PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 1 of 7
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
PHARM TECH PARATAK PLUS 40
SYNONYMS
PRODUCT USE
For treatment and control of roundworms, hookworms, whipworms and all tapeworms,
including Echinococcus granulosus (Hydatids), in dogs. For oral use only.
SUPPLIER
Company: Pharm Tech Pty Ltd
Address:
8 Appolo Avenue
West Pymble
NSW, 2073
AUS
Fax: +61 500 886 669
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to
the Criteria of NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK
None under normal operating conditions.
SAFETY
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
active ingredient, as
praziquantel 55268-74-1 0-0.1
50mg/tab
pyrantel pamoate 22204-24-6 0-0.1
140mg/tab
oxantel pamoate 68813-55-8 0-0.1
545 mg/tab
continued...
PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 2 of 7
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
No other ingredient information supplied.
Section 4 - FIRST AID MEASURES
SWALLOWED
鈥? Immediately give a glass of water.
鈥? First aid is not generally required. If in doubt, contact a Poisons
Information Centre or a doctor.
EYE
If this product comes in contact with eyes:
鈥? Wash out immediately with water.
鈥? If irritation continues, seek medical attention.
鈥? Removal of contact lenses after an eye injury should only be undertaken by
skilled personnel.
SKIN
If skin or hair contact occurs:
鈥? Flush skin and hair with running water (and soap if available).
鈥? Seek medical attention in event of irritation.
INHALED
鈥? If fumes or combustion products are inhaled remove from contaminated area.
鈥? Other measures are usually unnecessary.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
鈥? There is no restriction on the type of extinguisher which may be used.
Use extinguishing media suitable for surrounding area.
FIRE FIGHTING
鈥? Use water delivered as a fine spray to control fire and cool adjacent area.
鈥? Do not approach containers suspected to be hot.
鈥? Cool fire exposed containers with water spray from a protected location.
鈥? If safe to do so, remove containers from path of fire.
鈥? Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
鈥? Non combustible.
鈥? Not considered a significant fire risk, however containers may burn.
FIRE INCOMPATIBILITY
None known.
HAZCHEM
None
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PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 3 of 7
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Vacuum or sweep up.
MAJOR SPILLS
鈥? Minor hazard.
鈥? Clear area of personnel.
鈥? Alert Fire Brigade and tell them location and nature of hazard.
鈥? Wear physical protective gloves e.g. Leather.
鈥? Contain spill/secure load if safe to do so.
鈥? Bundle/collect recoverable product and label for recycling.
鈥? Collect remaining product and place in appropriate containers for disposal.
鈥? Clean up/sweep up area.
鈥? Water may be required.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
鈥? Limit all unnecessary personal contact.
鈥? Wear protective clothing when risk of exposure occurs.
鈥? Use in a well-ventilated area.
鈥? When handling DO NOT eat, drink or smoke.
鈥? Always wash hands with soap and water after handling.
鈥? Avoid physical damage to containers.
鈥? Use good occupational work practice.
鈥? Observe manufacturer's storing and handling recommendations.
SUITABLE CONTAINER
鈥? Polyethylene or polypropylene container.
鈥? Packing as recommended by manufacturer
鈥? Check all containers are clearly labelled and free from leaks.
No restriction on the type of containers. Packing as recommended by
manufacturer. Check all material is clearly labelled.
STORAGE INCOMPATIBILITY
Avoid contamination of water, foodstuffs, feed or seed.
STORAGE REQUIREMENTS
鈥? Store in original containers.
鈥? Keep containers securely sealed.
鈥? Store in a cool, dry, well-ventilated area.
鈥? Store away from incompatible materials and foodstuff containers.
鈥? Protect containers against physical damage and check regularly for leaks.
鈥? Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
No data available: praziquantel as (CAS: 55268-74-1)
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PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 4 of 7
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
No data available: praziquantel as (CAS: 55268-74-1)
No data available: pyrantel pamoate as (CAS: 22204-24-6)
No data available: oxantel pamoate as (CAS: 68813-55-8)
No data available: pyrantel pamoate as (CAS: 22204-24-6)
No data available: oxantel pamoate as (CAS: 68813-55-8)
No data for Pharm Tech Paratak Plus 40.
INGREDIENT DATA
For each of the following
PRAZIQUANTEL:
PYRANTEL PAMOATE:
OXANTEL PAMOATE:
Airborne particulate or vapour must be kept to levels as low as is practicably
achievable given access to modern engineering controls and monitoring hardware.
Biologically active compounds may produce idiosyncratic effects which are
entirely unpredictable on the basis of literature searches and prior clinical
experience (both recent and past).
PERSONAL PROTECTION
EYE
No special equipment needed when handling small quantities.
HANDS/FEET
No special equipment needed when handling small quantities.
OTHER
None under normal operating conditions.
The local concentration of material, quantity and
conditions of use determine the type of personal
protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
None under normal operating conditions.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Pale, yellow, oval shaped, flat tablet with flat edges and slightly curved top
and bottom. The tablet is branded Bomac on one side with a single score line on
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PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 5 of 7
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
the other side.
PHYSICAL PROPERTIES
Molecular Weight: Not Applicable Boiling Range (C): Not Applicable
Melting Range (C): Not Available Specific Gravity (water=1): Not Available
Solubility in water (g/L): Not Available pH (as supplied): Not Available
pH (1% solution): Not Available Vapour Pressure (kPa): Not Available
Volatile Component (%vol): Not Available Evaporation Rate: Not Applicable
Relative Vapour Density (air=1): Not Applicable Flash Point (C): Not Applicable
Lower Explosive Limit (%): Not Available Upper Explosive Limit (%): Not Available
Autoignition Temp (C): Not Available Decomposition Temp (掳C): Not Available
State: Manufactured Viscosity: Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
Product is considered stable and hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The material has NOT been classified by EC Directives or other classification
systems as "harmful by ingestion". This is because of the lack of corroborating
animal or human evidence. The material may still be damaging to the health of
the individual, following ingestion, especially where pre-existing organ (eg.
liver, kidney) damage is evident. Present definitions of harmful or toxic
substances are generally based on doses producing mortality rather than those
producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may
produce nausea and vomiting. In an occupational setting however, ingestion of
insignificant quantities is not thought to be cause for concern.
EYE
Although the material is not thought to be an irritant (as classified by EC
Directives), direct contact with the eye may produce transient discomfort
characterised by tearing or conjunctival redness (as with windburn).
SKIN
The material is not thought to produce adverse health effects or skin irritation
following contact (as classified by EC Directives using animal models).
Nevertheless, good hygiene practice requires that exposure be kept to a minimum
and that suitable gloves be used in an occupational setting.
INHALED
The material is not thought to produce adverse health effects or irritation of
the respiratory tract (as classified by EC Directives using animal models).
Nevertheless, good hygiene practice requires that exposure be kept to a minimum
and that suitable control measures be used in an occupational setting.
CHRONIC HEALTH EFFECTS
Long-term exposure to the product is not thought to produce chronic effects
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PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 6 of 7
Section 11 - TOXICOLOGICAL INFORMATION
adverse to the health (as classified by EC Directives using animal models);
nevertheless exposure by all routes should be minimised as a matter of course.
TOXICITY AND IRRITATION
Not available. Refer to individual constituents.
unless otherwise specified data extracted from RTECS - Register of Toxic Effects
of Chemical Substances
PRAZIQUANTEL:
TOXICITY IRRITATION
Oral (rat) LD50: 2840 mg/kg Nil Reported
Intraperitoneal (rat) LD50: 586 mg/kg
Subcutaneous (rat) LD50: >16000 mg/kg
Intramuscular (rat) LD50: >2000 mg/kg
Oral (mouse) LD50: 2454 mg/kg
Intraperitoneal (mouse) LD50: 376 mg/kg
Subcutaneous (mouse) LD50: 7172 mg/kg
Intramuscular (mouse) LD50: >2000 mg/kg
Oral (dog) LD50: >200 mg/kg
Oral (rabbit) LD50: 1050 mg/kg
NOTE: Substance has been shown to be mutagenic in at least one assay, or belongs
to a family of chemicals producing damage or change to cellular DNA.
* Bayer
ADI: 0.02 mg/kg/day
NOEL: 20 mg/kg/day
PYRANTEL PAMOATE:
TOXICITY IRRITATION
Oral (rat) LD50: >24000 mg/kg Nil Reported
Oral (rat) LD50: >4000 mg/kg *
Intraperitoneal (rat) LD50: 198 mg/kg *
Oral (mouse) LD: >24000 mg/kg
Oral (mouse) LD50: >5000 mg/kg *
Intraperitoneal (mouse) LD50: 205 mg/kg *
NOAEL rat, rabbit 250 mg/kg/day. * [* = PFIZER]
Somnolence, convulsions, respiratory stimulation, foetotoxicity, maternal
effects, effects on newborn recorded.
OXANTEL PAMOATE:
No significant acute toxicological data identified in literature search.
Section 12 - ECOLOGICAL INFORMATION
Refer to data for ingredients, which follows:
PRAZIQUANTEL:
Ecotoxicology:
Fish LC0 (96 h): Zebra barbel (Brachydanio rerio) 31.6 mg/l
LC100 (96 h): " " " 100 mg/l
Daphnia EC50 (48 h): 35 mg/l
EC100 (48 h): 100 mg/l
Bacterial toxicity EC50: >10000 mg/l; activated sludge
Water pollution class (WGK): 1 - slight water hazard (Bayer classification)
WGK: Classification in accordance with German Water Resources Act.
EC50 is the Median Effective Concentration necessary to produce the biological
effect under study in 50% of the test species.
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PHARM TECH PARATAK PLUS 40
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jun-2005 CHEMWATCH 4638-49
CD 2006/1 Page 7 of 7
Section 13 - DISPOSAL CONSIDERATIONS
鈥? Recycle wherever possible or consult manufacturer for recycling options.
鈥? Consult State Land Waste Management Authority for disposal.
鈥? Bury residue in an authorised landfill.
鈥? Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM
None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN,IATA,IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
None
REGULATIONS
praziquantel (CAS: 55268-74-1) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
Australia Poisons Schedule
pyrantel pamoate (CAS: 22204-24-6) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
Australia Poisons Schedule
oxantel pamoate (CAS: 68813-55-8) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
Australia Poisons Schedule
Section 16 - OTHER INFORMATION
This document is copyright. Apart from any fair dealing for the purposes of
private study, research, review or criticism, as permitted under the Copyright
Act, no part may be reproduced by any process without written permission from
CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 22-Jun-2005
Print Date: 9-Aug-2006
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