Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Section 1 - Chemical Product and Company Identification
MSDS Name:
Histomount Xylene Substitute Mountant
Catalog Numbers:
1900231, 1900233, 9999122
Synonyms:
None Known.
Company Identification:
Thermo Fisher Scientific
4481 Campus Drive
Kalamazoo, MI 49008
Company Phone Number:
(800) 522-7270
Emergency Phone Number:
(800) 424-9300
CHEMTREC Phone Number, US:
(800) 424-9300
CHEMTREC Phone Number, Europe:
(202) 483-7616
Section 2 - Composition, Information on Ingredients
EINECS/
CAS# Chemical Name: Hazard Risk Phrases
Percent ELINCS
Symbols
F XN 11 20
108-88-3 Toluene >60 203-625-9
97-86-9 Acrylate Resin <40.0 202-613-0
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: No information found
Warning! Flammable liquid and vapor. Causes eye, skin, and respiratory tract
irritation. Breathing vapors may cause drowsiness and dizziness. May be absorbed
through intact skin. Aspiration hazard if swallowed. Can enter lungs and cause
damage. Possible risk of harm to the unborn child. May cause central nervous
system depression. Flash Point: 4.4癈.
Target Organs: Central nervous system, Respiratory system, Eyes, Skin
Potential Health Effects
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Eye:
Causes eye irritation. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. Repeated or prolonged exposure may cause
drying and cracking of the skin. Not expected to cause an allergic skin reaction.
Ingestion:
May cause effects similar to those for inhalation exposure. Aspiration of material into the lungs may cause
chemical pneumonitis, which may be fatal. May cause central nervous system depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of high concentrations (>200 ppm) of toluene are clearly
associated with CNS encephalopathy, headache, depression, lassitude (weakness, exhaustion), impaired
coordination, transient memory loss, and impaired reaction time.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Repeated exposure in combination
with constant, loud noise can produce hearing loss and dizziness. Chronic hydrocarbon abuse (for
example, sniffing glue or light hydrocarbons such as contained in this material) has been associated with
irregular heart rhythms and potential cardiac arrest. Toluene abuse has been linked with kidney disease,
as evidenced by blood, protein, & pus in the urine, accompanied by elevated serum creatinine, decreased
urinary output, & metabolic & renal tubular acidosis. Although kidney toxicity has not been common in
cases of occupational toluene exposure, there has been at least one report of renal toxicity following a
40-year occupational toluene exposure. Toluene does not cause the severe injury to the bone marrow that
is characteristic of benzene poisoning.
Section 4 - First Aid Measures
Eyes:
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical
aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed
to do so by medical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs
naturally, have victim lean forward.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical aid.
Notes to Physician:
Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Section 5 - Fire Fighting Measures
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or
equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water
used to fight fire. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material
is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors are
heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground
and collect in low or confined areas. This liquid floats on water and may travel to a source of ignition and
spread fire. May accumulate static electricity.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam. Solid streams of water may be
ineffective and spread material.
Autoignition Temperature:
480癈 ( 896.00癋)
Explosion Limits:
Lower: 1.2% Upper: 7.1%
Flash Point:
4.4癈 ( 39.92癋)
NFPA Rating:
(estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information:
Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all
sources of ignition. Provide ventilation. Use only non-sparking tools and equipment. Control runoff and
isolate discharged material for proper disposal. Use water spray to cool and disperse vapors and protect
personnel.
Section 7 - Handling and Storage
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond
containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated
area away from incompatible substances. Separate from oxidizing materials.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible
exposure limits. Ventilation fans and other electrical service must be non-sparking and have an
explosion-proof design.
Exposure Limits
Chemical Name: ACGIH NIOSH OSHA
20 ppm TWA 100 ppm TWA; 375 200 ppm TWA; 300
Toluene
mg/m3 TWA 500 ppm ppm Ceiling;
IDLH
None listed None listed None listed
Acrylate Resin
OSHA Vacated PELs
Toluene: 100 ppm TWA; 375 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Color: No information found
Odor: No information found
pH: No information found
Vapor Pressure: No information found
Vapor Density: No information found
Evaporation Rate: No information found
Viscosity: No information found
Boiling Point: No information found
Freezing/Melting Point: No information found
Decomposition Temperature: No information found
Solubility in water: No information found
Specific Gravity/Density: No information found
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Molecular Formula: No information found
Molecular Weight: No information found
Section 10 - Stability and Reactivity
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces
Incompatibilities with Other Materials
Strong oxidizing agents, nitric acid, sulfuric acid
Hazardous Decomposition Products
Carbon monoxide, carbon dioxide
Hazardous Polymerization
Will not occur.
Section 11 - Toxicological Information
RTECS:
CAS# 108-88-3: XS5250000
CAS# 97-86-9: OZ4900000
LD50/LC50:
CAS# 108-88-3:
Draize test, rabbit, eye: 870 ug Mild
Draize test, rabbit, eye: 2 mg/24H Severe
Draize test, rabbit, skin: 435 mg Mild
Draize test, rabbit, skin: 500 mg Moderate
Draize test, rabbit, skin: 20 mg/24H Moderate
Inhalation, mouse: LC50 = 400 ppm/24H
Inhalation, mouse: LC50 = 30000 mg/m3/2H
Inhalation, mouse: LC50 = 19900 mg/m3/7H
Inhalation, mouse: LC50 = 10000 mg/m3
Inhalation, rat: LC50 = 49 gm/m3/4H
Oral, rat: LD50 = 636 mg/kg
Skin, rabbit: LD50 = 14100 uL/kg.
CAS# 97-86-9:
Oral, mouse: LD50 = 11990 mg/kg.
Carcinogenicity:
CAS# 108-88-3: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 97-86-9: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information available.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Teratogenicity:
In an epidemiologic study of toluene and pregnancy, occupational exposures to toluene were said to be
associated with an increased incidence of renal, urinary, gastrointestinal, and cardiac
anomalies.Fetotoxicity (reduced fetal weight), behavioural effects (effects on learning and memory) and
hearing loss (in males) were observed in the offspring of rats exposed by inhalation to toluene, in the
absence of maternal toxicity.
Reproductive:
Many reports of reproductive effects of toluene abuse or heavy occupational exposure are confounded by
mixed solvent exposure or fetal alcohol syndrome. Women exposed to toluene in lab work had a 4.7-fold
increased risk of spontaneous abortions.
Mutagenicity:
No information available.
Neurotoxicity:
No information available.
Other:
See actual entry in RTECS for complete information.
Section 12 - Ecological Information
Ecotoxicity:
Bluegill LC50=17 mg/L/24H
Shrimp LC50=4.3 ppm/96H
Fathead minnow LC50=36.2 mg/L/96H
Sunfish (fresh water) TLm=1180 mg/L/96H
Environmental:
From soil, substance evaporates and is microbially biodegraded. In water, substance volatilizes and
biodegrades.
Physical:
Photochemically produced hydroxyl radicals degrade substance.
Other:
No information found
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous
waste. US EPA guidelines for the classification determination are listed in 40 CFR Part 261.3. Additionally,
waste generators must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
RCRA P Series Wastes
None of the components are on this list.
RCRA U Series Wastes
CAS# 108-88-3: waste number U220.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Section 14 - Transport Information
US DOT Canadian TDG
RESIN SOLUTION RESIN
Proper Shipping
SOLUTION
Name:
3 3
Hazard Class:
UN1866 UN1866
UN Number:
II II
Packing Group:
USA RQ: CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ
Section 15 - Regulatory Information
US Federal
TSCA
CAS# 108-88-3 is listed on the TSCA Inventory.
CAS# 97-86-9 is listed on the TSCA Inventory.
Health and Safety Reporting List
CAS# 108-88-3: Effective 10/4/82, Sunset 10/4/92
Chemical Test Rules
TSCA Section 12b
None of the components are on this list.
TSCA Significant New Use Rule (SNUR)
None of the components are on this list.
CERCLA Hazardous Substances and corresponding RQs
CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the components are on this list.
SARA Hazard Categories
CAS# 108-88-3: immediate, fire.
CAS# 97-86-9: immediate, fire, reactive.
SARA Section 313
This material contains Toluene (CAS# 108-88-3, >60%), which is subject to the reporting requirements of
Section 313 of SARA Title III and 40 CFR Part 372.
Clean Air Act - Hazardous Air Pollutants (HAPs)
CAS# 108-88-3 is listed as a hazardous air pollutant (HAP).
Clean Air Act - Class 1 Ozone Depletors
None of the components are on this list.
Clean Air Act - Class 2 Ozone Depletors
None of the components are on this list.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Clean Water Act - Hazardous Substances
CAS# 108-88-3 is listed as a Hazardous Substance under the CWA.
Clean Water Act - Priority Pollutants
CAS# 108-88-3 is listed as a Priority Pollutant under the CWA.
Clean Water Act - Toxic Pollutants
CAS# 108-88-3 is listed as a Toxic Pollutant under the CWA.
OSHA - Highly Hazardous
None of the components are on this list.
OSHA - Specifically Regulated Chemicals
None of the components are on this list.
US State
State Right to Know
Toluene can be found on the following state Right-to-Know lists: California, New Jersey, Pennsylvania,
Minnesota, Massachusetts.
Acrylate Resin can be found on the following state Right-to-Know lists: New Jersey.
California Prop 65
WARNING: This product contains Toluene, a chemical known to the state of California to cause
developmental reproductive toxicity.
California No Significant Risk Level
None of the components are on this list.
None of the components are on this list.
European/International Regulations
European Labelling in Accordance with EC Directives:
Hazard Symbols: F XN
Risk Phrases: R 11 Highly flammable.
R 38 Irritating to skin.
R 48/20 Harmful : danger of serious damage to health by prolonged exposure through inhalation.
R 63 Possible risk of harm to the unborn child.
R 65 Harmful: may cause lung damage if swallowed.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases: S 36/37 Wear suitable protective clothing and gloves.
S 46 If swallowed, seek medical advice immediately and show this container or label.
S 62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or
label.
WGK (Water Danger/Protection)
No information found
United Kingdom Occupational Exposure Limits
No information found
United Kingdom Maximum Exposure Limits
No information found
Canadian DSL/NDSL
CAS# 108-88-3 is listed on Canada's DSL List.
CAS# 97-86-9 is listed on Canada's DSL List.
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Print Date: 12/20/07
ACC# 90756
Revision Date: 11/15/2007
Version: 9
Material Safety Data Sheet
Histomount Xylene Substitute Mountant
Canadian WHMIS Classifications
This product has a WHMIS classification of B2, D2A, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 108-88-3 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Other Information
Color information has been
MSDS Creation Date: May 24, 1999
Revision Date: November 15, 2007
Revisions were made in Sections:
14
This MSDS is intended for review and guidance in the receipt, storage, handling, use and disposal of product purchased from
us, and for no other purpose. Use this product only as directed and in accordance with applicable instructions and warnings
provided with the product. Please consult your institution's policies regarding use of this product. If you have obtained this
MSDS other than in connection with the supply of this product from us, this MSDS should be consulted for general
information only, and should not be relied upon for any purpose. As with the use of all hazardous materials, you should in all
instances follow the guidance of the MSDS provided or available with the specific product purchased.
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