MATERIAL SAFETY DATA SHEET
MORPHINE SULFATE
PADDOCK LABORATORIES, INC. EMERGENCY ASSISTANCE:
3940 QUEBEC AVENUE NORTH CHEMTREC 800-424-9300
MINNEAPOLIS, MINNESOTA 55427 202-483-7616
PHONE: (763)-546-4676 PADDOCK TECH. ASST. 800-328-5113
SECTION 1 - PRODUCT IDENTIFICATION AND HAZARDOUS COMPONENTS
PRODUCT NAME: Morphine Sulfate, USP
SYNONYMS: N/A
MOLECULAR FORMULA: C34 H40 N2 O10 S MOLECULAR WEIGHT: 668.76
CHEMICAL NAME: 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol sulfate salt (2:1)
pentahydrate
CHEMICAL FAMILY: Narcotic analgesic (CII)
INGREDIENT (CAS NUMBER) % OSHA PEL ACGIH TLV
Morphine sulfate (6211-15-0) Pure material N/A N/A
SECTION 2 - PHYSICAL AND CHEMICAL CHARACTERISTICS
BOILING POINT: N/A VAPOR PRESSURE: N/A
~250o C (decomp.)
MELTING POINT: VAPOR DENSITY: N/A
DENSITY: ~1.3 EVAPORATION RATE: N/A
(BUTYL ACETATE = 1)
1 gm/15.5 mL (@25o C)
WATER SOLUBILITY: WATER REACTIVE: No
APPEARANCE AND ODOR: Fine, white, odorless powder.
SECTION 3 - FIRE AND EXPLOSION DATA
FLASH POINT (METHOD): N/A NFPA RATING: N/A
AUTOIGNITION TEMPERATURE: N/A
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FLAMMABLE LIMITS: LOWER: N/A UPPER: N/A
EXTINGUISHING MEDIA: Water spray, carbon dioxide, dry chemical, or foam as appropriate for
surrounding fire conditions and materials.
SPECIAL FIRE FIGHTING PROCEDURES: Fire fighters should wear full protective gear including
self-contained breathing apparatus.
UNUSUAL FIRE AND EXPLOSION HAZARDS: As with most organic compounds, this material may be
flammable at elevated tempertures and produce toxic fumes if heated to decomposition under fire conditions.
SECTION 4 - REACTIVITY HAZARD DATA
STABILITY: This product is stable but will darken upon exposure to light.
INCOMPATIBILITY (MATERIALS TO AVOID): Alkalies, tannic acid, iodic acid, potassium
permanganate, borax, chlorates, ferric chloride, iodides, lead acetate, magnesia, spirit nitrous ether, mercury
bichloride, gold salts.
HAZARDOUS DECOMPOSITION PRODUCTS: As with any organic compound, this material may
produce toxic fumes if heated to decomposition.
HAZARDOUS POLYMERIZATION: May Occur ( ) Will Not Occur ( X )
SECTION 5 - HEALTH HAZARD DATA
TOXICITY: LD50 : Oral (rat) 461 mg/kg
Oral (mouse) 600 mg/kg
Investigated as a mutagen, reproductive effector.
CARCINOGEN LISTED BY: NTP Yes ( ) No ( X )
IARC Yes ( ) No ( X )
OSHA Yes ( ) No ( X )
Other Yes ( ) No ( X )
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
INHALATION: Narcotic. May irritate respiratory tract. Produces anesthetic effect. Inhalation of
significant quantities may produce lung edema, dizziness, and respiratory difficulties (see Ingestion).
EYE CONTACT: May cause slight to moderate irritation. Will have strong narcotic effect evidenced
by pupil contraction. Significant absorption may occur.
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SKIN CONTACT: May cause slight irritation, absorption may occur through skin breakage or
inflammation.
INGESTION: Narcotic. Human lethal dose estimated to be 120-250 mg of morphine sulfate. In
addition to analgesic action, may cause gastric disturbance, nausea, vomiting, and constipation.
Ingestion of large amounts may cause central nervous system depression, respiratory or cardiac
collapse, coma and death.
CHRONIC EFFECTS OF OVEREXPOSURE: May cause addiction. Possible hypersensitization to this
material.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Sensitization may occur evidenced by
skin rashes, cough, stuffy nose, asthma and other allergic complaints.
OTHER PRECAUTIONS TO CONSIDER: Persons developing hypersensitivity (anaphylactic) reactions must
receive immediate medical attention.
EMERGENCY FIRST AID PROCEDURES:
INHALATION: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Seek immediate medical attention.
EYE CONTACT: Flush with plenty of water for at least 15 minutes. Seek medical attention.
SKIN CONTACT: Flush area thoroughly with water for at least 15 minutes and seek immediate
medical attention.
INGESTION: Flush mouth out with water and induce vomiting. Seek medical attention or contact a
poison control center immediately.
SECTION 6 - CONTROL AND PROTECTIVE MEASURES
RESPIRATORY PROTECTION: Use of a NIOSH/MSHA-approved dust/mist respirator is recommended.
PROTECTIVE GLOVES: Latex gloves recommended.
EYE PROTECTION: Safety glasses or goggles. Avoid wearing contact lenses when working with this or any
chemical due to the possibility of increased severity of eye damage should contact occur.
VENTILATION: Source-capture local exhaust is recommended to avoid generation of significant airborne
dust levels.
OTHER PROTECTIVE EQUIPMENT: It is recommended that a safety shower and eyewash station be
maintained in the work area.
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HYGIENIC WORK PRACTICES: Wash thoroughly after handling and remove and wash contaminated
clothing before reuse.
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SECTION 7 - HANDLING AND STORAGE PRECAUTIONS
HANDLING PRECAUTIONS: Avoid contact with eyes, skin or clothing. Wash thoroughly after handling
and wash any contaminated clothing before reuse.
STORAGE PRECAUTIONS: Store in a tightly closed container in a cool, dry location. Avoid exposure to
direct sunlight. SCHEDULE 2 (C-II) CONTROLLED SUBSTANCE. Storage location must meet all
applicable Drug Enforcement Agency regulations.
SECTION 8 - SPILL AND DISPOSAL PROCEDURES
STEPS TO BE TAKEN IN CASE OF SPILL OR DISCHARGE: Wearing suitable eye, hand, and
respiratory protection sweep or vacuum up spillage and place in a tight container. Wash spill site. Wash
thoroughly or shower after handling and wash all clothing before reuse.
WASTE DISPOSAL METHOD: Dispose of in accordance with all applicable local, state, federal, and
environmental regulations.
SECTION 9 - DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources and is
believed to be correct as of the date issued. It is the responsibility of the user to determine the appropriateness
and applicability to their situation. Paddock Laboratories, Inc. disclaims any expressed or implied warranty as
to the accuracy of the above information and shall not be held liable for any direct, incidental, or consequential
damages from use or reliance on the above information.
____________________________________________________________________________________
DEFINITIONS OF ABBREVIATIONS USED:
ACGIH: American Conference of Governmental Industrial Hygienists
CAS: Chemical Abstract Service
IARC: Internal Agency for Research on Cancer
IDLH: Immediately Dangerous to Life or Health level
LC50 : Median Lethal Concentration
LD50 : Median Lethal Dose
MSHA: Mine Safety and Health Administration
N/A: Not available
NIOSH: National Institute for Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
TWA: Time Weighted Average
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