MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 1 of 9
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
MONOSODIUM GLUTAMATE
SYNONYMS
C5-H8-N-O4.Na, HO2C(CH2)2CH(NH2)CO2Na, MSG, "monosodium glutamate", monosodium-L
-glutamate, monosodium-l-glutamate, "sodium glutamate monohydrate", sodium-L-glutamate,
"L sodium glutamate", "glutamic acid monosodium salt, L-", "glutamic acid, sodium salt"
, "alpha-monosodium glutamate", "chinese cooking seasoning", "flavour enhance MSG 621",
Accent, Ajinomoto, Zest, Vetsin, RL50, Glutacyl, Glutavene, "amino-acid salt"
PRODUCT USE
Used as a flavour enhancer at 0.2 to 0.9%, originally in Chinese cooking. Most effective
at pH 6 to 8. Used with sugar to sweeten bitter drugs. Material is a known SENSITISER; "
Chinese cooking syndrome" or " MSG syndrome"
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 2 of 9
Section 2 - HAZARDS IDENTIFICATION
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Ingestion may produce health damage*. Do not breathe dust.
Possible respiratory and skin sensitiser*. Take off immediately all contaminated clothing.
* (limited evidence).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
monosodium glutamate 100
Section 4 - FIRST AID MEASURES
SWALLOWED
DO NOT delay.
Rinse mouth out with plenty of water.
For advice, contact a Poisons Information Centre or a doctor.
路 IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.
路 For advice, contact a Poisons Information Centre or a doctor.
Where Medical attention is not immediately available or where the patient is more than 15
minutes from a hospital or unless instructed otherwise:
路 Induce vomiting with fingers down the back of the of the throat, ONLY IF CONSCIOUS.
路 Lean patient forward or place on left side (head-down position if possible) to maintain
open airway and prevent aspiration.
NOTE: Wear a protective glove when inducing vomiting by mechanical means.
路 In the mean time, qualified first-aid personnel should treat the patient following
observation and employing supportive measures as indicated by the patient's condition.
路 If the services of a medical officer or medical doctor are readily available, the
patient should be placed in his/her care and a copy of the MSDS should be provided.
Further action will be the responsibility of the medical specialist.
路 If medical attention is not available on the worksite or surroundings send the patient
to a hospital together with a copy of the MSDS.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If dust is inhaled, remove from contaminated area.
路 Encourage patient to blow nose to ensure clear passage of breathing.
路 If irritation or discomfort persists seek medical attention.
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 3 of 9
Section 4 - FIRST AID MEASURES
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Water spray or fog.
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves for fire only.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Solid which exhibits difficult combustion or is difficult to ignite.
路 Avoid generating dust, particularly clouds of dust in a confined or unventilated space
as dusts may form an explosive mixture with air, and any source of ignition, i.e.
flame or spark, will cause fire or explosion. Dust clouds generated by the fine
grinding of the solid are a particular hazard; accumulations of fine dust may burn
rapidly and fiercely if ignited
路 Dry dust can also be charged electrostatically by turbulence, pneumatic transport,
pouring, in exhaust ducts and during transport.
路 Build-up of electrostatic charge may be prevented by bonding and grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
路 All movable parts coming in contact with this material should have a speed of less than
1-meter/sec.
Combustion products include: carbon monoxide (CO), ammonia and nitrogen oxides (NOx).
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Gas tight chemical resistant suit.
Limit exposure duration to 1 BA set30 mins.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Wear protective clothing, gloves, safety glasses and dust respirator.
路 Use dry clean up procedures and avoid generating dust.
路 Sweep up or
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 4 of 9
Section 6 - ACCIDENTAL RELEASE MEASURES
路 Vacuum up (consider explosion-proof machines designed to be grounded during storage and
use).
路 Place in clean drum then flush area with water.
MAJOR SPILLS
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Control personal contact by using protective equipment and dust respirator.
路 Prevent spillage from entering drains, sewers or water courses.
路 Avoid generating dust.
路 Sweep, shovel up. Recover product wherever possible.
路 Put residues in labelled plastic bags or other containers for disposal.
路 If contamination of drains or waterways occurs, advise emergency services.
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ + + + + +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
Avoid generating and breathing dust.
路 Limit all unnecessary personal contact.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Glass container.
Plastic container.
Multi-ply woven plastic or paper bag with sealed plastic liner
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse.
路 Check that containers are clearly labelled.
Packaging as recommended by manufacturer.
STORAGE INCOMPATIBILITY
Avoid storage with oxidisers.
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 5 of 9
Section 7 - HANDLING AND STORAGE
STORAGE REQUIREMENTS
路 Keep dry.
路 Store under cover.
路 Store in a well ventilated area.
路 Store away from sources of heat or ignition.
路 Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
The following materials had no OELs on our records
鈥? monosodium glutamate: CAS:142-47-2 CAS:6106-04-3
MATERIAL DATA
No exposure limits set by NOHSC or ACGIH.
Material is a known SENSITISER.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields; or as required,
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Wear general protective gloves: i.e. Disposable polythene gloves or Cotton gloves or
Light weight rubber gloves, with Barrier cream preferably Safety footwear.
OTHER
路 Overalls.
路 Barrier cream
路 Eyewash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air
Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 6 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Use in a well-ventilated area.
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 Exhaust ventilation should be designed to prevent accumulation and recirculation of
particulates in the workplace.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered. Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks
路 Build-up of electrostatic charge on the dust particle, may be prevented by bonding and
grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to efficiently
remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow 1- 2.5 m/s (200- 500 f/min.)
booths, drum filling, conveyer loading,
crusher dusts, gas discharge (active
generation into zone of rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 7 of 9
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White crystalline powder; very soluble in water. Practically odourless. Soluble in
alcohol. Sodium salt of naturally occurring L(+)- glutamic acid. Monohydrate is available
as technical and food grades.
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Molecular Weight: 169.13 Boiling Range (掳C): Not applicable.
Melting Range (掳C): 200 Specific Gravity (water=1): 1.62
Solubility in water (g/L): Soluble. pH (as supplied): Not applicable
pH (1% solution): 6.7- 7.0 Vapour Pressure (kPa): 4 @ 25 deg C
Volatile Component (%vol): Not available. Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not Flash Point (掳C): Not available.
available.
Lower Explosive Limit (%): Not available. Upper Explosive Limit (%): Not available.
Autoignition Temp (掳C): Not available. Decomposition Temp (掳C): 190
State: Divided solid
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Considered an unlikely route of entry in commercial/industrial environments.
The material may be regarded as non-toxic if swallowed but may cause in some cases,
sensitisation.
Sensitisation reactions may appear suddenly after repeated
symptom free exposures.
Respiratory sensitisation may result in allergic/asthma like responses; from coughing and
minor breathing difficulties to bronchitis with wheezing, gasping.
Sensitisation may result in allergic dermatitis responses including rash, itching, hives
or swelling of extremities.
Small amounts or low dose rates are regarded as practically non-harmful.
The material may bind to the N-methyl-D-aspartate (NMDA) neuroreceptor.The receptor
regulates the flow of ions into and out of the cell. NMDA agonists such as glutamates may
be highly toxic to nerve cells in very high doses, and may contribute to the death of
brain cells in stroke, epilepsy and neurodegenerative diseases. Decreased supply of
oxygen in stroke has been shown to result in excess glutamate release.
Overactivation of glutamates and other excitatory amino-acids (EAAs) such as cysteines
and homocysteines cause excitement of nerve cells and eventually their death. Excess
calcium flow into the nerve cell occurs, triggering a vicious circle of cell damage.
Blockade of the receptor can produce amnesia in animals. While NMDA antagonists are
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 8 of 9
Section 11 - TOXICOLOGICAL INFORMATION
generally safe, in high doses they may also be harmful, causing arousal, seizures, and a
schizophrenia-like psychosis.
Large doses of calcium channel blockers may produce nausea, weakness, dizziness,
drowsiness, confusion and slurred speech. Marked and prolonged low blood pressure and
slow heart rate may result from second- or third-degree heart block, decreased cardiac
output and junctional rhythms, and can cause death.
Certain NMDA receptor antagonists may produce lightheadedness, inco-ordination and mood
elevation. Side-effects of uptake of these antagonists by nerve cells include dizziness,
inco-ordination, a feeling of well-being, muscle twitches, and initially psychic
stimulations followed by dream-filled sleep. More severe ingestions may produce visual
disturbances, fever, confusion, seizures, dilated pupils, and coma. Headache may persist
for several days.
There are a number of binding sites for the NMDA receptor.
EYE
The dust is mildly discomforting to the eyes.
SKIN
The material may be mildly discomforting to the skin if exposure is prolonged.
INHALED
The dust is slightly discomforting to the upper respiratory tract and may cause in some
cases, sensitisation.
Sensitisation reactions may appear suddenly after repeated
symptom free exposures.
Respiratory sensitisation may result in allergic/asthma like responses; from coughing and
minor breathing difficulties to bronchitis with wheezing, gasping.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are usually by ingestion and inhalation of generated dust.
The material may be regarded as non-toxic but may cause in some cases, sensitisation.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (man) TDLo: 3.57 mg/kg Nil Reported
Oral (human) TDLo: 43 mg/kg
Oral (human) TDLo: 50 mg/kg
Oral (rat) LD50: 16600 mg/kg
Reproductive Effects in animal testing.
Section 12 - ECOLOGICAL INFORMATION
No data for monosodium glutamate.
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Dilute with water and flush to sewer.
路 Decontaminate empty containers with water.
路 Recycle containers if possible, or dispose of in authorised landfill.
MONOSODIUM GLUTAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 26128
NC317TCP CD 2006/4 Page 9 of 9
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
monosodium glutamate (CAS: 142-47-2) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in
Food in General, Unless Otherwise Specified, in Accordance with GMP
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
monosodium glutamate (CAS: 6106-04-3) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in
Food in General, Unless Otherwise Specified, in Accordance with GMP
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 12-May-2005
Print Date: 5-Jan-2007
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