METHYL ISOBUTYL KETONE Page 1 of 6
MSDS Number: M3588 * * * * * Effective Date: 07/06/06 * * * * * Supercedes: 08/17/05
MSDS MATERIAL SAFETY DATA SHEET CHEMTREC: 800-424-9300 (USA)
--------------------------- 703-527-3887(Outside USA and Canada)
CANUTEC: 613-996-6666
From: Mallinckrodt Baker, Inc
222 Red School Lane
Phillipsburg, NJ 08865 NOTE: Use CHEMTREC and CANUTEC
phone numbers only in the event
Emergency Telephone Number: 908-859-2151 of a chemical emergency.
All non-emergency questions should be directed to Customer Service (1-800-582-2537) for assistance.
MALLINCKRODT J. T. B A K E R
METHYL ISOBUTYL KETONE
1. Product Identification
Synonyms: 2-Pentanone,4-methyl-; Hexone; MIBK; Isopropylacetone
CAS No.: 108-10-1
Molecular Weight: 100.16
Chemical Formula: CH3COCH2CH(CH3)2
Product Codes:
J.T. Baker: 4855, 5384, 9212, 9320, 9322, 9405
Mallinckrodt: 5923, 6247, 6264
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
Methyl Isobutyl Ketone 108-10-1 90 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! HARMFUL OR FATAL IF SWALLOWED. FLAMMABLE LIQUID AND VAPOR. MAY FORM
EXPLOSIVE PEROXIDES IN AIR. HARMFUL IF INHALED. AFFECTS CENTRAL NERVOUS SYSTEM,
LIVER AND KIDNEYS. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate (Life)
Flammability Rating: 3 - Severe (Flammable)
Reactivity Rating: 2 - Moderate
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B
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METHYL ISOBUTYL KETONE Page 2 of 6
EXTINGUISHER
Storage Color Code: Red (Flammable)
-----------------------------------------------------------------------------------------------------------
Potential Health Effects
----------------------------------
Inhalation:
Causes irritation to the nose and throat. Concentrations above the TLV may cause headache, dizziness, nausea,
shortness of breath, and vomiting. Higher concentrations may cause central nervous system depression and
unconsciousness.
Ingestion:
May produce abdominal pain, nausea. Aspiration into lungs can produce severe lung damage and is a medical
emergency. Other symptoms expected to parallel inhalation.
Skin Contact:
Causes irritation to skin. Symptoms include redness, itching, and pain.
Eye Contact:
Vapors can irritate the eyes. Splashes cause severe pain and irritation.
Chronic Exposure:
Prolonged skin contact may defat the skin and produce dermatitis. Based on animal studies, chronic exposure may
affect liver and kidneys.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders, eye problems, impaired respiratory function or central nervous system
conditions may be more susceptible to the effects of this substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention.
Ingestion:
Aspiration hazard. If swallowed, vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting occurs, keep
head below hips to prevent aspiration into lungs. Never give anything by mouth to an unconscious person. Call a
physician immediately.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes.
Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get
medical attention.
5. Fire Fighting Measures
Fire:
Flash point: 14C (57F) CC
Autoignition temperature: 448C (838F)
Flammable limits in air % by volume:
lel: 1.2; uel: 8.0
Flammable Liquid
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along
surfaces to distant ignition source and flash back. Contact with strong oxidizers may cause fire. Sealed containers may
rupture when heated. Sensitivity to mechanical impact: Yes, if peroxides are formed. Sensitive to static discharge.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire exposed
containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full
facepiece operated in the pressure demand or other positive pressure mode.
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6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as
specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and
recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or
absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use
combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to
disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. US
Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The
toll free number for the US Coast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB?solvent adsorbent is recommended for spills of this product.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard
may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and
grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type
tools and equipment, including explosion proof ventilation. Before using bulk quantities of this material, test for
presence of explosive peroxides. Containers of this material may be hazardous when empty since they retain product
residues (vapors, liquid); observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
100 ppm (TWA)
-ACGIH Threshold Limit Value (TLV):
50 ppm (TWA), 75 ppm (STEL)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure
Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its
source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial
Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a full facepiece respirator with organic vapor cartridge may be worn up to 50 times
the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-
facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in
oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent
skin contact. Polyvinyl alcohol (PVA) is a recommended material for personal protective equipment.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and
quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless liquid.
Odor:
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Slight camphor odor
Solubility:
Moderately soluble in water (1-10%).
Specific Gravity:
0.80 @ 20C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
117C (243F)
Melting Point:
-85C (-121F)
Vapor Density (Air=1):
3.5
Vapor Pressure (mm Hg):
16 @ 20C (68F)
Evaporation Rate (BuAc=1):
1.6
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage. May form explosive peroxides in air.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Aldehydes, Nitric Acid, Perchloric Acid, Strong Oxidizers. Violent reaction with Potassium-tert-butoxide.
Conditions to Avoid:
Heat, flame, ignition sources, air, incompatibles
11. Toxicological Information
Oral rat LD50: 2080 mg/kg; Skin rabbit > 20 mL/kg; irritation eye rabbit, Standard Draize, 40 mg severe; investigated
as a reproductive effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Methyl Isobutyl Ketone (108-10-1) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this
material may leach into groundwater. When released into the soil, this material may evaporate to a moderate extent.
When released into water, this material may evaporate to a moderate extent. This material has an estimated
bioconcentration factor (BCF) of less than 100. This material is not expected to significantly bioaccumulate. When
released into the air, this material is expected to be readily degraded by reaction with photochemically produced
hydroxyl radicals. When released into the air, this material is expected to be readily degraded by photolysis. When
released into the air, this material is expected to have a half-life between 1 and 10 days.
Environmental Toxicity:
This material is not expected to be toxic to terrestrial life. The LC50/96-hour values for fish are over 100 mg/l.
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13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA
approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product
may change the waste management options. State and local disposal regulations may differ from federal disposal
regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: METHYL ISOBUTYL KETONE
Hazard Class: 3
UN/NA: UN1245
Packing Group: II
Information reported for product/size: 20L
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: METHYL ISOBUTYL KETONE
Hazard Class: 3
UN/NA: UN1245
Packing Group: II
Information reported for product/size: 20L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Methyl Isobutyl Ketone (108-10-1) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Methyl Isobutyl Ketone (108-10-1) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Methyl Isobutyl Ketone (108-10-1) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Methyl Isobutyl Ketone (108-10-1) 5000 U161 No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: Yes
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: Yes (Pure / Liquid)
Australian Hazchem Code: 3[Y]E
Poison Schedule: S5
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the
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MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 3 Reactivity: 1
Label Hazard Warning:
DANGER! HARMFUL OR FATAL IF SWALLOWED. FLAMMABLE LIQUID AND VAPOR. MAY FORM
EXPLOSIVE PEROXIDES IN AIR. HARMFUL IF INHALED. AFFECTS CENTRAL NERVOUS SYSTEM, LIVER
AND KIDNEYS. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT.
Label Precautions:
Keep away from heat, sparks and flame.
Avoid contact with eyes, skin and clothing.
Avoid breathing vapor.
Keep container tightly closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
Aspiration hazard. If swallowed, vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting occurs, keep
head below hips to prevent aspiration into lungs. Never give anything by mouth to an unconscious person. Call a
physician immediately. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention. In case of contact, immediately flush eyes or skin with plenty of water for
at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
Disclaimer:
************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as
to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate
precautionary handling of the material by a properly trained person using this product. Individuals receiving the
information must exercise their independent judgment in determining its appropriateness for a particular
purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)
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