Page 1/5
Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 18.05.2009 Revision: 18.05.2009
* 1 Identification of substance:
?Product details:
?Trade name: Brefeldin A
?Article number: 15100
?Application of the substance / the preparation Laboratory chemicals
?Manufacturer/Supplier:
SERVA Electrophoresis GmbH
Carl-Benz-Str. 7
D-69115 Heidelberg
Tel.: +49 6221 13840-0
FAX: +49 6221 13840-10
msds.info@serva.de
?Information department: Product Safety department Tel.: +49 6221 13840-35
?Emergency information: +49 6131 19240 (university hospital Mainz)
* 2 Hazards identification
?Hazard description:
Xn Harmful
?Information pertaining to particular dangers for man and environment
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
Only for trade users / technical specialists
?Classification system
The classification was made according to the latest editions of the EU-lists, and expanded upon fom company
and literature data.
?GHS label elements
Danger
3.1/3 - Toxic if swallowed.
3.1/3 - Toxic in contact with skin.
3.1/4 - Harmful if inhaled.
?Prevention:
Avoid breathing dust/fume/gas/mist/vapours/spray.
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
?Response:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Wash with plenty of soap and water.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
Specific treatment (see label).
Specific measures (see label).
Rinse mouth.
Remove/Take off immediately all contaminated clothing.
Wash contaminated clothing before reuse.
?Storage:
Store locked up.
(Contd. on page 2)
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Page 2/5
Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 18.05.2009 Revision: 18.05.2009
Trade name: Brefeldin A
(Contd. of page 1)
?Disposal:
Dispose of contents/container in accordance with local/regional/national/international regulations.
* 3 Composition/information on ingredients
?Chemical characterization:
?CAS No. Description:
20350-15-6 (+)-Brefeldin A
?Identification number(s): -
?Chemical characterization
?Description:
?Empirical formula: C H O
?MW: 280,40
* 4 First aid measures
?General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48
hours after the accident.
?After inhalation Supply fresh air and to be sure call for a doctor.
?After skin contact Immediately wash with water and soap and rinse thoroughly.
?After eye contact Rinse opened eye for several minutes under running water.
?After swallowing Drink copious amounts of water and provide fresh air. Call for doctor immediately.
* 5 Fire fighting measures
?Suitable extinguishing agents
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
?Special hazards caused by the material, its products of combustion or resulting gases:
In case of fire, the following can be released:
Carbon monoxide and carbon dioxide
?Protective equipment: Mount respiratory protective device.
* 6 Accidental release measures
?Person-related safety precautions: Wear protective clothing.
?Measures for environmental protection: Do not allow to enter sewers/ surface or ground water.
?Measures for cleaning/collecting:
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
* 7 Handling and storage
?Handling
?Information for safe handling:
Prevent formation of dust.
Ensure good ventilation/exhaustion at the workplace.
?Information about protection against explosions and fires: No special measures required.
?Storage
?Requirements to be met by storerooms and receptacles: Store in a cool location.
?Information about storage in one common storage facility: Not required.
(Contd. on page 3)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 18.05.2009 Revision: 18.05.2009
Trade name: Brefeldin A
(Contd. of page 2)
?Further information about storage conditions: Keep receptacle tightly sealed.
* 8 Exposure controls and personal protection
?Additional information about design of technical systems: No further data; see item 7.
?Components with limit values that require monitoring at the workplace: Not required.
?Additional information: The lists that were valid during the creation were used as basis.
?Personal protective equipment
?General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
?Breathing equipment:
Short term filter device:
Filter P2.
?Protection of hands:
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/
the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradation
?Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality
and varies from manufacturer to manufacturer.
?Penetration time of glove material
The exact break trough time has to be found out by the manufacturer of the protective gloves and has to be
observed.
?For the permanent contact of a maximum of 15 minutes gloves made of the following materials are
suitable:
Natural rubber, NR
Nitrile rubber, NBR
?Eye protection: Safety glasses
?Body protection: Protective work clothing.
* 9 Physical and chemical properties:
?General Information
Crystalline powder
Form:
White
Colour:
Characteristic
Odour:
?Change in condition
Melting point/Melting range: 200 - 205癈
Boiling point/Boiling range: undetermined
Not applicable
?Flash point:
?Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
?Danger of explosion:
Not determined
?Density:
?Solubility in / Miscibility with
Slightly soluble
Water:
10 g/l (Methanol)
?Alcohols at 20癈:
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(Contd. on page 4)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 18.05.2009 Revision: 18.05.2009
Trade name: Brefeldin A
(Contd. of page 3)
* 10 Stability and reactivity
?Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
?Dangerous reactions No dangerous reactions known
?Dangerous products of decomposition: No dangerous decomposition products known
11 Toxicological information
?Acute toxicity:
?Primary irritant effect:
?on the skin: No irritant effect.
?on the eye: No irritating effect.
?Sensitization: No sensitizing effects known.
* 12 Ecological information:
?General notes:
Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for water.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage
system.
13 Disposal considerations
?Product:
?Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
?Uncleaned packagings:
?Recommendation: Disposal must be made according to official regulations.
* 14 Transport information
?Land transport ADR/RID (cross-border)
?ADR/RID class: -
?Maritime transport IMDG:
-
?IMDG Class:
?Air transport ICAO-TI and IATA-DGR:
?ICAO/IATA Class: -
?UN "Model Regulation": -
?Transport/Additional information: Not dangerous according to the above specifications.
* 15 Regulations
?Markings according to EU guidelines:
Caution - substance not yet fully tested
The product has been classified and marked in accordance with EU Directives / Ordinance on Hazardous
Materials
?Code letter and hazard designation of product:
Xn Harmful
(Contd. on page 5)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 18.05.2009 Revision: 18.05.2009
Trade name: Brefeldin A
(Contd. of page 4)
?Risk phrases:
20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
?Safety phrases:
36 Wear suitable protective clothing.
45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
?Special labeling of certain preparations:
Only for trade users / technical specialists
?National regulations
?Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
* 16 Other information:
This information is based on our present knowledge. However, this shall not constitute a guarantee for any
specific product features and shall not establish a legally valid contractual relationship.
?Department issuing MSDS: Product safety department
?Contact: +49 6221 13840-35
?Abbreviations and acronyms:
ADR: Accord europ閑n sur le transport des marchandises dangereuses par Route (European Agreement concerning the International
Carriage of Dangerous Goods by Road)
RID: R鑗lement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning the
International Transport of Dangerous Goods by Rail)
IMDG: International Maritime Code for Dangerous Goods
IATA: International Air Transport Association
IATA-DGR: Dangerous Goods Regulations by the "International Air Transport Association" (IATA)
ICAO: International Civil Aviation Organization
ICAO-TI: Technical Instructions by the "International Civil Aviation Organization" (ICAO)
GHS: Globally Harmonized System of Classification and Labelling of Chemicals
CAS: Chemical Abstracts Service (division of the American Chemical Society)
?* Data compared to the previous version altered.
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