SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 11/12/2003
Date Updated: 09/05/2002
Version 1.1
Section 1 - Product and Company Information
Product Name POTASSIUM BROMATE, 99.8%, A.C.S.
REAGENT
Product Number 309087
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
POTASSIUM BROMATE 7758-01-2 Yes
Formula KBrO3
Synonyms EEC No. E924,Potassium bromate
RTECS Number: EF8725000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Toxic.
May cause cancer. Explosive when mixed with combustible material.
Toxic if swallowed. Irritating to eyes, respiratory system and
skin.
Target organ(s): Kidneys. Ears.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Contact with other material may cause fire.
Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid all contact. Do not
get in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame. Store in a cool dry
place.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
Section 9 - Physical/Chemical Properties
Appearance Color: Colorless
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 167.01 AMU
pH 5-8
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 3.27 g/cm3
Bulk Density N/A
Odor Threshold N/A
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Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 M in H2O, 20掳C
complete, colorless
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong reducing agents, Finely powdered metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Hydrogen bromide gas, Oxygen.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Absorption: May be harmful if absorbed through the skin.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed. Ingestion can cause nausea,
vomiting, diarrhea, abdominal pain, and hemolysis.
Multiple Routes: Causes eye and skin irritation.
TARGET ORGAN(S) OR SYSTEM(S)
Kidneys. Ears. Liver. Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer.
TOXICITY DATA
Oral Oral
Rat Rat
157 mg/kg 321 mg/kg
LD50 LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Gastrointestinal:Hypermotility,
diarrhea. Behavioral:Change in motor activity (specific assay).
Lungs, Thorax, or Respiration:Respiratory stimulation.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
Intraperitoneal Intraperitoneal
Rat Rat
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50 MG/KG 50 MG/KG
LD50 LD50
Oral Oral
Mouse Mouse
289 mg/kg 289 mg/kg
LD50 LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
177 MG/KG 177 MG/KG
LD50 LD50
Oral
Hamster
388 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Lungs, Thorax, or Respiration:Respiratory
stimulation. Gastrointestinal:Hypermotility, diarrhea.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 4200 MG/KG 4200 MG/KG
Exposure Time: 13W 13W
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors. Tumorigenic:Carcinogenic by RTECS
criteria. Gastrointestinal:Tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 38500 MG/KG 38500 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic:Carcinogenic by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 19635 MG/KG 19635 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Endocrine:Thyroid tumors.
Tumorigenic:Carcinogenic by RTECS criteria. Kidney, Ureter,
Bladder:Kidney tumors. Endocrine:Thyroid tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 19250 MG/KG 19250 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic:Carcinogenic by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
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Species: Rat Rat
Route of Application: Oral Oral
Dose: 10500 MG/KG 10500 MG/KG
Exposure Time: 39W 39W
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 9625 MG/KG 9625 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Endocrine:Thyroid tumors.
Tumorigenic:Carcinogenic by RTECS criteria. Kidney, Ureter,
Bladder:Kidney tumors. Endocrine:Thyroid tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 9625 MG/KG 9625 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic:Carcinogenic by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 5460 MG/KG 5460 MG/KG
Exposure Time: 2Y 2Y
Frequency: C C
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic:Neoplastic by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Species: Rat Rat
Route: Intraperitoneal Intraperitoneal
Dose: 60 MG/KG 60 MG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Rat Rat
Route: Intraperitoneal Intraperitoneal
Dose: 80 MG/KG 80 MG/KG
Mutation test: DNA damage DNA damage
Species: Rat Rat
Route: Intraperitoneal Intraperitoneal
Dose: 251 MG/KG 251 MG/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Rat Rat
Route: Oral Oral
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Dose: 3 MMOL/KG 3 MMOL/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Rat Rat
Dose: 20 UMOL/L 20 UMOL/L
Cell Type: leukocyte leukocyte
Mutation test: Sister chromatid exchange Sister chromatid
exchange
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 25 MG/KG 25 MG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Mouse Mouse
Route: Oral Oral
Dose: 200 MG/KG 200 MG/KG
Exposure Time: 24H 24H
Mutation test: Micronucleus test Micronucleus test
Species: Mouse Mouse
Dose: 7500 UMOL/L 7500 UMOL/L
Cell Type: leukocyte leukocyte
Mutation test: DNA damage DNA damage
Species: Hamster Hamster
Dose: 125 MG/L 125 MG/L
Cell Type: lung lung
Mutation test: Micronucleus test Micronucleus test
Species: Hamster Hamster
Dose: 85 MG/L 85 MG/L
Cell Type: lung lung
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Pig Pig
Dose: 7500 UMOL/L 7500 UMOL/L
Cell Type: kidney kidney
Mutation test: DNA damage DNA damage
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Potassium bromate
UN#: 1484
Class: 5.1
Packing Group: Packing Group II
Hazard Label: Oxidizer
PIH: Not PIH
IATA
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Proper Shipping Name: Potassium bromate
IATA UN Number: 1484
Hazard Class: 5.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: O T
Indication of Danger: Oxidizing. Toxic.
R: 45 9 25
Risk Statements: May cause cancer. Explosive when mixed with
combustible material. Also toxic if swallowed.
S: 53 45
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Toxic.
Risk Statements: May cause cancer. Explosive when mixed with
combustible material. Toxic if swallowed. Irritating to eyes,
respiratory system and skin.
Safety Statements: Keep away from combustible material. Avoid
exposure - obtain special instructions before use. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible). Wear suitable protective
clothing, gloves, and eye/face protection.
US Statements: Target organ(s): Kidneys. Ears.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: California Proposition 65: This product is
or contains chemical(s) known to the state of California to
cause cancer. California Proposition 65: This product is or
contains chemical(s) known to the state of California to cause
cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
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Sigma-Aldrich Inc., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License
granted to make unlimited paper copies for internal use only.
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