Material Safety Data Sheet (MSDS)
Issue/Revision Date: 15 April 2008
Section 1. Product and Company Information
Chemical Name: Derivatizing Solution containing 1-(2-Methoxyphenyl) Piperazine (MOPIP) in Toluene
Synonym(s): None
Tradename: A component of ISO-CHEK?Sampling System
Catalog No.: 225-9050, -9023, and -9023A
Company: SKC Inc.
Address: 863 Valley View Road
Eighty Four, PA 15330 U.S.A.
Phone: 724-941-9701
Fax: 724-941-1369
Toll-free (U.S.): 800-752-8472
Email: skctech@skcinc.com
Web: www.skcinc.com
Section 2. Composition/Information on Ingredient(s)
Chemical Name Formula CAS # Molecular Weight
1-(2-Methoxyphenyl) Piperazine Cl1H16N2O 35386-24-4 Not reported
Toluene C6H5-CH3, C7H8 108-88-3 92.14
Section 3. Hazards Identification
Label Precautionary Statements
?Irritant
?Irritating to eyes, respiratory system, and skin
?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
?Wear suitable gloves and eye/face protection.
?Hygroscopic
?Keep tightly closed.
Emergency Overview
POISON! DANGER! HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. VAPOR
HARMFUL. FLAMMABLE LIQUID AND VAPOR. MAY AFFECT LIVER, KIDNEYS, BLOOD SYSTEM, OR CENTRAL NERVOUS
SYSTEM. CAUSES IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
SAF-T-DATATM Ratings (Provided here for your convenience)
Health Rating: 2 - Moderate (Life)
Flammability Rating: 3 - Severe (Flammable)
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
Potential Health Effects
Inhalation
Inhalation may cause irritation of the upper respiratory tract. Symptoms of overexposure may include fatigue, confusion, headache, dizziness, and
drowsiness. Peculiar skin sensations (e. g. pins and needles) or numbness may be produced. Very high concentrations may cause unconsciousness
and death.
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Ingestion
Swallowing may cause abdominal spasms and other symptoms that parallel over-exposure from inhalation. Aspiration of material into the lungs can
cause chemical pneumonitis, which may be fatal.
Skin Contact
Causes irritation. May be absorbed through skin.
Eye Contact
Causes severe eye irritation with redness and pain.
Chronic Exposure
Reports of chronic poisoning describe anemia, decreased blood cell count, and bone marrow hypoplasia. Liver and kidney damage may occur.
Repeated or prolonged contact has a defatting action, causing drying, redness, and/or dermatitis. Exposure to toluene may affect the developing fetus.
Aggravation of Pre-existing Conditions
Persons with pre-existing skin disorders or impaired liver or kidney function may be more susceptible to the effects of this substance. Alcoholic
beverage consumption can enhance the toxic effects of this substance.
Section 4. First Aid Measures
Eye Contact
Immediately flush eyes with copious amounts of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention
immediately.
Skin Contact
In case of contact, immediately wash skin with soap and copious amounts of water for at least 15 minutes while removing contaminated clothing and
shoes. Wash clothing before reuse. Call a physician immediately.
Inhalation
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. CALL A PHYSICIAN
IMMEDIATELY.
Ingestion
Aspiration hazard. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious
person. Get medical attention immediately. If vomiting occurs, keep head below hips to prevent aspiration into lungs.
Section 5. Fire Fighting Measures
Fire:
Flash point: 7 C (45 F) CC
Autoignition
temperature: 422 C (792 F)
Flammable limits
in air % by volume: LEL: 3.3; UEL: 19
Flammable liquid and vapor!
Dangerous fire hazard when exposed to heat or flame. Vapors can flow along surfaces to distant ignition source and
flash back.
Explosion
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Contact with strong oxidizers may cause fire or explosion.
Sensitive to static discharge.
Fire Extinguishing Media
Dry chemical, foam, or carbon dioxide. Water may be used to flush spills away from exposures and to dilute spills to non-flammable mixtures.
Special Information
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode. Water spray may be used to keep fire exposed containers cool.
Unusual Fire and Explosion Hazards
Emits toxic fumes under fire conditions.
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Section 6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate
hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and
equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical
waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to
disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. U.S. Regulations (CERCLA) require
reporting spills and releases to soil, water, and air in excess of reportable quantities. The toll free number for the U.S. Coast Guard National Response
Center is (800) 424-8802.
J. T. Baker SOLUSORB?solvent adsorbent is recommended for spills of this product.
Section 7. Handling and Storage
Protect against physical damage. Store in a cool, dry, well-ventilated location, away from any area where the fire hazard may be acute. Outside or
detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage
and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Containers of this
material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the
product.
Refer to Section 8.
Section 8. Exposure Controls/Personal Protective Equipment (PPE)
Airborne Exposure Limits:
Toluene:
?OSHA Permissible Exposure Limit (PEL):
200 ppm (TWA); 300 ppm (acceptable ceiling conc.); 500 ppm (maximum conc.)
?ACGIH Threshold Limit Value (TLV):
50 ppm (TWA) skin, A4 - Not Classifiable as a Human Carcinogen
Ventilation System
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust
ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved)
If the exposure limit is exceeded and engineering controls are not feasible, a half-face organic vapor respirator may be worn for up to ten times the
exposure limit, or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-
face piece organic vapor respirator may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate
regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-face
piece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection
Wear impervious protective clothing, including boots, heavy gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Use appropriate PPE material as substance will attack some forms of plastics, rubber, and coatings.
Eye Protection
Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work
area.
? Avoid contact and inhalation.
? Do not get in eyes, on skin, or on clothing.
? Wash thoroughly after handling.
? Irritant
? Keep tightly closed.
? Store in a cool, dry place.
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Section 9. Physical/Chemical Properties
Appearance of 1-(2-Methoxyphenyl) Piperazine (MOPIP)
Color: Off-white
Form: Liquid
Chemical Properties of MOPIP
Property Value
Boiling Point 130 C to 133 C/.1 mm
Melting Point 37 C to 40 C
Flashpoint > 230 F (95 C)
Specific Gravity 1.095
Appearance of Toluene
Color: Clear, colorless liquid
Form: Aromatic benzene-like
Chemical Properties of Toluene
Property Value
Solubility 0.05 gm/100 gm water @ 20 C (68 F)
Specific Gravity 0.86 @ 20 C / 4 C
% Volatiles by vol. @ 21 C (70 F) 100
Boiling Point 111 C (232 F)
Melting Point -95 C (-139 F)
Vapor Density (Air=1) 3.14
Vapor Pressure (mm Hg) 22 @ 20 C (68 F)
Evaporation Rate (BuAc=1) 2.24
Section 10. Stability and Reactivity
Stability
Stable under ordinary conditions of use and storage. Containers may burst when heated.
Hazardous Decomposition Products
Toxic fumes of carbon dioxide, carbon monoxide, and nitrogen oxides may form when heated to decomposition.
Hazardous Polymerization
Will not occur
Incompatibilities
Heat, flame, strong oxidizers, nitric, sulfuric, and other strong acids, chlorine, nitrogen tetraoxide; will attack some forms of plastics, rubber, coatings.
Conditions to Avoid
Heat, flames, ignition sources, and incompatibles
Section 11. Toxicological Information
Acute Effects of MOPIP:
?May be harmful by inhalation, ingestion, or skin absorption
?Vapor or mist is irritating to the eyes, mucous membranes, and upper respiratory tract.
?Causes skin irritation
To the best of our knowledge, the chemical, physical, and toxicological properties of MOPIP have not been thoroughly investigated.
Toxicological Data for Toluene
Oral rat LD50: 636 mg/kg; skin rabbit LD50: 14100 uL/kg; inhalation rat LC50: 49 gm/m3/4H; Irritation data: skin rabbit, 500 mg, Moderate; eye
rabbit, 2 mg/24H, Severe. Investigated as a tumorigen, mutagen, reproductive effector.
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Reproductive Toxicity of Toluene
Has shown some evidence of reproductive effects in laboratory animals
Cancer Lists
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
Toluene (108-88-3) No No 3
Section 12. Ecological Information
Environmental Fate
When released into the soil, this material may evaporate to a moderate extent. When released into the soil, this material is expected to leach into
groundwater. When released into the soil, this material may biodegrade to a moderate extent. When released into water, this material may evaporate
to a moderate extent. When released into water, this material may biodegrade to a moderate extent. When released into the air, this material may be
moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to have a
half-life of less than 1 day. This material is not expected to significantly bioaccumulate. This material has a log octanol-water partition coefficient of
less than 3.0. Bioconcentration factor = 13.2 (eels).
Environmental Toxicity
This material is expected to be toxic to aquatic life. The LC50/96-hour values for fish are between 10 and 100 mg/l.
Section 13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a
RCRA approved waste facility. Processing, use, or contamination of this product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local
requirements.
Section 14. Transport Information
Domestic (Land, D.O.T.) International (Water, I.M.O.)
Proper Shipping Name TOLUENE TOLUENE
Hazard Class 3 3
UN/NA UN1294 UN1294
Packing Group II II
Information reported for product/size 390 LB 390 LB
Contact company for further transportation information.
Section 15. Regulatory Information
Chemical Inventory Status - Part 1
Ingredient TSCA EC Japan Australia
Toluene (108-88-3) Yes Yes Yes Yes
Chemical Inventory Status - Part 2
Ingredient Korea DSL NDSL Phil.
Toluene (108-88-3) Yes Yes No Yes
Federal, State, & International Regulations - Part 1
---------------SARA 302--------------- ---------------SARA 313---------------
Ingredient RQ TPQ List Chemical Catg.
Toluene (108-88-3) No No Yes No
Federal, State, & International Regulations - Part 2
------------RCRA------------ ------------TSCA------------
Ingredient CERCLA 261.33 8(d)
Toluene (108-88-3) 1000 U220 No Publication No. 1700 Rev 0804 Page 5 of 6
Chemical Weapons Convention: No
TSCA 12(b): No
CDTA: Yes
SARA 311/312:
Acute: Yes
Chronic: Yes
Fire: Yes
Pressure: No
Reactivity: No (Pure / Liquid)
WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE BIRTH DEFECTS OR OTHER
REPRODUCTIVE HARM.
Australian Hazchem Code: 3[Y]E
Poison Schedule: S6
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR), and the MSDS contains all of the
information required by the CPR.
Section 16. Other Information
NFPA Ratings
Health: 2
Flammability: 3
Reactivity: 0
Label Hazard Warning:
POISON! DANGER! HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. VAPOR
HARMFUL. FLAMMABLE LIQUID AND VAPOR. MAY AFFECT LIVER, KIDNEYS, BLOOD SYSTEM, OR CENTRAL NERVOUS
SYSTEM. CAUSES IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
?Keep away from heat, sparks and flame.
?Keep container closed.
?Use only with adequate ventilation.
?Wash thoroughly after handling.
?Avoid breathing vapor.
?Avoid contact with eyes, skin, and clothing.
Label First Aid:
?Aspiration hazard. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an
unconscious person. If vomiting occurs, keep head below hips to prevent aspiration into lungs.
?If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
?In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes.
?Wash clothing before reuse.
?In all cases, call a physician immediately.
Product Use:
Laboratory Reagent
Disclaimer
For approved uses only. Not for drug, household, or other uses.
The above information is believed to be correct, but does not purport to be all-inclusive and shall be used only as a guide. SKC Inc. shall not be held
liable for any damage resulting from handling or from contact with the above product.
Publication No. 1700 Rev 0804 Page 6 of 6
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