Product Name: MSDS# E-4615-D Date: 10/15/2007
Liqui-Med Analgesic Gas
Mixture
Praxair Material Safety Data Sheet
1. Chemical Product and Company Identification
Product Name: Liqui-Med Analgesic Gas Mixture Liqui-Med Analgesic Gas Mixture
Trade Name:
Analgesic.
Product Use:
Liqui-Med Analgesic Gas Mixture
Chemical Name: Synonym:
Not applicable.
Chemical Formula: Not applicable. Chemical Family: Not applicable.
* 1-800-363-0042
Telephone: Emergencies: Praxair Canada Inc.
Supplier
1 City Centre Drive
/Manufacture:
Suite 1200
Mississauga, ON L5B 1M2
905-803-1600
Phone:
905-803-1682
Fax:
*Call emergency numbers 24 hours a day only for spills, leaks, fire, exposure, or accidents involving this
product. For routine information, contact your supplier or Praxair sales representative.
2. Composition and Information on Ingredients
INGREDIENTS % (VOL) CAS LD50 LC50 TLV-TWA
(Species (Rat, 4 hrs.) (ACGIH)
NUMBER
&
Routes)
10024-97-2
Nitrous oxide 50 Not Not 50 ppm
available. available.
7782-44-7
Oxygen 50 Not Not Not available.
available. available.
3. Hazards Identification
Emergency Overview
WARNING! High-pressure, oxidizing gas. Vigorously accelerates combustion. Harmful if inhaled. Can
cause rapid suffociation. May cause nervous system damage. May cause red blood cell
damage. May cause frostbite. May cause dizziness and drowsiness. May cause embryo fetal
toxicity.
Inhalation.
ROUTES OF
EXPOSURE:
THRESHOLD LIMIT VALUE: TLV-TWA Data from 2007 Guide to Occupational Exposure Values (ACGIH).
TLV-TWAs should be used as a guide in the control of health hazards and not as fine lines between safe and
dangerous concentrations.
EFFECTS OF A SINGLE (ACUTE) OVEREXPOSURE:
May cause excitation, euphoria, dizziness, drowsiness, incoordination, and narcosis.
INHALATION:
Analgesia (reduced sensitivity to pain) begins to occur at 10% nitrous oxide and exposure to
concentrations of Nitrous Oxide of 50% and greater will produce clinical anesthesia.
Anesthesia is accompanied by depressed pulse rate and high concentrations may cause
asphyxia and death. This mixture contains 50% oxygen to support life and avoid the
asphyxiation hazard of pure Nitrous oxide.
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Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
No evidence of adverse effects from available information.
SKIN CONTACT:
No evidence of adverse effects from available information.
SKIN
ABSORPTION:
An unlikely route of exposure. This product is a gas at normal temperature and pressure.
SWALLOWING:
No evidence of adverse effects from available information.
EYE CONTACT:
EFFECTS OF REPEATED (CHRONIC) OVEREXPOSURE:
Metabolic injury to the nervous system has resulted from frequent exposure to anaesthetic concentrations of Nitrous
Oxide. Complaints include numbness, tingling of hands and legs, loss of feeling in fingers, poor balance, and muscular
weakness.
OTHER EFFECTS OF OVEREXPOSURE:
Exposure to Nitrous Oxide has produced embryo fetal toxicity in laboratory animals as evidenced by reduced fetal
weight, delayed ossification, and increased incidence of visceral and skeletal variations. Exposure to Nitrous Oxide
may be associated with an increased incidence of abortion in humans. Single prolonged exposure to high
concentrations of Nitrous Oxide has resulted in bone marrow injury and adverse effects on the blood.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE:
Haemostatic gases in general, and Nitrous Oxide in particular, may suppress immunological function when
administered for anaesthetic purpose. This may reduce the resistance to infection and other immuno-dependent
disease process.
SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION:
None.
CARCINOGENICITY:
Classified A4 (Not classifiable for human or animal.) by ACGIH [Nitrous oxide].
4. First Aid Measures
INHALATION:
Remove to fresh air. If not breathing, give artifical respiration. If breathing is difficult, qualified personnel may give
oxygen. Call a physician.
SKIN CONTACT:
No emergency care anticipated.
SWALLOWING:
This product is a gas at normal temperature and pressure.
EYE CONTACT:
No emergency care anticipated.
NOTES TO PHYSICIAN:
Treatment of overexposure should be directed at the control of symptoms and the clinical condition. Nitrous Oxide may
cause vitamin B12 deficiency. Megaloblastic anemia and nervous system disorders can occur as a result of this
chemically induced deficiency.
5. Fire Fighting Measures
No. Not applicable.
FLAMMABLE : IF YES, UNDER WHAT
CONDITIONS?
Not applicable. Not applicable.
FLASH POINT AUTOIGNITION
(test method) TEMPERATURE
Not applicable. Not applicable.
FLAMMABLE LIMITS LOWER: UPPER:
IN AIR, % by volume:
EXTINGUISHING MEDIA:
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Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
This mixture cannot catch fire. Use media appropriate for surrounding fire.
SPECIAL FIRE FIGHTING PROCEDURES:
WARNING! Evacuate all personnel from danger area. Immediately deluge cylinders with water from maximum distance
until cool; then move them away from fire area if without risk. Self-contained breathing apparatus may be
required by rescue workers. If containers are leaking, reduce vapours with water spray or fog. Shut off leak
if without risk. Move containers away form fire area if without risk.
UNUSUAL FIRE AND EXPLOSION HAZARD:
Oxidizing agent; vigorously accelerates combustion. Heat of fire can build pressure in cylinder and cause it to rupture.
No part of cylinder should be subjected to a temperature higher than 52 C. Cylinders containing this mixture are
equipped with a pressure relief device. (Exceptions may exist where authorized by TDG regulations.)
HAZARDOUS COMBUSTION PRODUCTS:
See "Hazardous Decomposition Products" section.
SENSITIVITY TO IMPACT:
Avoid impact against container.
SENSITIVITY TO STATIC DISCHARGE:
Possible, see "Unusual Fire and Explosion Hazards" section.
6. Accidental Release Measures
STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED:
WARNING! High-pressure, oxidizing gas. May be harmful if inhaled. Evacuate all personnel from danger area. Use
self-contained breathing apparatus where needed. Shut off flow if you can do so without risk. Ventilate
area or move cylinder to a well-ventilated area. Test for sufficient oxygen, especially in confined spaces,
before allowing reentry.
WASTE DISPOSAL METHOD:
Prevent waste from contaminating the surrounding environment. Keep personnel away. Discard any product, residue,
disposable container, or liner in an environmentally acceptable manner, in full compliance with federal, provincial, and
local regulations. If necessary, call your local supplier for assistance.
7. Handling and Storage
PRECAUTIONS TO BE TAKEN IN STORAGE:
Store and use with adequate ventilation. Firmly secure cylinders upright to keep them from falling or being knocked
over. Screw valve protection cap firmly in place by hand. Store only where temperature will not exceed 52 C. Store full
and empty cylinders separately. Use a first-in, first-out inventory system to prevent storing full cylinders for long
periods.
PRECAUTIONS TO BE TAKEN IN HANDLING:
Protect cylinders from damage. Use a suitable hand truck to move cylinders; do not drag, roll, slide, or drop. Never
attempt to lift a cylinder by its cap; the cap is intended solely to protect the valve. Never insert an object (e.g., wrench,
screwdriver, pry bar) into cap openings; doing so may damage the valve and cause a leak. Use an adjustable strap
wrench to remove over-tight or rusted caps. Open valve slowly. If valve is hard to open, discontinue use and contact
your supplier.
For additional information on stroage and handling, refer to Compressed Gas Association (CGA) pamphlet P-1, Safe
Handling of Compressed Gases in Containers, available from the CGA. Refer to section 16 for the address and phone
number along with a list of other available publications.
OTHER HAZARDOUS CONDITIONS OF HANDLING, STORAGE, AND USE:
Copyright ?2004, Praxair Canada Inc. Page 3 of 7
Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
HIGH-PRESSURE, OXIDIZING GAS Use piping and equipment adequately designed to withstand pressures to be
encountered. Vigorously accelerates combustion. Keep oil, grease, and combustibles away. Store and use with
adequate ventilation. Close valve after each use; keep closed even when empty. Never work on a pressurized
system. If there is a leak, close the cylinder valve. Blow the system down in an environmentally safe manner in
compliance with all federal, provincial, and local laws, then repair the leak. Never allow a compressed gas cylinder to
become part of an electrical circuit. Electric arcs weaken cylinder metal and can cause catastrophic failure.
8. Exposure Controls/Personal Protection
VENTILATION/ENGINEERING CONTROLS:
LOCAL EXHAUST: Acceptable. See SPECIAL.
MECHANICAL (general): Inadequate. See SPECIAL.
SPECIAL: Use only in a closed system.
OTHER: See SPECIAL.
PERSONAL PROTECTION:
RESPIRATORY PROTECTION: Use respirable fume respirator or air supplied respirator when
working in confined space or where local exhaust or ventilation
does not keep exposure below TLV. Select in accordance with
the provincial regulations or guidelines. Selection should also be
based on the current CSA standards Z94.4, "Selection, care and
use of respirators". Respirators should be approved by NIOSH
and MSHA.
SKIN PROTECTION: Preferred for cylinder handling.
EYE PROTECTION: Wear safety glasses when handling cylinders.
Select in accordance with the current CSA standard Z94.3,
"Industrial Eye and Face Protection", and any provincial
regulations, local bylaws or guidelines.
OTHER PROTECTIVE EQUIPMENT: Metatarsal shoes for cylinder handling. Protective clothing where
needed. Cuffless trousers should be worn outside the shoes.
Select in accordance with the current CSA standard Z195,
"Protective Foot Wear", and any provincial regulations, local
bylaws or guidelines.
9. Physical and Chemical Properties
PHYSICAL STATE: FREEZING POINT: pH:
Gas. Not available. Not available.
BOILING POINT VAPOUR MOLECULAR WEIGHT:
Gas Not applicable.
Not available.
PRESSURE
Not available.
SPECIFIC SOLUBILITY IN
Not available.
GRAVITY: WATER,
LIQUID ( Water = 1)
SPECIFIC EVAPORATION COEFFICIENT OF
1.25 Not available. Not applicable.
GRAVITY: RATE WATER/OIL
DISTRIBUTION:
VAPOUR (Butyl Acetate=1):
(air = 1)
VAPOUR DENSITY: Not available. % VOLATILES BY ODOUR THRESHOLD:
100% Not available.
VOLUME:
APPEARANCE & ODOUR: Sweet odour
Copyright ?2004, Praxair Canada Inc. Page 4 of 7
Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
Colourless gas at
normal temperature
and pressure.
10. Stability and Reactivity
The product is stable.
STABILITY:
Avoid high temperatures at cylinder
CONDITIONS OF CHEMICAL INSTABILITY:
pressure. See Section VII-Preventive
Measures.
INCOMPATIBILITY (materials to avoid): Oils, greases, flammable materials, alkali
metals, aluminum, boron, tungsten carbide.
HAZARDOUS DECOMPOSITION PRODUCTS: Nitrous oxide decomposes explosively at
high temperature forming a mixture of
Nitrogen and Oxygen. This reaction will
occur at lower temperatures in the presence
of catalytic surfaces such as silver, platinum,
cobalt, copper oxides or nickel oxides.
Will not occur.
HAZARDOUS POLYMERIZATION:
CONDITIONS OF REACTIVITY: None.
11. Toxicological Information
See section 3.
12. Ecological Information
No adverse ecological effects expected. This product does not contain any Class I or Class II ozone-depleting chemicals.
The components of this mixture are not listed as marine pollutants by TDG Regulations.
13. Disposal Considerations
Do not attempt to dispose of residual or unused quantities. Return cylinder to supplier.
WASTE DISPOSAL
METHOD:
14. Transport Information
TDG/IMO SHIPPING Compressed gas, oxidizing, n.o.s.
NAME:
HAZARD IDENTIFICATION PRODUCT RQ:
CLASS: #: UN3156
CLASS 2.2: Any accidental release in a
100L
Non-flammable, quantity that could pose a danger
to public safety or any sustained
non-poisonous gas.
release of 10 minutes or more
CLASS 5.1: Oxidizing
material.
Special/Oxidizer with Class 2 at bottom.
SHIPPING LABEL(s):
Special/Oxidizer with Class 2 at bottom.
PLACARD (when
required):
SPECIAL SHIPPING INFORMATION:
Cylinders should be transported in a secure position, in a well-ventilated vehicle. Cylinders transported in an enclosed,
nonventilated compartment of vehicle can present serious safety hazards.
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Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
15. Regulatory Information
The following selected regulatory requirements may apply to this product. Not all such requirements are identified. Users of this
product are solely responsible for compliance with all applicable federal, provincial, and local regulations.
CLASS A: Compressed gas.
WHMIS (Canada)
CLASS C: Oxidizing material.
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
International Regulations
Not available.
EINECS
R8- Contact with combustible material may cause fire.
DSCL (EEC)
International Lists No products were found.
16. Other Information
MIXTURES:
When two or more gases, or liquefied gases are mixed, their hazardous properties may combine to create additional,
unexpected hazards. Obtain and evaluate the safety information for each component before you produce the mixture.
Consult an Industrial Hygienist, or other trained person when you make your safety evaluation of the end product.
Remember, gases and liquids have properties which can cause serious injury or death.
HAZARD RATING SYSTEM:
HMIS RATINGS:
HEALTH 0 *
FLAMMABILITY 0
PHYSICAL HAZARD 2
*An Asterisk used in conjuction whith HMIS health hazards ratings
designates a carcinogenic or reproductive hazard.
STANDARD VALVE CONNECTIONS FOR U.S. AND CANADA:
CGA-280
THREADED:
Not applicable.
PIN-INDEXED YOKE:
Not applicable.
ULTRA-HIGH-INTEGRITY
CONNECTION:
Use the proper CGA connections. DO NOT USE ADAPTERS. Additional limited-standard connections may
apply. See CGA pamphlets V-1 and V-7 listed below.
Ask your supplier about free Praxair safety literature as referred to in this MSDS and on the label for this product.
Further information about this product can be found in the following pamphlets published by the Compressed Gas
Association, Inc. (CGA), 4221 Walney Road, 5th Floor, Chantilly, VA 20151-2923, Telephone (703) 788-2700, Fax (703)
961-1831, website: www.cganet.com.
AV-1 Safe Handling and Storage of Compressed Gas
P-1 Safe Handling of Compressed Gases in Containers
V-1 Compressed Gas Cylinder Valve Inlet and Outlet Connections
V-7 Standard Method of Determining Cylinder Valve Outlet Connections for Industrial Gas Mixtures
-- Handbook of Compressed Gases, Forth Edition
Only medical grade gases may be administered and then only under the supervision of qualified personnel for both their
own and the patient's protection. Non-supervised inhalation of medical or non-medical gases in this class can be very
dangerous if there is no one to help control the effects. Refer to special handling procedure.
Copyright ?2004, Praxair Canada Inc. Page 6 of 7
Product Name: Liqui-Med Analgesic Gas MSDS# E-4615-D Date: 10/15/2007
Mixture
For more indepth information for each component, refer to the pure product MSDS.
The information contained in this MSDS is generated from technical sources using the Chemmate Mixture
MSDS system and the pure-product MSDS for each component. These mixtures are not tested as a whole for
chemical, physical, or health effects.
PREPARATION INFORMATION:
DATE: 10/15/2007
DEPARTMENT: Safety and Environmental Services
TELEPHONE: 905-803-1600
The opinions expressed herein are those of qualified experts within Praxair Canada Inc. We believe that the information
contained herein is current as of the date of this Material Safety Data Sheet. Since the use of this information and the
conditions of use of the product are not within the control of Praxair Canada Inc., it is the user's obligation to determine the
conditions of safe use of the product.
Praxair Canada Inc. requests the users of this product to study this Material Data Sheet (MSDS) and become aware of
product hazards and safety information. To promote safe use of this product, a user should (1) notify its employees,
agents and contractors of the information on this MSDS and any product hazards and safety nformation, (2) furnish this
same information to each of its customers for the product, and (3) request such customers to notify their employees and
customers for the product of the same product hazards and safety information.
Praxair and the Flowing Airstream design are trademarks of
Praxair Canada Inc.
Other trademarks used herein are trademarks or registered trademarks of their respective owners.
Praxair Canada Inc.
1 City Centre Drive
Suite 1200
Mississauga, ON L5B 1M2
Copyright ?2004, Praxair Canada Inc. Page 7 of 7
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