocktail Halt Protease Phosphatase Inhibitor Cocktail
11 . Toxicological information 15 . Regulatory information
: No known significant effects or critical hazards.
Fertility effects Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
12 . Ecological information : United States inventory (TSCA 8b): At least one component is not listed.
United States inventory
(TSCA 8b)
: No known significant effects or critical hazards.
Environmental effects
Canada
United States
: Class D-1B: Material causing immediate and serious toxic effects (Toxic).
WHMIS (Canada)
Aquatic ecotoxicity
Class D-2A: Material causing other toxic effects (Very toxic).
Test results available upon request. Class D-2B: Material causing other toxic effects (Toxic).
: Not available.
Conclusion/Summary
: CEPA Toxic substances: The following components are listed: Trade Secret #1
Canadian lists
Canadian ARET: None of the components are listed.
13 . Disposal considerations Canadian NPRI: The following components are listed: Trade Secret #1;Trade Secret
#2
: The generation of waste should be avoided or minimized wherever possible. Dispose of
Waste disposal
Alberta Designated Substances: None of the components are listed.
surplus and non-recyclable products via a licensed waste disposal contractor. Disposal
Ontario Designated Substances: None of the components are listed.
of this product, solutions and any by-products should at all times comply with the
Quebec Designated Substances: None of the components are listed.
requirements of environmental protection and waste disposal legislation and any regional
local authority requirements. Avoid dispersal of spilled material and runoff and contact : Canada inventory: At least one component is not listed.
Canada inventory
with soil, waterways, drains and sewers.
EU regulations
: Within the present knowledge of the supplier, this product is not regarded as
Hazardous waste
: This product is not classified according to EU legislation.
Risk phrases
hazardous waste, as defined by EU Directive 91/689/EEC.
:
Disposal should be in accordance with applicable regional, national and local laws and regulations.
International regulations
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees. : Australia inventory (AICS): Not determined.
International lists
China inventory (IECSC): Not determined.
14 . Transport information Korea inventory (KECI): Not determined.
Philippines inventory (PICCS): Not determined.
Regulatory UN number Proper shipping Classes PG* Japan inventory (ENCS): Not determined.
information name
16 . Other information
Not - - -
DOT Classification
regulated.
: HARMFUL IF SWALLOWED. CAUSES RESPIRATORY TRACT, EYE AND SKIN
Label requirements
IRRITATION. MAY BE HARMFUL IF ABSORBED THROUGH SKIN. CONTAINS
Not - - -
IATA-DGR Class
MATERIAL THAT CAN CAUSE TARGET ORGAN DAMAGE. SUSPECT CANCER
regulated.
HAZARD - CONTAINS MATERIAL WHICH MAY CAUSE CANCER.
PG* : Packing group
Hazardous Material :
Information System (U.S.A.)
15 . Regulatory information 3
Health
United States
0
Flammability
: Toxic material
HCS Classification
0
Irritating material Physical hazards
Carcinogen
Target organ effects
: TSCA 8(a) PAIR: Trade Secret #2
U.S. Federal regulations The customer is responsible for determining the PPE code for this material.
United States inventory (TSCA 8b): At least one component is not listed. National Fire Protection :
TSCA precursor chemical list: Trade Secret #1
Association (U.S.A.)
SARA 302/304/311/312 extremely hazardous substances: No products were found.
Flammability
0
SARA 302/304 emergency planning and notification: No products were found.
3 0
SARA 302/304/311/312 hazardous chemicals: Trade Secret #1; Trade Secret #2 Health Instability
SARA 311/312 MSDS distribution - chemical inventory - hazard identification:
Special
Trade Secret #1: Immediate (acute) health hazard, Delayed (chronic) health hazard;
Trade Secret #2: Delayed (chronic) health hazard
Date of printing : 12/7/2007.
Clean Water Act (CWA) 307: No products were found. : 12/7/2007.
Date of issue
Clean Water Act (CWA) 311: Trade Secret #1 Date of previous issue : No previous validation.
Clean Air Act (CAA) 112 accidental release prevention: No products were found. Version : 0.01
7/9 8/9
12/7/2007. 12/7/2007.
Halt Protease Phosphatase Inhibitor Cocktail
Material Safety Data Sheet
16 . Other information 0.5 M EDTA
Indicates information that has changed from previously issued version.
: R25- Toxic if swallowed.
Full text of R-phrases
1. Product and company identification
R22- Harmful if swallowed.
referred to in sections 2 and
R36/38- Irritating to eyes and skin.
3 - Europe : 0.5 M EDTA
Product name
R36/37/38- Irritating to eyes, respiratory system and skin.
: ThermoFisher Scientific : ThermoFisher Scientific
Supplier Manufacturer
R32- Contact with acids liberates very toxic gas.
Pierce Biotechnology Pierce Biotechnology
: T - Toxic
Full text of classifications
P.O. Box 117 P.O. Box 117
Xn - Harmful
referred to in sections 2 and
Rockford, IL 61105 Rockford, IL 61105
Xi - Irritant
3 - Europe United States United States
815.968.0747 or 815.968.0747
800.874.3723 800.874.3723
Notice to reader
1858567 1860851 1861274 1861275 1861276 1861283 1890941 1900351
Product No. :
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the 3881
MSDS # :
information contained herein.
Validation date : 1/4/2008.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
1/4/2008.
Print date :
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
Responsible name : MSDS (Regulatory Affairs)
guarantee that these are the only hazards that exist.
CHEMTREC: Use of : Refer to the instruction booklet for
:
In case of emergency
800.424.9300 Substance/Preparation proper and intended use.
OUTSIDE US: Otherwise, contact supplier for
202.483.7616 specific applications.
2. Hazards identification
: Liquid. [Clear sparkling liquid.]
Physical state
: This material is considered hazardous by the OSHA Hazard Communication Standard
OSHA/HCS status
(29 CFR 1910.1200).
: WARNING !
Emergency overview
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. CONTAINS
MATERIAL THAT MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL
DATA.
Irritating to eyes, respiratory system and skin. Avoid exposure - obtain special
instructions before use. Do not breathe vapor or mist. Avoid contact with eyes, skin and
clothing. Contains material that may cause target organ damage, based on animal data.
Use only with adequate ventilation. Keep container tightly closed and sealed until ready
for use. Wash thoroughly after handling.
: Eye contact. Inhalation. Ingestion.
Routes of entry
Potential acute health effects
: Irritating to respiratory system. Exposure to decomposition products may cause a health
Inhalation
hazard. Serious effects may be delayed following exposure.
: No known significant effects or critical hazards.
Ingestion
: Irritating to skin.
Skin
: Irritating to eyes.
Eyes
Potential chronic health effects
: Contains material that may cause target organ damage, based on animal data.
Chronic effects
: No known significant effects or critical hazards.
Carcinogenicity
: No known significant effects or critical hazards.
Mutagenicity
: No known significant effects or critical hazards.
Teratogenicity
: No known significant effects or critical hazards.
Developmental effects
: No known significant effects or critical hazards.
Fertility effects
: Contains material which causes damage to the following organs: mucous membranes,
Target organs
upper respiratory tract, skin, eyes.
9/9 1/8
12/7/2007. 1/4/2008.
0.5 M EDTA 0.5 M EDTA
2. Hazards identification 4. First aid measures
The exposed person may need to be kept under medical surveillance for 48 hours.
Over-exposure signs/symptoms
: Wash out mouth with water. Remove dentures if any. Move exposed person to fresh
Ingestion
: Adverse symptoms may include the following:
Inhalation
air. Keep person warm and at rest. If material has been swallowed and the exposed
respiratory tract irritation
person is conscious, give small quantities of water to drink. Stop if the exposed person
coughing
feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do
: No specific data.
Ingestion
so by medical personnel. If vomiting occurs, the head should be kept low so that vomit
: Adverse symptoms may include the following:
Skin does not enter the lungs. Get medical attention if adverse health effects persist or are
irritation severe. Never give anything by mouth to an unconscious person. If unconscious, place
redness in recovery position and get medical attention immediately. Maintain an open airway.
Loosen tight clothing such as a collar, tie, belt or waistband.
: Adverse symptoms may include the following:
Eyes
pain or irritation : No action shall be taken involving any personal risk or without suitable training. If it is
Protection of first-aiders
watering suspected that fumes are still present, the rescuer should wear an appropriate mask or
redness self-contained breathing apparatus. It may be dangerous to the person providing aid to
give mouth-to-mouth resuscitation.
: Pre-existing disorders involving any target organs mentioned in this MSDS as being at
Medical conditions
risk may be aggravated by over-exposure to this product. See section 11 for more detailed information on health effects and symptoms.
aggravated by over-
exposure
5. Fire-fighting measures
The preparation is not classified as dangerous according to Directive 1999/45/EC and its amendments.
: In a fire or if heated, a pressure increase will occur and the container may burst.
Flammability of the product
: Not classified.
Classification
Extinguishing media
See toxicological information (section 11)
: Use an extinguishing agent suitable for the surrounding fire.
Suitable
3. Composition/information on ingredients : None known.
Not suitable
: Promptly isolate the scene by removing all persons from the vicinity of the incident if
Special exposure hazards
United States
there is a fire. No action shall be taken involving any personal risk or without suitable
Name CAS number %
training.
Ethylenediamine Tetraacetic Acid, Disodium Salt 6381-92-6 10 - 20
: Decomposition products may include the following materials:
Hazardous combustion
Europe carbon oxides
products
: Preparation nitrogen oxides
Substance/preparation
metal oxide/oxides
Ingredient name CAS % EC number Classification
number : Fire-fighters should wear appropriate protective equipment and self-contained breathing
Special protective
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
Ethylenediamine Tetraacetic Acid, Disodium Salt 6381-92-6 10 - 20 205-358-3Xi; [1] equipment for fire-fighters
R36/37/38
6. Accidental release measures
There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and
in the concentrations applicable, are classified as hazardous to health or the environment and hence require
: No action shall be taken involving any personal risk or without suitable training.
Personal precautions
reporting in this section.
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
[1] Substance classified with a health or environmental hazard entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist.
Provide adequate ventilation. Wear appropriate respirator when ventilation is
[2] Substance with a workplace exposure limit
inadequate. Put on appropriate personal protective equipment (see section 8).
Occupational exposure limits, if available, are listed in section 8.
: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
Environmental precautions
4. First aid measures and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting
Eye contact
: Stop leak if without risk. Move containers from spill area. Approach release from
Large spill
the upper and lower eyelids. Check for and remove any contact lenses. Get medical
upwind. Prevent entry into sewers, water courses, basements or confined areas. Wash
attention.
spillages into an effluent treatment plant or proceed as follows. Contain and collect
: Flush contaminated skin with plenty of water. Remove contaminated clothing and
Skin contact spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or
shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing diatomaceous earth and place in container for disposal according to local regulations
before reuse. Clean shoes thoroughly before reuse. (see section 13). Dispose of via a licensed waste disposal contractor. Contaminated
absorbent material may pose the same hazard as the spilled product. Note: see section
: Move exposed person to fresh air. If it is suspected that fumes are still present, the
Inhalation
1 for emergency contact information and section 13 for waste disposal.
rescuer should wear an appropriate mask or self-contained breathing apparatus. Keep
person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest
: Stop leak if without risk. Move containers from spill area. Dilute with water and mop up
Small spill
occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous if water-soluble or absorb with an inert dry material and place in an appropriate waste
to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention. disposal container. Dispose of via a licensed waste disposal contractor.
If unconscious, place in recovery position and get medical attention immediately.
Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.
In case of inhalation of decomposition products in a fire, symptoms may be delayed.
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7. Handling and storage 9. Physical and chemical properties
: Put on appropriate personal protective equipment (see section 8). Eating, drinking and : Liquid. [Clear sparkling liquid.]
Handling Physical state
smoking should be prohibited in areas where this material is handled, stored and : Colorless.
Color
processed. Workers should wash hands and face before eating, drinking and smoking.
: Easily soluble in the following materials: cold water and hot water.
Solubility
Do not get in eyes or on skin or clothing. Do not breathe vapor or mist. Do not ingest.
Use only with adequate ventilation. Wear appropriate respirator when ventilation is
10 . Stability and reactivity
inadequate. Keep in the original container or an approved alternative made from a
compatible material, kept tightly closed when not in use. Empty containers retain
: The product is stable. Under normal conditions of storage and use, hazardous
Stability
product residue and can be hazardous. Do not reuse container.
polymerization will not occur.
: Store in accordance with local regulations. Store in original container protected from
Storage
: No specific data.
Conditions to avoid
direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials
: No specific data.
Materials to avoid
(see section 10) and food and drink. Keep container tightly closed and sealed until ready
for use. Containers that have been opened must be carefully resealed and kept upright : Under normal conditions of storage and use, hazardous decomposition products should
Hazardous decomposition
to prevent leakage. Do not store in unlabeled containers. Use appropriate containment not be produced.
products
to avoid environmental contamination.
: Will not occur.
Hazardous polymerization
8. Exposure controls/personal protection 11 . Toxicological information
Europe United States
No exposure limit value known.
Acute toxicity
Consult local authorities for acceptable exposure limits. Product/ingredient name Result Species Dose Exposure
: If this product contains ingredients with exposure limits, personal, workplace atmosphere
Recommended monitoring glycine, n,n'-1,2-ethanedlylbis[n- LD50 Oral Rabbit 2300 mg/kg -
or biological monitoring may be required to determine the effectiveness of the ventilation (carboxymethyl), disodium salt, dihydrate
procedures
or other control measures and/or the necessity to use respiratory protective equipment. LD50 Oral Mouse 2050 mg/kg -
LD50 Oral Rat >2000 mg/kg -
: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor
Engineering measures
or mist, use process enclosures, local exhaust ventilation or other engineering controls : Not available.
Conclusion/Summary
to keep worker exposure to airborne contaminants below any recommended or statutory Chronic toxicity
limits.
: Not available.
Conclusion/Summary
: Wash hands, forearms and face thoroughly after handling chemical products, before
Hygiene measures
Carcinogenicity
eating, smoking and using the lavatory and at the end of the working period. Appropriate
techniques should be used to remove potentially contaminated clothing. Wash : Not available.
Conclusion/Summary
contaminated clothing before reusing. Ensure that eyewash stations and safety showers Classification
are close to the workstation location.
Product/ingredient name ACGIH IARC EPA NIOSH NTP OSHA
Personal protection glycine, n,n'-1,2-ethanedlylbis[n- - - - None. - None.
: Use a properly fitted, air-purifying or air-fed respirator complying with an approved (carboxymethyl), disodium salt, dihydrate
Respiratory
standard if a risk assessment indicates this is necessary. Respirator selection must be Mutagenicity
based on known or anticipated exposure levels, the hazards of the product and the safe
: Not available.
Conclusion/Summary
working limits of the selected respirator.
Teratogenicity
: Chemical-resistant, impervious gloves complying with an approved standard should be
Hands
: Not available.
worn at all times when handling chemical products if a risk assessment indicates this is Conclusion/Summary
necessary. Reproductive toxicity
: Safety eyewear complying with an approved standard should be used when a risk
Eyes Europe
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
: Not available.
Conclusion/Summary
gases or dusts.
: No known significant effects or critical hazards.
Chronic effects
: Personal protective equipment for the body should be selected based on the task being
Skin
: No known significant effects or critical hazards.
performed and the risks involved and should be approved by a specialist before handling Carcinogenicity
this product. : No known significant effects or critical hazards.
Mutagenicity
: Emissions from ventilation or work process equipment should be checked to ensure they
Environmental exposure : No known significant effects or critical hazards.
Teratogenicity
comply with the requirements of environmental protection legislation. In some cases,
controls
: No known significant effects or critical hazards.
Developmental effects
fume scrubbers, filters or engineering modifications to the process equipment will be
: No known significant effects or critical hazards.
Fertility effects
necessary to reduce emissions to acceptable levels.
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0.5 M EDTA 0.5 M EDTA
15 . Regulatory information
12 . Ecological information
: CEPA Toxic substances: None of the components are listed.
Canadian lists
: No known significant effects or critical hazards.
Environmental effects
Canadian ARET: None of the components are listed.
United States Canadian NPRI: None of the components are listed.
Aquatic ecotoxicity Alberta Designated Substances: None of the components are listed.
Ontario Designated Substances: None of the components are listed.
Test results available upon request.
Quebec Designated Substances: None of the components are listed.
: Not available.
Conclusion/Summary
: Canada inventory: All components are listed or exempted.
Canada inventory
: No known significant effects or critical hazards.
Other adverse effects
EU regulations
13 . Disposal considerations : This product is not classified according to EU legislation.
Risk phrases
: The generation of waste should be avoided or minimized wherever possible. Dispose of
Waste disposal :
surplus and non-recyclable products via a licensed waste disposal contractor. Disposal
International regulations
of this product, solutions and any by-products should at all times comply with the
requirements of environmental protection and waste disposal legislation and any regional : Australia inventory (AICS): All components are listed or exempted.
International lists
local authority requirements. Avoid dispersal of spilled material and runoff and contact China inventory (IECSC): All components are listed or exempted.
with soil, waterways, drains and sewers. Korea inventory (KECI): All components are listed or exempted.
Philippines inventory (PICCS): All components are listed or exempted.
: Within the present knowledge of the supplier, this product is not regarded as
Hazardous waste
Japan inventory (ENCS): All components are listed or exempted.
hazardous waste, as defined by EU Directive 91/689/EEC.
Disposal should be in accordance with applicable regional, national and local laws and regulations.
16 . Other information
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees. : CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. CONTAINS
Label requirements
MATERIAL THAT MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL
14 . Transport information DATA.
Hazardous Material :
Regulatory UN number Proper shipping Classes PG*
Information System (U.S.A.)
information name
2
Health
Not - - -
DOT Classification 0
Flammability
regulated.
0
Physical hazards
Not available. Not available. Not available. -
IATA-DGR Class
PG* : Packing group
The customer is responsible for determining the PPE code for this material.
15 . Regulatory information National Fire Protection :
Association (U.S.A.)
United States
Flammability
0
: Irritating material
HCS Classification
2 0
Target organ effects Health Instability
: United States inventory (TSCA 8b): At least one component is not listed.
U.S. Federal regulations Special
SARA 302/304/311/312 extremely hazardous substances: No products were found.
Date of printing : 1/4/2008.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found. : 1/4/2008.
Date of issue
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No Date of previous issue : 12/17/2007.
products were found.
Version :2
Clean Water Act (CWA) 307: No products were found.
Indicates information that has changed from previously issued version.
Clean Water Act (CWA) 311: No products were found.
: R36/37/38- Irritating to eyes, respiratory system and skin.
Full text of R-phrases
Clean Air Act (CAA) 112 accidental release prevention: No products were found. referred to in sections 2 and
Clean Air Act (CAA) 112 regulated flammable substances: No products were found. 3 - Europe
: Xi - Irritant
Full text of classifications
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
referred to in sections 2 and
: United States inventory (TSCA 8b): At least one component is not listed.
United States inventory
3 - Europe
(TSCA 8b)
Canada
Notice to reader
: Not controlled under WHMIS (Canada).
WHMIS (Canada)
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0.5 M EDTA
16 . Other information
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
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